{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:41:38Z","timestamp":1791160898269,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.brainres.2007.01.085","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T17:24:27Z","timestamp":1170437067000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Extracellular glutamine is a critical modulator for regulatory volume increase in human glioma cells"],"prefix":"10.1016","volume":"1144","author":[{"given":"Nola Jean","family":"Ernest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Sontheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2007.01.085_bib1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1046\/j.1471-4159.2001.00322.x","article-title":"Transfer of glutamine between astrocytes and neurons","volume":"77","author":"Broer","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2007.01.085_bib2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1096\/fasebj.10.8.8666170","article-title":"The stimulation of Na,K,Cl cotransport and of system A for neutral amino acid transport is a mechanism for cell volume increase during the cell cycle","volume":"10","author":"Bussolati","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2007.01.085_bib3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1432-1033.1988.tb13807.x","article-title":"The Na+\/K+\/Cl\u2212 cotransport in C6 glioma cells. Properties and role in volume regulation","volume":"171","author":"Chassande","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.brainres.2007.01.085_bib4","doi-asserted-by":"crossref","first-page":"10485","DOI":"10.1016\/S0021-9258(17)34085-1","article-title":"Response of human fibroblasts to hypertonic stress. Cell shrinkage is counteracted by an enhanced active transport of neutral amino acids","volume":"269","author":"Dall'Asta","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2007.01.085_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mrfmmm.2004.06.053","article-title":"Hypertonic stress response","volume":"569","author":"Dmitrieva","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.brainres.2007.01.085_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0197-0186(00)00017-6","article-title":"Glutamine transport in C6 glioma cells","volume":"37","author":"Dolinska","year":"2000","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2007.01.085_bib7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/jnr.10047","article-title":"Glutamine transport in C6 glioma cells: substrate specificity and modulation in a glutamine deprived culture medium","volume":"66","author":"Dolinska","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2007.01.085_bib8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00249-003-0364-1","article-title":"The influence of cell volume changes on tumour cell proliferation","volume":"33","author":"Dubois","year":"2004","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.brainres.2007.01.085_bib9","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1471-4159.1985.tb04066.x","article-title":"Decreased cerebrospinal fluid glutamine levels in patients with benign brain tumors","volume":"45","author":"el Yazigi","year":"1985","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2007.01.085_bib10","doi-asserted-by":"crossref","first-page":"C1451","DOI":"10.1152\/ajpcell.00503.2004","article-title":"Relative contribution of chloride channels and transporters to regulatory volume decrease in human glioma cells","volume":"288","author":"Ernest","year":"2005","journal-title":"Am. J. Physiol.: Cell Physiol."},{"key":"10.1016\/j.brainres.2007.01.085_bib11","first-page":"2387","article-title":"Management of hyponatremia","volume":"69","author":"Goh","year":"2004","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.brainres.2007.01.085_bib12","first-page":"196","article-title":"Riding the tides: K+ concentration and volume regulation by muscle Na+\u2013K+\u20132Cl\u2212 cotransport activity","volume":"18","author":"Gosmanov","year":"2003","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.brainres.2007.01.085_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1023\/A:1020521308985","article-title":"The Na\u2013K\u2013Cl cotransporters","volume":"30","author":"Haas","year":"1998","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.brainres.2007.01.085_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/ndt\/16.3.483","article-title":"Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: protective effect of betaine","volume":"16","author":"Horio","year":"2001","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.brainres.2007.01.085_bib15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neuint.2005.11.017","article-title":"Glutamine in the mechanism of ammonia-induced astrocyte swelling","volume":"48","author":"Jayakumar","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2007.01.085_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1471-4159.2005.03170.x","article-title":"Suppression of glial glutamine release to the extracellular fluid studied in vivo by NMR and microdialysis in hyperammonemic rat brain","volume":"94","author":"Kanamori","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2007.01.085_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0006-8993(83)90180-4","article-title":"Volume regulation and metabolism of suspended C6 glioma cells: an in vitro model to study cytotoxic brain edema","volume":"279","author":"Kempski","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2007.01.085_bib18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/physrev.1998.78.1.247","article-title":"Functional significance of cell volume regulatory mechanisms","volume":"78","author":"Lang","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2007.01.085_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000016269","article-title":"The diversity of volume regulatory mechanisms","volume":"8","author":"Lang","year":"1998","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.brainres.2007.01.085_bib20","first-page":"G665","article-title":"Regulatory volume increase in mammalian jejunal villus cells is due to bumetanide-sensitive NaKCl2 cotransport","volume":"258","author":"MacLeod","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2007.01.085_bib21","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.140216197","article-title":"Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis","volume":"97","author":"Maeno","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.01.085_bib22","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/00000542-199306000-00017","article-title":"Acute volume regulation of brain cells in response to hypertonic challenge","volume":"78","author":"McManus","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2007.01.085_bib23","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1056\/NEJM199511093331906","article-title":"Regulation of cell volume in health and disease","volume":"333","author":"McManus","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2007.01.085_bib24","doi-asserted-by":"crossref","first-page":"C1041","DOI":"10.1152\/ajpcell.1996.271.4.C1041","article-title":"Electrolyte transport mechanisms involved in regulatory volume increase in C6 glioma cells","volume":"271","author":"Mountian","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2007.01.085_bib25","doi-asserted-by":"crossref","first-page":"C1191","DOI":"10.1152\/ajpcell.1993.265.5.C1191","article-title":"In defense of cell volume?","volume":"265","author":"Parker","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2007.01.085_bib26","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0003-4975(97)00998-3","article-title":"Hypertonicity induces injury to cultured human endothelium: attenuation by glutamine","volume":"64","author":"Parolari","year":"1997","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.brainres.2007.01.085_bib27","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1523\/JNEUROSCI.21-19-07674.2001","article-title":"Volume-activated chloride currents contribute to the resting conductance and invasive migration of human glioma cells","volume":"21","author":"Ransom","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.085_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physrev.2000.80.1.211","article-title":"Sodium\u2013potassium\u2013chloride cotransport","volume":"80","author":"Russell","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2007.01.085_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1515\/BC.2002.059","article-title":"The cellular hydration state: a critical determinant for cell death and survival","volume":"383","author":"Schliess","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.brainres.2007.01.085_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0003-9861(02)00047-4","article-title":"Expression and regulation of the Na(+)\/K(+)\/2Cl(\u2212) cotransporter NKCC1 in rat liver and human HuH-7 hepatoma cells","volume":"401","author":"Schliess","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.brainres.2007.01.085_bib31","doi-asserted-by":"crossref","first-page":"39941","DOI":"10.1074\/jbc.M308232200","article-title":"KCl cotransport is an important modulator of human cervical cancer growth and invasion","volume":"278","author":"Shen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2007.01.085_bib32","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1523\/JNEUROSCI.19-14-05942.1999","article-title":"Modulation of glioma cell migration and invasion using Cl\u2212 and K+ ion channel blockers","volume":"19","author":"Soroceanu","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.085_bib33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF00852580","article-title":"Maintenance of cell volume in the central nervous system","volume":"7","author":"Strange","year":"1993","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.brainres.2007.01.085_bib34","doi-asserted-by":"crossref","first-page":"C412","DOI":"10.1152\/ajpcell.1992.263.2.C412","article-title":"Volume regulation during recovery from chronic hypertonicity in brain glial cells","volume":"263","author":"Strange","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2007.01.085_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuroscience.2004.10.045","article-title":"Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats","volume":"131","author":"Tanigami","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2007.01.085_bib36","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1521-690X(03)00056-3","article-title":"Diagnosis and management of electrolyte emergencies","volume":"17","author":"Weiss-Guillet","year":"2003","journal-title":"Best Pract. Res., Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2007.01.085_bib37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0306-4522(95)00462-9","article-title":"Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat","volume":"71","author":"Willard-Mack","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2007.01.085_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1113\/jphysiol.2004.066423","article-title":"Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells","volume":"560","author":"Zhao","year":"2004","journal-title":"J. Physiol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307002223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307002223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:36:21Z","timestamp":1757784981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899307002223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":38,"alternative-id":["S0006899307002223"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2007.01.085","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular glutamine is a critical modulator for regulatory volume increase in human glioma cells","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2007.01.085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}