{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:46:52Z","timestamp":1790477212000,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.brainres.2010.01.089","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T09:52:55Z","timestamp":1265709175000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Distribution of apoptosis-related proteins in sporadic Creutzfeldt\u2013Jakob disease"],"prefix":"10.1016","volume":"1323","author":[{"given":"Gabor G.","family":"Kovacs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Budka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.01.089_bib1","doi-asserted-by":"crossref","first-page":"19704","DOI":"10.1074\/jbc.M707744200","article-title":"All JNKs can kill, but nuclear localization is critical for neuronal death","volume":"283","author":"Bjorkblom","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.01.089_bib2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature05293","article-title":"Cell death in the nervous system","volume":"443","author":"Bredesen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2010.01.089_bib3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1073\/pnas.0406173102","article-title":"Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease","volume":"102","author":"Chiesa","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2010.01.089_bib4","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1097\/00005072-199909000-00010","article-title":"PrPc glycoform heterogeneity as a function of brain region: implications for selective targeting of neurons by prion strains","volume":"58","author":"DeArmond","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.01.089_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s004010050949","article-title":"Nuclear DNA fragmentation in Creutzfeldt\u2013Jakob disease: does a mere positive in situ nuclear end-labeling indicate apoptosis?","volume":"97","author":"Ferrer","year":"1999","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2010.01.089_bib6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1006\/cbir.2001.0768","article-title":"Expression of BAX in cell nucleus after experimentally induced apoptosis revealed by immunogold and embedment-free electron microscopy","volume":"25","author":"Gajkowska","year":"2001","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.brainres.2010.01.089_bib7","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/j.1582-4934.2008.00402.x","article-title":"Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling","volume":"12","author":"Gorman","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.brainres.2010.01.089_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00005072-199904000-00002","article-title":"Neuronal apoptosis in Creutzfeldt\u2013Jakob disease","volume":"58","author":"Gray","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.01.089_bib9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/nbdi.2002.0477","article-title":"Oxidative damage to nucleic acids in human prion disease","volume":"9","author":"Guentchev","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2010.01.089_bib10","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1099\/vir.0.83622-0","article-title":"Prion propagation in mice lacking central nervous system NF-kappaB signalling","volume":"89","author":"Julius","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.brainres.2010.01.089_bib11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.neuroscience.2006.09.034","article-title":"The role of poly(ADP-ribose) polymerase-1 in CNS disease","volume":"145","author":"Kauppinen","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.01.089_bib12","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1006\/nbdi.2001.0418","article-title":"Prominent stress response of Purkinje cells in Creutzfeldt\u2013Jakob disease","volume":"8","author":"Kovacs","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2010.01.089_bib13","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/nen.0b013e318093ecc7","article-title":"Involvement of the endosomal\u2013lysosomal system correlates with regional pathology in Creutzfeldt\u2013Jakob disease","volume":"66","author":"Kovacs","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.01.089_bib14","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2353\/ajpath.2008.070442","article-title":"Prion diseases: from protein to cell pathology","volume":"172","author":"Kovacs","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2010.01.089_bib15","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3390\/ijms10030976","article-title":"Molecular pathology of human prion diseases","volume":"10","author":"Kovacs","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2010.01.089_bib16","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.biocel.2004.04.016","article-title":"Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy","volume":"36","author":"Liberski","year":"2004","journal-title":"Int. J. Biochem. Cell. Biol."},{"issue":"Pt 2","key":"10.1016\/j.brainres.2010.01.089_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/brain\/122.2.247","article-title":"Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease","volume":"122","author":"Love","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2010.01.089_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0197-0186(96)00153-2","article-title":"Internucleosomal breakdown of the DNA of brain cortex in human spongiform encephalopathy","volume":"31","author":"Lucas","year":"1997","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2010.01.089_bib19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00401-006-0094-4","article-title":"Correlation between Bax overexpression and prion deposition in medulla oblongata from natural scrapie without evidence of apoptosis","volume":"112","author":"Lyahyai","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2010.01.089_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2007.08.085","article-title":"Differential expression and protein distribution of Bax in natural scrapie","volume":"1180","author":"Lyahyai","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.01.089_bib21","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/ars.2007.1511","article-title":"Neuronal apoptosis in neurodegeneration","volume":"9","author":"Okouchi","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainres.2010.01.089_bib22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/NEN.0b013e318196cd7c","article-title":"Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt\u2013Jakob disease","volume":"68","author":"Paquet","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.01.089_bib23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","article-title":"Classification of sporadic Creutzfeldt\u2013Jakob disease based on molecular and phenotypic analysis of 300 subjects","volume":"46","author":"Parchi","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2010.01.089_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s004010100368","article-title":"Cell death signaling in the cerebellum in Creutzfeldt\u2013Jakob disease","volume":"102","author":"Puig","year":"2001","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2010.01.089_bib25","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroscience.2008.07.007","article-title":"NF-kappaB signaling in cerebral ischemia","volume":"158","author":"Ridder","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.01.089_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neulet.2003.12.011","article-title":"Activation of the c-Jun transcription factor following neurodegeneration in vivo","volume":"361","author":"Schenkel","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.01.089_bib27","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1097\/01.wnr.0000136175.51954.ce","article-title":"The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease","volume":"15","author":"Soos","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2010.01.089_bib28","first-page":"1459","article-title":"Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease","volume":"155","author":"Stadelmann","year":"1999","journal-title":"Evidence for apoptotic cell death. Am. J. Pathol."},{"key":"10.1016\/j.brainres.2010.01.089_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.nbd.2005.11.010","article-title":"No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases","volume":"22","author":"Woodhouse","year":"2006","journal-title":"Neurobiol. Dis."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310002805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310002805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:41:56Z","timestamp":1757785316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899310002805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":29,"alternative-id":["S0006899310002805"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.01.089","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution of apoptosis-related proteins in sporadic Creutzfeldt\u2013Jakob disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2010.01.089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}