{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:20:45Z","timestamp":1777418445699,"version":"3.51.4"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Alcohol Research Council"},{"DOI":"10.13039\/501100002706","name":"AFA Insurance","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.brainres.2009.08.069","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T08:17:47Z","timestamp":1251879467000},"page":"S37-S49","source":"Crossref","is-referenced-by-count":30,"special_numbering":"S","title":["Two repeated maternal separation procedures differentially affect brain 5-hydroxytryptamine transporter and receptors in young and adult male and female rats"],"prefix":"10.1016","volume":"1305","author":[{"given":"Sadia","family":"Oreland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"G\u00f6kturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Oreland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotta","family":"Arborelius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Nylander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2009.08.069_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.mp.4000473","article-title":"Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia","volume":"4","author":"Agid","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2009.08.069_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","article-title":"Trajectories of brain development: point of vulnerability or window of opportunity?","volume":"27","author":"Andersen","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.069_bib3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.neuroscience.2006.12.007","article-title":"Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female rats","volume":"145","author":"Arborelius","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.08.069_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1600001","article-title":"The role of corticotropin-releasing factor in depression and anxiety disorders","volume":"160","author":"Arborelius","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.brainres.2009.08.069_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00213-004-1883-x","article-title":"Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation","volume":"176","author":"Arborelius","year":"2004","journal-title":"Psychopharmacology. (Berl.)"},{"issue":"5","key":"10.1016\/j.brainres.2009.08.069_bib6","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s10519-009-9285-9","article-title":"Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A population-based study","volume":"39","author":"Aslund","year":"2009","journal-title":"Behav. Genet."},{"key":"10.1016\/j.brainres.2009.08.069_bib7","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/01.ALC.0000067976.62827.ED","article-title":"Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress","volume":"27","author":"Barr","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib8","doi-asserted-by":"crossref","first-page":"12358","DOI":"10.1073\/pnas.0403763101","article-title":"Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques","volume":"101","author":"Barr","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.08.069_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1098-2302(199809)33:2<107::AID-DEV2>3.0.CO;2-N","article-title":"Thermoregulatory competence and behavioral expression in the young of altricial species\u2014revisited","volume":"33","author":"Blumberg","year":"1998","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.brainres.2009.08.069_bib10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0306-4530(01)00019-1","article-title":"Brief vs. long maternal separations in infancy: contrasting relationships with adult maternal behavior and lactation levels of aggression and anxiety","volume":"26","author":"Boccia","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2009.08.069_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-2999(87)90016-1","article-title":"Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain","volume":"144","author":"Bodnoff","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.08.069_bib12","series-title":"Substance abuse: a comprehensive textbook","first-page":"121","article-title":"Substances of abuse","author":"Boehm","year":"2005"},{"key":"10.1016\/j.brainres.2009.08.069_bib13","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1111\/j.1460-9568.2004.03286.x","article-title":"Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats","volume":"19","author":"Brake","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.069_bib14","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1073\/pnas.95.9.5335","article-title":"Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat","volume":"95","author":"Caldji","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.08.069_bib15","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0006-3223(00)01084-2","article-title":"Variations in maternal care in infancy regulate the development of stress reactivity","volume":"48","author":"Caldji","year":"2000","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2009.08.069_bib16","series-title":"The ecology and sociology of the Norway rat","author":"Calhoun","year":"1962"},{"key":"10.1016\/j.brainres.2009.08.069_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2007.04.069","article-title":"Maternal isolation alters the expression of neural proteins during development: \u2018stroking\u2019 stimulation reverses these effects","volume":"1158","author":"Chatterjee","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0031-9384(01)00456-5","article-title":"Role of environmental factors on brain development and nerve growth factor expression","volume":"73","author":"Cirulli","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.biopsych.2007.03.001","article-title":"Evolving knowledge of sex differences in brain structure, function, and chemistry","volume":"62","author":"Cosgrove","year":"2007","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2009.08.069_bib20","first-page":"S2","article-title":"Neuropharmacology of emesis in relation to clinical response","volume":"19","author":"Costall","year":"1992","journal-title":"Br. J. Cancer Suppl."},{"key":"10.1016\/j.brainres.2009.08.069_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0091-3057(90)90414-D","article-title":"Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse","volume":"36","author":"Costall","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0091-3057(90)90132-2","article-title":"Sites of action of ondansetron to inhibit withdrawal from drugs of abuse","volume":"36","author":"Costall","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4530(01)00042-7","article-title":"Developmental traumatology: a contributory mechanism for alcohol and substance use disorders","volume":"27","author":"De Bellis","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2009.08.069_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neubiorev.2004.10.008","article-title":"Stress, genes and the mechanism of programming the brain for later life","volume":"29","author":"de Kloet","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.069_bib25","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2004.04.044","article-title":"Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats","volume":"126","author":"Drossopoulou","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.08.069_bib26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bbr.2006.05.015","article-title":"Twice daily long maternal separations in Wistar rats decreases anxiety-like behaviour in females but does not affect males","volume":"172","author":"Eklund","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbr.2009.04.017","article-title":"Differential effects of repeated long and brief maternal separation on behaviour and neuroendocrine parameters in Wistar dams","volume":"203","author":"Eklund","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/(SICI)1096-9861(20000313)418:3<323::AID-CNE7>3.0.CO;2-Y","article-title":"Pontomedullary distribution of 5-HT2A receptor-like protein in the rat","volume":"418","author":"Fay","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2009.08.069_bib29","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1037\/h0036414","article-title":"Maternal behavior in the virgin and lactating rat","volume":"86","author":"Fleming","year":"1974","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.brainres.2009.08.069_bib30","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1046\/j.1460-9568.2003.02668.x","article-title":"Early life adversity programs changes in central 5-HT neuronal function in adulthood","volume":"17","author":"Gartside","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.069_bib31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1360-0443.2002.00023.x","article-title":"Evolutionary underpinnings of excessive alcohol consumption","volume":"97","author":"Gerald","year":"2002","journal-title":"Addiction"},{"key":"10.1016\/j.brainres.2009.08.069_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-0327(03)00046-6","article-title":"Early experience and depressive disorders: human and non-human primate studies","volume":"75","author":"Gilmer","year":"2003","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2009.08.069_bib33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00737-008-0033-6","article-title":"Serotonin transporter (5-HTTLPR) and monoamine oxidase (MAOA) promoter polymorphisms in women with severe alcoholism","volume":"11","author":"Gokturk","year":"2008","journal-title":"Arch. Womens Ment. Health"},{"key":"10.1016\/j.brainres.2009.08.069_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1550-8579(06)80199-3","article-title":"Gender differences in depression and response to psychotropic medication","volume":"3","author":"Gorman","year":"2006","journal-title":"Gend. Med."},{"key":"10.1016\/j.brainres.2009.08.069_bib35","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1111\/j.1530-0277.2006.00247.x","article-title":"Time-dependent alterations in ethanol intake in male wistar rats exposed to short and prolonged daily maternal separation in a 4-bottle free-choice paradigm","volume":"30","author":"Gustafsson","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib36","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.pbb.2005.03.016","article-title":"Effects of maternal separation on voluntary ethanol intake and brain peptide systems in female Wistar rats","volume":"81","author":"Gustafsson","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib37","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.neuroscience.2007.02.037","article-title":"Ethanol-induced effects on opioid peptides in adult male Wistar rats are dependent on early environmental factors","volume":"146","author":"Gustafsson","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.08.069_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.npep.2007.10.006","article-title":"The impact of postnatal environment on opioid peptides in young and adult male Wistar rats","volume":"42","author":"Gustafsson","year":"2008","journal-title":"Neuropeptides"},{"key":"10.1016\/j.brainres.2009.08.069_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0014-2999(98)00349-5","article-title":"Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor","volume":"352","author":"Hansen","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.08.069_bib40","series-title":"Principles of laboratory animal science; a contribution to the humane use and care of animals and to the quality of experimental results","first-page":"24","article-title":"Biology and husbandry of laboratory animals","author":"Havenaar","year":"2001"},{"key":"10.1016\/j.brainres.2009.08.069_bib41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF01252130","article-title":"Serotoninergic development in the postnatal rat brain","volume":"49","author":"Hedner","year":"1980","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.brainres.2009.08.069_bib42","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1073\/pnas.88.16.7261","article-title":"Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption","volume":"88","author":"Higley","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.08.069_bib43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-2999(96)00490-6","article-title":"Neuronal responses to delta 9-tetrahydrocannabinol in the solitary tract nucleus","volume":"312","author":"Himmi","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.08.069_bib45","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Statist."},{"key":"10.1016\/j.brainres.2009.08.069_bib44","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.neubiorev.2005.04.012","article-title":"Early life genetic, epigenetic and environmental factors shaping emotionality in rodents","volume":"29","author":"Holmes","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.069_bib46","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0022-3565(25)13363-6","article-title":"Antidepressant binding sites in brain: autoradiographic comparison of [3H]paroxetine and [3H]imipramine localization and relationship to serotonin transporter","volume":"252","author":"Hrdina","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2009.08.069_bib47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s002130100701","article-title":"Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment","volume":"158","author":"Huot","year":"2001","journal-title":"Psychopharmacology. (Berl.)"},{"key":"10.1016\/j.brainres.2009.08.069_bib48","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2165\/00023210-200418150-00005","article-title":"Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment","volume":"18","author":"Johnson","year":"2004","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2009.08.069_bib49","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.neuroimage.2007.10.016","article-title":"Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET","volume":"39","author":"Jovanovic","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2009.08.069_bib50","first-page":"518","article-title":"Early neonatal experience of Long-Evans rats results in long-lasting changes in reactivity to a novel environment and morphine-induced sensitization and tolerance","volume":"27","author":"Kalinichev","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2009.08.069_bib51","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/archpsyc.57.10.953","article-title":"Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis","volume":"57","author":"Kendler","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2009.08.069_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0165-0327(93)90026-G","article-title":"Sex and depression in the National Comorbidity Survey. I. Lifetime prevalence, chronicity and recurrence","volume":"29","author":"Kessler","year":"1993","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2009.08.069_bib53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1472-8206.1997.tb00187.x","article-title":"Stress-induced alterations of somatodendritic 5-HT1A autoreceptor sensitivity in the rat dorsal raphe nucleus\u2014in vitro electrophysiological evidence","volume":"11","author":"Laaris","year":"1997","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2009.08.069_bib54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0079-6123(08)62132-9","article-title":"Long-term behavioral and neuroendocrine adaptations to adverse early experience","volume":"122","author":"Ladd","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399407000245","article-title":"Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes","volume":"9","author":"Lam","year":"2007","journal-title":"Expert. Rev. Mol. Med."},{"key":"10.1016\/j.brainres.2009.08.069_bib56","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/syn.890100402","article-title":"Quantitative autoradiographic mapping of 5-HT3 receptors in the rat CNS using [125I]iodo-zacopride and [3H]zacopride as radioligands","volume":"10","author":"Laporte","year":"1992","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2009.08.069_bib57","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neures.2007.01.008","article-title":"Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation","volume":"58","author":"Lee","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib58","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/REVNEURO.2000.11.4.383","article-title":"Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing?","volume":"11","author":"Lehmann","year":"2000","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.069_bib59","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0091-3057(99)00150-1","article-title":"The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats","volume":"64","author":"Lehmann","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib60","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejphar.2005.09.027","article-title":"Alcohol dependence and gene\u00d7environment interaction in emotion regulation: is serotonin the link?","volume":"526","author":"Lesch","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2009.08.069_bib61","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0361-9230(82)90077-6","article-title":"An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields","volume":"8","author":"Lidov","year":"1982","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2009.08.069_bib62","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.277.5332.1659","article-title":"Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress","volume":"277","author":"Liu","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.brainres.2009.08.069_bib63","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2826.2000.00422.x","article-title":"Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinepherine release in the hypothalamic paraventricular nucleus","volume":"12","author":"Liu","year":"2000","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainres.2009.08.069_bib64","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.yhbeh.2006.06.015","article-title":"Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis","volume":"50","author":"Macri","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib65","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1460-9568.2004.03541.x","article-title":"Dissociation in the effects of neonatal maternal separations on maternal care and the offspring's HPA and fear responses in rats","volume":"20","author":"Macri","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.069_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1098-2396(200104)40:1<1::AID-SYN1020>3.0.CO;2-E","article-title":"Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain","volume":"40","author":"Matthews","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2009.08.069_bib67","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-3806(99)00005-X","article-title":"Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects","volume":"113","author":"McIntosh","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib68","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0306-4522(92)90011-P","article-title":"Baroreceptor reflex inhibition induced by the stimulation of serotonin3 receptors in the nucleus tractus solitarius of the rat","volume":"46","author":"Merahi","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.08.069_bib69","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bcp.2006.08.003","article-title":"Maternal separation alters drug intake patterns in adulthood in rats","volume":"73","author":"Moffett","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2009.08.069_bib70","doi-asserted-by":"crossref","first-page":"6793","DOI":"10.1073\/pnas.86.17.6793","article-title":"5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system","volume":"86","author":"Molineaux","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2009.08.069_bib71","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0306-4522(93)90447-N","article-title":"Ontogeny of 5-hydroxytryptamine2 receptor immunoreactivity in the developing rat brain","volume":"55","author":"Morilak","year":"1993","journal-title":"Neuroscience"},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2009.08.069_bib72","first-page":"18","article-title":"Neurobiological consequences of childhood trauma","volume":"65","author":"Nemeroff","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainres.2009.08.069_bib73","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0006-3223(01)01371-3","article-title":"5-HT(1B) mrna regulation in two animal models of altered stress reactivity","volume":"51","author":"Neumaier","year":"2002","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2009.08.069_bib74","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/01.ALC.0000159112.98941.B0","article-title":"Role of the serotonin transporter gene and family function in adolescent alcohol consumption","volume":"29","author":"Nilsson","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib75","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0031-9384(94)00308-R","article-title":"Postnatal handling reduces emotionality ratings and accelerates two-way active avoidance in female rats","volume":"57","author":"Nunez","year":"1995","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0165-1781(81)90004-4","article-title":"Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controls","volume":"4","author":"Oreland","year":"1981","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib77","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1749-6632.1997.tb51914.x","article-title":"Brain systems for the mediation of social separation-distress and social-reward. Evolutionary antecedents and neuropeptide intermediaries","volume":"807","author":"Panksepp","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2009.08.069_bib78","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0006-8993(02)03243-2","article-title":"Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635","volume":"954","author":"Parsey","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib79","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2006.04.136","article-title":"Repeated maternal separation of male Wistar rats alters glutamate receptor expression in the hippocampus but not the prefrontal cortex","volume":"1099","author":"Pickering","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib80","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0091-3057(02)00778-5","article-title":"Effects of maternal separation on brain nociceptin\/orphanin FQ peptide levels in male Wistar rats","volume":"73","author":"Ploj","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib81","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0306-4522(03)00499-8","article-title":"Long-term effects of maternal separation on ethanol intake and brain opioid and dopamine receptors in male Wistar rats","volume":"121","author":"Ploj","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.08.069_bib82","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0169-328X(93)90189-V","article-title":"Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats","volume":"18","author":"Plotsky","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib83","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1523\/JNEUROSCI.12-02-00440.1992","article-title":"Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding","volume":"12","author":"Pompeiano","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.069_bib84","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0149-7634(03)00009-5","article-title":"Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms","volume":"27","author":"Pryce","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.069_bib85","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neubiorev.2005.03.011","article-title":"Long-term effects of early-life environmental manipulations in rodents and primates: potential animal models in depression research","volume":"29","author":"Pryce","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.069_bib86","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","article-title":"Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data","volume":"339","author":"Ramakers","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2009.08.069_bib87","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/10253890500188666","article-title":"The impact of emotional stress early in life on adult voluntary ethanol intake-results of maternal separation in rats","volume":"8","author":"Roman","year":"2005","journal-title":"Stress"},{"key":"10.1016\/j.brainres.2009.08.069_bib88","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1530-0277.2003.tb02717.x","article-title":"Maternal separation alters acquisition of ethanol intake in male ethanol-preferring AA rats","volume":"27","author":"Roman","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib89","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0741-8329(04)00077-1","article-title":"Maternal separation has no effect on voluntary ethanol intake in female Wistar rats","volume":"33","author":"Roman","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.brainres.2009.08.069_bib90","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/01.ALC.0000158933.70242.FC","article-title":"Short and prolonged periods of maternal separation and voluntary ethanol intake in male and female ethanol-preferring AA and ethanol-avoiding ANA rats","volume":"29","author":"Roman","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib91","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.yhbeh.2006.06.016","article-title":"Behavioral profiles and stress-induced corticosteroid secretion in male Wistar rats subjected to short and prolonged periods of maternal separation","volume":"50","author":"Roman","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib92","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/dev.20014","article-title":"Circadian- and temperature-specific effects of early deprivation on rat maternal care and pup development: short-term markers for long-term effects?","volume":"45","author":"Ruedi-Bettschen","year":"2004","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.brainres.2009.08.069_bib93","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00213-005-0247-5","article-title":"5-HT receptor subtypes involved in the anxiogenic-like action and associated Fos response of acute fluoxetine treatment in rats","volume":"185","author":"Salchner","year":"2006","journal-title":"Psychopharmacology. (Berl.)"},{"key":"10.1016\/j.brainres.2009.08.069_bib94","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1017\/S1461145705005936","article-title":"Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene","volume":"9","author":"Sjoberg","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2009.08.069_bib95","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0165-3806(94)90103-1","article-title":"Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression","volume":"80","author":"Smythe","year":"1994","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2009.08.069_bib96","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1460-9568.1990.tb00026.x","article-title":"Direct Immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei","volume":"2","author":"Sotelo","year":"1990","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.069_bib97","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.yfrne.2005.10.002","article-title":"Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat","volume":"26","author":"Szyf","year":"2005","journal-title":"Front. Neuroendocrinol."},{"issue":"7","key":"10.1016\/j.brainres.2009.08.069_bib98","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.brainres.2009.08.069_bib99","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0306-4530(01)00048-8","article-title":"Brain 5-HT receptor system in the stressed infant rat: implications for vulnerability to substance abuse","volume":"27","author":"Vazquez","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2009.08.069_bib100","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neuroscience.2006.02.008","article-title":"Maternal separation alters serotonergic transporter densities and serotonergic 1A receptors in rat brain","volume":"140","author":"Vicentic","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2009.08.069_bib101","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0149-7634(05)80164-2","article-title":"A new animal model of endogenous depression: a summary of present findings","volume":"14","author":"Vogel","year":"1990","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2009.08.069_bib102","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"7","author":"Weaver","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2009.08.069_bib103","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ng1726","article-title":"The sex-specific genetic architecture of quantitative traits in humans","volume":"38","author":"Weiss","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2009.08.069_bib104","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0031-9384(98)00300-X","article-title":"Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats","volume":"66","author":"Wigger","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2009.08.069_bib105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0306-4522(99)00234-1","article-title":"Sex differences in expression of serotonin receptors (subtypes 1A and 2A) in rat brain: a possible role of testosterone","volume":"94","author":"Zhang","year":"1999","journal-title":"Neuroscience"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309018071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899309018071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T23:22:53Z","timestamp":1739316173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899309018071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":105,"alternative-id":["S0006899309018071"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2009.08.069","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}