{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:51:52Z","timestamp":1773309112103,"version":"3.50.1"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.brainres.2008.09.059","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T08:29:34Z","timestamp":1222849774000},"page":"167-177","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Time-dependent alterations of cholinergic markers after experimental traumatic brain injury"],"prefix":"10.1016","volume":"1246","author":[{"given":"Cornelius K.","family":"Donat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin U.","family":"Schuhmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Nieber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winnie","family":"Deuther-Conrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2008.09.059_bib1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/syn.890020504","article-title":"[3H]vesamicol binding in brain: autoradiographic distribution, pharmacology, and effects of cholinergic lesions","volume":"2","author":"Altar","year":"1988","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2008.09.059_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11920-003-0074-5","article-title":"The cholinergic hypothesis of cognitive impairment caused by traumatic brain injury","volume":"5","author":"Arciniegas","year":"2003","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.brainres.2008.09.059_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1155\/2006\/460592","article-title":"Pharmacotherapy of posttraumatic cognitive impairments","volume":"17","author":"Arciniegas","year":"2006","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.brainres.2008.09.059_bib4","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1523\/JNEUROSCI.14-05-02476.1994","article-title":"Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions","volume":"14","author":"Aubert","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.09.059_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3171\/jns.1997.86.2.0241","article-title":"Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study","volume":"86","author":"Bergsneider","year":"1997","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2008.09.059_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0197-4580(89)90040-7","article-title":"Aging and brain cholinergic muscarinic receptor subtypes: an autoradiographic study in the rat","volume":"10","author":"Biegon","year":"1989","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2008.09.059_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1152\/jn.1946.9.5.349","article-title":"Presence and action of acetylcholine in experimental brain trauma","volume":"9","author":"Bornstein","year":"1946","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2008.09.059_bib8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s004010050602","article-title":"Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia","volume":"93","author":"Bramlett","year":"1997","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.brainres.2008.09.059_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-4274(98)00160-X","article-title":"Are cholinergic pathways involved in the anesthetic response to \u03b12 agonists","volume":"100\u2013101","author":"Buttermann","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.brainres.2008.09.059_bib10","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1602\/neurorx.2.3.410","article-title":"Animal models of head trauma","volume":"2","author":"Cernak","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.brainres.2008.09.059_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/exnr.1998.6831","article-title":"Chronic effects of traumatic brain injury on hippocampal vesicular acetylcholine transporter and M2 muscarinic receptor protein in rats","volume":"152","author":"Ciallella","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2008.09.059_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0006-8993(96)00819-0","article-title":"Delayed, selective neuronal death following experimental cortical impact injury in rats: possible role in memory deficits","volume":"739","author":"Colicos","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(97)81946-2","article-title":"Vesamicol and some of its derivatives: questionable ligands for selectively labelling acetylcholine transporters in rat brain","volume":"338","author":"Custers","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2008.09.059_bib14","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1046\/j.1471-4159.2003.02230.x","article-title":"Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients","volume":"88","author":"Darreh-Shori","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2008.09.059_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(94)90369-7","article-title":"Traumatic brain injury causes a decrease in M2 muscarinic cholinergic receptor binding in the rat brain","volume":"653","author":"DeAngelis","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/syn.20232","article-title":"Autoradiography of 2\u2212[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitro","volume":"59","author":"Deuther-Conrad","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2008.09.059_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-0270(91)90104-8","article-title":"A controlled cortical impact model of traumatic brain injury in the rat","volume":"39","author":"Dixon","year":"1991","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2008.09.059_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3940(94)90503-7","article-title":"Traumatic brain injury reduces hippocampal high-affinity [3H]choline uptake but not extracellular choline levels in rats","volume":"180","author":"Dixon","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2008.09.059_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/neu.1999.16.109","article-title":"One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats","volume":"16","author":"Dixon","year":"1999","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib20","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/02699050701630359","article-title":"Alterations of acetylcholinesterase activity after traumatic brain injury in rats","volume":"21","author":"Donat","year":"2007","journal-title":"Brain Inj."},{"key":"10.1016\/j.brainres.2008.09.059_bib21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0197-0186(95)00004-R","article-title":"Effects of JO 1784, a selective sigma ligand, on the autoradiographic localization of M1 and M2 muscarinic receptor subtypes in trimethyltin treated rats","volume":"26","author":"Earley","year":"1995","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2008.09.059_bib22","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/00001756-200004070-00007","article-title":"Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess","volume":"11","author":"Fass","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2008.09.059_bib23","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1007\/s00259-003-1320-0","article-title":"Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET","volume":"30","author":"Fujita","year":"2003","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.brainres.2008.09.059_bib24","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0026-895X(25)10533-6","article-title":"Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors","volume":"48","author":"Gerzanich","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2008.09.059_bib25","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1523\/JNEUROSCI.20-12-04745.2000","article-title":"Sustained visual attention performance-associated prefrontal neuronal activity: evidence for cholinergic modulation","volume":"20","author":"Gill","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.09.059_bib26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1089\/neu.1994.11.587","article-title":"Lateral cortical impact injury in rats: pathologic effects of varying cortical compression and impact velocity","volume":"11","author":"Goodman","year":"1994","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib27","first-page":"203","article-title":"Analysis of acetylcholine release following concussive brain injury in the rat","volume":"6","author":"Gorman","year":"1989","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/neu.1996.13.457","article-title":"Effects of traumatic brain injury on the cholinergic system in the rat","volume":"13","author":"Gorman","year":"1996","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s004140000185","article-title":"Neuronal changes in the arcuate and hypoglossal nuclei of brain stem induced by head injury","volume":"115","author":"Gotohda","year":"2001","journal-title":"Int. J. Legal Med."},{"key":"10.1016\/j.brainres.2008.09.059_bib30","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1227\/00006123-199212000-00013","article-title":"The effect of age on motor and cognitive deficits after traumatic brain injury in rats","volume":"31","author":"Hamm","year":"1992","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2008.09.059_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1364-6613(99)01365-0","article-title":"Neuromodulation: acetylcholine and memory consolidation","volume":"3","author":"Hasselmo","year":"1999","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.brainres.2008.09.059_bib32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/jnnp.64.4.486","article-title":"Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain","volume":"64","author":"Hillered","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainres.2008.09.059_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1254\/jjp.64.57","article-title":"Binding of fentanyl and pethidine to muscarinic receptors in rat brain","volume":"64","author":"Hustveit","year":"1994","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.brainres.2008.09.059_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0891-0618(97)00021-5","article-title":"Localization of two cholinergic markers, choline acetyltransferase and vesicular acetylcholine transporter in the central nervous system of the rat: in situ hybridization histochemistry and immunohistochemistry","volume":"13","author":"Ichikawa","year":"1997","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.brainres.2008.09.059_bib35","first-page":"878","article-title":"Evaluation of 5\u2212(11)C-methyl-A-85380 as an imaging agent for PET investigations of brain nicotinic acetylcholine receptors","volume":"45","author":"Iida","year":"2004","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.brainres.2008.09.059_bib36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-2999(93)90518-M","article-title":"Inhibition of hippocampal acetylcholine release by benzodiazepines: antagonism by flumazenil","volume":"238","author":"Imperato","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2008.09.059_bib37","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00019052-200412000-00012","article-title":"Head injury and dementia","volume":"17","author":"Jellinger","year":"2004","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.brainres.2008.09.059_bib38","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0892-0362(02)00314-8","article-title":"Increased high-affinity nicotinic receptor-binding in rats exposed to lead during development","volume":"24","author":"Jett","year":"2002","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.brainres.2008.09.059_bib39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-8993(94)90687-4","article-title":"Muscarinic cholinergic receptor binding in rat brain at 15\u00a0days following traumatic brain injury","volume":"651","author":"Jiang","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/30741","article-title":"Acute stress facilitates long-lasting changes in cholinergic gene expression","volume":"393","author":"Kaufer","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2008.09.059_bib41","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0009-2797(99)00046-0","article-title":"Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission","volume":"119\u2013120","author":"Kaufer","year":"1999","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.brainres.2008.09.059_bib42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/08977150252932370","article-title":"Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact","volume":"19","author":"Kline","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib43","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1074\/mcp.M600157-MCP200","article-title":"Novel differential neuroproteomics analysis of traumatic brain injury in rats","volume":"5","author":"Kobeissy","year":"2006","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.brainres.2008.09.059_bib44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000094151","article-title":"Pediatric traumatic brain injury: quo vadis?","volume":"28","author":"Kochanek","year":"2006","journal-title":"Dev. Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2008.09.059_bib45","first-page":"S359","article-title":"Neurobehavioral recovery","volume":"9","author":"Levin","year":"1992","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1988.5.1","article-title":"Controlled cortical impact: a new experimental brain injury model","volume":"5","author":"Lighthall","year":"1988","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib47","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0006-8993(94)91879-1","article-title":"Muscarinic cholinergic receptor binding in rat brain following traumatic brain injury","volume":"640","author":"Lyeth","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/08977150150502604","article-title":"Injury severity and sensitivity to treatment after controlled cortical impact in rats","volume":"18","author":"Markgraf","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0006-8993(98)00558-7","article-title":"Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (+\/\u2212)[3H]epibatidine","volume":"801","author":"Marutle","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib50","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1093\/brain\/awh294","article-title":"Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury","volume":"127","author":"Maxwell","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2008.09.059_bib51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/01.jnen.0000229241.28619.75","article-title":"Thalamic nuclei after human blunt head injury","volume":"65","author":"Maxwell","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2008.09.059_bib52","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0193-953X(18)30245-4","article-title":"Neuropsychiatric sequelae of head injuries","volume":"15","author":"McAllister","year":"1992","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.brainres.2008.09.059_bib53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/nimg.1995.1008","article-title":"Autoradiographic evidence that QNB displays in vivo selectivity for the M2 subtype","volume":"2","author":"McRee","year":"1995","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2008.09.059_bib54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/neu.2007.0359","article-title":"Validation of brain extracellular glycerol as an indicator of cellular membrane damage due to free radical activity after traumatic brain injury","volume":"25","author":"Merenda","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(98)00642-6","article-title":"GABA receptors and benzodiazepine binding sites modulate hippocampal acetylcholine release in vivo","volume":"359","author":"Moor","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2008.09.059_bib56","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/00000542-199904000-00021","article-title":"Fentanyl and morphine, but not remifentanil, inhibit acetylcholine release in pontine regions modulating arousal","volume":"90","author":"Mortazavi","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2008.09.059_bib57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/neu.1998.15.295","article-title":"Cortical cholinergic dysfunction after human head injury","volume":"15","author":"Murdoch","year":"1998","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib58","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/08977150252807018","article-title":"Nucleus basalis of Meynert pathology in the human brain after fatal head injury","volume":"19","author":"Murdoch","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00001756-199412300-00039","article-title":"Increased transmitter amino acid concentration in human ventricular CSF after brain trauma","volume":"6","author":"Palmer","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2008.09.059_bib60","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.brainres.2008.09.059_bib61","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0022-3565(25)12091-0","article-title":"[3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study","volume":"275","author":"Perry","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2008.09.059_bib63","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1046\/j.1471-4159.2002.00951.x","article-title":"Measuring nicotinic receptors with characteristics of \u03b14\u03b22, \u03b13\u03b22 and \u03b13\u03b24 subtypes in rat tissues by autoradiography","volume":"82","author":"Perry","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2008.09.059_bib62","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0166-2236(98)01361-7","article-title":"Acetylcholine in mind: a neurotransmitter correlate of consciousness?","volume":"22","author":"Perry","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2008.09.059_bib64","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1089\/neu.2007.0424","article-title":"Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysis","volume":"25","author":"Peterson","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib65","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2006.08.005","article-title":"Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition","volume":"51","author":"Prado","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2008.09.059_bib66","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1111\/j.1530-0277.1996.tb01706.x","article-title":"Long-term effects of chronic ethanol on muscarinic receptor binding in rat brain","volume":"20","author":"Rothberg","year":"1996","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2008.09.059_bib67","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1007\/s00259-007-0701-1","article-title":"Acetylcholine receptors in dementia and mild cognitive impairment","volume":"35","author":"Sabri","year":"2008","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.brainres.2008.09.059_bib68","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(88)90034-0","article-title":"The effect of concussive head injury on central cholinergic neurons","volume":"452","author":"Saija","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/exnr.1996.0099","article-title":"Alterations in CNS gene expression in a rodent model of moderate traumatic brain injury complicated by acute alcohol intoxication","volume":"139","author":"Sall","year":"1996","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2008.09.059_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02736691","article-title":"Distribution of the vesicular acetylcholine transporter (VAChT) in the central and peripheral nervous systems of the rat","volume":"5","author":"Sch\u00e4fer","year":"1994","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2008.09.059_bib71","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0165-3806(01)00248-6","article-title":"A critical maturational period of reduced brain vulnerability to injury. A study of cerebral glucose metabolism in cats","volume":"131","author":"Schmanke","year":"2001","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib72","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3171\/jns.1995.83.3.0496","article-title":"Loss of forebrain cholinergic neurons following fluid-percussion injury: implications for cognitive impairment in closed head injury","volume":"83","author":"Schmidt","year":"1995","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2008.09.059_bib73","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1179\/016164103101201896","article-title":"Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury","volume":"25","author":"Schuhmann","year":"2003","journal-title":"Neurol. Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib74","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1089\/089771503767869962","article-title":"Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study","volume":"20","author":"Schuhmann","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib75","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/0024-3205(96)00192-0","article-title":"Cholinergic control of cerebral blood flow in stroke, trauma and aging","volume":"58","author":"Scremin","year":"1996","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2008.09.059_bib76","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/neu.1999.16.555","article-title":"Differential effects of traumatic brain injury on vesicular acetylcholine transporter and M2 muscarinic receptor mRNA and protein in rat","volume":"16","author":"Shao","year":"1999","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib77","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s001090000104","article-title":"Antisense prevention of neuronal damages following head injury in mice","volume":"78","author":"Shohami","year":"2000","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.brainres.2008.09.059_bib78","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0306-4522(97)00652-0","article-title":"Laminar distribution of nicotinic receptor subtypes in human cerebral cortex as determined by [3H](\u2212)nicotine, [3H]cytisine and [3H]epibatidine in vitro autoradiography","volume":"85","author":"Sihver","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.09.059_bib79","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1471-4159.2001.00428.x","article-title":"Changes in mACh, NMDA and GABAA receptor binding after lateral fluid-percussion injury: in vitro autoradiography of rat brain frozen sections","volume":"78","author":"Sihver","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2008.09.059_bib80","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11011-006-9007-4","article-title":"Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs","volume":"21","author":"Szutowicz","year":"2006","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.brainres.2008.09.059_bib81","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/sleep\/18.6.478","article-title":"Magnocellular nuclei of the basal forebrain: substrates of sleep and arousal regulation","volume":"18","author":"Szymusiak","year":"1995","journal-title":"Sleep"},{"key":"10.1016\/j.brainres.2008.09.059_bib82","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/neu.2007.0486","article-title":"Injury severity differentially affects short- and long-term neuroendocrine outcomes of traumatic brain injury","volume":"25","author":"Taylor","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib83","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1471-4159.1997.68020778.x","article-title":"Acetylcholine release in the rat prefrontal cortex in vivo: modulation by alpha 2-adrenoceptor agonists and antagonists","volume":"68","author":"Tellez","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2008.09.059_bib84","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/157488506776930932","article-title":"Cholinergic treatment of traumatic brain injury","volume":"1","author":"Tenovuo","year":"2006","journal-title":"Curr. Drug Ther."},{"key":"10.1016\/j.brainres.2008.09.059_bib85","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.neuroscience.2006.03.011","article-title":"Chronic treatment with first or second generation antipsychotics in rodents: effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain","volume":"140","author":"Terry","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.09.059_bib86","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/exnr.2002.7941","article-title":"Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability","volume":"176","author":"Tong","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2008.09.059_bib87","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.neuroscience.2003.09.028","article-title":"Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging: an autoradiographic study in the rat brain","volume":"124","author":"Tribollet","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.09.059_bib88","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2005.11.015","article-title":"Differential regulation of the CXCR2 chemokine network in rat brain trauma: implications for neuroimmune interactions and neuronal survival","volume":"22","author":"Valles","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2008.09.059_bib89","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.neuroimage.2006.10.036","article-title":"Quantification of \u03b14\u03b22\u204e nicotinic receptors in the rat brain with microPET and 2\u2212[18F]F-A-85380","volume":"34","author":"Vaupel","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2008.09.059_bib90","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1089\/neu.2000.17.1001","article-title":"Traumatic brain injury reduces hippocampal \u03b17 nicotinic cholinergic receptor binding","volume":"17","author":"Verbois","year":"2000","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib91","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1089\/089771502762300238","article-title":"Time-dependent changes in rat brain cholinergic receptor expression after experimental brain injury","volume":"19","author":"Verbois","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib92","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/jnr.490360511","article-title":"Immediate early gene activation during the initial phases of the excitotoxic cascade","volume":"36","author":"Walker","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2008.09.059_bib93","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0022-3565(25)25074-1","article-title":"[3H]pirenzepine and (\u2212)[3H]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. II. Characterization and regulation of antagonist binding to putative muscarinic subtypes","volume":"237","author":"Watson","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2008.09.059_bib94","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1089\/neu.2006.23.1320","article-title":"Inbred mouse strains as a tool to analyze hippocampal neuronal loss after brain injury: a stereological study","volume":"23","author":"Witgen","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2008.09.059_bib95","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0166-2236(92)90351-8","article-title":"Choline metabolism as a basis for the selective vulnerability of cholinergic neurons","volume":"15","author":"Wurtman","year":"1992","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2008.09.059_bib96","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuint.2005.12.001","article-title":"Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury","volume":"48","author":"Yi","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2008.09.059_bib97","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0006-8993(91)90755-K","article-title":"Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: evidence of a hyper- and subsequent hypometabolic state","volume":"561","author":"Yoshino","year":"1991","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308023366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308023366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T09:55:01Z","timestamp":1738403701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899308023366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":97,"alternative-id":["S0006899308023366"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2008.09.059","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}