{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:26:20Z","timestamp":1759692380427},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.brainres.2009.06.055","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T09:15:24Z","timestamp":1246007724000},"page":"53-59","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Heterogeneity of the infant stage of rat development: Inflammatory pain response, depression-related behavior, and effects of prenatal stress"],"prefix":"10.1016","volume":"1286","author":[{"given":"Irina P.","family":"Butkevich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor A.","family":"Mikhailenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena A.","family":"Vershinina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel O.","family":"Semionov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir A.","family":"Otellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Aloisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.06.055_bib1","series-title":"The Behavior of the Laboratory Rat","first-page":"266","article-title":"Infancy","author":"Alberts","year":"2005"},{"key":"10.1016\/j.brainres.2009.06.055_bib3","unstructured":"Anand, K.J.S., 2006. Pain Clinical Updates IASP. XIV, 1\u20134."},{"key":"10.1016\/j.brainres.2009.06.055_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/10253890310001650277","article-title":"Programming of the hypothalamo\u2013pituitary\u2013adrenal axis: serotonergic involvement","volume":"7","author":"Andrews","year":"2004","journal-title":"Stress"},{"key":"10.1016\/j.brainres.2009.06.055_bib5","doi-asserted-by":"crossref","unstructured":"Baccei, M., Fitzgerald, M., 2006. Development of pain pathways and mechanisms. In: Wall and Melzack's Textbook of Pain. S.B. McMahon, M. Koltzenburg, eds. 5th ed. Elsevier, Amsterdam; Churchill Livingstone, London, pp. 143\u2013158.","DOI":"10.1016\/B0-443-07287-6\/50013-8"},{"key":"10.1016\/j.brainres.2009.06.055_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0091-3057(97)00602-3","article-title":"Maturation of the biphasic behavioral and heart rate response in the formalin test","volume":"60","author":"Barr","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.06.055_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0006-8993(92)90667-X","article-title":"5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents","volume":"571","author":"Bell","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.06.055_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00213-002-1046-x","article-title":"Influence of forced swimming-induced stress on the anxiolytic-like effect of 5-HT(1A) agents in mice","volume":"162","author":"Biones-Aranda","year":"2002","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainres.2009.06.055_bib9","series-title":"Abstracts, 35st Annual Meeting of Soc. for Neurosci. N 512.4. Washington, DC: Society of Neuroscience","article-title":"Effect of prenatal stress on behavioral and neural indices of formalin-induced pain in infant rats","author":"Butkevich","year":"2005"},{"key":"10.1016\/j.brainres.2009.06.055_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainres.2005.02.022","article-title":"Reduced serotonin synthesis during early embryogeny changes effect of subsequent prenatal stress on persistent pain in the formalin test in adult male and female rats","volume":"1042","author":"Butkevich","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.06.055_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neulet.2006.04.059","article-title":"Increased formalin-induced pain and expression of fos neurons in the lumbar spinal cord of prenatally stressed infant rats","volume":"403","author":"Butkevich","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.06.055_bib12","series-title":"Perinatal Programming. Early Life Determinants of Adult Health and Disease","first-page":"211","article-title":"Pain sensitivity during ontogeny and long-term effects of prenatal noxious events","author":"Butkevich","year":"2006"},{"key":"10.1016\/j.brainres.2009.06.055_bib13","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.ejpain.2007.02.001","article-title":"Sex differences in formalin-induced pain in prenatally stressed infant rats","volume":"11","author":"Butkevich","year":"2007","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.brainres.2009.06.055_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S0012496608050013","article-title":"Prenatal imbalance between serotonergic and hypothalamo\u2013pituitary\u2013adrenocortical systems and body weight during different periods of rat ontogeny","volume":"422","author":"Butkevich","year":"2008","journal-title":"Dokl. Biol. Sci."},{"key":"10.1016\/j.brainres.2009.06.055_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.yhbeh.2008.09.008","article-title":"Effects of maternal corticosterone and stress on behavioral and hormonal indices of formalin pain in male and female offspring of different ages","volume":"55","author":"Butkevich","year":"2009","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainres.2009.06.055_bib16","first-page":"223","article-title":"Refinement of pain evaluation techniques. The formalin test","volume":"40","author":"Capone","year":"2004","journal-title":"Ann. 1st Super Sanit\u00e0"},{"key":"10.1016\/j.brainres.2009.06.055_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","article-title":"The formalin test: a quantitative study of the analgesic effects of morphine, meperidine and brain stimulation in rats and cats","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.055_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/bja\/75.2.177","article-title":"Developmental biology of inflammatory pain","volume":"75","author":"Fitzgerald","year":"1995","journal-title":"Br. J. Anaesthesia"},{"key":"10.1016\/j.brainres.2009.06.055_bib19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrn1701","article-title":"The development of nociceptive circuits","volume":"6","author":"Fitzgerald","year":"2005","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.brainres.2009.06.055_bib20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pain.2006.09.029","article-title":"Infant pain traces","volume":"125","author":"Fitzgerald","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.055_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/107385840100700309","article-title":"The neurobiology of pain: developmental aspects","volume":"7","author":"Fitzgerald","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.06.055_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0165-3806(86)90194-X","article-title":"The functional development of descending inhibitory pathways in the dorsolateral funiculus of the newborn rat cord","volume":"389","author":"Fitzgerald","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.06.055_bib23","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1210\/endo-124-6-2686","article-title":"Onset of glucocorticoid responsiveness of anterior pituitary corticotrophs during development is scheduled by corticotropin-releasing factor","volume":"124","author":"Grino","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2009.06.055_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0304-3959(94)90174-0","article-title":"Early pain experience, child and family factors, as precursors of somatization: a prospective study of extremely premature and full-term children","volume":"56","author":"Grunau","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.055_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0304-3959(92)90012-Z","article-title":"The behavioral response to formalin in preweanling rats","volume":"51","author":"Guy","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.055_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0736-5748(98)00028-8","article-title":"Maternal stress induces synaptic loss and developmental disabilities of offspring","volume":"16","author":"Hayashi","year":"1998","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainres.2009.06.055_bib27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0278-5846(03)00149-0","article-title":"Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats","volume":"27","author":"Hill","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2009.06.055_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1037\/0033-2909.130.1.115","article-title":"Prenatal stress and risk for psychopathology: specific effects or induction of general susceptibility?","volume":"130","author":"Huizink","year":"2004","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.brainres.2009.06.055_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","article-title":"Structure and function of the brain serotonin system","volume":"72","author":"Jacobs","year":"1992","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2009.06.055_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000054713","article-title":"Forced swimming differentially affects male and female brain corticosteroid receptors","volume":"75","author":"Karandrea","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2009.06.055_bib31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00213-007-0735-x","article-title":"Spinal cord ionotropic glutamate receptors function in formalin-induced nociception in preweaning rats","volume":"192","author":"King","year":"2007","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainres.2009.06.055_bib32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1098-2396(20000615)36:4<254::AID-SYN2>3.0.CO;2-A","article-title":"Maturation of NK1 receptor involvement in the nociceptive response to formalin","volume":"36","author":"King","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2009.06.055_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/cne.20916","article-title":"Reduced density of functional 5-HT1A receptors in the brain, medulla and spinal cord of monoamine oxidase-A knockout mouse neonates","volume":"495","author":"Lanoir","year":"2006","journal-title":"J. Compar. Neurol."},{"key":"10.1016\/j.brainres.2009.06.055_bib34","first-page":"1656","article-title":"Pain and pain relief during the neonatal period. Early pain experiences can result in negative late-effects","volume":"98","author":"Larsson","year":"2001","journal-title":"Lakartidningen"},{"key":"10.1016\/j.brainres.2009.06.055_bib35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0006-3223(98)00186-3","article-title":"Hypothalamic serotonin in control of eating behavior, meal size, and body weight","volume":"44","author":"Leibowitz","year":"1998","journal-title":"Biol. Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2009.06.055_bib36","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.psyneuen.2007.06.005","article-title":"Effects of prenatal restraint stress on the hypothalamus\u2013pituitary\u2013adrenal axis and related behavioral and neurobiological alterations","author":"Maccari","year":"2007","journal-title":"Psychoendocrinology"},{"key":"10.1016\/j.brainres.2009.06.055_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2165\/00023210-200822020-00005","article-title":"Antidepressants as analgesics","volume":"22","author":"McCleane","year":"2008","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2009.06.055_bib38","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.2174\/156802606778522195","article-title":"The role of 5-HT1A receptors in research strategy for extensive pain treatment","volume":"6","author":"Mico","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.brainres.2009.06.055_bib39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0006-8993(03)03293-1","article-title":"Prenatal stress in rats predicts immobility behavior in the forced swim test. Effects of a chronic treatment with tianeptine","volume":"989","author":"Morley-Fletcher","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.06.055_bib40","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"issue":"Suppl. 2","key":"10.1016\/j.brainres.2009.06.055_bib41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/15622970510030018","article-title":"Can stress cause depression?","volume":"6","author":"Praag","year":"2005","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2009.06.055_bib42","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.brainresrev.2007.08.005","article-title":"Postnatal ontogeny of expression of the corticosteroid receptor genes in mammalian brains: inter-species and intra-species differences","volume":"57","author":"Pryce","year":"2008","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainres.2009.06.055_bib44","first-page":"807","article-title":"Fetal pain","volume":"29","author":"Rokyta","year":"2008","journal-title":"Neuroendocrinol. Lett."},{"issue":"Suppl. 3","key":"10.1016\/j.brainres.2009.06.055_bib45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/eje.0.151U049","article-title":"Prenatal glucocorticoids and long-term programming","volume":"151","author":"Seckl","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.brainres.2009.06.055_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0079-6123(07)67002-2","article-title":"Glucocorticoids, developmental \u201cprogramming\u201d and the risk of affective dysfunction","volume":"167","author":"Seckl","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2009.06.055_bib47","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0165-3806(96)00027-2","article-title":"Programming of brainstem serotonin transporter development by prenatal glucocorticoids","volume":"93","author":"Slotkin","year":"1996","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2009.06.055_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2006.03.057","article-title":"Prenatal stress in the rat alters 5-HT1A receptor binding in the ventral hippocampus","volume":"1090","author":"Van den Hove","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.06.055_bib49","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1210\/endo-118-4-1445","article-title":"Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus","volume":"118","author":"Walker","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2009.06.055_bib50","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bbi.2004.09.006","article-title":"The potential influence of maternal stress hormones on development and mental health of the offspring","volume":"19","author":"Weinstock","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2009.06.055_bib51","series-title":"Perinatal Programming: Early Life Determinants of Adult Health and Disease","first-page":"241","article-title":"The role of prenatal stress in the programming of behavior","author":"Weinstock","year":"2006"},{"key":"10.1016\/j.brainres.2009.06.055_bib52","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.neubiorev.2008.03.002","article-title":"The long-term behavioural consequences of prenatal stress","volume":"32","author":"Weinstock","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.06.055_bib53","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0304-3959(97)00119-X","article-title":"Formalin-induced c-fos expression in the spinal cord of fetal rats","volume":"73","author":"Yi","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.055_bib54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309012712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309012712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T23:07:05Z","timestamp":1558393625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309012712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":52,"alternative-id":["S0006899309012712"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.06.055","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}