{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:32:28Z","timestamp":1785213148475,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.brainres.2006.12.036","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:23:40Z","timestamp":1166685820000},"page":"78-83","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["The distribution of apolipoprotein E in mouse olfactory epithelium"],"prefix":"10.1016","volume":"1137","author":[{"given":"Britto P.","family":"Nathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivas","family":"Nannapaneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salina","family":"Gairhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikemefuna","family":"Nwosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Struble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.12.036_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0021-9681(75)90058-2","article-title":"Olfactory function in patients with Parkinson's disease","volume":"28","author":"Ansari","year":"1975","journal-title":"J. Chronic. Dis."},{"key":"10.1016\/j.brainres.2006.12.036_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/089771504323004520","article-title":"Olfactory ensheathing cells: unique glial cell types?","volume":"21","author":"Barnett","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2006.12.036_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0173(98)00008-3","article-title":"The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease","volume":"27","author":"Beffert","year":"1998","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.brainres.2006.12.036_bib4","doi-asserted-by":"crossref","first-page":"27063","DOI":"10.1074\/jbc.270.45.27063","article-title":"Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth","volume":"270","author":"Bellosta","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.12.036_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1126\/science.7063870","article-title":"Cytochrome P-450-dependent monooxygenases in olfactory epithelium of dogs: possible role in tumorigenicity","volume":"216","author":"Dahl","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.12.036_bib6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/exnr.1998.6818","article-title":"Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (\u2212\/\u2212) mice but impaired clearance of axonal degeneration products following injury","volume":"151","author":"Fagan","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2006.12.036_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000008157","article-title":"Age-dependent decline in the apolipoprotein E level in cerebrospinal fluid from control subjects and its increase in cerebrospinal fluid from patients with Alzheimer's disease","volume":"43","author":"Fukuyama","year":"2000","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.brainres.2006.12.036_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0301-0082(84)90008-X","article-title":"Perireceptor and receptor events in vertebrate olfaction","volume":"23","author":"Getchell","year":"1984","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2006.12.036_bib9","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.4049\/jimmunol.173.10.6366","article-title":"Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice","volume":"173","author":"Grainger","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2006.12.036_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01175561","article-title":"Neurogenesis and neuron regeneration in the olfactory system of mammals: II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy","volume":"8","author":"Graziadei","year":"1979","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.brainres.2006.12.036_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1749-6632.1985.tb20802.x","article-title":"Neurogenesis and plasticity of the olfactory sensory neurons","volume":"457","author":"Graziadei","year":"1985","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2006.12.036_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000093759","article-title":"Olfaction in neurodegenerative disorder","volume":"63","author":"Hawkes","year":"2006","journal-title":"Adv. Oto-rhino-laryngol."},{"key":"10.1016\/j.brainres.2006.12.036_bib13","doi-asserted-by":"crossref","first-page":"14009","DOI":"10.1074\/jbc.M313828200","article-title":"Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures","volume":"279","author":"Hayashi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.12.036_bib14","doi-asserted-by":"crossref","first-page":"9480","DOI":"10.1073\/pnas.92.21.9480","article-title":"Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line","volume":"92","author":"Holtzman","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.12.036_bib15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.3576212","article-title":"Lipoprotein uptake by neuronal growth cones in vitro","volume":"236","author":"Ignatius","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.12.036_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.10642","article-title":"Globose basal cells are required for reconstitution of olfactory epithelium after methyl bromide lesion","volume":"460","author":"Jang","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2006.12.036_bib17","doi-asserted-by":"crossref","first-page":"10771","DOI":"10.1016\/S0021-9258(18)87014-4","article-title":"Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein","volume":"265","author":"Kowal","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.12.036_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jnr.490250203","article-title":"Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerve","volume":"25","author":"LeBlanc","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2006.12.036_bib19","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0736-5748(96)00046-9","article-title":"The aging olfactory epithelium: neurogenesis, response to damage, and odorant-induced activity","volume":"14","author":"Loo","year":"1996","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainres.2006.12.036_bib20","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.12.036_bib21","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.8171342","article-title":"Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro","volume":"264","author":"Nathan","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.12.036_bib22","doi-asserted-by":"crossref","first-page":"19791","DOI":"10.1074\/jbc.270.34.19791","article-title":"The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization","volume":"270","author":"Nathan","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.12.036_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/exnr.2001.7762","article-title":"Apolipoprotein E is upregulated in olfactory bulb glia following peripheral receptor lesion in mice","volume":"172","author":"Nathan","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2006.12.036_bib24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(01)03367-4","article-title":"Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein","volume":"928","author":"Nathan","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.12.036_bib25","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1210\/en.2003-1707","article-title":"Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons","volume":"145","author":"Nathan","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2006.12.036_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2005.02.011","article-title":"Delayed olfactory nerve regeneration in ApoE-deficient mice","volume":"1041","author":"Nathan","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.12.036_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0361-9230(97)00463-2","article-title":"Olfactory ensheathing glia: properties and function","volume":"46","author":"Ramon-Cueto","year":"1998","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2006.12.036_bib28","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1073\/pnas.83.4.1130","article-title":"Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells","volume":"83","author":"Snipes","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.12.036_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0304-3940(99)00352-3","article-title":"Apolipoprotein E immunoreactivity in human and mouse olfactory bulb","volume":"267","author":"Struble","year":"1999","journal-title":"Neurosci. Lett."},{"issue":"1\u22122","key":"10.1016\/j.brainres.2006.12.036_bib29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exger.2006.05.013","article-title":"Estradiol regulation of astroglia and apolipoprotein E: An important role in neuronal regeneration","volume":"42","author":"Struble","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainres.2006.12.036_bib31","doi-asserted-by":"crossref","first-page":"9252","DOI":"10.1073\/pnas.89.19.9252","article-title":"Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity","volume":"89","author":"Takahashi","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.12.036_bib32","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/337736a0","article-title":"Pathological changes in olfactory neurons in patients with Alzheimer's disease","volume":"337","author":"Talamo","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2006.12.036_bib33","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1046\/j.1471-4159.1999.0732613.x","article-title":"Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture","volume":"73","author":"Teter","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.12.036_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/exnr.2001.7655","article-title":"Alterations in ApoE and ApoJ in relation to degeneration and regeneration in a mouse model of entorhinal cortex lesion","volume":"169","author":"White","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2006.12.036_bib35","doi-asserted-by":"crossref","first-page":"8460","DOI":"10.1073\/pnas.93.16.8460","article-title":"Defective forebrain development in mice lacking gp330\/megalin","volume":"93","author":"Willnow","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.12.036_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1177\/000348949810700511","article-title":"Increased density of olfactory receptor neurons immunoreactive for apolipoprotein E in patients with Alzheimer's disease","volume":"107","author":"Yamagishi","year":"1998","journal-title":"Ann. Otol. Rhinol. Laryngol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930603592X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930603592X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T20:28:02Z","timestamp":1628281682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689930603592X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":36,"alternative-id":["S000689930603592X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.12.036","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}