{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:44:32Z","timestamp":1790250272814,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.brainres.2006.12.011","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T13:26:01Z","timestamp":1167917161000},"page":"77-84","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Lipid-lowering drugs in the MPTP mouse model of Parkinson's disease: Fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not"],"prefix":"10.1016","volume":"1135","author":[{"given":"Alexandre","family":"Kreisler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Gel\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Wiart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lhermitte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Dest\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Bordet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.12.011_bib1","first-page":"25","article-title":"Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease","volume":"12","author":"Anglade","year":"1996","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.brainres.2006.12.011_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2006.12.011_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1471-4159.2002.00990.x","article-title":"Protective action of the peroxisome proliferators-activated receptor-\u03b3 agonist pioglitazone in a mouse model of Parkinson's disease","volume":"82","author":"Breidert","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.12.011_bib4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/00031305.1981.10479327","article-title":"Rank transformations as a bridge between parametric and nonparametric statistics","volume":"35","author":"Conover","year":"1981","journal-title":"Am. Stat."},{"key":"10.1016\/j.brainres.2006.12.011_bib5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1471-4159.2003.02210.x","article-title":"Protection with pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation","volume":"88","author":"Dehmer","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.12.011_bib6","doi-asserted-by":"crossref","first-page":"32048","DOI":"10.1074\/jbc.274.45.32048","article-title":"Peroxisome proliferator-activated receptor \u03b1 regulates the inflammatory gene response by negative cross-talk with transcription factors NF-kB and AP-1","volume":"274","author":"Delerive","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.12.011_bib7","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1523\/JNEUROSCI.23-15-06264.2003","article-title":"Peroxisome proliferator-activated receptor-\u03b1 activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment","volume":"23","author":"Deplanque","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2006.12.011_bib8","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(92)90031-7","article-title":"Control of peroxisomal beta-oxidation pathway by a novel family of nuclear receptors","volume":"68","author":"Dreyer","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2006.12.011_bib9","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1996"},{"key":"10.1016\/j.brainres.2006.12.011_bib10","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1073\/pnas.040556597","article-title":"Caspase 3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease","volume":"97","author":"Hartmann","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.12.011_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neulet.2004.11.021","article-title":"Long-chain fatty acids increase cellular dopamine in an immortalized cell line (MN9D) derived from mouse mesencephalon","volume":"376","author":"Heller","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.12.011_bib12","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1128\/IAI.67.7.3488-3493.1999","article-title":"Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia","volume":"67","author":"Hill","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.brainres.2006.12.011_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jneumeth.2004.02.011","article-title":"High-performance liquid chromatography\/tandem mass spectroscopy assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates","volume":"137","author":"Hows","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2006.12.011_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0306-4522(95)00578-1","article-title":"Nitric oxide synthase and neuronal vulnerability in Parkinson's disease","volume":"72","author":"Hunot","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2006.12.011_bib15","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1073\/pnas.94.14.7531","article-title":"Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease","volume":"94","author":"Hunot","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.12.011_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/meta.2001.19415","article-title":"The ligands\/activators for peroxisome proliferators-activated receptor alpha (PPAR alpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells","volume":"50","author":"Inoue","year":"2001","journal-title":"Metabolism"},{"key":"10.1016\/j.brainres.2006.12.011_bib17","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/01.CIR.0000112596.06954.00","article-title":"Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-alpha partly via blockade of c-Jun NH2-terminal kinase pathway","volume":"109","author":"Irukayama-Tomobe","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2006.12.011_bib18","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1097\/00001756-199412000-00019","article-title":"Localization of the peroxisome proliferator-activated receptor in the brain","volume":"20","author":"Kainu","year":"1994","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2006.12.011_bib19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0021-9150(03)00301-0","article-title":"All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells","volume":"170","author":"Kaneta","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.brainres.2006.12.011_bib20","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1073\/pnas.90.6.2160","article-title":"Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers","volume":"90","author":"Keller","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.12.011_bib21","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1523\/JNEUROSCI.5236-05.2006","article-title":"The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr 1 activation","volume":"26","author":"Kim","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2006.12.011_bib22","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1210\/mend.11.6.0007","article-title":"Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay","volume":"11","author":"Krey","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.brainres.2006.12.011_bib23","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1172\/JCI10852","article-title":"Statin-induced inhibition of the Rho-signaling pathway activates PPAR alpha and induces HDL apo-A","volume":"107","author":"Martin","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2006.12.011_bib24","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1161\/01.CIR.99.24.3125","article-title":"PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells","volume":"99","author":"Marx","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2006.12.011_bib25","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2006.12.011_bib26","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1046\/j.1460-9568.1999.00774.x","article-title":"Immunocytochemical characterization of catecholaminergic neurons in the rat striatum following dopamine-depleting lesions","volume":"11","author":"Meredith","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2006.12.011_bib27","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1074\/jbc.270.10.5511","article-title":"p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-jun kinase, JNK1","volume":"270","author":"Milne","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.12.011_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2003.08.064","article-title":"Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS","volume":"123","author":"Moreno","year":"2003","journal-title":"Neurosciences"},{"key":"10.1016\/j.brainres.2006.12.011_bib29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0006-8993(00)02011-4","article-title":"Protective effect of fluvastatin, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on MPP+-induced hydroxyl radical in the rat striatum","volume":"860","author":"Obata","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.12.011_bib30","first-page":"16725","article-title":"Activation of c-jun N-terminal kinase antagonizes an anti-apoptotic function of Bcl-2","volume":"272","author":"Park","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.12.011_bib31","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.yexcr.2004.03.034","article-title":"Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferators-activated receptor-gamma via the JNK-dependent pathway","volume":"297","author":"Park","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainres.2006.12.011_bib32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0306-4522(01)00295-0","article-title":"Mouse model of parkinsonism: a comparison between subacute MPTP and chronic MPTP\/probenecid treatment","volume":"106","author":"Petroske","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2006.12.011_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/cimm.1999.1525","article-title":"Age-associated alterations in splenic iNOS regulation: influence of constitutively expressed IFN-gamma and correction following supplementation with PPARalpha activators or vitamin E","volume":"195","author":"Poynter","year":"1999","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.brainres.2006.12.011_bib34","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.taap.2003.08.009","article-title":"Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors","volume":"193","author":"Rabkin","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.brainres.2006.12.011_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/carcin\/19.1.43","article-title":"Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha)","volume":"19","author":"Roberts","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.brainres.2006.12.011_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0300-483X(02)00275-5","article-title":"PPAR alpha and the regulation of cell division and apoptosis","volume":"181\u2013182","author":"Roberts","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.brainres.2006.12.011_bib37","first-page":"732","article-title":"The neuroprotective effect of atorvastatin in a murine MCAO model id dependent on PPAR\u03b1","volume":"37","author":"Sayah-Jeanne","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2006.12.011_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1001958023096","article-title":"MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences","volume":"30","author":"Sedelis","year":"2000","journal-title":"Behav. Genet."},{"key":"10.1016\/j.brainres.2006.12.011_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2004.02.083","article-title":"Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice","volume":"1037","author":"Selley","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.12.011_bib40","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/31701","article-title":"Activation of human aortic smooth-muscle cells is inhibited by PPAR\u03b1 but not by PPAR\u03b3 activators","volume":"393","author":"Staels","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2006.12.011_bib41","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1074\/jbc.274.13.8531","article-title":"Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NfkappaB activation in primary hippocampal neurons","volume":"274","author":"Tamatani","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.12.011_bib43","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1096\/fj.01-0793com","article-title":"Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarction size","volume":"16","author":"Wayman","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2006.12.011_bib44","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1357-2725(00)00044-3","article-title":"Lovastatin and simvastatin are modulators of the proteasome","volume":"32","author":"Wojcik","year":"2000","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2006.12.011_bib45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-1119(99)00176-6","article-title":"Induction of the rat Cu\/Zn superoxide dismutase gene through the peroxisome proliferators-responsive element by arachidonic acid","volume":"234","author":"Yoo","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.brainres.2006.12.011_bib46","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1073\/pnas.1131955100","article-title":"Evidence for neurogenesis in the adult mammalian substantia nigra","volume":"100","author":"Zhao","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930603558X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930603558X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T19:49:39Z","timestamp":1736711379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689930603558X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":45,"alternative-id":["S000689930603558X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.12.011","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}