{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T16:19:59Z","timestamp":1774455599374,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.brainres.2008.11.102","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T11:21:42Z","timestamp":1229512902000},"page":"153-161","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Intraventricular orexin-A improves arousal and early EEG entropy in rats after cardiac arrest"],"prefix":"10.1016","volume":"1255","author":[{"given":"Matthew A.","family":"Koenig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Velasquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitish V.","family":"Thakor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romergryko G.","family":"Geocadin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2008.11.102_bib1","series-title":"Greenfield's Neuropathology","first-page":"243","article-title":"Hypoxia and related conditions","author":"Auer","year":"2002"},{"key":"10.1016\/j.brainres.2008.11.102_bib2","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1523\/JNEUROSCI.22-18-07835.2002","article-title":"Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons","volume":"22","author":"Bayer","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.11.102_bib3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1056\/NEJM198309083091001","article-title":"Survival after cardiopulmonary resuscitation in the hospital","volume":"309","author":"Bedell","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2008.11.102_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000117426","article-title":"The prognostication of cerebral hypoxia after out-of-hospital cardiac arrest in adults","volume":"37","author":"Berek","year":"1997","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.brainres.2008.11.102_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00000542-199011000-00004","article-title":"Electroencephalographic changes during brief cardiac arrest in humans","volume":"73","author":"Clute","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2008.11.102_bib6","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/00000542-200605000-00019","article-title":"Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia","volume":"104","author":"Dong","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2008.11.102_bib7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0306-4522(03)00197-0","article-title":"Integrated contributions of basal forebrain and thalamus to neocortical activation elicited by pedunculopontine tegmental stimulation in urethane-anesthetized rats","volume":"119","author":"Dringenberg","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.11.102_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0306-4522(01)00512-7","article-title":"Orexins\/hypocretins excite basal forebrain cholinergic neurons","volume":"108","author":"Eggermann","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.11.102_bib9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/01.STR.21.2.299","article-title":"Histologic assessment of neurons in rat models of cerebral ischemia","volume":"21","author":"Eke","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2008.11.102_bib10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/sleep\/26.8.953","article-title":"Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog","volume":"26","author":"Fujiki","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.brainres.2008.11.102_bib11","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S1388-2457(00)00379-5","article-title":"A novel quantitative EEG injury measure of global cerebral ischemia","volume":"111","author":"Geocadin","year":"2000","journal-title":"Clin. Neurophysiol."},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2008.11.102_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mds.870150704","article-title":"Early electrophysiological and histologic changes after global cerebral ischemia in rats","volume":"15","author":"Geocadin","year":"2000","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2008.11.102_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0300-9572(02)00196-X","article-title":"Neurological recovery by EEG bursting after resuscitation from cardiac arrest in rats","volume":"55","author":"Geocadin","year":"2002","journal-title":"Resuscitation"},{"key":"10.1016\/j.brainres.2008.11.102_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1212\/01.wnl.0000223335.86166.b4","article-title":"Neurologic prognosis and withdrawal of life support after resuscitation from cardiac arrest","volume":"67","author":"Geocadin","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2008.11.102_bib15","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.neuropharm.2006.03.030","article-title":"Modulation of thalamic neuron excitability by orexins","volume":"51","author":"Govidaiah","year":"2006","journal-title":"Neuropharmacol."},{"key":"10.1016\/j.brainres.2008.11.102_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0300-9572(72)90051-2","volume":"1","author":"Gurvitch","year":"1972","journal-title":"Resuscitation"},{"key":"10.1016\/j.brainres.2008.11.102_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/155005948301400308","article-title":"Significance of reactive burst suppression following asphyxia in full term infants","volume":"14","author":"Holmes","year":"1983","journal-title":"Clin. Electroencephalogr."},{"key":"10.1016\/j.brainres.2008.11.102_bib18","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1152\/jn.00927.2005","article-title":"Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus excited by hypocretin: a feedforward circuit that may enhance cognitive arousal","volume":"95","author":"Huang","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2008.11.102_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(02)00176-3","article-title":"Increased cortical expression of the orexin-1 receptor following permanent middle cerebral artery occlusion in the rat","volume":"324","author":"Irving","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2008.11.102_bib20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.resuscitation.2007.08.014","article-title":"Improving neurological outcomes post-cardiac arrest in a rat model: immediate hypothermia and quantitative EEG monitoring","volume":"76","author":"Jia","year":"2008","journal-title":"Resuscitation"},{"key":"10.1016\/j.brainres.2008.11.102_bib21","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.brainres.2006.04.121","article-title":"Quantitative EEG and neurological recovery with therapeutic hypothermia after asphyxial cardiac arrest in rats","volume":"1111","author":"Jia","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2008.11.102_bib22","first-page":"23","article-title":"Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs","volume":"3","author":"John","year":"2000","journal-title":"Sleep Res. Online"},{"key":"10.1016\/j.brainres.2008.11.102_bib23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1113\/jphysiol.2002.038729","article-title":"Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats","volume":"548","author":"John","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2008.11.102_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0300-9572(81)90023-X","article-title":"Natural history of global and critical brain ischaemia. Part I: EEG and neurological signs during the first year after cardiopulmonary resuscitation in patients subsequently regaining consciousness","volume":"9","author":"Jorgensen","year":"1981","journal-title":"Resuscitation"},{"key":"10.1016\/j.brainres.2008.11.102_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0300-9572(81)90024-1","article-title":"Natural history of global and critical brain ischaemia. Part II: EEG and neurological signs in patients remaining unconscious after cardiopulmonary resuscitation","volume":"9","author":"Jorgensen","year":"1981","journal-title":"Resuscitation"},{"key":"10.1016\/j.brainres.2008.11.102_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0022-3565(24)38126-1","article-title":"Orexin A but not orexin B rapidly enters brain from blood by simple diffusion","volume":"289","author":"Kastin","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2008.11.102_bib27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.0707146105","article-title":"An essential role for orexins in emergence from general anesthesia","volume":"105","author":"Kelz","year":"2008","journal-title":"Proc. Nat. Acad. Sci."},{"key":"10.1016\/j.brainres.2008.11.102_bib28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0306-4522(03)00554-2","article-title":"Orexinergic neurons and barbiturate anesthesia","volume":"121","author":"Kushikata","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2008.11.102_bib29","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1523\/JNEUROSCI.0719-05.2005","article-title":"Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat","volume":"25","author":"Lambe","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2008.11.102_bib30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00004424-197707000-00005","article-title":"Cerebral water content, blood flow and EEG changes after cardiac arrest in the dog","volume":"12","author":"Lin","year":"1977","journal-title":"Invest. Radiol."},{"key":"10.1016\/j.brainres.2008.11.102_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0300-9572(75)90071-4","article-title":"Total brain ischaemia in dogs: cerebral physiological and metabolic changes after 15 minutes of circulatory arrest","volume":"4","author":"Lind","year":"1975","journal-title":"Resuscitation"},{"key":"10.1016\/j.brainres.2008.11.102_bib32","series-title":"Neurology and General Medicine","first-page":"497","article-title":"Neurologic complications of cardiac arrest","author":"Longstreth","year":"2001"},{"key":"10.1016\/j.brainres.2008.11.102_bib33","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1213\/00000539-199212000-00025","article-title":"Electroencephalographic monitoring of cerebral function during asystole and successful cardiopulmonary resuscitation","volume":"75","author":"Losasso","year":"1992","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2008.11.102_bib34","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/00004691-200212000-00007","article-title":"Early restitution of electrocorticogram predicts subsequent behavioral recovery from cardiac arrest","volume":"19","author":"Luft","year":"2002","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.brainres.2008.11.102_bib35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2008.11.102_bib36","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1001\/jama.1980.03310240042022","article-title":"EEG monitoring during cardiac arrest and resuscitation","volume":"244","author":"Moss","year":"1980","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.brainres.2008.11.102_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archneur.1977.00500140019003","article-title":"Nervous system effects of cardiac arrest in monkeys. Preservation of vision","volume":"34","author":"Myers","year":"1977","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2008.11.102_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.regpep.2004.08.037","article-title":"Orexin-1 receptor expression after global ischemia in mice","volume":"126","author":"Nakamachi","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.brainres.2008.11.102_bib39","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.brainres.2008.11.102_bib40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/CIRCULATIONAHA.107.187998","article-title":"Heart disease and stroke statistics \u2014 2008 update: a report from the American heart association statistics committee and stroke statistics subcommittee","volume":"117","author":"Rosamond","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2008.11.102_bib41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0079-6123(08)62175-5","article-title":"Quantitative EEG and evoked potentials after experimental brain ischemia in the rat; correlation with cerebral metabolism and blood flow","volume":"62","author":"Rosen","year":"1984","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2008.11.102_bib42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0166-4328(01)00307-2","article-title":"Cortical arousal induced by microinjection of orexins into the paraventricular nucleus of the rat","volume":"128","author":"Sato-Suzuki","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2008.11.102_bib43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000116329","article-title":"Prognostic value of EEG in post-anoxic coma after cardiac arrest","volume":"26","author":"Scollo-Lavizzari","year":"1987","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.brainres.2008.11.102_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/155005949903000410","article-title":"Quantitative EEG during early recovery from hypoxic\u2013ischemic injury in immature piglets: burst occurrence and duration","volume":"30","author":"Sherman","year":"1999","journal-title":"Clin. Electroencephalogr."},{"key":"10.1016\/j.brainres.2008.11.102_bib45","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1109\/IEMBS.2006.260739","article-title":"Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest","volume":"1","author":"Shin","year":"2006","journal-title":"Conf. Proc. IEEE End. Med. Biol. Soc."},{"key":"10.1016\/j.brainres.2008.11.102_bib46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrn2092","article-title":"The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness","volume":"8","author":"Sakurai","year":"2007","journal-title":"Nat. Rev., Neurosci."},{"issue":"Suppl. 2","key":"10.1016\/j.brainres.2008.11.102_bib47","first-page":"57","article-title":"Cerebral resuscitation from cardiac arrest: pathophysiologic mechanisms","volume":"24","author":"Vaagenes","year":"1997","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.brainres.2008.11.102_bib48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1212\/01.wnl.0000227183.21314.cd","article-title":"Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the quality standards subcommittee of the American academy of neurology","volume":"67","author":"Wijdicks","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2008.11.102_bib49","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1213\/01.ANE.0000089964.85834.EF","article-title":"Orexin A elicits arousal electroencephalography without sympathetic cardiovascular activation in isoflurane-anesthetized rats","volume":"97","author":"Yasuda","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2008.11.102_bib50","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0304-3940(03)00571-8","article-title":"Differential kinetics of hypocretins in the cerebrospinal fluid after intracerebroventricular administration in rats","volume":"346","author":"Yoshida","year":"2003","journal-title":"Neurosci. Lett."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930802903X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689930802903X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T06:48:43Z","timestamp":1738824523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689930802903X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":50,"alternative-id":["S000689930802903X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2008.11.102","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}