{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:56:45Z","timestamp":1760853405249},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.brainres.2009.03.004","type":"journal-article","created":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T08:08:22Z","timestamp":1236931702000},"page":"190-199","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["A splice variant of the TATA-box binding protein encoding the polyglutamine-containing N-terminal domain that accumulates in Alzheimer's disease"],"prefix":"10.1016","volume":"1268","author":[{"given":"Suzanne J.","family":"Reid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell G.","family":"Snell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.03.004_bib1","doi-asserted-by":"crossref","first-page":"41414","DOI":"10.1074\/jbc.M407201200","article-title":"The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue","volume":"279","author":"Ben-Saadon","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2009.03.004_bib2","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/molbev\/msg205","article-title":"Early vertebrate evolution of the TATA-binding protein, TBP","volume":"20","author":"Bondareva","year":"2003","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.brainres.2009.03.004_bib3","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1128\/MCB.19.8.5237","article-title":"Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins","volume":"19","author":"Bustin","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2009.03.004_bib4","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.1073\/pnas.95.16.9620","article-title":"Expression profiles of multiple genes in single neurons of Alzheimer's disease","volume":"95","author":"Chow","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.03.004_bib5","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/jnr.21695","article-title":"Transcription factor Sp1 dysregulation in Alzheimer's disease","volume":"86","author":"Citron","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.03.004_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/embo-reports\/kvd092","article-title":"Finding nuclear localization signals","volume":"1","author":"Cokol","year":"2000","journal-title":"EMBO Rep."},{"key":"10.1016\/j.brainres.2009.03.004_bib7","doi-asserted-by":"crossref","first-page":"32597","DOI":"10.1074\/jbc.M011792200","article-title":"The binding interaction of HMG-1 with the TATA-binding protein\/TATA complex","volume":"276","author":"Das","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2009.03.004_bib8","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1021\/bi011580v","article-title":"The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol","volume":"41","author":"Deeks","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2009.03.004_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-5793(93)80446-2","article-title":"Generation of beta A4 from the amyloid protein precursor and fragments thereof","volume":"335","author":"Dyrks","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2009.03.004_bib10","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/nn2011","article-title":"Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration","volume":"10","author":"Friedman","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2009.03.004_bib11","doi-asserted-by":"crossref","first-page":"8283","DOI":"10.1074\/jbc.M709674200","article-title":"Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity","volume":"283","author":"Friedman","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2009.03.004_bib12","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.141.5.1097","article-title":"The influence of huntingtin protein size on nuclear localization and cellular toxicity","volume":"141","author":"Hackam","year":"1998","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.brainres.2009.03.004_bib13","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1101\/gad.7.7b.1291","article-title":"TBP, a universal eukaryotic transcription factor?","volume":"7","author":"Hernandez","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2009.03.004_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(02)00806-1","article-title":"Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system","volume":"110","author":"Hobbs","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2009.03.004_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/B:SCAM.0000007124.19463.e5","article-title":"Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins","volume":"24","author":"Huang","year":"1998","journal-title":"Somat. Cell. Mol. Genet."},{"key":"10.1016\/j.brainres.2009.03.004_bib16","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/sj.cdd.4402120","article-title":"Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons","volume":"14","author":"Komatsu","year":"2007","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.brainres.2009.03.004_bib17","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/j.1460-2075.1994.tb06366.x","article-title":"The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters","volume":"13","author":"Lescure","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2009.03.004_bib18","series-title":"Models of Alzheimer's disease. handbook of models for human aging","first-page":"121","author":"LeVine","year":"2006"},{"key":"10.1016\/j.brainres.2009.03.004_bib19","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0306-4522(00)00391-2","article-title":"Amyloid-like inclusions in Huntington's disease","volume":"100","author":"McGowan","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.03.004_bib38","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.03.004_bib20","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/hmg\/10.14.1441","article-title":"SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein","volume":"10","author":"Nakamura","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2009.03.004_bib21","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1242\/jcs.019265","article-title":"Autophagy, amyloidogenesis and Alzheimer disease","volume":"120","author":"Nixon","year":"2007","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.brainres.2009.03.004_bib22","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s00018-003-3013-z","article-title":"Polyglutamine diseases: a transcription disorder?","volume":"60","author":"Okazawa","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.brainres.2009.03.004_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/ncb1553","article-title":"Proteome analysis of soluble nuclear proteins reveals that HMGB1\/2 suppress genotoxic stress in polyglutamine diseases","volume":"9","author":"Qi","year":"2007","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.brainres.2009.03.004_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0969-9961(03)00014-7","article-title":"Molecular investigation of TBP allele length: a SCA17 cellular model and population study","volume":"13","author":"Reid","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2009.03.004_bib25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molbrainres.2004.03.018","article-title":"TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease","volume":"125","author":"Reid","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2009.03.004_bib39","doi-asserted-by":"crossref","unstructured":"Shapiro, M.B., Senapathy, P., 1987. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 15 (17) (Sep 11), 7155\u20137174. PMID: 3658675.","DOI":"10.1093\/nar\/15.17.7155"},{"key":"10.1016\/j.brainres.2009.03.004_bib26","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/11.17.1953","article-title":"Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses","volume":"11","author":"Sipione","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2009.03.004_bib27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molmed.2004.09.005","article-title":"Alzheimer's disease meets the ubiquitin\u2013proteasome system","volume":"10","author":"Song","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.brainres.2009.03.004_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2990.1999.00164.x","article-title":"The amyloid precursor protein of Alzheimer's disease and the Abeta peptide","volume":"25","author":"Storey","year":"1999","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2009.03.004_bib29","doi-asserted-by":"crossref","unstructured":"Thierry-Mieg, D., Thierry-Mieg, J., 2006. AceView: a comprehensive cDNA-supported gene and transcripts annotation. Genome Biol. 7 Suppl 1, S12 1\u201314.","DOI":"10.1186\/gb-2006-7-s1-s12"},{"key":"10.1016\/j.brainres.2009.03.004_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/sj.ejhg.5201721","article-title":"Repeat expansion in spinocerebellar ataxia type 17 alleles of the TATA-box binding protein gene: an evolutionary approach","volume":"15","author":"Tomiuk","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.brainres.2009.03.004_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(02)00450-3","article-title":"Insoluble TATA-binding protein accumulation in Huntington's disease cortex","volume":"109","author":"van Roon-Mom","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2009.03.004_bib32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.neuroscience.2005.03.024","article-title":"TATA-binding protein in neurodegenerative disease","volume":"133","author":"van Roon-Mom","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.03.004_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF03033775","article-title":"The roles of proteolysis and nuclear localisation in the toxicity of the polyglutamine diseases. A review","volume":"7","author":"Walsh","year":"2005","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2009.03.004_bib34","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002","article-title":"Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease","volume":"22","author":"Wellington","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2009.03.004_bib35","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/IAI.02011-06","article-title":"Evading the proteasome: absence of lysine residues contributes to pertussis toxin activity by evasion of proteasome degradation","volume":"75","author":"Worthington","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.brainres.2009.03.004_bib36","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2005.10.030","article-title":"In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets","volume":"123","author":"Zhai","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2009.03.004_bib37","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0092-8674(02)00648-7","article-title":"A regulated two-step mechanism of TBP binding to DNA: a solvent-exposed surface of TBP inhibits TATA box recognition","volume":"108","author":"Zhao","year":"2002","journal-title":"Cell"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309005125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309005125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T19:02:35Z","timestamp":1558206155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309005125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":39,"alternative-id":["S0006899309005125"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.03.004","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}