{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:53Z","timestamp":1791274433704,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.brainres.2007.08.058","type":"journal-article","created":{"date-parts":[[2007,9,6]],"date-time":"2007-09-06T16:07:28Z","timestamp":1189094848000},"page":"140-154","source":"Crossref","is-referenced-by-count":114,"special_numbering":"C","title":["Evolution of the inflammatory response in the brain following intracerebral hemorrhage and effects of delayed minocycline treatment"],"prefix":"10.1016","volume":"1180","author":[{"given":"Jason K.","family":"Wasserman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyanne C.","family":"Schlichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2007.08.058_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3171\/jns.2003.99.1.0065","article-title":"Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage","volume":"99","author":"Abilleira","year":"2003","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2007.08.058_bib2","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1161\/01.STR.0000126827.69286.90","article-title":"Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome","volume":"35","author":"Alvarez-Sabin","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2007.08.058_bib3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/00004647-199908000-00001","article-title":"Inflammatory mediators and stroke: new opportunities for novel therapeutics","volume":"19","author":"Barone","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2007.08.058_bib4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/385729a0","article-title":"A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells","volume":"385","author":"Black","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2007.08.058_bib5","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/00005072-199511000-00003","article-title":"Evolution of neuropathologic abnormalities associated with blood\u2013brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes","volume":"54","author":"Brett","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nm0796-788","article-title":"Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors","volume":"2","author":"Bruce","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2007.08.058_bib7","first-page":"155","article-title":"Pitfalls of quantitative real-time reverse-transcription polymerase chain reaction","volume":"15","author":"Bustin","year":"2004","journal-title":"J. Biomol. Tech."},{"key":"10.1016\/j.brainres.2007.08.058_bib8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/bbrc.1996.1677","article-title":"Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein","volume":"228","author":"Chandler","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2007.08.058_bib9","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1161\/01.STR.31.7.1715","article-title":"Lack of interleukin-6 expression is not protective against focal central nervous system ischemia","volume":"31","author":"Clark","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2007.08.058_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.expneurol.2003.12.006","article-title":"Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection","volume":"186","author":"Fagan","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/ana.10160","article-title":"Cell death in experimental intracerebral hemorrhage: the \u201cblack hole\u201d model of hemorrhagic damage","volume":"51","author":"Felberg","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000026331","article-title":"The role of cytokines in the neuropathology of stroke and neurotrauma","volume":"5","author":"Feuerstein","year":"1998","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.brainres.2007.08.058_bib13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/jnen\/60.4.320","article-title":"Production of MMPs in human cerebral endothelial cells and their role in shedding adhesion molecules","volume":"60","author":"Hummel","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1096\/fj.01-0594fje","article-title":"Characteristic gene expression profile of primary human cerebral endothelial cells","volume":"16","author":"Kallmann","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2007.08.058_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3171\/jns.2005.103.2.0289","article-title":"Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke","volume":"103","author":"Lee","year":"2005","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2007.08.058_bib16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1212\/01.WNL.0000133204.81153.AC","article-title":"Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors","volume":"63","author":"Leira","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.08.058_bib17","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1471-4159.2004.02420.x","article-title":"Pro-regenerative properties of cytokine-activated astrocytes","volume":"89","author":"Liberto","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2007.08.058_bib18","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/00004647-199609000-00017","article-title":"Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat","volume":"16","author":"Loddick","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2007.08.058_bib19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00004647-199802000-00008","article-title":"Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat","volume":"18","author":"Loddick","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2007.08.058_bib20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/sj.jcbfm.9600183","article-title":"Brain genomics of intracerebral hemorrhage","volume":"26","author":"Lu","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2007.08.058_bib21","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.1038\/sj.bjp.0706400","article-title":"The role of inflammation in CNS injury and disease","volume":"147","author":"Lucas","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2007.08.058_bib22","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ana.20850","article-title":"Evaluating therapeutic targets for reperfusion-related brain hemorrhage","volume":"59","author":"Maier","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3171\/jns.2001.95.4.0680","article-title":"Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist","volume":"95","author":"Masada","year":"2001","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2007.08.058_bib24","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/385733a0","article-title":"Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha","volume":"385","author":"Moss","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2007.08.058_bib25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/sj.bjp.0705462","article-title":"Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat","volume":"140","author":"Mulcahy","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2007.08.058_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2007.08.058_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0014-4886(02)00051-1","article-title":"Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury","volume":"181","author":"Penkowa","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib28","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ana.10553","article-title":"Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases","volume":"53","author":"Power","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib29","first-page":"1041","article-title":"Apoptosis as a form of cell death in intracerebral hemorrhage","volume":"52","author":"Qureshi","year":"2003","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2007.08.058_bib30","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1161\/01.STR.0000223001.06264.af","article-title":"Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke","volume":"37","author":"Rosell","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2007.08.058_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/glia.10108","article-title":"Matrix metalloproteinases in neuroinflammation","volume":"39","author":"Rosenberg","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2007.08.058_bib32","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.STR.21.5.801","article-title":"Collagenase-induced intracerebral hemorrhage in rats","volume":"21","author":"Rosenberg","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2007.08.058_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1161\/01.STR.0000149615.51204.0b","article-title":"Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage","volume":"36","author":"Silva","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2007.08.058_bib34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1089\/089771502320317087","article-title":"Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury","volume":"19","author":"Singhal","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2007.08.058_bib35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1073858405275175","article-title":"Minocycline as a neuroprotective agent","volume":"11","author":"Stirling","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.brainres.2007.08.058_bib36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0301-0082(98)00069-0","article-title":"Reactive microgliosis","volume":"57","author":"Streit","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2007.08.058_bib37","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/00004647-199808000-00003","article-title":"Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat","volume":"18","author":"Stroemer","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2007.08.058_bib38","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.expneurol.2005.09.011","article-title":"Minocycline and intracerebral hemorrhage: influence of injury severity and delay to treatment","volume":"197","author":"Szymanska","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib39","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1046\/j.1460-9568.2002.02030.x","article-title":"Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia","volume":"15","author":"Tang","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2007.08.058_bib40","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/sj.jcbfm.9600354","article-title":"Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage","volume":"27","author":"Tejima","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2007.08.058_bib41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.expneurol.2004.01.011","article-title":"Minocycline worsens hypoxic\u2013ischemic brain injury in a neonatal mouse model","volume":"189","author":"Tsuji","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.08.058_bib42","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1161\/01.STR.31.10.2325","article-title":"Proinflammatory cytokines and early neurological worsening in ischemic stroke","volume":"31","author":"Vila","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2007.08.058_bib43","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/sj.jcbfm.9600403","article-title":"Inflammation after intracerebral hemorrhage","volume":"27","author":"Wang","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2007.08.058_bib44","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/brain\/awh489","article-title":"Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage","volume":"128","author":"Wang","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2007.08.058_bib45","doi-asserted-by":"crossref","unstructured":"Wasserman J.K., Schlichter L.C., in press. Minocycline protects the blood\u2013brain barrier and reduces edema following intracerebral hemorrhage in the rat. Exp. Neurol. doi:10.1016\/j.expneurol.2007.06.025.","DOI":"10.1016\/j.expneurol.2007.06.025"},{"key":"10.1016\/j.brainres.2007.08.058_bib46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2006.12.035","article-title":"Neuron death and inflammation in a rat model of intracerebral hemorrhage: effects of delayed minocycline treatment","volume":"1136","author":"Wasserman","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2007.08.058_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1460-9568.2004.03829.x","article-title":"Matrix metalloproteinase (MMP)-12 expression has a negative impact on sensorimotor function following intracerebral haemorrhage in mice","volume":"21","author":"Wells","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2007.08.058_bib48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/370270a0","article-title":"Structure and mechanism of interleukin-1 beta converting enzyme","volume":"370","author":"Wilson","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2007.08.058_bib49","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0304-3940(00)00971-X","article-title":"Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death","volume":"283","author":"Xue","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2007.08.058_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(96)01277-2","article-title":"Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury","volume":"751","author":"Yang","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2007.08.058_bib51","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/01.STR.0000206281.77178.ac","article-title":"Microglia potentiate damage to blood\u2013brain barrier constituents: improvement by minocycline in vivo and in vitro","volume":"37","author":"Yenari","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2007.08.058_bib52","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35081571","article-title":"Metalloproteinases in biology and pathology of the nervous system","volume":"2","author":"Yong","year":"2001","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.brainres.2007.08.058_bib53","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.08.058_bib54","doi-asserted-by":"crossref","first-page":"13496","DOI":"10.1073\/pnas.96.23.13496","article-title":"A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window","volume":"96","author":"Yrjanheikki","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.08.058_bib55","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nm1387","article-title":"Role of matrix metalloproteinases in delayed cortical responses after stroke","volume":"12","author":"Zhao","year":"2006","journal-title":"Nat. Med."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307019543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899307019543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T18:02:21Z","timestamp":1629655341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899307019543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":55,"alternative-id":["S0006899307019543"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2007.08.058","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}