{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:15:16Z","timestamp":1784171716696,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.brainres.2009.07.019","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T04:54:23Z","timestamp":1247806463000},"page":"111-120","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Corticostriatal dysfunction underlies diminished striatal ascorbate release in the R6\/2 mouse model of Huntington's disease"],"prefix":"10.1016","volume":"1290","author":[{"given":"Jenelle L.","family":"Dorner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Murphy-Nakhnikian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George V.","family":"Rebec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.07.019_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/jnr.10272","article-title":"Striatal neurochemical changes in transgenic models of Huntington's disease","volume":"68","author":"Ariano","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0091-3057(90)90204-U","article-title":"Corticostriatal and thalamic regulation of amphetamine\u2013induced ascorbate release in the neostriatum","volume":"35","author":"Basse-Tomusk","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.07.019_bib3","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/brain\/awf180","article-title":"Impaired glutamate transport and glutamate\u2013glutamine cycling: downstream effects of the Huntington mutation","volume":"125","author":"Behrens","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2009.07.019_bib4","doi-asserted-by":"crossref","unstructured":"Berger, U.V., Hediger, M.A., 2000.The vitamin C transporter is expressed by astrocytes in culture but not in situ. 11, 1395\u20139.","DOI":"10.1097\/00001756-200005150-00009"},{"key":"10.1016\/j.brainres.2009.07.019_bib5","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1089\/ars.2006.8.2061","article-title":"Oxidative damage in Huntington's disease pathogenesis","volume":"8","author":"Browne","year":"2006","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.brainres.2009.07.019_bib6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pbb.2007.11.003","article-title":"Effects on spontaneous and cocaine-induced behavior of pharmacological inhibition of noradrenergic and serotonergic systems","volume":"89","author":"Carey","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.07.019_bib7","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1523\/JNEUROSCI.23-03-00961.2003","article-title":"Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease","volume":"23","author":"Cepeda","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pneurobio.2006.11.001","article-title":"The corticostriatal pathway in Huntington's disease","volume":"81","author":"Cepeda","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2009.07.019_bib10","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1073\/pnas.95.11.6480","article-title":"Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene","volume":"95","author":"Cha","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.07.019_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2006.03.079","article-title":"Ascorbate modulation of sensorimotor processing in striatum of freely moving rats","volume":"1092","author":"Cortright","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbr.2006.12.004","article-title":"Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington's disease","volume":"178","author":"Dorner","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib13","series-title":"Monitoring Neurotransmitter Release During Behaviour","first-page":"144","article-title":"Changes in extracellular brain ascorbate concentration as an index of excitatory aminoacid release","author":"Fillenz","year":"1986"},{"key":"10.1016\/j.brainres.2009.07.019_bib14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.physbeh.2007.06.002","article-title":"Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice","volume":"92","author":"Fukushiro","year":"2007","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2009.07.019_bib15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0006-8993(91)90587-L","article-title":"Dynamic changes in extracellular fluid ascorbic acid monitored by in vivo electrochemistry","volume":"547","author":"Ghasemzedah","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0006-8993(81)90807-6","article-title":"Voltammetry in the striatum of chronic freely moving rats: detection of catechols and ascorbic acid","volume":"223","author":"Gonon","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0165-0173(83)90011-5","article-title":"A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement","volume":"286","author":"Groves","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0197-0186(84)90120-7","article-title":"Release of ascorbate from synaptosomal fraction of rat Brain","volume":"6","author":"Gr\u00fcnewald","year":"1984","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2009.07.019_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1471-4159.2002.00804.x","article-title":"The role of dopamine in motor symptoms in the R6\/2 transgenic mouse model of Huntington's disease","volume":"81","author":"Hickey","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.07.019_bib20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1471-4159.2006.03762.x","article-title":"Dopamine release is severely compromised in the R6\/2 mouse model of Huntington's disease","volume":"97","author":"Johnson","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.07.019_bib21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/syn.890020511","article-title":"Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington's disease and schizophrenia","volume":"2","author":"Joyce","year":"1988","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2009.07.019_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0006-8993(86)90458-0","article-title":"Multiple amphetamine injections reduce the release of ascorbic acid in the neostriatum of the rat","volume":"362","author":"Kamata","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0006-8993(98)00814-2","article-title":"Ascorbate modulates glutamate-induced excitations of striatal neurons","volume":"812","author":"Kiyatkin","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib24","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1006\/nbdi.2001.0430","article-title":"Impaired glutamate uptake in the R6 Huntington's disease transgenic mice","volume":"8","author":"Lievens","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2009.07.019_bib25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/13556219971489","article-title":"Involvement of the corticostriatal glutamatergic pathway in ethanol-induced ascorbic acid release in rat striatum","volume":"4","author":"Liu","year":"1999","journal-title":"Addict. Biol."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2009.07.019_bib66","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0006-8993(90)90379-P","article-title":"Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate","volume":"537","author":"Majewska","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2009.07.019_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0165-0270(96)00094-5","article-title":"In vivo determination of extracellular brain ascorbate","volume":"70","author":"Miele","year":"1996","journal-title":"J. Neurosci. Meth."},{"key":"10.1016\/j.brainres.2009.07.019_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0091-3057(94)00209-2","article-title":"Cortical ablation and drug-induced changes in striatal ascorbic acid oxidation and behavior in the rat","volume":"50","author":"Miele","year":"1995","journal-title":"Pharm. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.07.019_bib29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuroscience.2008.02.004","article-title":"Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6\/2 mouse","volume":"153","author":"Miller","year":"2008","journal-title":"Neuroscience."},{"key":"10.1016\/j.brainres.2009.07.019_bib30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0091-3057(87)90563-6","article-title":"Effects of haloperidol on amphetamine-induced increases in ascorbic acid as determined by voltammetry in vivo","volume":"27","author":"Mueller","year":"1987","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.07.019_bib31","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/jnr.20751","article-title":"Immunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat Brain","volume":"83","author":"Mun","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-3940(85)90599-3","article-title":"Circadian changes in extracellular ascorbate in rat cortex, accumbens, striatum and hippocampus: correlations with motor activity","volume":"60","author":"O'Neill","year":"1985","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.07.019_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(83)90430-5","article-title":"The effect of unilateral cortical lesions on the circadian changes in rat striatal ascorbate and homovanillic acid levels measured in vivo using voltammetry","volume":"42","author":"O'Neill","year":"1983","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.07.019_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0304-3940(84)90166-6","article-title":"Voltammetrically monitored brain ascorbate as an index of excitatory amino acid release in the unrestrained rat","volume":"52","author":"O'Neill","year":"1984","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.07.019_bib35","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.brainres.2009.07.019_bib36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-2999(90)94161-P","article-title":"Stimulation of both D1 and D2 dopamine receptors increases behavioral activation and ascorbate release in the neostriatum of freely moving rats","volume":"191","author":"Pierce","year":"1990","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.brainres.2009.07.019_bib64","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0006-8993(92)90741-Q","article-title":"Dopamine-, NMDA- and sigma-receptor antagonists exert differential effects on basal and amphetamine-induced changes in neostriatal ascorbate and DOPAC in awake behaving rats","volume":"579","author":"Pierce","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0006-8993(92)91515-G","article-title":"Unilateral neostriatal kainate, but not 6-OHDA, lesions block dopamine agonist-induced ascorbate release in the neostriatum of freely moving rats","volume":"597","author":"Pierce","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib38","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1046\/j.1471-4159.1994.63041499.x","article-title":"Amphetamine promotes neostriatal ascorbate release via a nigro-thalamo-cortico-neostriatal loop","volume":"63","author":"Pierce","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.07.019_bib39","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1471-4159.2008.05786.x","article-title":"Glutamate receptors modulate sodium-dependent and calcium-independent vitamin C bedirectional transport in cultured avian retinal cells","volume":"108","author":"Portugal","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.07.019_bib40","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/jnr.21204","article-title":"Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity","volume":"85","author":"Qiu","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib41","series-title":"Electrochemical Methods for Neuroscience","first-page":"149","article-title":"From interferant anion to neuromodulator: ascorbate oxidizes its way to respectability","author":"Rebec","year":"2007"},{"key":"10.1016\/j.brainres.2009.07.019_bib65","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0301-0082(94)90052-3","article-title":"A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission","volume":"6","author":"Rebec","year":"1994","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2009.07.019_bib42","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1523\/JNEUROSCI.21-02-00668.2001","article-title":"Behavioral activation in rats requires endogenous ascorbate release in striatum","volume":"21","author":"Rebec","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib43","doi-asserted-by":"crossref","first-page":"RC202","DOI":"10.1523\/JNEUROSCI.22-02-j0006.2002","article-title":"Dysregulation of ascorbate release in the striatum of behaving mice expressing the Huntington's disease gene","volume":"22","author":"Rebec","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib44","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/00001756-200307010-00015","article-title":"Ascorbate treatment attenuates the Huntington behavioral phenotype in mice","volume":"14","author":"Rebec","year":"2003","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2009.07.019_bib45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neulet.2004.12.027","article-title":"Extracellular ascorbate modulates cortically evoked glutamate dynamics in rat striatum","volume":"378","author":"Rebec","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.07.019_bib46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neuroscience.2005.08.062","article-title":"Hyperactive striatal neurons in symptomatic Huntington R6\/2 mice: variations with behavioral state and repeated ascorbate treatment","volume":"137","author":"Rebec","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.07.019_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF03033272","article-title":"Ascorbate compartmentalization in the CNS","volume":"1","author":"Rice","year":"1999","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib48","first-page":"209","article-title":"Ascorbate and its neuroprotective role in the Brain","volume":"23","author":"Rice","year":"2000","journal-title":"TINS"},{"key":"10.1016\/j.brainres.2009.07.019_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3940(91)90448-3","article-title":"Heterogeneous dopamine receptor changes in early and late Huntington's disease","volume":"132","author":"Richfield","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.07.019_bib50","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0197-0186(98)00055-2","article-title":"The family of sodium-dependent glutamate transporters: a focus on the GLT-1\/EAAT2 subtype","volume":"33","author":"Robinson","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2009.07.019_bib51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/0735-7044.103.1.3","article-title":"Antidromically identified striatonigral projection neurons in the chronically implanted behaving rat: relations of cell firing to amphetamine-induced behaviors","volume":"103","author":"Ryan","year":"1989","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2202-8-32","article-title":"Extracellular ascorbate modulates glutamate dynamics: role of behavioral activation","volume":"8","author":"Sandstrom","year":"2007","journal-title":"BMC. Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1471-4159.1995.65010041.x","article-title":"Ascorbate transport and intracellular concentration in cerebral astrocytes","volume":"65","author":"Siushansian","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.07.019_bib54","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0165-0173(02)00233-3","article-title":"Neurotransmitter systems of the medial prefrontal cortex: potential role in sensitization to psychostimulants","volume":"41","author":"Steketee","year":"2003","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.brainres.2009.07.019_bib55","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1523\/JNEUROSCI.1396-07.2007","article-title":"Dopaminergic signaling and striatal neurodegeneration in Huntington's disease","volume":"27","author":"Tang","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib56","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1471-4159.2006.04323.x","article-title":"Neurochemical changes in Huntington R6\/2 mouse striatum detected by in vivo 1H NMR spectroscopy","volume":"100","author":"Tkac","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.07.019_bib57","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3940(91)90523-V","article-title":"Bilateral cortical ablations attenuate amphetamine-induced excitations of neostriatal motor-related neurons in freely moving rats","volume":"134","author":"Tschanz","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.07.019_bib58","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/19986","article-title":"A family of mammalian Na+-dependent l-ascorbic acid transporters","volume":"399","author":"Tsukaguchi","year":"1999","journal-title":"Nature"},{"issue":"Pt 3","key":"10.1016\/j.brainres.2009.07.019_bib59","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/brain\/118.3.689","article-title":"Striatal D1 and D2 receptor binding in patients with Huntington's disease and other choreas. A PET study","volume":"118","author":"Turjanski","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2009.07.019_bib60","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1471-4159.1989.tb07396.x","article-title":"Ascorbic acid uptake by a high-affinity sodium-dependent mechanism in cultured rat astrocytes","volume":"53","author":"Wilson","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2009.07.019_bib61","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0006-8993(01)02099-6","article-title":"Increased extracellular ascorbate release reflects glutamate re-uptake during the early stage of reperfusion after forebrain ischemia in rats","volume":"897","author":"Yusa","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.019_bib62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/mcne.2000.0909","article-title":"Mutant huntingtin enhances excitotoxic cell death","volume":"17","author":"Zeron","year":"2001","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.brainres.2009.07.019_bib63","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/j.1460-9568.1991.tb00029.x","article-title":"Striatal ascorbate and its relationship to dopamine receptor stimulation and motor activity","volume":"3","author":"Zetterstrom","year":"1991","journal-title":"Eur. J. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309014231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309014231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T10:35:01Z","timestamp":1558434901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309014231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":66,"alternative-id":["S0006899309014231"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.07.019","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}