{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:13:09Z","timestamp":1791036789711,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.brainres.2008.08.021","type":"journal-article","created":{"date-parts":[[2008,8,17]],"date-time":"2008-08-17T04:41:52Z","timestamp":1218948112000},"page":"176-184","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Expression of methyl CpG binding protein 2 (Mecp2) during the postnatal development of the mouse brainstem"],"prefix":"10.1016","volume":"1236","author":[{"given":"Emmanuelle","family":"Dura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Villard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2008.08.021_bib1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1006\/nbdi.2001.0420","article-title":"Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex","volume":"8","author":"Akbarian","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2008.08.021_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0887-8994(02)00624-0","article-title":"Identification of MeCP2 mutations in a series of females with autistic disorder","volume":"28","author":"Carney","year":"2003","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.brainres.2008.08.021_bib4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.nbd.2003.10.011","article-title":"Expression of the methyl-CpG-binding protein MeCP2 in rat brain. An ontogenetic study","volume":"15","author":"Cassel","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2008.08.021_bib5","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome, from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2008.08.021_bib6","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.brainres.2008.08.021_bib7","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1093\/hmg\/ddh282","article-title":"Mild overexpression of MeCP2 causes a progressive neurological disorder in mice","volume":"13","author":"Collins","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib8","series-title":"Development and Developmental Disorders of the Brain Stem in Clinical neuroembryologie Springer","author":"Donkelaar","year":"2006"},{"key":"10.1016\/j.brainres.2008.08.021_bib9","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1177\/08830738040190121001","article-title":"Autonomic dysfunction in mental retardation and spastic paraparesis with MECP2 mutation","volume":"19","author":"Dotti","year":"2004","journal-title":"J. Child. Neurol."},{"key":"10.1016\/j.brainres.2008.08.021_bib10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/08830738050200090501","article-title":"MECP2 abnormality phenotypes: clinicopathologic area with broad variability","volume":"20","author":"Erlandson","year":"2005","journal-title":"J. Child. Neurol."},{"key":"10.1016\/j.brainres.2008.08.021_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ajmg.a.20247","article-title":"MECP2 gene mutations in non-syndromic X-linked mental retardation: phenotype-genotype correlation","volume":"123","author":"Gomot","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.brainres.2008.08.021_bib12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib13","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.brainres.2008.08.021_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib15","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.braindev.2005.02.012","article-title":"Assessment of the maturity-related brainstem functions reveals the heterogeneous phenotypes and facilitates clinical management of Rett syndrome","volume":"27","author":"Julu","year":"2005","journal-title":"Brain Develop."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2008.08.021_bib16","first-page":"47","article-title":"Functional evidence of brain stem immaturity in Rett syndrome","volume":"6","author":"Julu","year":"1997","journal-title":"Eur. Child. Adolesc. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.021_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/adc.85.1.29","article-title":"Characterisation of breathing and associated central autonomic dysfunction in the Rett disorder","volume":"85","author":"Julu","year":"2001","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.brainres.2008.08.021_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/neu.10201","article-title":"The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells","volume":"55","author":"Jung","year":"2003","journal-title":"J. Neurobiol."},{"issue":"S1","key":"10.1016\/j.brainres.2008.08.021_bib19","first-page":"71","article-title":"Rett syndrome: analysis of deaths in the British survey","volume":"6","author":"Kerr","year":"1997","journal-title":"Eur. Chil. Adolesc. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.021_bib20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mcn.2004.07.006","article-title":"MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions","volume":"27","author":"Kishi","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.021_bib21","doi-asserted-by":"crossref","first-page":"E41","DOI":"10.1136\/jmg.37.12.e41","article-title":"Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome","volume":"37","author":"Lam","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib22","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1093\/hmg\/10.17.1729","article-title":"Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry","volume":"10","author":"LaSalle","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpeds.2005.10.037","article-title":"Rett syndrome in Australia: a review of the epidemiology","volume":"148","author":"Laurvick","year":"2006","journal-title":"J. Pediatr."},{"key":"10.1016\/j.brainres.2008.08.021_bib24","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/hmg\/ddl099","article-title":"Identification of cis-regulatory elements for MECP2 expression","volume":"15","author":"Liu","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.brainres.2008.08.021_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1152\/jn.00826.2007","article-title":"Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome","volume":"99","author":"Medrihan","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2008.08.021_bib27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neuroscience.2003.11.025","article-title":"Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain","volume":"123","author":"Mullaney","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.08.021_bib28","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2008.08.021_bib29","first-page":"42","article-title":"Involvement of the autonomic nervous system in the pathophysiology of Rett syndrome","volume":"6S1","author":"Nomura","year":"1997","journal-title":"Eur. Child. Adolesc. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.021_bib30","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/01.jnen.0000187054.59018.f2","article-title":"Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction","volume":"64","author":"Paterson","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2008.08.021_bib31","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.brainres.2008.08.021_bib32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ygeno.2004.12.002","article-title":"Distinct expression profiles of Mecp2 transcripts with different lengths of 3\u00a2UTR in the brain and visceral organs during mouse development","volume":"85","author":"Pelka","year":"2005","journal-title":"Genomics"},{"key":"10.1016\/j.brainres.2008.08.021_bib33","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.pediatrneurol.2007.06.009","article-title":"Disturbances in cardiorespiratory function during day and night in Rett syndrome","volume":"37","author":"Rohdin","year":"2007","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.brainres.2008.08.021_bib34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00702-002-0767-7","article-title":"Neurochemical development of the brainstem catecholaminergic cell groups in rat","volume":"110","author":"Roux","year":"2003","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.brainres.2008.08.021_bib35","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/hmg\/ddn062","article-title":"A partial loss of function allele of Methyl-CpG-binding protein predicts a human neurodevelopmental syndrome","volume":"17","author":"Samaco","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/11.2.115","article-title":"Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation","volume":"11","author":"Shahbazian","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib37","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1113\/jphysiol.2006.119966","article-title":"Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-\/y knockout mice","volume":"579","author":"Stettner","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2008.08.021_bib38","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1086\/444549","article-title":"Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males","volume":"77","author":"Van Esch","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib39","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1523\/JNEUROSCI.4373-05.2005","article-title":"Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice","volume":"25","author":"Viemari","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.021_bib40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/jmg.2007.049452","article-title":"MECP2 mutations in males","volume":"44","author":"Villard","year":"2007","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.brainres.2008.08.021_bib41","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1523\/JNEUROSCI.1810-06.2006","article-title":"Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice","volume":"26","author":"Wang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.021_bib42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1203\/01.pdr.0000238302.84552.d0","article-title":"Autonomic nervous system dysregulation: breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome","volume":"60","author":"Weese-Mayer","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2008.08.021_bib43","doi-asserted-by":"crossref","first-page":"17551","DOI":"10.1073\/pnas.0507856102","article-title":"Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2","volume":"102","author":"Young","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308019379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308019379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T15:25:53Z","timestamp":1588865153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899308019379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":42,"alternative-id":["S0006899308019379"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2008.08.021","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}