{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:26:34Z","timestamp":1791293194646,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.brainres.2007.08.039","type":"journal-article","created":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T10:57:05Z","timestamp":1188212225000},"page":"1-6","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Ube3a mRNA and protein expression are not decreased in Mecp2 mutant mice"],"prefix":"10.1016","volume":"1180","author":[{"given":"Amy","family":"Lawson-Yuen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun I.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochuan E.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alo C.","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Picker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Coyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2007.08.039_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1469-8749.1965.tb07844.x","article-title":"\u201cPuppet children.\u201d A report of three cases","volume":"7","author":"Angelman","year":"1965","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.brainres.2007.08.039_bib3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg1878","article-title":"Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized","volume":"7","author":"Bienvenu","year":"2006","journal-title":"Nat. Rev., Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1006\/geno.2001.6543","article-title":"The Prader\u2013Willi syndrome imprinting center activates the paternally expressed murine Ube3a antisense transcript but represses paternal Ube3a","volume":"73","author":"Chamberlain","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.brainres.2007.08.039_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib6","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.brainres.2007.08.039_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/jmg.40.2.87","article-title":"Angelman syndrome: a review of the clinical and genetic aspects","volume":"40","author":"Clayton-Smith","year":"2003","journal-title":"J. Med. Genet."},{"issue":"10","key":"10.1016\/j.brainres.2007.08.039_bib8","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/sj.ejhg.5201451","article-title":"Early onset seizures and Rett-like features associated with mutations in CDKL5","volume":"13","author":"Evans","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ana.410140412","article-title":"A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases","volume":"14","author":"Hagberg","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2007.08.039_bib11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0387-7604(85)80048-6","article-title":"Rett syndrome: criteria for inclusion and exclusion","volume":"7","author":"Hagberg","year":"1985","journal-title":"Brain Develop."},{"key":"10.1016\/j.brainres.2007.08.039_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/ejpn.2002.0612","article-title":"An update on clinically applicable diagnostic criteria in Rett syndrome. Comments to Rett Syndrome Clinical Criteria Consensus Panel Satellite to European Paediatric Neurology Society Meeting, Baden, Germany, 11 September 2001","volume":"6","author":"Hagberg","year":"2002","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.brainres.2007.08.039_bib13","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/hmg\/ddl146","article-title":"Ube3a expression is not altered in Mecp2 mutant mice","volume":"15","author":"Jordan","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ng0197-70","article-title":"UBE3A\/E6-AP mutations cause Angelman syndrome","volume":"15","author":"Kishino","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib15","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1093\/nar\/gki705","article-title":"Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans","volume":"33","author":"Landers","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.brainres.2007.08.039_bib16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ajmg.1320280407","article-title":"Is Angelman syndrome an alternate result of del(15)(q11q13)?","volume":"28","author":"Magenis","year":"1987","journal-title":"Am. J. Med. Genet."},{"issue":"8","key":"10.1016\/j.brainres.2007.08.039_bib17","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/ddi097","article-title":"MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS\/AS imprinting center that affect UBE3A expression","volume":"14","author":"Makedonski","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib18","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1093\/hmg\/ddi198","article-title":"CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome","volume":"14","author":"Mari","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.gde.2006.04.009","article-title":"MeCP2 dysfunction in Rett syndrome and related disorders","volume":"16","author":"Moretti","year":"2006","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.brainres.2007.08.039_bib20","first-page":"723","article-title":"On a unusual brain atrophy syndrome in hyperammonemia in childhood","volume":"116","author":"Rett","year":"1966","journal-title":"Wien Med. Wochenschr."},{"key":"10.1016\/j.brainres.2007.08.039_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ng0997-14","article-title":"The Angelman syndrome candidate gene, UBE3A\/E6-AP, is imprinted in brain","volume":"17","author":"Rougeulle","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng0598-15","article-title":"An imprinted antisense RNA overlaps UBE3A and a second maternally expressed transcript","volume":"19","author":"Rougeulle","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib23","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1093\/hmg\/10.23.2687","article-title":"The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A","volume":"10","author":"Runte","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/hmg\/ddi045","article-title":"Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3","volume":"14","author":"Samaco","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/jmg.2004.026237","article-title":"CDKL5\/STK9 is mutated in Rett syndrome variant with infantile spasms","volume":"42","author":"Scala","year":"2005","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib26","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1086\/426460","article-title":"Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5\/STK9) gene are associated with severe neurodevelopmental retardation","volume":"75","author":"Tao","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib27","doi-asserted-by":"crossref","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.08.039_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/ng0997-12","article-title":"Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain","volume":"17","author":"Vu","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ajmg.1320560224","article-title":"Angelman syndrome: consensus for diagnostic criteria. Angelman Syndrome Foundation","volume":"56","author":"Williams","year":"1995","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.brainres.2007.08.039_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity-dependent BDNF transcription, dendritic growth, and spine maturation","volume":"52","author":"Zhou","year":"2006","journal-title":"Neuron"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307018744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307018744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T13:00:00Z","timestamp":1549630800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899307018744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":30,"alternative-id":["S0006899307018744"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2007.08.039","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}