{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:55:28Z","timestamp":1792508128084,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.brainres.2008.06.087","type":"journal-article","created":{"date-parts":[[2008,7,3]],"date-time":"2008-07-03T08:46:14Z","timestamp":1215074774000},"page":"233-248","source":"Crossref","is-referenced-by-count":174,"special_numbering":"C","title":["Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats"],"prefix":"10.1016","volume":"1229","author":[{"given":"Seong-Ho","family":"Koh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ran","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Hwa","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Sun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Gyu","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonjae","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jin","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ju","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Min","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2008.06.087_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/CS20050161","article-title":"Clinical relevance of the neurotrophins and their receptors","volume":"110","author":"Allen","year":"2006","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.brainres.2008.06.087_bib2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/75705","article-title":"Cell replacement therapies for central nervous system disorders","volume":"3","author":"Bjorklund","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2008.06.087_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-510X(01)00557-3","article-title":"Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats","volume":"189","author":"Chen","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2008.06.087_bib4","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2008.06.087_bib5","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1161\/01.STR.0000125011.93188.c6","article-title":"Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats","volume":"35","author":"Chen","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2008.06.087_bib6","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1590\/S0100-879X2003000900006","article-title":"Isolation and culture of umbilical vein mesenchymal stem cells","volume":"36","author":"Covas","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.brainres.2008.06.087_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.nbd.2007.06.010","article-title":"Enhancement of neuroplasticity through upregulation of beta1-integrin in human umbilical cord-derived stromal cell implanted stroke model","volume":"27","author":"Ding","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2008.06.087_bib8","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/BF02256131","article-title":"Transformation of human umbilical mesenchymal cells into neurons in vitro","volume":"11","author":"Fu","year":"2004","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.brainres.2008.06.087_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1634\/stemcells.2005-0053","article-title":"Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism","volume":"24","author":"Fu","year":"2006","journal-title":"Stem. Cells."},{"key":"10.1016\/j.brainres.2008.06.087_bib10","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1097\/00001756-200111160-00030","article-title":"Neural phenotype expression of cultured human cord blood cells in vitro","volume":"12","author":"Ha","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2008.06.087_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00019052-200502000-00012","article-title":"Adult stem cell therapy in stroke","volume":"18","author":"Haas","year":"2005","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.brainres.2008.06.087_bib12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2008.06.087_bib13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1634\/stemcells.18-4-252","article-title":"Evidence of peripheral blood-derived, plastic-adherent CD34(-\/low) hematopoietic stem cell clones with mesenchymal stem cell characteristics","volume":"18","author":"Huss","year":"2000","journal-title":"Stem. Cells"},{"key":"10.1016\/j.brainres.2008.06.087_bib14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbrc.2005.12.047","article-title":"In vitro cardiomyogenic potential of human umbilical vein-derived mesenchymal stem cells","volume":"340","author":"Kadivar","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2008.06.087_bib15","first-page":"527","article-title":"Towards the replacement therapy using neural stem\/progenitor cells for neurological disorders: strategies to enhance therapeutic capacity of transplantation approaches","volume":"24","author":"Kim","year":"2006","journal-title":"J. Korean Neurol. Assoc."},{"key":"10.1016\/j.brainres.2008.06.087_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0270(00)00351-4","article-title":"Experimental thromboembolic stroke in cynomolgus monkey","volume":"105","author":"Kito","year":"2001","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2008.06.087_bib17","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1460-9568.2004.03632.x","article-title":"The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals","volume":"20","author":"Koh","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2008.06.087_bib18","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1371\/journal.pone.0000156","article-title":"Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2008.06.087_bib19","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/81395","article-title":"Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep","volume":"6","author":"Liechty","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2008.06.087_bib20","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1073\/pnas.0336479100","article-title":"Transplanted bone marrow generates new neurons in human brains","volume":"100","author":"Mezey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2008.06.087_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuroimage.2003.08.030","article-title":"Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study","volume":"21","author":"Modo","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2008.06.087_bib22","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1634\/stemcells.2006-0735","article-title":"Functional expression of ion channels in mesenchymal stem cells derived from umbilical cord vein","volume":"25","author":"Park","year":"2007","journal-title":"Stem. Cells"},{"key":"10.1016\/j.brainres.2008.06.087_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainres.2003.07.004","article-title":"Cell death and long-term maintenance of neuron-like state after differentiation of rat bone marrow stromal cells: a comparison of protocols","volume":"991","author":"Rismanchi","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.06.087_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1634\/stemcells.21-1-105","article-title":"Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord","volume":"21","author":"Romanov","year":"2003","journal-title":"Stem. Cells"},{"key":"10.1016\/j.brainres.2008.06.087_bib25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1634\/stemcells.2004-0166","article-title":"Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors","volume":"23","author":"Sarugaser","year":"2005","journal-title":"Stem. Cells"},{"key":"10.1016\/j.brainres.2008.06.087_bib26","article-title":"A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)","author":"Schabitz","year":"2007","journal-title":"J. Cereb. Blood. Flow Metab."},{"key":"10.1016\/j.brainres.2008.06.087_bib27","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1634\/stemcells.2006-0589","article-title":"Concise review: adipose tissue-derived stromal cells\u2013basic and clinical implications for novel cell-based therapies","volume":"25","author":"Schaffler","year":"2007","journal-title":"Stem. Cells"},{"key":"10.1016\/j.brainres.2008.06.087_bib28","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1002\/jnr.21341","article-title":"Decreased focal inflammatory response by G-CSF may improve stroke outcome after transient middle cerebral artery occlusion in rats","volume":"85","author":"Sehara","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2008.06.087_bib29","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bone.2003.07.005","article-title":"Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells","volume":"33","author":"Stenderup","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.brainres.2008.06.087_bib30","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia","volume":"111","author":"Sun","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2008.06.087_bib31","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1073\/pnas.0337659100","article-title":"Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains","volume":"100","author":"Weimann","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2008.06.087_bib32","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1634\/stemcells.2005-0330","article-title":"Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease","volume":"24","author":"Weiss","year":"2006","journal-title":"Stem. Cells"},{"key":"10.1016\/j.brainres.2008.06.087_bib33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3171\/jns.2004.100.1.0088","article-title":"Proliferation, migration, and differentiation of human neural stem\/progenitor cells after transplantation into a rat model of traumatic brain injury","volume":"100","author":"Wennersten","year":"2004","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2008.06.087_bib34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C","article-title":"Adult rat and human bone marrow stromal cells differentiate into neurons","volume":"61","author":"Woodbury","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2008.06.087_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neulet.2005.12.009","article-title":"Differential gene expression pattern of neurotrophins and their receptors during neuronal differentiation of rat bone marrow stromal cells","volume":"397","author":"Yaghoobi","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2008.06.087_bib36","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/01.STR.32.8.1890","article-title":"Neurogenesis by progenitor cells in the ischemic adult rat hippocampus","volume":"32","author":"Yagita","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2008.06.087_bib37","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1042\/BST0341310","article-title":"Neuroprotection and neurosupplementation in ischaemic brain","volume":"34","author":"Yamashita","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.brainres.2008.06.087_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00004647-200404000-00009","article-title":"Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats","volume":"24","author":"Zhang","year":"2004","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.brainres.2008.06.087_bib39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/scd.2006.0092","article-title":"Comparison of the behavior of neural stem cells in the brain of normal and twitcher mice after neonatal transplantation","volume":"16","author":"Zhao","year":"2007","journal-title":"Stem. Cells Dev."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308015278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308015278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T12:58:10Z","timestamp":1545915490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899308015278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":39,"alternative-id":["S0006899308015278"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2008.06.087","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}