{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:19:23Z","timestamp":1791033563272,"version":"4.1.0"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.brainres.2009.06.094","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T08:34:11Z","timestamp":1247214851000},"page":"42-49","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats"],"prefix":"10.1016","volume":"1288","author":[{"given":"Shuxing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grewo","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Backil","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Wen","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Hernstadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Rusanescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianren","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.06.094_bib1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0306-4530(95)00018-6","article-title":"Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats","volume":"20","author":"Armario","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2009.06.094_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0304-3959(88)90198-4","article-title":"Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain","volume":"33","author":"Arner","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.psy.0000204851.15499.fc","article-title":"Comorbid depression, chronic pain, and disability in primary care","volume":"68","author":"Arnow","year":"2006","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.brainres.2009.06.094_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0304-3959(98)00064-5","article-title":"A placebo-controlled randomized clinical trial of nortriptyline for chronic low back pain","volume":"76","author":"Atkinson","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib5","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1001\/archinte.163.20.2433","article-title":"Depression and pain comorbidity; a literature review","volume":"163","author":"Bair","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.brainres.2009.06.094_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1037\/0033-2909.119.1.95","article-title":"Explaining high rates of depression in chronic pain. A diathesis-stress framework","volume":"119","author":"Banks","year":"1996","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.brainres.2009.06.094_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0447.1985.tb02531.x","article-title":"Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome","volume":"71","author":"Beck-Friis","year":"1985","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.brainres.2009.06.094_bib8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1245\/ASO.2003.08.007","article-title":"Dextromethorphan mitigates phantom pain in cancer amputees","volume":"10","author":"Ben Abraham","year":"2003","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.brainres.2009.06.094_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1056\/NEJM199701163360306","article-title":"Melatonin in humans","volume":"336","author":"Brzezinski","year":"1997","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.brainres.2009.06.094_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.0001-5172.2004.0325.x","article-title":"Analgesic effect of dextromethorphan in neuropathic pain","volume":"48","author":"Carlsson","year":"2004","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.brainres.2009.06.094_bib14","first-page":"454","article-title":"Antidepressants in pain management","volume":"3","author":"Carter","year":"2002","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.brainres.2009.06.094_bib15","first-page":"179","article-title":"Postoperative intramuscular dextromethorphan injection provides postoperative pain relief and decreases opioid requirement after hemorrhoidectomy","volume":"37","author":"Chang","year":"1999","journal-title":"Acta Anaesthesiol. Sin."},{"key":"10.1016\/j.brainres.2009.06.094_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s100670050003","article-title":"The effect of melatonin in patients with fibromyalgia: a pilot study","volume":"19","author":"Citera","year":"2000","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.brainres.2009.06.094_bib17","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1213\/01.ANE.0000136953.11583.7B","article-title":"The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain","volume":"99","author":"Cohen","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2009.06.094_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jpain.2005.12.010","article-title":"The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients","volume":"7","author":"Cohen","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0885-3924(00)00218-9","article-title":"Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review","volume":"20","author":"Collins","year":"2000","journal-title":"J. Pain Symptom. Manage."},{"key":"10.1016\/j.brainres.2009.06.094_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.brainres.2004.06.052","article-title":"A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression","volume":"1021","author":"De La Garza","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.06.094_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"21","author":"Detke","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"issue":"Suppl. 2","key":"10.1016\/j.brainres.2009.06.094_bib23","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00002508-198906002-00002","article-title":"The neurobiology of pain and its modulation","author":"Dubner","year":"1989","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-6576.2006.00900.x","article-title":"A qualitative systematic review of peri-operative dextromethorphan in post-operative pain","volume":"50","author":"Duedahl","year":"2006","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.brainres.2009.06.094_bib27","first-page":"286","article-title":"Effect of dextromethorphan on antinociception and tolerance induced by swim-stress in the formalin test","volume":"11","author":"Fazli-Tabaei","year":"2008","journal-title":"Arch Iran Med."},{"key":"10.1016\/j.brainres.2009.06.094_bib28","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"307","article-title":"The depression\u2013pain complex: overlap between the two problems and implications for neuropathic pain","author":"Ferrer-Garcia","year":"2006"},{"key":"10.1016\/j.brainres.2009.06.094_bib31","first-page":"269","article-title":"Patterns of melatonin rhythms in depression","volume":"21","author":"Frazer","year":"1986","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.brainres.2009.06.094_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpain.2006.05.010","article-title":"Placebo-controlled comparison of a morphine\/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers","volume":"8","author":"Frymoyer","year":"2007","journal-title":"J. Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib33","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pain.2005.03.004","article-title":"MorphiDex (morphine sulfate\/dextromethorphan hydrobromide combination) in the treatment of chronic pain: three multicenter, randomized, double-blind, controlled clinical trials fail to demonstrate enhanced opioid analgesia or reduction in tolerance","volume":"115","author":"Galer","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-2999(91)90119-B","article-title":"Time-dependent melatonin analgesia in mice: inhibition by opiate or benzodiazepine antagonism","volume":"194","author":"Golombek","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.06.094_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pbb.2005.03.001","article-title":"The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific","volume":"81","author":"Grisel","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.06.094_bib37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0165-1781(81)90014-7","article-title":"An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives","volume":"4","author":"Halbreich","year":"1981","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.brainres.2009.06.094_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1533-2500.2003.03020.x","article-title":"Antidepressant pharmacotherapy: considerations for the pain clinician","volume":"3","author":"Jackson","year":"2003","journal-title":"Pain Pract."},{"key":"10.1016\/j.brainres.2009.06.094_bib40","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/0140-6736(92)91194-D","article-title":"Morphine responsiveness of chronic pain: double-blind randomized crossover study with patient-controlled analgesia","volume":"339","author":"Jadad","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2009.06.094_bib44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(91)90004-H","article-title":"Morphine differentially affects the sensory and affective pain rating in neurogenic pain and idiopathic forms of pain","volume":"47","author":"Kupers","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3959(93)90060-3","article-title":"Depression and distress symptoms as predictors of low back pain, neck\u2013shoulder pain, and other musculoskeletal morbidity: a 10\u00a0year follow-up of metal industry employees","volume":"53","author":"Leino","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib47","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1468-2982.1996.1607494.x","article-title":"Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups","volume":"16","author":"Leone","year":"1996","journal-title":"Cephalalgia"},{"key":"10.1016\/j.brainres.2009.06.094_bib48","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1468-2982.1995.015003224.x","article-title":"Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache","volume":"15","author":"Leone","year":"1995","journal-title":"Cephalalgia"},{"key":"10.1016\/j.brainres.2009.06.094_bib49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.brainres.2005.02.067","article-title":"Melatonin enhances antinociceptive effects of delta-, but not mu-opioid agonist in mice","volume":"1043","author":"Li","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.06.094_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/138161206775193253","article-title":"Fibromyalgia syndrome: which antidepressant drug should we choose?","volume":"12","author":"Littlejohn","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.brainres.2009.06.094_bib51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0893-133X(99)00100-1","article-title":"Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test","volume":"22","author":"Lopez-Rubalcava","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2009.06.094_bib52","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pain.2004.03.010","article-title":"Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model","volume":"110","author":"Lynch","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-3959(93)90076-2","article-title":"Chronic musculoskeletal pain and depression symptoms in the National Health and Nutrition Examination. I. Epidemiologic follow-up study","volume":"53","author":"Magni","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib54","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0304-3959(94)90167-8","article-title":"Prospective study on the relationship between depression symptoms and chronic musculoskeletal pain","volume":"56","author":"Magni","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib55","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF00380984","article-title":"Pain as a symptom in elderly depressed patients","volume":"235","author":"Magni","year":"1985","journal-title":"Eur. Arch. Psychiatry Neurol. Sci."},{"key":"10.1016\/j.brainres.2009.06.094_bib56","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1213\/00000539-200009000-00034","article-title":"Gabapentin in pain management","volume":"91","author":"Mao","year":"2000","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2009.06.094_bib57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-3959(00)00229-3","article-title":"Systemic lidocaine for neuropathic pain relief","volume":"87","author":"Mao","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib58","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(95)00073-2","article-title":"Mechanisms of hyperalgesia and opiate tolerance: a current view of their possible interactions","volume":"62","author":"Mao","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0304-3959(95)00022-K","article-title":"Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain","volume":"61","author":"Mao","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib60","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0304-3959(97)00063-8","article-title":"The inhibition of nitric oxide-activated poly (ADP-ribose) synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat","volume":"72","author":"Mao","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0304-3959(91)90157-S","article-title":"Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial","volume":"45","author":"Max","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib62","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1056\/NEJM199205073261904","article-title":"Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy","volume":"326","author":"Max","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2009.06.094_bib63","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1002\/ana.410350715","article-title":"Treatment of post-herpetic neuralgia: antidepressants","volume":"35","author":"Max","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2009.06.094_bib64","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1212\/WNL.37.4.589","article-title":"Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood","volume":"37","author":"Max","year":"1987","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.06.094_bib66","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tips.2006.05.004","article-title":"Antidepressants and pain","volume":"27","author":"Mico","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2009.06.094_bib67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0197-0186(94)90100-7","article-title":"Melatonin receptor: localization, molecular pharmacology and physiological significance","volume":"24","author":"Morgan","year":"1994","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2009.06.094_bib70","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1253\/jcj.27.282","article-title":"Development of a stroma of spontaneously hypertensive rats","volume":"27","author":"Okamoto","year":"1963","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.brainres.2009.06.094_bib71","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1742-7843.2007.00095.x","article-title":"Effects of paracetamol combined with dextromethorphan in human experimental muscle and skin pain","volume":"101","author":"Olesen","year":"2007","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.brainres.2009.06.094_bib72","first-page":"35","article-title":"Intrathecal melatonin increases the mechanical nociceptive threshold in the rat","volume":"16","author":"Onal","year":"2004","journal-title":"Agri"},{"key":"10.1016\/j.brainres.2009.06.094_bib73","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3940(95)12022-V","article-title":"The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive","volume":"199","author":"Ossipov","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.06.094_bib74","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neubiorev.2005.03.015","article-title":"The Flinders sensitive line rat: a selectively bred putative animal model of depression","volume":"29","author":"Overstreet","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.06.094_bib75","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00001756-199801260-00014","article-title":"Effects of melatonin receptor ligands on swim test immobility","volume":"9","author":"Overstreet","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2009.06.094_bib76","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","article-title":"Melatonin: nature's most versatile biological signal?","volume":"273","author":"Pandi-Perumal","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.brainres.2009.06.094_bib77","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0024-3205(00)00996-6","article-title":"Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice","volume":"68","author":"Pang","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2009.06.094_bib78","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0006-3223(95)00220-0","article-title":"Enhanced retrieval of unpleasant memories influenced by shock controllability, shock sequence and rat strain","volume":"39","author":"Pare","year":"1996","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2009.06.094_bib79","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0031-9384(94)90097-3","article-title":"Open field, learned helplessness, defensive burying, and forced-swim tests in WKY rats","volume":"55","author":"Pare","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2009.06.094_bib80","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0031-9384(93)90291-M","article-title":"Passive-avoidance behavior in Wistar\u2013Kyoto (WKY), Wistar and Fischer-344 rats","volume":"54","author":"Pare","year":"1993","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2009.06.094_bib81","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioral despair in rats: a new model sensitive to antidepressant treatment","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.06.094_bib82","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90414-4","article-title":"\u2018Behavioral despair\u2019 in rats and mice: strain differences and the effects of imipramine","volume":"51","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.06.094_bib83","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2009.06.094_bib85","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-2999(00)00196-5","article-title":"Melatonin reversal of lipopolysaccharides-induced thermal and behavioral hyperalgesia in mice","volume":"395","author":"Raghavendra","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.06.094_bib86","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0014-2999(00)00849-9","article-title":"Possible mechanisms of action in melatonin reversal of morphine tolerance and dependence in mice","volume":"409","author":"Raghavendra","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.06.094_bib87","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pbb.2003.08.009","article-title":"Effects of NMDA receptor antagonists on acute mu-opioid analgesia in the rat","volume":"76","author":"Redwine","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.06.094_bib88","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-2999(02)02119-2","article-title":"Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine","volume":"450","author":"Sawynok","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.06.094_bib89","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/s0304-3959(02)00373-1","article-title":"Peripheral interactions between dextromethorphan, ketamine and amitriptyline on ormalin-evoked behaviors and paw edema in rats","volume":"102","author":"Sawynok","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib91","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0304-3959(87)90036-4","article-title":"The analgesic effect of amitriptyline on chronic facial pain","volume":"31","author":"Sharav","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib92","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.brainresbull.2004.09.008","article-title":"Melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by increasing the release of beta-endorphin an endogenous opioid","volume":"64","author":"Shavali","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2009.06.094_bib93","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0304-3959(99)00154-2","article-title":"Efficacy of pharmacological treatment of neuropathic pain: an update and effect related to mechanism of drug action","volume":"83","author":"Sindrup","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib94","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1527-3458.2007.00006.x","article-title":"Dextromethorphan: a review of N-methyl-d-aspartate receptor antagonist in the management of pain","volume":"13","author":"Siu","year":"2007","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.brainres.2009.06.094_bib95","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/gut.2004.062034","article-title":"Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study","volume":"54","author":"Song","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.brainres.2009.06.094_bib96","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0304-3940(91)90059-3","article-title":"Localization and characterization of melatonin binding sites in the brain of the rabbit (Oryctolagus cuniculus) by autoradiography and in vitro ligand\u2013receptor binding","volume":"133","author":"Stankov","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.06.094_bib97","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jpain.2005.01.357","article-title":"Effects of the N-methyl-d-aspartate receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal control subjects","volume":"6","author":"Staud","year":"2005","journal-title":"J. Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib98","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0022-3565(25)22029-8","article-title":"Psychopharmacological effects of melatonin in mouse and rat","volume":"227","author":"Sugden","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2009.06.094_bib99","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90107-M","article-title":"The treatment of depression in chronic low back pain: review and recommendations","volume":"50","author":"Sullivan","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib101","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0304-3959(94)90013-2","article-title":"Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve","volume":"57","author":"Tal","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib100","series-title":"Peripheral Neuropathy","first-page":"1169","article-title":"Clinical features and differential diagnosis of peripheral neuropathy","author":"Thomas","year":"1984"},{"key":"10.1016\/j.brainres.2009.06.094_bib102","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pain.2004.01.027","article-title":"Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats","volume":"109","author":"Tu","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib103","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1152\/physrev.1998.78.3.687","article-title":"Cellular mechanisms of melatonin action","volume":"78","author":"Vanecek","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2009.06.094_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(90)90777-7","article-title":"Brain autoradiographic study in the golden hamster after intracarotid injection of [14C]melatonin","volume":"110","author":"Vitte","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.06.094_bib106","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","article-title":"Mammalian melatonin receptors: molecular biology and signal transduction","volume":"309","author":"Von Gall","year":"2002","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.brainres.2009.06.094_bib107","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0304-3959(83)90003-9","article-title":"Pain as a symptom in depressive disorders. I. Relationship to diagnostic subgroup and depressive symptomatology","volume":"15","author":"Von Knorring","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib109","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/jnnp.50.2.207","article-title":"Circadian secretion of cortisol and melatonin in cluster headache during active cluster periods and remission","volume":"50","author":"Waldenlind","year":"1987","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainres.2009.06.094_bib111","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1212\/WNL.32.6.671","article-title":"Amitriptyline versus placebo in postherpetic neuralgia","volume":"32","author":"Watson","year":"1982","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.06.094_bib112","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3959(97)03337-X","article-title":"Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal and nerve-injured rats","volume":"71","author":"Wegert","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2009.06.094_bib113","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.brainresbull.2005.09.016","article-title":"Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating","volume":"68","author":"Weil","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2009.06.094_bib114","first-page":"253","article-title":"Melatonin and affective disorders","volume":"17","author":"Wetterberg","year":"1985","journal-title":"Ciba Found Symp."},{"key":"10.1016\/j.brainres.2009.06.094_bib115","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: aetiology, symptoms, mechanisms, and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2009.06.094_bib116","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(00)00883-1","article-title":"Selective MT (2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats","volume":"24","author":"Yu","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.06.094_bib117","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(00)00421-0","article-title":"The analgesic effects of peripheral and central administration of melatonin in rats","volume":"l","author":"Yu","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.06.094_bib118","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1034\/j.1600-079X.2003.00047.x","article-title":"Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation","volume":"35","author":"Zahn","year":"2003","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.brainres.2009.06.094_bib119","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainres.2008.01.038","article-title":"Exacerbated mechanical allodynia in rats with depression-like behavior","volume":"1200","author":"Zeng","year":"2008","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309013687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309013687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T21:51:31Z","timestamp":1739224291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309013687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":99,"alternative-id":["S0006899309013687"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.06.094","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}