{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:14:53Z","timestamp":1791015293653,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.brainres.2008.03.031","type":"journal-article","created":{"date-parts":[[2008,3,29]],"date-time":"2008-03-29T09:12:30Z","timestamp":1206781950000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone"],"prefix":"10.1016","volume":"1212","author":[{"given":"Takefumi","family":"Mikuriya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Sugahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimogori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiye","family":"Inouye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2008.03.031_bib1","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1007\/PL00000792","article-title":"Geranylgeranylacetone protects human monocytes from mitochondrial membrane depolarization independently of Hsp70 expression","volume":"58","author":"Aron","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.brainres.2008.03.031_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2008.03.031_bib3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/35019501","article-title":"Heat shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome","volume":"2","author":"Beere","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2008.03.031_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/35023595","article-title":"HSP 27 negatively regulates cell death by interacting with cytochrome c","volume":"2","author":"Bruey","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2008.03.031_bib5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1379\/1466-1268(2000)005<0276:THAGSP>2.0.CO;2","article-title":"The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s","volume":"5","author":"Easton","year":"2000","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.brainres.2008.03.031_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5955(02)00607-X","article-title":"Expression and localization of heat shock factor (Hsf) 1 in the rodent cochlea","volume":"173","author":"Fairfield","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jnr.20417","article-title":"Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation","volume":"81","author":"Fairfield","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib8","doi-asserted-by":"crossref","first-page":"32272","DOI":"10.1016\/S0021-9258(18)31631-4","article-title":"Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1","volume":"269","author":"Fawcett","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2008.03.031_bib9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0006-8993(03)03540-6","article-title":"Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone","volume":"991","author":"Fujiki","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib10","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1038\/sj.emboj.7600435","article-title":"HSF4 is required for normal cell growth and differentiation during mouse lens development","volume":"23","author":"Fujimoto","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2008.03.031_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00005537-199702000-00016","article-title":"Localization of inducible heat shock protein mRNA in the guinea pig cochlea with a nonradioactive in situ hybridization technique","volume":"107","author":"Gower","year":"1997","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brainres.2008.03.031_bib12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1053\/gast.1996.v111.pm8690199","article-title":"Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa","volume":"111","author":"Hirakawa","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.brainres.2008.03.031_bib13","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/bbrc.2000.3392","article-title":"Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes","volume":"275","author":"Hirota","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2008.03.031_bib14","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1167\/iovs.02-0912","article-title":"Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model","volume":"44","author":"Ishii","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.brainres.2008.03.031_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/geno.2002.6858","article-title":"Ahl2, a second locus affecting age-related hearing loss in mice","volume":"80","author":"Johnson","year":"2002","journal-title":"Genomics"},{"key":"10.1016\/j.brainres.2008.03.031_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","article-title":"A major gene affecting age-related hearing loss in C57BL\/6J mice","volume":"114","author":"Johnson","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/geno.2000.6377","article-title":"A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice","volume":"70","author":"Johnson","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.brainres.2008.03.031_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.febslet.2004.06.087","article-title":"Feeding induces expression of heat shock proteins that reduce oxidative stress","volume":"571","author":"Katsuki","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2008.03.031_bib19","doi-asserted-by":"crossref","first-page":"16801","DOI":"10.1073\/pnas.0506249102","article-title":"Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease","volume":"102","author":"Katsuno","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2008.03.031_bib20","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1046\/j.1432-1327.1999.00762.x","article-title":"HSF3 is a major heat shock responsive factor during chicken embryonic development","volume":"265","author":"Kawazoe","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.brainres.2008.03.031_bib21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jnr.10298","article-title":"Effect of geranylgeranylacetone on cellular damage induced by proteasome inhibition in cultured spinal neurons","volume":"69","author":"Kikuchi","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib22","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1440-1746.1996.tb01857.x","article-title":"Increase in hepatic tissue blood flow by geranylgeranylacetone","volume":"11","author":"Kurihara","year":"1996","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.brainres.2008.03.031_bib23","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1523\/JNEUROSCI.2488-05.2006","article-title":"Nuclear factor \u03ba-B deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss","volume":"26","author":"Lang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.03.031_bib24","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1146\/annurev.bi.55.070186.005443","article-title":"The heat-shock response","volume":"55","author":"Lindquist","year":"1986","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.brainres.2008.03.031_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainres.2005.10.045","article-title":"Geranylgeranylacetone, a heat shock protein inducer, prevents acoustic injury in the guinea pig","volume":"1065","author":"Mikuriya","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib26","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1101\/gad.12.24.3788","article-title":"Regulation of heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators","volume":"12","author":"Morimoto","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2008.03.031_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1091\/mbc.e03-07-0532","article-title":"Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones","volume":"15","author":"Morley","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.brainres.2008.03.031_bib28","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1128\/MCB.17.9.5317","article-title":"Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis","volume":"17","author":"Mosser","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2008.03.031_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0378-5955(91)90028-8","article-title":"Detection and localization of heat shock protein 70 in the normal guinea pig cochlea","volume":"52","author":"Neely","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib30","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.bbrc.2004.09.186","article-title":"Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss","volume":"324","author":"Nemoto","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2008.03.031_bib31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/000164800750000793","article-title":"Expression of heat shock protein 72 in rat cochlea with cisplatin-induced acute ototoxicity","volume":"120","author":"Oh","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.brainres.2008.03.031_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2006.03.017","article-title":"Contributions of mouse models to understanding of age- and noise-related hearing loss","volume":"1091","author":"Ohlemiller","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cne.20326","article-title":"Apical-to-basal gradients in age-related cochlear degeneration and their relationship to \u201cprimary\u201d loss of cochlear neurons","volume":"479","author":"Ohlemiller","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2008.03.031_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbrc.2006.12.031","article-title":"The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by geranylgeranylacetone (HSP-inducer)","volume":"353","author":"Otaka","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2008.03.031_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.ge.27.120193.002253","article-title":"The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins","volume":"27","author":"Parsell","year":"1993","journal-title":"Ann. Rev. Genet."},{"key":"10.1016\/j.brainres.2008.03.031_bib36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s005350070046","article-title":"Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase","volume":"35","author":"Rokutan","year":"2000","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.brainres.2008.03.031_bib37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/35019510","article-title":"Negative regulation of the Apaf-1 apoptosome by HSP70","volume":"2","author":"Saleh","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2008.03.031_bib38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00005537-200005000-00003","article-title":"Effects of dietary restriction and antioxidants on presbyacusis","volume":"110","author":"Seidman","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brainres.2008.03.031_bib39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1568-1637(02)00004-1","article-title":"Molecular mechanisms of age-related hearing loss","volume":"1","author":"Seidman","year":"2002","journal-title":"Aging Res. Rev."},{"key":"10.1016\/j.brainres.2008.03.031_bib40","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nature02483","article-title":"Cadherin 23 is a component of the tip link in hair-cell stereocilia","volume":"428","author":"Siemens","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2008.03.031_bib41","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.neurobiolaging.2006.06.024","article-title":"Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis","volume":"28","author":"Someya","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2008.03.031_bib42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-0186(02)00043-8","article-title":"Chaperones and aging: role in neurodegeneration and in other civilizational diseases","volume":"41","author":"Soti","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2008.03.031_bib43","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0378-5955(03)00180-1","article-title":"Heat shock transcription factor HSF1 is required for survival of sensory hair cells against acoustic overexposure","volume":"182","author":"Sugahara","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib51","doi-asserted-by":"crossref","first-page":"37285","DOI":"10.1074\/jbc.M704562200","article-title":"Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice","volume":"282","author":"Takaki","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2008.03.031_bib44","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1006\/cbir.2001.0789","article-title":"Heat shock response and aging: mechanisms and applications","volume":"25","author":"Verbeke","year":"2001","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.brainres.2008.03.031_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2004.04.016","article-title":"The guide to plotting a cochleogram","volume":"197","author":"Viberg","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-5955(98)00029-X","article-title":"Genetics of age-related hearing loss in mice. IV. Cochlear pathology and hearing loss in 25 BXD recombinant inbred mouse strains","volume":"119","author":"Willott","year":"1998","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.heares.2006.06.004","article-title":"Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss","volume":"226","author":"Yamasoba","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib48","doi-asserted-by":"crossref","first-page":"10116","DOI":"10.1523\/JNEUROSCI.19-22-10116.1999","article-title":"Heat stress and protection from permanent acoustic injury in mice","volume":"19","author":"Yoshida","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.03.031_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-5955(01)00215-5","article-title":"Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice","volume":"154","author":"Zheng","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.03.031_bib50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0378-5955(99)00003-9","article-title":"Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses","volume":"130","author":"Zheng","year":"1999","journal-title":"Hear. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308006756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308006756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:37:32Z","timestamp":1757785052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899308006756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":51,"alternative-id":["S0006899308006756"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2008.03.031","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2008.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}