{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:57:38Z","timestamp":1792292258055,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.brainres.2007.09.048","type":"journal-article","created":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T16:47:35Z","timestamp":1191257255000},"page":"284-294","source":"Crossref","is-referenced-by-count":398,"special_numbering":"C","title":["Concurrence of TDP-43, tau and \u03b1-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies"],"prefix":"10.1016","volume":"1184","author":[{"given":"Shinji","family":"Higashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizo","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Minegishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Hino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshiro","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Togo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omi","family":"Katsuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotake","family":"Uchikado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heii","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2007.09.048_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ana.21154","article-title":"TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease","volume":"61","author":"Amador-Ortiz","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"Arai","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2007.09.048_bib3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jmb.2005.02.038","article-title":"Human, Drosophila, and C. elegans TDP43: nucleic acid binding properties and splicing regulatory function","volume":"348","author":"Ayala","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.brainres.2007.09.048_bib4","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2007.09.048_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00401-007-0235-4","article-title":"Frontotemporal lobar degeneration: recent progress in antemortem diagnosis","volume":"114","author":"Bian","year":"2007","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib7","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/emboj\/20.7.1774","article-title":"Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping","volume":"20","author":"Buratti","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2007.09.048_bib8","doi-asserted-by":"crossref","first-page":"37572","DOI":"10.1074\/jbc.M505557200","article-title":"TDP-43 binds heterogeneous nuclear ribonucleoprotein A\/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing","volume":"280","author":"Buratti","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2007.09.048_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-007-0237-2","article-title":"Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration","volume":"114","author":"Cairns","year":"2007","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib10","first-page":"S1","article-title":"The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease","volume":"18","author":"Consensus recommendations for the postmortem diagnosis of Alzheimer's disease","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2007.09.048_bib11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2007.09.048_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00401-006-0189-y","article-title":"Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43","volume":"113","author":"Davidson","year":"2007","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00005072-200606000-00005","article-title":"Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations","volume":"65","author":"Forman","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1440-1789.2003.00538.x","article-title":"Ubiquitin and ubiquitin-related proteins in neurons and dendrites of brains of atypical Pick's disease without Pick bodies","volume":"24","author":"Furukawa","year":"2004","journal-title":"Neuropathology"},{"key":"10.1016\/j.brainres.2007.09.048_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archneur.56.1.33","article-title":"Diagnostic criteria for Parkinson disease","volume":"56","author":"Gelb","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib16","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/brain\/awm065","article-title":"TDP-43 is deposited in the Guam parkinsonism\u2013dementia complex brains","volume":"130","author":"Hasegawa","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2007.09.048_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neulet.2007.04.051","article-title":"Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions","volume":"419","author":"Higashi","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2007.09.048_bib18","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1001\/jama.284.13.1664","article-title":"Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21\u2013q22","volume":"284","author":"Hosler","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.brainres.2007.09.048_bib19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2007.09.048_bib20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0022-510X(98)00168-3","article-title":"Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies","volume":"159","author":"Iseki","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2007.09.048_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004010000333","article-title":"Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells","volume":"102","author":"Iseki","year":"2001","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00401-003-0728-8","article-title":"4-Repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy","volume":"106","author":"Katsuse","year":"2003","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2990.2005.00704.x","article-title":"Ubiquitin-positive inclusions and progression of pathology in frontotemporal dementia and motor neurone disease identifies a group with mainly early pathology","volume":"32","author":"Kersaitis","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2007.09.048_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tins.2004.01.007","article-title":"More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases","volume":"27","author":"Lee","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2007.09.048_bib25","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/brain\/awm069","article-title":"A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology","volume":"130","author":"Leverenz","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2007.09.048_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00401-006-0138-9","article-title":"Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype","volume":"112","author":"Mackenzie","year":"2006","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00401-004-0869-4","article-title":"Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease","volume":"108","author":"Marui","year":"2004","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib28","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.09.048_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/archneur.64.3.330","article-title":"Establishing subtypes of the continuum of frontal lobe impairment in amyotrophic lateral sclerosis","volume":"64","author":"Murphy","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00401-007-0261-2","article-title":"Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases","volume":"114","author":"Nakashima-Yasuda","year":"2007","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib31","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.09.048_bib32","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S1474-4422(05)70223-4","article-title":"Frontotemporal dementia","volume":"4","author":"Neary","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.brainres.2007.09.048_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/01.jnen.0000248554.45456.58","article-title":"TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions","volume":"66","author":"Neumann","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/nen.0b013e31803020b9","article-title":"TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations","volume":"66","author":"Neumann","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib36","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1212\/01.wnl.0000231510.89311.8b","article-title":"ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)","volume":"67","author":"Parkinson","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.09.048_bib37","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/ana.410430617","article-title":"Tau is a candidate gene for chromosome 17 frontotemporal dementia","volume":"43","author":"Poorkaj","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib38","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/jnen\/62.6.644","article-title":"Accumulation of phosphorylated alpha-synuclein in aging human brain","volume":"62","author":"Saito","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2007.09.048_bib39","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2353\/ajpath.2006.060438","article-title":"Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies","volume":"169","author":"Sampathu","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2007.09.048_bib40","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/brain\/awm024","article-title":"TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations","volume":"130","author":"Seelaar","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2007.09.048_bib41","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"Skibinski","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.09.048_bib42","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1073\/pnas.95.13.7737","article-title":"Mutation in the tau gene in familial multiple system tauopathy with presenile dementia","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.09.048_bib43","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1212\/01.wnl.0000254460.31273.2d","article-title":"Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation","volume":"68","author":"Spina","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2007.09.048_bib44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-007-0206-9","article-title":"TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation","volume":"113","author":"Tan","year":"2007","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/PL00007400","article-title":"NACP\/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains","volume":"99","author":"Wakabayashi","year":"2000","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2007.09.048_bib46","doi-asserted-by":"crossref","first-page":"13583","DOI":"10.1073\/pnas.212483099","article-title":"Higher order arrangement of the eukaryotic nuclear bodies","volume":"99","author":"Wang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2007.09.048_bib47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng1332","article-title":"Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein","volume":"36","author":"Watts","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2007.09.048_bib48","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0304-3940(92)90569-S","article-title":"Hippocampal and neocortical ubiquitin-immunoreactive inclusions in amyotrophic lateral sclerosis with dementia","volume":"139","author":"Wightman","year":"1992","journal-title":"Neurosci. Lett."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930702224X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930702224X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T19:41:07Z","timestamp":1587930067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689930702224X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":48,"alternative-id":["S000689930702224X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2007.09.048","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}