{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:50:29Z","timestamp":1792194629233,"version":"4.4.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.brainres.2009.08.058","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T09:27:49Z","timestamp":1251278869000},"page":"41-56","source":"Crossref","is-referenced-by-count":176,"special_numbering":"C","title":["Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk"],"prefix":"10.1016","volume":"1297","author":[{"given":"Kristen M.","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naftali","family":"Raz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.08.058_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0197-4580(01)00318-9","article-title":"Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis","volume":"23","author":"Abe","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib2","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/00001756-199607290-00013","article-title":"Age-related changes in fibre composition of the human corpus callosum: sex differences","volume":"7","author":"Aboitiz","year":"1996","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2009.08.058_bib3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.neurobiolaging.2005.05.023","article-title":"Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region","volume":"26","author":"Allen","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mri.2006.09.045","article-title":"Exploratory voxel-based analysis of diffusion indices and hemispheric asymmetry in normal aging","volume":"25","author":"Ardekani","year":"2007","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.brainres.2009.08.058_bib5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/jnnp.2003.023713","article-title":"Neuroanatomical localisation and clinical correlates of white matter lesions in the elderly","volume":"75","author":"Artero","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainres.2009.08.058_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neurobiolaging.2003.03.001","article-title":"Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease","volume":"25","author":"Bartzokis","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1001\/archpsyc.58.5.461","article-title":"Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study","volume":"58","author":"Bartzokis","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2009.08.058_bib8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/archneur.60.3.393","article-title":"White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study","volume":"60","author":"Bartzokis","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2009.08.058_bib9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neurobiolaging.2003.09.005","article-title":"Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical \u201cdisconnection\u201d in aging and Alzheimer's disease","volume":"25","author":"Bartzokis","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/01.wnl.0000198510.73363.c6","article-title":"Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRI","volume":"66","author":"Benedetti","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jmri.20102","article-title":"Diffusion anisotropy in subcortical white matter and cortical gray matter: changes with aging and the role of CSF-suppression","volume":"20","author":"Bhagat","year":"2004","journal-title":"J. Magn. Res. Imag."},{"key":"10.1016\/j.brainres.2009.08.058_bib13","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1212\/WNL.44.7.1246","article-title":"Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study","volume":"44","author":"Breteler","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib14","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.neurobiolaging.2007.02.008","article-title":"Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity","volume":"7","author":"Bucur","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1212\/01.wnl.0000194256.15247.83","article-title":"White matter damage on diffusion tensor imaging correlates with age-related cognitive decline","volume":"66","author":"Charlton","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib16","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.neurobiolaging.2007.03.017","article-title":"A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage","volume":"29","author":"Charlton","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib17","first-page":"447","article-title":"Diffusion tensor trace mapping in normal adult brain using single-shot EPI technique. A methodological study of the aging brain","volume":"42","author":"Chen","year":"2001","journal-title":"Acta Radiol."},{"key":"10.1016\/j.brainres.2009.08.058_bib18","first-page":"803","volume":"23","author":"Chepuri","year":"2002","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.brainres.2009.08.058_bib20","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1148\/radiology.216.3.r00au37672","article-title":"Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers","volume":"216","author":"Courchesne","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.brainres.2009.08.058_bib21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1037\/a0014283","article-title":"Aging, vascular risk and cognition: blood glucose, pulse pressure, and cognitive performance in healthy adults","volume":"24","author":"Dahle","year":"2009","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib22","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/cercor\/bhm155","article-title":"Que PASA? The posterior\u2013anterior shift in aging","volume":"18","author":"Davis","year":"2008","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2009.08.058_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.STR.30.3.529","article-title":"Predictors of brain morphology for the men of the NHLBI twin study","volume":"30","author":"DeCarli","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2009.08.058_bib25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/brain\/125.4.765","article-title":"Hypertension and cerebral white matter lesions in a prospective cohort study","volume":"125","author":"de Leeuw","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2009.08.058_bib27","series-title":"The Human Brain: Surface, Three-Dimensional Sectional Anatomy With MRI, and Blood Supply","author":"Duvernoy","year":"1999"},{"key":"10.1016\/j.brainres.2009.08.058_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2214\/ajr.175.2.1750425","article-title":"The effect of aging on the apparent diffusion coefficient of normal-appearing white matter","volume":"175","author":"Engelter","year":"2000","journal-title":"Am. J. Roentgen."},{"key":"10.1016\/j.brainres.2009.08.058_bib29","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(01)01429-5","article-title":"Developmental myelogenetic localisation of the cerebral cortex in the human subject","author":"Flechsig","year":"1901","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2009.08.058_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.brainres.2009.08.058_bib31","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1212\/01.WNL.0000154530.72969.11","article-title":"Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD","volume":"64","author":"Fotenos","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.CIR.96.1.308","article-title":"Hemodynamic patterns of age-related changes in blood pressure: the Framingham Heart Study","volume":"96","author":"Franklin","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2009.08.058_bib33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2152\/jmi.52.186","article-title":"Regional changes of fractional anisotropy with normal aging using statistical parametric mapping SPM","volume":"52","author":"Furutani","year":"2005","journal-title":"J. Med. Invest."},{"key":"10.1016\/j.brainres.2009.08.058_bib34","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/01.STR.29.4.765","article-title":"Relationship between blood pressure and subcortical lesions in healthy elderly people","volume":"29","author":"Goldstein","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2009.08.058_bib35","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1212\/01.WNL.0000164712.24389.BB","article-title":"Ambulatory blood pressure and the brain: a 5-year follow-up","volume":"64","author":"Goldstein","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib36","first-page":"226","article-title":"Cognitive aging, executive function, and fractional anisotropy: a diffusion tensor MR imaging study","volume":"28","author":"Grieve","year":"2007","journal-title":"Am. J. Neurorad."},{"key":"10.1016\/j.brainres.2009.08.058_bib37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1037\/0894-4105.14.2.224","article-title":"The cognitive correlates of white matter abnormalities in normal aging: a quantitative review","volume":"14","author":"Gunning-Dixon","year":"2000","journal-title":"Neuropsychology"},{"key":"10.1016\/j.brainres.2009.08.058_bib38","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0028-3932(03)00129-5","article-title":"Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study","volume":"41","author":"Gunning-Dixon","year":"2003","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.brainres.2009.08.058_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jama.290.2.199","article-title":"Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000","volume":"290","author":"Hajjar","year":"2003","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.brainres.2009.08.058_bib40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-0404.2008.01098.x","article-title":"Cognitive impairment and white matter damage in hypertension: a pilot study","volume":"119","author":"Hannesdottir","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.brainres.2009.08.058_bib42","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/cercor\/bhh003","article-title":"Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging","volume":"14","author":"Head","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2009.08.058_bib43","first-page":"194","article-title":"Diffusion-weighted MR imaging in normal human brains in various age groups","volume":"23","author":"Helenius","year":"2002","journal-title":"Am. J. Neurorad."},{"key":"10.1016\/j.brainres.2009.08.058_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jad.2008.07.024","article-title":"Blood pressure and white matter integrity in geriatric depression","volume":"115","author":"Hoptman","year":"2009","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.brainres.2009.08.058_bib45","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1097\/00029330-200608010-00012","article-title":"Diffusion tensor imaging on white matter in normal adults and elderly patients with hypertension","volume":"119","author":"Huang","year":"2006","journal-title":"Chinese Med. J."},{"key":"10.1016\/j.brainres.2009.08.058_bib46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/cercor\/bhm080","article-title":"Relating imaging indices of white matter integrity and volume in healthy older adults","volume":"18","author":"Hugenschmidt","year":"2008","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2009.08.058_bib47","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0197-4580(01)00217-2","article-title":"Effects of age on tissues and regions of the cerebrum and cerebellum","volume":"22","author":"Jernigan","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib48","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1001\/archinte.1997.00440420033005","article-title":"The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure","volume":"157","year":"1997","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.brainres.2009.08.058_bib49","series-title":"Clinical Neurology of Aging","first-page":"3","article-title":"Neuroanatomical and neuropathological changes during aging and dementia","author":"Kemper","year":"1994"},{"key":"10.1016\/j.brainres.2009.08.058_bib50","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.neuropsychologia.2009.01.001","article-title":"Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed","volume":"47","author":"Kennedy","year":"2009","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.brainres.2009.08.058_bib51","article-title":"Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry","author":"Kennedy","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib52","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.neuroimage.2006.12.021","article-title":"Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging","volume":"35","author":"Kochunov","year":"2007","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib53","first-page":"S45","article-title":"Arterial stiffness: a new surrogate end point for cardiovascular disease?","volume":"20","author":"Laurent","year":"2007","journal-title":"J. Nephrol."},{"key":"10.1016\/j.brainres.2009.08.058_bib54","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/01.wnr.0000209012.24341.7f","article-title":"Combining voxel-based morphometry and diffusion tensor imaging to detect age-related brain changes","volume":"17","author":"Lehmbeck","year":"2006","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2009.08.058_bib55","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.neuroimage.2007.03.053","article-title":"Sexual dimorphism of brain developmental trajectories during childhood and adolescence","volume":"36","author":"Lenroot","year":"2007","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib56","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.neuroimage.2003.11.004","article-title":"Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time","volume":"21","author":"Madden","year":"2004","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib57","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.neurobiolaging.2006.01.005","article-title":"Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study","volume":"28","author":"Madden","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib58","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1161\/01.STR.0000012808.81667.4B","article-title":"Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities","volume":"33","author":"Marstrand","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2009.08.058_bib59","series-title":"MRI atlas of Human White Matter","author":"Mori","year":"2005"},{"key":"10.1016\/j.brainres.2009.08.058_bib60","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1148\/radiol.2371041496","article-title":"Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people","volume":"237","author":"Murray","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.brainres.2009.08.058_bib61","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/mrm.21461","article-title":"Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease","volume":"59","author":"Nitkunan","year":"2008","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.brainres.2009.08.058_bib63","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1212\/WNL.57.4.632","article-title":"Evidence for cortical \u2018disconnection\u2019 as a mechanism of age-related cognitive decline","volume":"57","author":"O'Sullivan","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.brainres.2009.08.058_bib65","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.neuroimage.2006.02.008","article-title":"Age-related degeneration of corpus callosum measured with diffusion tensor imaging","volume":"31","author":"Ota","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib66","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.neuroimage.2008.03.021","article-title":"Voxel-based analysis derived from fractional anisotropy images of white matter volume changes with aging","volume":"41","author":"Pagani","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib67","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/01.STR.28.3.652","article-title":"Pathogenesis of leukoaraiosis: a review","volume":"28","author":"Pantoni","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2009.08.058_bib68","article-title":"Growth of white matter in the adolescent brain: myelin or axon?","author":"Paus","year":"2009","journal-title":"Brain Cogn."},{"key":"10.1016\/j.brainres.2009.08.058_bib69","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0079-6123(02)36038-2","article-title":"Structural changes in the normally aging cerebral cortex of primates","volume":"136","author":"Peters","year":"2002","journal-title":"Prog. Brain. Res."},{"key":"10.1016\/j.brainres.2009.08.058_bib70","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/mrm.10452","article-title":"Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming","volume":"49","author":"Pfefferbaum","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.brainres.2009.08.058_bib71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/1522-2594(200008)44:2<259::AID-MRM13>3.0.CO;2-6","article-title":"Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging","volume":"44","author":"Pfefferbaum","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.brainres.2009.08.058_bib72","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuroimage.2005.02.034","article-title":"Frontal circuitry degradation marks healthy adult aging: evidence from diffusion tensor imaging","volume":"26","author":"Pfefferbaum","year":"2005","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib73","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/mrm.1910360612","article-title":"Toward a quantitative assessment of diffusion anisotropy","volume":"36","author":"Pierpaoli","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.brainres.2009.08.058_bib74","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl. Psychol. Meas."},{"key":"10.1016\/j.brainres.2009.08.058_bib75","series-title":"Handbook of Aging and Cognition- II","first-page":"1","article-title":"Aging of the brain and its impact on cognitive performance: integration of structural and functional findings","author":"Raz","year":"2000"},{"key":"10.1016\/j.brainres.2009.08.058_bib76","series-title":"Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging","first-page":"17","article-title":"The aging brain observed in vivo: differential changes and their modifiers","author":"Raz","year":"2004"},{"key":"10.1016\/j.brainres.2009.08.058_bib77","series-title":"Imaging the Aging Brain","article-title":"A systems approach to age-related change: neuroanatomical changes, their modifiers, and cognitive correlates","author":"Raz","year":"2009"},{"key":"10.1016\/j.brainres.2009.08.058_bib78","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.neubiorev.2006.07.001","article-title":"Differential aging of the brain: patterns, cognitive correlates and modifiers","volume":"30","author":"Raz","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.058_bib79","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1037\/0735-7044.117.6.1169","article-title":"Hypertension and the brain: vulnerability of the prefrontal regions and executive functions","volume":"117","author":"Raz","year":"2003","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.058_bib80","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/cercor\/bhi044","article-title":"Regional brain changes in aging healthy adults: general trends, individual differences and modifiers","volume":"15","author":"Raz","year":"2005","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2009.08.058_bib81","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1037\/0894-4105.21.2.149","article-title":"Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults","volume":"212","author":"Raz","year":"2007","journal-title":"Neuropsychology"},{"key":"10.1016\/j.brainres.2009.08.058_bib84","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1148\/radiol.2273020721","article-title":"Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis","volume":"227","author":"Rovaris","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.brainres.2009.08.058_bib85","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/01.STR.30.3.556","article-title":"Neuro-psychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy","volume":"30","author":"Sabri","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2009.08.058_bib86","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neurobiolaging.2004.09.017","article-title":"Age-related alterations in white matter microstructure measured by diffusion tensor imaging","volume":"26","author":"Salat","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib87","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00001756-200303030-00010","article-title":"Childhood and current cognitive function in healthy 80-year-olds: a DT-MRI study","volume":"14","author":"Shenkin","year":"2003","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2009.08.058_bib88","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000087930","article-title":"Cognitive correlates of cerebral white matter lesions and water diffusion tensor parameters in community-dwelling older people","volume":"20","author":"Shenkin","year":"2005","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.brainres.2009.08.058_bib90","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: uses in assessing raters reliability","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.brainres.2009.08.058_bib91","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0010-9452(08)70879-7","article-title":"High prevalence of white matter hyperintensities in normal aging: relation to blood pressure and cognition","volume":"39","author":"S\u00f6derlund","year":"2003","journal-title":"Cortex"},{"key":"10.1016\/j.brainres.2009.08.058_bib92","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1148\/radiol.2471070707","article-title":"Age-related degradation in the central nervous system: assessment with diffusion-tensor imaging and quantitative fiber tracking","volume":"247","author":"Stadlbauer","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.brainres.2009.08.058_bib93","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/01.STR.28.7.1410","article-title":"Interactive effects of age and hypertension on volumes of brain structures","volume":"28","author":"Strassburger","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2009.08.058_bib94","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neubiorev.2006.06.002","article-title":"Diffusion tensor imaging and aging","volume":"30","author":"Sullivan","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.058_bib95","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00001756-200101220-00027","article-title":"Equivalent disruption of regional white matter microstructure in ageing healthy men and women","volume":"12","author":"Sullivan","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2009.08.058_bib96","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/cercor\/bhj045","article-title":"Selective age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking","volume":"16","author":"Sullivan","year":"2006","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2009.08.058_bib97","article-title":"Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance","author":"Sullivan","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2009.08.058_bib98","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1212\/WNL.51.4.986","article-title":"Association of midlife blood pressure to late-life cognitive decline and brain morphology","volume":"51","author":"Swan","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib99","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2214\/AJR.06.1163","article-title":"Widespread effects of hyperintense lesions on cerebral white matter structure","volume":"188","author":"Taylor","year":"2007","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.brainres.2009.08.058_bib104","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1006\/nimg.2002.1173","article-title":"Regional frontal cortical volumes decrease differentially in aging: an MRI study to compare volumetric approaches and voxel-based morphometry","volume":"17","author":"Tisserand","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib100","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuroimage.2008.07.052","article-title":"White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging","volume":"43","author":"Vernooij","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.brainres.2009.08.058_bib101","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/HYPERTENSIONAHA.107.093674","article-title":"Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging","volume":"51","author":"Waldstein","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.brainres.2009.08.058_bib102","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1212\/01.wnl.0000249119.95747.1f","article-title":"Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD","volume":"67","author":"Yoshita","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2009.08.058_bib103","first-page":"1059","article-title":"Age-related changes of normal adult brain structure: analysed with diffusion tensor imaging","volume":"118","author":"Zhang","year":"2005","journal-title":"Chinese Med. J."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309017260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309017260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T05:18:19Z","timestamp":1558502299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309017260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":95,"alternative-id":["S0006899309017260"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.08.058","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}