{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:29:06Z","timestamp":1791293346400,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.brainres.2007.01.093","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T02:46:44Z","timestamp":1170470804000},"page":"183-192","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Alteration of conditioned emotional response and conditioned taste aversion after neonatal ventral hippocampus lesions in rats"],"prefix":"10.1016","volume":"1143","author":[{"given":"Marie-Jos\u00e9e","family":"Angst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Guiberteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Sandner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2007.01.093_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0920-9964(99)00160-7","article-title":"Neurocognitive and social functioning in schizophrenia: a 2.5 year follow-up study","volume":"44","author":"Addington","year":"2000","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10897-005-1622-4","article-title":"Schizophrenia: an update and review","volume":"14","author":"Austin","year":"2005","journal-title":"J. Genet. Couns."},{"key":"10.1016\/j.brainres.2007.01.093_bib4","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1037\/0735-7044.113.6.1170","article-title":"Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions","volume":"113","author":"Bannerman","year":"1999","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.093_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0166-4328(02)00268-1","article-title":"Ventral hippocampal lesions affect anxiety but not spatial learning","volume":"139","author":"Bannerman","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/schbul\/sbi051","article-title":"Developing drugs for cognitive impairment in schizophrenia","volume":"31","author":"Breier","year":"2005","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.brainres.2007.01.093_bib6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.pnpbp.2006.01.006","article-title":"Psychosis: a costly by-product of social brain evolution in Homo sapiens","volume":"30","author":"Burns","year":"2006","journal-title":"Prog. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2007.01.093_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s002130100809","article-title":"Non-monotonic dependency of PPI on temporal parameters: differential alteration by ketamine and MK-801 as opposed to apomorphine and DOI","volume":"156","author":"Canal","year":"2001","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2007.01.093_bib8","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0893-133X(96)00132-7","article-title":"Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia","volume":"15","author":"Chambers","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2007.01.093_bib9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/(SICI)1096-8628(200021)97:1<52::AID-AJMG7>3.0.CO;2-6","article-title":"Sustained attention deficits as markers of genetic susceptibility to schizophrenia","volume":"97","author":"Chen","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.brainres.2007.01.093_bib10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.biopsych.2006.02.024","article-title":"Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models","volume":"99","author":"Chen","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2007.01.093_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0306-4522(92)90270-C","article-title":"Aspiration lesions of rat ventral hippocampus disinhibit responding in conditioned suppression or extinction, but spare latent inhibition and the partial reinforcement extinction effect","volume":"48","author":"Clark","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2007.01.093_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0166-4328(98)00128-4","article-title":"A neurotoxic lesion of serotonergic neurones using 5,7-dihydroxytryptamine does not disrupt latent inhibition in paradigms sensitive to low doses of amphetamine","volume":"100","author":"De Oliveira Mora","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib13","first-page":"195","article-title":"New strategies in the search for anxiolytics","volume":"5","author":"File","year":"1990","journal-title":"Drug Des. Deliv."},{"key":"10.1016\/j.brainres.2007.01.093_bib14","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1523\/JNEUROSCI.16-06-02020.1996","article-title":"Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus","volume":"16","author":"Flores","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.093_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s002130100811","article-title":"Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review","volume":"156","author":"Geyer","year":"2001","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2007.01.093_bib16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0893-133X(98)00081-5","article-title":"Disruption of latent inhibition in rats with postnatal hippocampal lesions","volume":"20","author":"Grecksch","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2007.01.093_bib17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1469-8986.1991.tb01999.x","article-title":"Fear-potentiated startle in humans: effects of anticipatory anxiety on the acoustic blink reflex","volume":"28","author":"Grillon","year":"1991","journal-title":"Psychophysiology"},{"key":"10.1016\/j.brainres.2007.01.093_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0166-4328(99)00114-X","article-title":"Changes in adult brain and behavior caused by neonatal limbic damage: implications for the etiology of schizophrenia","volume":"107","author":"Hanlon","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1037\/0735-7044.107.1.23","article-title":"Selective hippocampal lesions abolish the contextual specificity of latent inhibition and conditioning","volume":"107","author":"Honey","year":"1993","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.093_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0166-4328(97)87583-3","article-title":"Electrolytic lesions of the medial prefrontal cortex in rats disrupt performance on an analog of the Wisconsin Card Sorting Test, but do not disrupt latent inhibition: implications for animal models of schizophrenia","volume":"85","author":"Joel","year":"1997","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2005.09.023","article-title":"Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum","volume":"48","author":"Kumar","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2007.01.093_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1037\/h0023485","article-title":"Conditioned fear and magnitude of startle response: a replication and extension","volume":"62","author":"Kurtz","year":"1966","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.brainres.2007.01.093_bib23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1023\/A:1025048802629","article-title":"The emotional brain, fear, and the amygdala","volume":"23","author":"LeDoux","year":"2003","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2007.01.093_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0893-133X(01)00383-9","article-title":"Disruption of prepulse inhibition of startle reflex in a neurodevelopmental model of schizophrenia: reversal by clozapine, olanzapine and risperidone but not by haloperidol","volume":"27","author":"Le Pen","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2007.01.093_bib24","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00213-002-1092-4","article-title":"Deficits in reward sensitivity in a neurodevelopmental rat model of schizophrenia","volume":"161","author":"Le Pen","year":"2002","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2007.01.093_bib25","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/S0006-3223(03)00374-3","article-title":"Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and a glycine transporter inhibitor","volume":"54","author":"Le Pen","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2007.01.093_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pnpbp.2005.10.018","article-title":"Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia","volume":"30","author":"Levin","year":"2005","journal-title":"Prog. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2007.01.093_bib28","first-page":"282","article-title":"Using animal models to test a neurodevelopmental hypothesis of schizophrenia","volume":"29","author":"Lipska","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.brainres.2007.01.093_bib31","doi-asserted-by":"crossref","first-page":"8906","DOI":"10.1073\/pnas.92.19.8906","article-title":"Genetic variation in vulnerability to the behavioral effects of neonatal hippocampal damage in rats","volume":"92","author":"Lipska","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.01.093_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0893-133X(98)00045-1","article-title":"Excitotoxic lesions of the rat medial prefrontal cortex. Effects on abnormal behaviors associated with neonatal hippocampal damage","volume":"19","author":"Lipska","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2007.01.093_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0893-133X(02)00282-8","article-title":"Neonatal damage of the ventral hippocampus impairs working memory in the rat","volume":"27","author":"Lipska","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2007.01.093_bib32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/schbul\/sbi005","article-title":"Construct validity of the animal latent inhibition model of selective attention deficits in schizophrenia","volume":"31","author":"Lubow","year":"2005","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.brainres.2007.01.093_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0166-4328(97)02308-5","article-title":"Bilateral ablation of the auditory cortex in the rat alters conditioned emotional suppression to a sound as appraised through a latent inhibition study","volume":"88","author":"Melo","year":"1997","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1155\/NP.2003.327","article-title":"Enhancement of latent inhibition by chronic mild stress in rats submitted to emotional response conditioning","volume":"10","author":"Melo","year":"2003","journal-title":"Neural Plast."},{"key":"10.1016\/j.brainres.2007.01.093_bib35","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/nn1562","article-title":"Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice","volume":"8","author":"Paterlini","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.093_bib36","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1037\/0735-7044.113.5.968","article-title":"The effects of hippocampal and fimbria-fornix lesions on prepulse inhibition","volume":"113","author":"Pouzet","year":"1999","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.093_bib37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0149-7634(03)00009-5","article-title":"Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms","volume":"27","author":"Pryce","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2007.01.093_bib38","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1523\/JNEUROSCI.4194-05.2006","article-title":"The role of CA3 hippocampal NMDA receptors in paired associate learning","volume":"26","author":"Rajji","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2007.01.093_bib39","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1440-1681.2005.04257.x","article-title":"Investigating the neurodevelopmental hypothesis of schizophrenia","volume":"32","author":"Rehn","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.brainres.2007.01.093_bib40","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00008877-199711000-00003","article-title":"Animal models of \u2018anxiety\u2019: where next?","volume":"8","author":"Rodgers","year":"1997","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.brainres.2007.01.093_bib41","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00213-004-1897-4","article-title":"Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophrenia","volume":"176","author":"Rueter","year":"2004","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2007.01.093_bib42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s002130050349","article-title":"Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood","volume":"132","author":"Sams-Dodd","year":"1997","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2007.01.093_bib43","first-page":"R251","article-title":"Lower animal conditioning studies help in the understanding of human memory and its disorders: the merits of conditioned taste, odor, and flavor aversion research","volume":"286","author":"Sandner","year":"2004","journal-title":"Am. J. Physiol.: Regul., Integr. Comp. Physiol."},{"key":"10.1016\/j.brainres.2007.01.093_bib44","doi-asserted-by":"crossref","unstructured":"Sandner G., Canal N., in press. Relationship between PPI and baseline startle response. Cogn Neurodynamics.","DOI":"10.1007\/s11571-006-9008-3"},{"key":"10.1016\/j.brainres.2007.01.093_bib45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.devbrainres.2004.06.013","article-title":"Prenatal exposure of Long-Evans rats to 17alpha-ethinylestradiol modifies neither latent inhibition nor prepulse inhibition of the startle reflex but elicits minor deficits in exploratory behavior","volume":"152","author":"Sandner","year":"2004","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib46","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.neubiorev.2005.02.005","article-title":"Brain\u2013behaviour relationships in latent inhibition: a computational model","volume":"29","author":"Schmajuk","year":"2005","journal-title":"Neurosci. Biobehav."},{"key":"10.1016\/j.brainres.2007.01.093_bib47","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1073\/pnas.97.14.7673","article-title":"Schizophrenia: more dopamine, more D2 receptors","volume":"97","author":"Seeman","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.01.093_bib48","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.brainresbull.2003.10.004","article-title":"Dual separate pathways for sensory and hedonic aspects of taste","volume":"62","author":"Sewards","year":"2004","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2007.01.093_bib49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0166-4328(81)90037-1","article-title":"Hippocampal lesion effects on conditioned taste aversion and pituitary\u2013adrenal activity in rats","volume":"2","author":"Smotherman","year":"1981","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.yebeh.2005.06.009","article-title":"Extreme obesity in female rats following prepubertal induction of lithium-pilocarpine seizures and a single injection of acepromazine","volume":"7","author":"St-Pierre","year":"2005","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainres.2007.01.093_bib51","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0306-4522(99)00528-X","article-title":"Hippocampal lesions enhance startle gating-disruptive effects of apomorphine in rats: a parametric assessment","volume":"96","author":"Swerdlow","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2007.01.093_bib52","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0893-133X(96)00217-5","article-title":"Enhancement of postsynaptic sensitivity to dopaminergic agonists induced by neonatal hippocampal lesions","volume":"16","author":"Wan","year":"1997","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2007.01.093_bib53","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/syn.10265","article-title":"Early environment contributes to developmental disruption of MPFC after neonatal ventral hippocampal lesions in rats","volume":"50","author":"Wood","year":"2003","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2007.01.093_bib54","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0168-0102(95)00875-T","article-title":"Conditioned taste aversion in rats with excitotoxic brain lesions","volume":"22","author":"Yamamoto","year":"1995","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2007.01.093_bib55","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1037\/0735-7044.109.2.227","article-title":"Latent inhibition in rats is abolished by NMDA-induced neuronal loss in the retrohippocampal region, but this lesion effect can be prevented by systemic haloperidol treatment","volume":"109","author":"Yee","year":"1995","journal-title":"Behav. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307001497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307001497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:12:43Z","timestamp":1556064763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899307001497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":55,"alternative-id":["S0006899307001497"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2007.01.093","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}