{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:10:45Z","timestamp":1790763045897,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.brainres.2009.07.020","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T04:54:23Z","timestamp":1247806463000},"page":"91-101","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["dl-3-n-butylphthalide protects endothelial cells against oxidative\/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose deprivation in vitro"],"prefix":"10.1016","volume":"1290","author":[{"given":"Ling","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.07.020_bib1","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1038\/sj.emboj.7601253","article-title":"Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons","volume":"25","author":"Barsoum","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2009.07.020_bib2","doi-asserted-by":"crossref","first-page":"H821","DOI":"10.1152\/ajpheart.00378.2007","article-title":"In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice: involvement of xanthine oxidase and mitochondria","volume":"294","author":"Baudry","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.brainres.2009.07.020_bib3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/jemt.1070270303","article-title":"Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria","volume":"27","author":"Bereiter-Hahn","year":"1994","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.brainres.2009.07.020_bib4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/ars.2007.1845","article-title":"Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia\u2013reperfusion injury","volume":"10","author":"Burwell","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainres.2009.07.020_bib5","first-page":"796","article-title":"Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats","volume":"24","author":"Chang","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2009.07.020_bib6","first-page":"95","article-title":"Effect of 3-n-butylphthalide on reperfusion induced lipid peroxidation following cerebral ischemia in rats and superoxide radical formation in vitro","volume":"8","author":"Chong","year":"1999","journal-title":"J. Chin. Pharm. Sci."},{"key":"10.1016\/j.brainres.2009.07.020_bib7","first-page":"251","article-title":"Effects of dl-3-butylphthalide on treatment of acute ischemic stroke with moderate symptoms: a multi-center, randomized, double-blind, placebo-control trial","volume":"38","author":"Cui","year":"2005","journal-title":"Chin. J. Neurol."},{"key":"10.1016\/j.brainres.2009.07.020_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2007.07.104","article-title":"Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress","volume":"1188","author":"Deguchi","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.07.020_bib9","first-page":"87","article-title":"Peroxynitrite and caspase-3 expression after ischemia\/reperfusion in mouse cardiac arrest model","volume":"86","author":"Dohi","year":"2003","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.brainres.2009.07.020_bib10","first-page":"93","article-title":"Effects of NBP on ATPase and anti-oxidant enzymes activities and lipid peroxidation in transient focal cerebral ischemic rats","volume":"24","author":"Dong","year":"2002","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"10.1016\/j.brainres.2009.07.020_bib11","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10495-007-0758-0","article-title":"The mitochondrial pathway in yeast apoptosis","volume":"12","author":"Eisenberg","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.brainres.2009.07.020_bib12","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1126\/science.1088805","article-title":"Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF-1alpha","volume":"302","author":"Hagen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.brainres.2009.07.020_bib13","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","article-title":"Regulation of hypoxia-inducible factor 1\u03b1 is mediated by an O2-dependant degradation domain via the ubiquitin\u2013proteasome pathway","volume":"95","author":"Huang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.07.020_bib14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neures.2006.04.005","article-title":"Mitochondrial membrane potential and ischemic neuronal death","volume":"55","author":"Iijima","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.07.020_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/FJC.0b013e3181583d80","article-title":"Peroxynitrite is involved in the dysfunction of vasorelaxation in SHR\/NDmcr-cp rats, spontaneously hypertensive obese rats","volume":"50","author":"Kagota","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.brainres.2009.07.020_bib16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1179\/016164104X3806","article-title":"Extracellular proteolytic pathophysiology in the neurovascular unit after stroke","volume":"26","author":"Lee","year":"2004","journal-title":"Neurol. Res."},{"key":"10.1016\/j.brainres.2009.07.020_bib17","doi-asserted-by":"crossref","first-page":"9936","DOI":"10.1073\/pnas.0502552102","article-title":"Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.07.020_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jns.2007.04.025","article-title":"dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP","volume":"260","author":"Liu","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2009.07.020_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(04)00218-2","article-title":"Peroxynitrite formation from the simultaneous reduction of nitrite and oxygen by xanthine oxidase","volume":"562","author":"Millar","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2009.07.020_bib20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/03602530701468516","article-title":"Reactive oxygen species in mitochondria-mediated cell death.","volume":"39","author":"Orrenius","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.brainres.2009.07.020_bib21","first-page":"527","article-title":"Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite","volume":"40","author":"Packer","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.brainres.2009.07.020_bib22","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/00005344-200406000-00018","article-title":"Antiplatelet and antithrombotic activity of l-3-n-butylphthalide in rats","volume":"43","author":"Peng","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.brainres.2009.07.020_bib23","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0006-2952(02)01168-1","article-title":"Signal transduction to hypoxia-inducible factor 1","volume":"64","author":"Semenza","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2009.07.020_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2008.03.045","article-title":"20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells","volume":"588","author":"Wang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.07.020_bib25","first-page":"433","article-title":"Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats","volume":"21","author":"Xu","year":"2000","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2009.07.020_bib26","first-page":"117","article-title":"Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats","volume":"19","author":"Yan","year":"1998","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"10.1016\/j.brainres.2009.07.020_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrm1697","article-title":"Mitochondrial fission in apoptosis","volume":"6","author":"Youle","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2009.07.020_bib28","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jpba.2005.09.022","article-title":"Raw material enzymatic activity determination: a specific case for validation and comparison of analytical methods\u2014the example of superoxide dismutase (SOD)","volume":"40","author":"Zhou","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.brainres.2009.07.020_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mrgentox.2009.03.001","article-title":"Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells","volume":"676","author":"Zou","year":"2009","journal-title":"Mutat. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309014255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309014255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T04:52:19Z","timestamp":1545108739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309014255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":29,"alternative-id":["S0006899309014255"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.07.020","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}