{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:08:18Z","timestamp":1785355698510,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.brainres.2009.05.029","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T05:09:44Z","timestamp":1242709784000},"page":"19-24","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Reduced glutathione regenerating enzymes undergo developmental decline and sexual dimorphism in the rat cerebral cortex"],"prefix":"10.1016","volume":"1286","author":[{"given":"Vikas V.","family":"Dukhande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred O.","family":"Isaac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanushree","family":"Chatterji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.K.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.05.029_bib1","first-page":"111","article-title":"Erythrocyte antioxidant enzymes in Parkinson's disease","volume":"121","author":"Abraham","year":"2005","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.brainres.2009.05.029_bib2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/ije\/31.6.1235","article-title":"Fetal origins of adult disease: strength of effects and biological basis","volume":"31","author":"Barker","year":"2002","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.brainres.2009.05.029_bib3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1115455","article-title":"Sex differences in the brain: implications for explaining autism","volume":"310","author":"Baron-Cohen","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.brainres.2009.05.029_bib4","doi-asserted-by":"crossref","first-page":"15605","DOI":"10.1073\/pnas.0806883105","article-title":"Gene expression changes in the course of normal brain aging are sexually dimorphic","volume":"105","author":"Berchtold","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2009.05.029_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0165-3806(00)00134-6","article-title":"Brain regional development of the activity of \u03b1-ketoglutarate dehydrogenase complex in the rat","volume":"125","author":"Buerstatte","year":"2000","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2009.05.029_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrn1909","article-title":"Why sex matters for neuroscience","volume":"7","author":"Cahill","year":"2006","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.brainres.2009.05.029_bib7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1471-4159.1982.tb08637.x","article-title":"Glycerol phosphate dehydrogenase, glucose-6-phosphate dehydrogenase, and lactate dehydrogenase: activities in oligodendrocytes, neurons, astrocytes, and myelin isolated from developing rat brains","volume":"38","author":"Cammer","year":"1982","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.05.029_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0047-6374(92)90035-C","article-title":"Age-related changes in antioxidant enzyme activities are region and organ, as well as sex, selective in the rat","volume":"65","author":"Carrillo","year":"1992","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.brainres.2009.05.029_bib9","first-page":"233","article-title":"Glycolytic, tricarboxylic acid cycle and related enzymes in brain","volume":"11","author":"Clark","year":"1989"},{"key":"10.1016\/j.brainres.2009.05.029_bib10","first-page":"899","article-title":"Canadian study of health and aging: study methods and prevalence of dementia","volume":"150","year":"1994","journal-title":"CMAJ"},{"key":"10.1016\/j.brainres.2009.05.029_bib11","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s11064-006-9179-7","article-title":"Manganese-induced neurotoxicity is differentially enhanced by glutathione depletion in astrocytoma and neuroblastoma cells","volume":"31","author":"Dukhande","year":"2006","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2009.05.029_bib12","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0891-5849(99)00176-8","article-title":"Biologic and pharmacologic regulation of mammalian glutathione synthesis","volume":"27","author":"Griffith","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2009.05.029_bib13","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.05.029_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/aje\/153.2.132","article-title":"Is the risk of developing Alzheimer's disease greater for women than for men?","volume":"153","author":"Hebert","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.brainres.2009.05.029_bib15","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1007\/s11064-007-9380-3","article-title":"Metabolic and antioxidant system alterations in an astrocytoma cell line challenged with mitochondrial DNA deletion","volume":"32","author":"Isaac","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2009.05.029_bib16","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/ajcn\/80.6.1611","article-title":"Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism","volume":"80","author":"James","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.brainres.2009.05.029_bib17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1096\/fj.00-0823hyp","article-title":"NAD(P)H, a directly operating antioxidant?","volume":"15","author":"Kirsch","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2009.05.029_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s005800070009","article-title":"Glutathione regeneration in mammalian erythrocytes","volume":"10","author":"Kurata","year":"2000","journal-title":"Comp. Haematol. Int."},{"key":"10.1016\/j.brainres.2009.05.029_bib19","doi-asserted-by":"crossref","first-page":"51360","DOI":"10.1074\/jbc.M302332200","article-title":"Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury","volume":"278","author":"Lee","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2009.05.029_bib20","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1196\/annals.1297.059","article-title":"Glutathione metabolism during aging and in Alzheimer disease","volume":"1019","author":"Liu","year":"2004","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2009.05.029_bib21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/jnr.20424","article-title":"Gender differences in glutathione metabolism in Alzheimer's disease","volume":"79","author":"Liu","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.05.029_bib22","series-title":"Basic Neurochemistry. Molecular, Cellular, and Medical Aspects","first-page":"531","article-title":"Energy metabolism of the brain","author":"McKenna","year":"2006"},{"key":"10.1016\/j.brainres.2009.05.029_bib23","doi-asserted-by":"crossref","first-page":"17205","DOI":"10.1016\/S0021-9258(19)77815-6","article-title":"Glutathione metabolism and its selective modification","volume":"263","author":"Meister","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2009.05.029_bib24","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/jcb.20261","article-title":"Aluminium decreases the glutathione regeneration by the inhibition of NADP-isocitrate dehydrogenase in mitochondria","volume":"93","author":"Murakami","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainres.2009.05.029_bib25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/ilar.47.1.73","article-title":"Animal models that elucidate basic principles of the developmental origins of adult diseases","volume":"47","author":"Nathanielsz","year":"2006","journal-title":"ILAR J."},{"key":"10.1016\/j.brainres.2009.05.029_bib26","unstructured":"NIMH, January 2007. Autism spectrum disorders\u2014pervasive developmental disorders."},{"issue":"Suppl. 3","key":"10.1016\/j.brainres.2009.05.029_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1289\/ehp.00108s3383","article-title":"Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain","volume":"108","author":"Olney","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"Suppl 3","key":"10.1016\/j.brainres.2009.05.029_bib28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/ehp.00108s3511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.brainres.2009.05.029_bib29","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1046\/j.1432-1327.2000.01595.x","article-title":"Glutathione, oxidative stress and neurodegeneration","volume":"267","author":"Schulz","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.brainres.2009.05.029_bib30","series-title":"Principles of Gender-Specific Medicine","first-page":"137","article-title":"Gender differences in psychiatric disorders with a focus on estrogen","author":"Seeman","year":"2004"},{"key":"10.1016\/j.brainres.2009.05.029_bib31","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/jn\/103.9.1327","article-title":"Vulnerability of developing brain: relative effects of growth restriction during the fetal and suckling periods on behavior and brain composition of adult rats","volume":"103","author":"Smart","year":"1973","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainres.2009.05.029_bib32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/jnr.20027","article-title":"Oxidation of vitamin E and vitamin C and the inhibition of brain mitochondrial oxidative phosphorylation by peroxynitrite","volume":"75","author":"Vatassery","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.05.029_bib33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3940(99)00748-X","article-title":"The regeneration of reduced glutathione in rat forebrain mitochondria identifies metabolic pathways providing the NADPH required","volume":"275","author":"Vogel","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.05.029_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brainres.2006.03.063","article-title":"Age-related changes in glutathione and glutathione-related enzymes in rat brain","volume":"1090","author":"Zhu","year":"2006","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309009482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309009482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T16:13:33Z","timestamp":1633450413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309009482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":34,"alternative-id":["S0006899309009482"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.05.029","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}