{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:18Z","timestamp":1791288678635,"version":"4.3.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer&apos;s Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014729","name":"Philip Morris International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.brainres.2006.09.084","type":"journal-article","created":{"date-parts":[[2006,10,28]],"date-time":"2006-10-28T07:18:00Z","timestamp":1162019880000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Aberrant localization of importin \u03b11 in hippocampal neurons in Alzheimer disease"],"prefix":"10.1016","volume":"1124","author":[{"given":"Hyoung-gon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.09.084_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00005072-198703000-00006","article-title":"Hirano body filaments contain actin and actin-associated proteins","volume":"46","author":"Galloway","year":"1987","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2006.09.084_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2990.1994.tb00951.x","article-title":"Hirano bodies and related neuronal inclusions","volume":"20","author":"Hirano","year":"1994","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2006.09.084_bib3","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1073\/pnas.0505598103","article-title":"ALADINI482S causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome","volume":"103","author":"Hirano","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.09.084_bib4","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1002\/j.1460-2075.1995.tb00031.x","article-title":"In vivo evidence for involvement of a 58\u00a0kDa component of nuclear pore-targeting complex in nuclear protein import","volume":"14","author":"Imamoto","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2006.09.084_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF00305865","article-title":"Elucidation of three-dimensional ultrastructure of Hirano bodies by the quick-freeze, deep-etch and replica method","volume":"81","author":"Izumiyama","year":"1991","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.brainres.2006.09.084_bib6","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/sj.cdd.4401432","article-title":"Multiple mechanisms promote the inhibition of classical nuclear import upon exposure to severe oxidative stress","volume":"11","author":"Kodiha","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainres.2006.09.084_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00401-004-0820-8","article-title":"Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease","volume":"107","author":"Lee","year":"2004","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.brainres.2006.09.084_bib8","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1128\/MMBR.65.4.570-594.2001","article-title":"Transport into and out of the nucleus","volume":"65","author":"Macara","year":"2001","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.brainres.2006.09.084_bib9","first-page":"1933","article-title":"Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease","volume":"150","author":"McShea","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2006.09.084_bib10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/BF01216709","article-title":"Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease","volume":"17","author":"Metuzals","year":"1988","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.brainres.2006.09.084_bib11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1083\/jcb.200312008","article-title":"Cellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import block","volume":"165","author":"Miyamoto","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2006.09.084_bib12","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1074\/jbc.M106845200","article-title":"Pathways mediating the nuclear import of histones H3 and H4 in yeast","volume":"277","author":"Mosammaparast","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.09.084_bib13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2006.09.084_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.1474-9728.2003.00042.x","article-title":"Increased p27, an essential component of cell cycle control, in Alzheimer's disease","volume":"2","author":"Ogawa","year":"2003","journal-title":"Aging Cell"},{"key":"10.1016\/j.brainres.2006.09.084_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00401-003-0684-3","article-title":"Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?","volume":"105","author":"Ogawa","year":"2003","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.brainres.2006.09.084_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-1998-1103","article-title":"Reactive oxygen species mediate cellular damage in Alzheimer disease","volume":"1","author":"Perry","year":"1998","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.brainres.2006.09.084_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.jnen.0000195939.40410.08","article-title":"Nuclear pore complex proteins in Alzheimer disease","volume":"65","author":"Sheffield","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2006.09.084_bib18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0092-8674(03)00082-5","article-title":"Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle","volume":"112","author":"Weis","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2006.09.084_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrm1331","article-title":"Nucleocytoplasmic shuttling of signal transducers","volume":"5","author":"Xu","year":"2004","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2006.09.084_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/bbrc.2000.3098","article-title":"Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor","volume":"274","author":"Zeng","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2006.09.084_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1471-4159.2003.01820.x","article-title":"Distribution, levels, and activation of MEK1 in Alzheimer's disease","volume":"86","author":"Zhu","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.09.084_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1385\/MN:31:1-3:205","article-title":"Oxidative imbalance in Alzheimer's disease","volume":"31","author":"Zhu","year":"2005","journal-title":"Mol. Neurobiol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306028599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306028599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:53:10Z","timestamp":1762102390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306028599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0006899306028599"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.09.084","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant localization of importin \u03b11 in hippocampal neurons in Alzheimer disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2006.09.084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}