{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:12:54Z","timestamp":1778695974166,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.brainres.2008.08.047","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T13:43:28Z","timestamp":1220795008000},"page":"84-90","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Perinatal choline deficiency produces abnormal sensory inhibition in Sprague\u2013Dawley rats"],"prefix":"10.1016","volume":"1237","author":[{"given":"Karen E.","family":"Stevens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany J.","family":"Mellott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Kisley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2008.08.047_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-3806(02)00547-3","article-title":"Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation","volume":"139","author":"Adams","year":"2002","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0006-8993(97)00978-5","article-title":"Nicotinic antagonist alpha-bungarotoxin binding to rat hippocampal neurons containing nitric oxide synthase","volume":"776","author":"Adams","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-3806(99)00057-7","article-title":"Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum","volume":"115","author":"Albright","year":"1999","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0165-3806(98)00183-7","article-title":"Choline availability alters embryonic development of the hippocampus and septum in the rat","volume":"113","author":"Albright","year":"1999","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib5","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1111\/j.1460-9568.1997.tb01702.x","article-title":"Choline is a selective agonist of \u03b17 nicotinic acetylcholine receptors in the rat brain neurons","volume":"9","author":"Alkondon","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.047_bib6","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1176\/ajp.150.12.1856","article-title":"Normalization of auditory physiology by cigarette smoking in schizophrenic patients","volume":"150","author":"Adler","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.047_bib7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/oxfordjournals.schbul.a033320","article-title":"Schizophrenia, sensory gating, and nicotinic receptors","volume":"24","author":"Adler","year":"1998","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.brainres.2008.08.047_bib8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0006-3223(86)90244-1","article-title":"Neurophysiological studies of sensory gating in rats: effects of amphetamine, phencyclidine, and haloperidol","volume":"21","author":"Adler","year":"1986","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.047_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0006-3223(90)90648-L","article-title":"Auditory sensory gating in hippocampal neurons: a model system in the rat","volume":"27","author":"Bickford-Wimer","year":"1990","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.047_bib10","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.281.5378.794","article-title":"Choline, a vital amine","volume":"281","author":"Blusztajn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.brainres.2008.08.047_bib11","first-page":"89","article-title":"Perinatal choline treatment modifies the effects of a visuo-spatial attractive cue upon spatial memory in na\u00efve adult rats","volume":"198","author":"Brandner","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1101\/lm.31506","article-title":"\u03b17 nicotinic acetylcholine receptors and temporal memory: synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock","volume":"13","author":"Cheng","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.brainres.2008.08.047_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0920-9964(93)90048-N","article-title":"Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia","volume":"10","author":"Cullum","year":"1993","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0163-7258(02)00182-1","article-title":"Structure-based design of cyclin-dependent kinase inhibitors","volume":"93","author":"Davies","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2008.08.047_bib15","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1101\/gad.12.15.2245","article-title":"The regulation E2F by pRB-family proteins","volume":"12","author":"Dyson","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2008.08.047_bib16","first-page":"989","article-title":"Neurophysiological studies of sensory gating in mania: comparison with schizophrenia","volume":"18","author":"Franks","year":"1983","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.047_bib17","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1523\/JNEUROSCI.18-04-01187.1998","article-title":"Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells","volume":"18","author":"Frazier","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.047_bib18","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1523\/JNEUROSCI.13-05-01965.1993","article-title":"Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression","volume":"13","author":"Freedman","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.047_bib19","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.91.5.1731","article-title":"KPA: a dual specificity phosphatase that interacts with cyclin-dependent kinases","volume":"91","author":"Hannon","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2008.08.047_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00213-005-0142-0","article-title":"Tropisetron improved deficient inhibitory auditory processing in DBA\/2 mice: role of \u03b17 nicotinic acetylcholine receptors","volume":"183","author":"Hashimoto","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2008.08.047_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-3806(99)00103-0","article-title":"Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation","volume":"118","author":"Jones","year":"1999","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0006-3223(02)01463-4","article-title":"Auditory sensory gating in hippocampus and reticular thalamic neurons in anesthetized rats","volume":"53","author":"Krause","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.047_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/schbul\/22.3.431","article-title":"Nicotinic receptor function in schizophrenia","volume":"22","author":"Leonard","year":"1996","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.brainres.2008.08.047_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0014-2999(00)00035-2","article-title":"Smoking and schizophrenia: abnormal nicotinic receptor expression","volume":"393","author":"Leonard","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2008.08.047_bib25","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1152\/jn.00785.2003","article-title":"Dietary prenatal choline supplementation alters postnatal hippocampal structure and function","volume":"91","author":"Li","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2008.08.047_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0012-1606(74)90196-1","article-title":"Development of cholinergic innervation in the hippocampal formation of the rat","volume":"36","author":"Matthews","year":"1974","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainres.2008.08.047_bib27","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.neubiorev.2005.12.003","article-title":"An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring","volume":"30","author":"McCann","year":"2006","journal-title":"Neruosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2008.08.047_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-8981(85)90267-0","article-title":"Measurement of free choline concentrations in maternal and neonatal blood by micropyrolysis gas chromatography","volume":"149","author":"McMahon","year":"1985","journal-title":"Clin. Chim. Acta."},{"key":"10.1016\/j.brainres.2008.08.047_bib29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1096\/fj.03-0877fje","article-title":"Prenatal choline supplementation advances hippocampal development and enhances AMPK and CREB activation","volume":"18","author":"Mellot","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2008.08.047_bib30","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1037\/0735-7044.103.6.1234","article-title":"Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both","volume":"103","author":"Meck","year":"1989","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.047_bib31","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1097\/00001756-199709290-00009","article-title":"Simultaneous temporal processing is sensitive to prenatal chline availability in mature and aged rats","volume":"8","author":"Meck","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2008.08.047_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0165-3806(99)00105-4","article-title":"Choline supplementation during prenatal development reduced proactive interference in spatial memory","volume":"118","author":"Meck","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0149-7634(03)00069-1","article-title":"Metabolic imprinting of choline by its availability during gestation: implication for memory and attentional processing across the lifespan","volume":"27","author":"Meck","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2008.08.047_bib34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/neuro.07.007.2007","article-title":"Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia","volume":"1","author":"Meck","year":"2008","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.brainres.2008.08.047_bib35","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0028-3908(92)90106-Y","article-title":"Phencyclidine and auditory gating in the hippocampus of the rat","volume":"31","author":"Miller","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2008.08.047_bib36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0306-4522(93)90506-B","article-title":"Medial septal neuron activity in relation to an auditory sensory gating paradigm","volume":"55","author":"Miller","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.08.047_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-3806(00)00075-4","article-title":"Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood","volume":"123","author":"Montoya","year":"2000","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib38","first-page":"848","article-title":"Effects of dietary choline on nicotinic receptors in brain","volume":"26","author":"Morley","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2008.08.047_bib39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0012-1606(74)90197-3","article-title":"Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities","volume":"36","author":"Nadler","year":"1974","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainres.2008.08.047_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1096\/fj.05-4707com","article-title":"Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains","volume":"20","author":"Niculescu","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2008.08.047_bib41","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1471-4159.2004.02414.x","article-title":"Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene","volume":"89","author":"Niculescu","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2008.08.047_bib42","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1001\/archpsyc.63.6.630","article-title":"Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia","volume":"63","author":"Olincy","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2008.08.047_bib43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0304-3940(96)12889-5","article-title":"An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the 7 subtype","volume":"213","author":"Papke","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2008.08.047_bib44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/cne.902690107","article-title":"Time of origin of cholinergic neuron in the rat basal forebrain","volume":"269","author":"Semba","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2008.08.047_bib45","doi-asserted-by":"crossref","DOI":"10.1007\/s00213-008-1170-3","article-title":"Increased perinatal choline permanently improved deficient sensory inhibition in DBA\/2 mice","author":"Stevens","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2008.08.047_bib46","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0893-133X(95)00178-G","article-title":"Genetic correlation of hippocampal auditory evoked response and \u03b1-bungarotoxin binding in inbred mouse strains","volume":"15","author":"Stevens","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2008.08.047_bib47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(91)90864-R","article-title":"Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating potentials","volume":"555","author":"Stevens","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib48","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s002130050573","article-title":"Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice","volume":"136","author":"Stevens","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2008.08.047_bib49","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0091-3057(96)00466-2","article-title":"Normalizing effects of nicotine and a novel nicotinic agonist on hippocampal auditory gating in two animal models","volume":"57","author":"Stevens","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2008.08.047_bib50","series-title":"Progress in Experimental Personality Research","first-page":"1","article-title":"Input dysfunction in schizophrenia","author":"Venables","year":"1964"},{"key":"10.1016\/j.brainres.2008.08.047_bib51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1749-6632.1992.tb22841.x","article-title":"Hippocampal function and schizophrenia. Experimental psychological evidence","volume":"658","author":"Venables","year":"1992","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2008.08.047_bib52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijpsycho.2007.10.008","article-title":"P50 sensory gating and attentional performance","volume":"67","author":"Wan","year":"2008","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.brainres.2008.08.047_bib53","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0006-8993(98)00229-7","article-title":"Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in prenatally choline supplemented rats","volume":"794","author":"Williams","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.08.047_bib54","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/jn\/132.7.1840","article-title":"Deficiency in methionine, tryptophan, isoleucine or choline induces apoptosis in cultured cells","volume":"132","author":"Yen","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainres.2008.08.047_bib55","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0899-9007(00)00349-X","article-title":"Choline: an essential nutrient for humans","volume":"16","author":"Zeisel","year":"2000","journal-title":"Nutrition"},{"issue":"5 Suppl","key":"10.1016\/j.brainres.2008.08.047_bib56","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/j.jpeds.2006.06.065","article-title":"The fetal origins of memory: the role of dietary choline in optimal brain development","volume":"149","author":"Zeisel","year":"2006","journal-title":"J. Pediatr."},{"key":"10.1016\/j.brainres.2008.08.047_bib57","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.nu.14.070194.001413","article-title":"Choline and human nutrition","volume":"14","author":"Zeisel","year":"1994","journal-title":"Ann. Rev. Nutr."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308020775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308020775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T17:01:53Z","timestamp":1557766913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899308020775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":57,"alternative-id":["S0006899308020775"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2008.08.047","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}