{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:35:29Z","timestamp":1768480529210,"version":"3.49.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2006CB500700"],"award-info":[{"award-number":["2006CB500700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30370494"],"award-info":[{"award-number":["30370494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30470615"],"award-info":[{"award-number":["30470615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.brainres.2007.01.005","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T13:39:38Z","timestamp":1168349978000},"page":"10-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Genetic association between polymorphisms of Pen2 gene and late onset Alzheimer's disease in the North Chinese population"],"prefix":"10.1016","volume":"1141","author":[{"given":"Longfei","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"L.V.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weishan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunkui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangtao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2007.01.005_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.brainres.2007.01.005_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1212\/01.WNL.0000103283.65914.0B","article-title":"PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample","volume":"62","author":"Bertram","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.01.005_bib3","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/1071576021000049890","article-title":"Amyloid beta-peptide (1\u201342)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain","volume":"36","author":"Butterfield","year":"2002","journal-title":"Free Radical Res."},{"key":"10.1016\/j.brainres.2007.01.005_bib4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nm0197-67","article-title":"Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice","volume":"3","author":"Citron","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2007.01.005_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1534-5807(02)00189-2","article-title":"aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of beta-APP, and presenilin protein accumulation","volume":"3","author":"Francis","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.brainres.2007.01.005_bib6","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1062097","article-title":"Formation of neurofibrillary tangles in P301L tau transgenic mice induced by A-beta42 fibrils","volume":"293","author":"Gotz","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.brainres.2007.01.005_bib7","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1126\/science.1058189","article-title":"Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP","volume":"293","author":"Lewis","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.brainres.2007.01.005_bib8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0006-291X(03)00797-6","article-title":"APH1, PEN2, and nicastrin increase Abeta levels and gamma-secretase activity","volume":"305","author":"Marlow","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2007.01.005_bib9","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.01.005_bib10","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1046\/j.1471-4159.1999.0732383.x","article-title":"Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells","volume":"73","author":"Refolo","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2007.01.005_bib11","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00415-005-0799-7","article-title":"PEN-2 gene mutation in a familial Alzheimer's disease case","volume":"252","author":"Sala Frigerio","year":"2005","journal-title":"J. Neurol."},{"key":"10.1016\/j.brainres.2007.01.005_bib12","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.01.005_bib13","doi-asserted-by":"crossref","first-page":"39062","DOI":"10.1074\/jbc.C200469200","article-title":"PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin","volume":"277","author":"Steiner","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2007.01.005_bib14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature01506","article-title":"The role of presenilin cofactors in the gamma-secretase complex","volume":"422","author":"Takasugi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2007.01.005_bib15","series-title":"Handbook of Human Genetic Linkage","author":"Terwilliger","year":"1994"},{"key":"10.1016\/j.brainres.2007.01.005_bib16","first-page":"643","article-title":"Apolipoprotein E: risk factor for Alzheimer disease","volume":"54","author":"Tsai","year":"1994","journal-title":"Am. J. Hum. Genet."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307000121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307000121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:33:33Z","timestamp":1757784813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899307000121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":16,"alternative-id":["S0006899307000121"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2007.01.005","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic association between polymorphisms of Pen2 gene and late onset Alzheimer's disease in the North Chinese population","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2007.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}