{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:48:22Z","timestamp":1787161702570,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.brainres.2008.11.070","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T06:05:17Z","timestamp":1228457117000},"page":"27-34","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Age-related hearing loss: Aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain"],"prefix":"10.1016","volume":"1253","author":[{"given":"Nathan","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"D'Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Frisina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2008.11.070_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0378-5955(99)00036-2","article-title":"Expression pattern of aquaporin water channels in the inner ear of the rat: the molecular basis for a water regulation system in the endolymphatic sac","volume":"132","author":"Beitz","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.11.070_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1023\/A:1023636620721","article-title":"Aquaporin-mediated fluid regulation in the inner ear","volume":"23","author":"Beitz","year":"2003","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2008.11.070_bib3","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1523\/JNEUROSCI.10-07-02363.1990","article-title":"Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis","volume":"10","author":"Caspary","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.11.070_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0531-5565(94)00052-5","article-title":"Central auditory aging: GABA changes in the inferior colliculus","volume":"30","author":"Caspary","year":"1995","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainres.2008.11.070_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0306-4522(99)00121-9","article-title":"Age-related changes in GABA(A) receptor subunit composition and function in rat auditory system","volume":"93","author":"Caspary","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.11.070_bib6","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.1523\/JNEUROSCI.2451-05.2005","article-title":"Age-related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: role of inhibitory inputs","volume":"47","author":"Caspary","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.11.070_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jneumeth.2008.02.022","article-title":"Novel approach for selecting genes from RMA normalized microarray data using functional hearing tests in aging mice","volume":"171","author":"D'Souza","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2008.11.070_bib8","series-title":"The Inferior Colliculus","first-page":"559","article-title":"Inferior colliculus: aging and plasticity","author":"Frisina","year":"2005"},{"key":"10.1016\/j.brainres.2008.11.070_bib9","series-title":"Handbook of Mouse Auditory Research: From Behavior to Molecular Biology","first-page":"339","article-title":"Aging of the mouse central auditory system","author":"Frisina","year":"2001"},{"key":"10.1016\/j.brainres.2008.11.070_bib10","doi-asserted-by":"crossref","first-page":"EL","DOI":"10.1121\/1.2401226","article-title":"Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noise","volume":"121","author":"Frisina","year":"2007","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.brainres.2008.11.070_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.heares.2004.01.013","article-title":"Sex differences in distortion product otoacoustic emissions as a function of age in CBA mice","volume":"192","author":"Guimaraes","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.11.070_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-5955(02)00288-5","article-title":"Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea","volume":"165","author":"Huang","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.11.070_bib13","doi-asserted-by":"crossref","first-page":"8071","DOI":"10.1523\/JNEUROSCI.19-18-08071.1999","article-title":"Serotonin differentially modulates responses to tones and frequency-modulated sweeps in the inferior colliculus","volume":"19","author":"Hurley","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.11.070_bib14","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1152\/jn.2001.85.2.828","article-title":"Serotonin effects on frequency tuning of inferior colliculus neurons","volume":"85","author":"Hurley","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2008.11.070_bib15","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1097\/00005537-200310000-00009","article-title":"Contralateral suppression of distortion-product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listeners","volume":"113","author":"Jacobson","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brainres.2008.11.070_bib16","doi-asserted-by":"crossref","first-page":"31233","DOI":"10.1074\/jbc.M104368200","article-title":"Impaired hearing in mice lacking aquaporin-4 water channels","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2008.11.070_bib17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0006-291X(02)02296-9","article-title":"Aquaporin 4 expression in the mammalian inner ear and its role in hearing","volume":"297","author":"Mhatre","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2008.11.070_bib18","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s00467-006-0411-0","article-title":"Aquaporin-4 and brain edema","volume":"22","author":"Papadopolous","year":"2007","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.brainres.2008.11.070_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.09.081","article-title":"Glutamate-related gene expression changes with age in the mouse auditory midbrain","volume":"1127","author":"Tadros","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.11.070_bib20","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.neurobiolaging.2006.05.021","article-title":"Serotonin 2B receptor: upregulated with age and hearing loss in mouse auditory system","volume":"28","author":"Tadros","year":"2007","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.brainres.2008.11.070_bib21","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1046\/j.1460-9568.1998.00360.x","article-title":"Select types of supporting cell in the inner ear express aquaporin-4 channel protein","volume":"10","author":"Takumi","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2008.11.070_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.heares.2005.06.006","article-title":"Age-related declines in contralateral suppression of distortion product otoacoustic emissions utilizing pure tones in CBA\/CaJ mice","volume":"209","author":"Varghese","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2008.11.070_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/ann.34.3.192.200","article-title":"Physiological importance of aquaporin water channels","volume":"34","author":"Verkman","year":"2002","journal-title":"Ann. Med."},{"key":"10.1016\/j.brainres.2008.11.070_bib24","unstructured":"Willott, J.F., 1991. Aging and the Auditory System: Anatomy, Physiology, and Psychophysics. Singular Pub. Group, San Diego, pp. 56\u2013131."},{"key":"10.1016\/j.brainres.2008.11.070_bib25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0378-5955(91)90215-U","article-title":"Comparison of the auditory sensitivity of neurons in the cochlear nucleus and inferior colliculus of young and aging C57BL\/6J and CBA\/J mice","volume":"53","author":"Willott","year":"1991","journal-title":"Hear. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308028011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899308028011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T20:45:02Z","timestamp":1557953102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899308028011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":25,"alternative-id":["S0006899308028011"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2008.11.070","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}