{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:51:40Z","timestamp":1789213900185,"version":"build-2803163510"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.brainres.2007.05.082","type":"journal-article","created":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T07:28:04Z","timestamp":1184743684000},"page":"67-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["1H magnetic resonance spectroscopy in preclinical Huntington disease"],"prefix":"10.1016","volume":"1168","author":[{"given":"Joost C.H.","family":"van Oostrom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Sijens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund A.C.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus L.","family":"Leenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2007.05.082_bib1","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/brain\/119.6.2085","article-title":"Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease","volume":"119","author":"Antonini","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2007.05.082_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/01.WNL.0000132965.14653.D1","article-title":"Onset and rate of striatal atrophy in preclinical Huntington disease","volume":"63","author":"Aylward","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.05.082_bib3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1212\/01.wnl.0000257090.01107.2f","article-title":"Decreased frontal choline and neuropsychological performance in preclinical Huntington disease","volume":"68","author":"Gomez-Anson","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.05.082_bib4","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1212\/WNL.50.5.1357","article-title":"1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers","volume":"50","author":"Jenkins","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.05.082_bib5","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1212\/WNL.57.4.658","article-title":"Clinical markers of early disease in persons near onset of Huntington's disease","volume":"57","author":"Paulsen","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.05.082_bib6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ana.410410521","article-title":"CAG repeat number governs the development rate of pathology in Huntington's disease","volume":"41","author":"Penney","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2007.05.082_bib7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.neubiorev.2006.07.001","article-title":"Differential aging of the brain: patterns, cognitive correlates and modifiers","volume":"30","author":"Raz","year":"2006","journal-title":"N. Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2007.05.082_bib8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2004.10.030","article-title":"Heterogeneity in 1H-MRS profiles of presymptomatic and early manifest Huntington's disease","volume":"1031","author":"Reynolds","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2007.05.082_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1212\/WNL.53.4.806","article-title":"Clinical correlation of striatal 1H MRS changes in Huntington's disease","volume":"53","author":"Sanchez-Pernaute","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.05.082_bib10","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1126\/science.282.5391.1072","article-title":"Experimental therapeutics of neurodegenerative disorders: unmet needs","volume":"282","author":"Shoulson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.brainres.2007.05.082_bib11","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1007\/s00330-001-1300-3","article-title":"1H chemical shift imaging characterization of human brain tumor and edema","volume":"12","author":"Sijens","year":"2002","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.brainres.2007.05.082_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1522-2594(199907)42:1<24::AID-MRM5>3.0.CO;2-3","article-title":"1H chemical shift imaging of the human brain at age 60\u201390\u00a0years reveals metabolic differences between women and men","volume":"42","author":"Sijens","year":"1999","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.brainres.2007.05.082_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/mds.870110209","article-title":"Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory","volume":"11","author":"Taylor-Robinson","year":"1996","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2007.05.082_bib14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2007.05.082_bib15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1212\/01.wnl.0000176071.08694.cc","article-title":"Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease","volume":"65","author":"van Oostrom","year":"2005","journal-title":"Neurology"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307013571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307013571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:36:49Z","timestamp":1757785009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899307013571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":15,"alternative-id":["S0006899307013571"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2007.05.082","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1H magnetic resonance spectroscopy in preclinical Huntington disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2007.05.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}