{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:55:03Z","timestamp":1771044903348,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.brainres.2010.02.029","type":"journal-article","created":{"date-parts":[[2010,2,13]],"date-time":"2010-02-13T09:24:16Z","timestamp":1266053056000},"page":"1-9","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Hypoxic preconditioning provides neuroprotection and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic\u2013ischemic model"],"prefix":"10.1016","volume":"1325","author":[{"given":"Yangzheng","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay J.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.02.029_bib1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10571-005-8472-3","article-title":"Quantification of vascular endothelial growth factor and neuropilins mRNAs during rat brain maturation by real-time PCR","volume":"25","author":"Adris","year":"2005","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2010.02.029_bib2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00008480-200112000-00003","article-title":"Animal models of neonatal stroke","volume":"13","author":"Ashwal","year":"2001","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.brainres.2010.02.029_bib3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1531-8249(200009)48:3<285::AID-ANA2>3.0.CO;2-8","article-title":"Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain","volume":"48","author":"Bergeron","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2010.02.029_bib4","doi-asserted-by":"crossref","first-page":"39728","DOI":"10.1074\/jbc.M204619200","article-title":"Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance","volume":"277","author":"Bernaudin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.02.029_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2010.02.029_bib6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1203\/00006450-199508000-00019","article-title":"Effect of status epilepticus on hypoxic\u2013ischemic brain damage in the immature rat","volume":"38","author":"Cataltepe","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2010.02.029_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2003.10.048","article-title":"Treatment with tamoxifen reduces hypoxic\u2013ischemic brain injury in neonatal rats","volume":"484","author":"Feng","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2010.02.029_bib8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1203\/PDR.0b013e318180ebe6","article-title":"Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats","volume":"64","author":"Feng","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2010.02.029_bib9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuroscience.2008.10.024","article-title":"Dexamethasone induces neurodegeneration but also up-regulates vascular endothelial growth factor A in neonatal rat brains","volume":"158","author":"Feng","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.02.029_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0092-8674(00)81883-8","article-title":"PI3K: downstream AKTion blocks apoptosis","volume":"88","author":"Franke","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2010.02.029_bib11","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1038\/sj.onc.1207115","article-title":"PI3K\/Akt and apoptosis: size matters","volume":"22","author":"Franke","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.brainres.2010.02.029_bib12","doi-asserted-by":"crossref","first-page":"30336","DOI":"10.1074\/jbc.273.46.30336","article-title":"Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3\u2032-kinase\/Akt signal transduction pathway. Requirement for Flk-1\/KDR activation","volume":"273","author":"Gerber","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.02.029_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3940(94)90455-3","article-title":"Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat","volume":"168","author":"Gidday","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.02.029_bib14","doi-asserted-by":"crossref","first-page":"13635","DOI":"10.1074\/jbc.M108703200","article-title":"A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR","volume":"277","author":"Goldberg-Cohen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.02.029_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1203\/01.PDR.0000151122.58665.70","article-title":"Hypoxic preconditioning confers long-term reduction of brain injury and improvement of neurological ability in immature rats","volume":"57","author":"Gustavsson","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2010.02.029_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1203\/pdr.0b013e3180332be4","article-title":"Global gene expression in the developing rat brain after hypoxic preconditioning: involvement of apoptotic mechanisms?","volume":"61","author":"Gustavsson","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2010.02.029_bib17","first-page":"210","article-title":"Angiogenesis and its regulatory factors in brain tissue of neonatal rat hypoxic\u2013ischemic encephalopathy","volume":"42","author":"Huang","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.brainres.2010.02.029_bib18","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1073\/pnas.97.18.10242","article-title":"Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia","volume":"97","author":"Jin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2010.02.029_bib19","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/00004647-200109000-00008","article-title":"Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain","volume":"21","author":"Jones","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2010.02.029_bib20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/sj.jcbfm.9600109","article-title":"VEGF protects brain against focal ischemia without increasing blood\u2013brain permeability when administered intracerebroventricularly","volume":"25","author":"Kaya","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2010.02.029_bib21","doi-asserted-by":"crossref","first-page":"12439","DOI":"10.1523\/JNEUROSCI.0434-06.2006","article-title":"Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1\/2 and Akt pathways","volume":"26","author":"Kilic","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2010.02.029_bib22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10495-006-0001-4","article-title":"Caspase-3 immunohistochemical expression is a marker of apoptosis, increased grade and early recurrence in intracranial meningiomas","volume":"12","author":"Konstantinidou","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.brainres.2010.02.029_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.nbd.2006.12.020","article-title":"Neonatal hypoxic preconditioning involves vascular endothelial growth factor","volume":"26","author":"Laudenbach","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2010.02.029_bib24","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1523\/JNEUROSCI.5497-08.2009","article-title":"VEGF-A\/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells","volume":"29","author":"Lee","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2010.02.029_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.brainres.2010.02.029_bib26","first-page":"512","article-title":"VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP","volume":"10","author":"McColm","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.brainres.2010.02.029_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2010.02.029_bib28","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1203\/00006450-199004000-00003","article-title":"Reduction of perinatal hypoxic\u2013ischemic brain damage with allopurinol","volume":"27","author":"Palmer","year":"1990","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2010.02.029_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic\u2013ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2010.02.029_bib30","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/MCB.18.6.3112","article-title":"Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia","volume":"18","author":"Stein","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2010.02.029_bib31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1471-4159.1998.71031215.x","article-title":"Hypoxic preconditioning and hypoxic\u2013ischemic brain damage in the immature rat: pathologic and metabolic correlates","volume":"71","author":"Vannucci","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2010.02.029_bib32","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1523\/JNEUROSCI.22-15-06401.2002","article-title":"Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt","volume":"22","author":"Wick","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2010.02.029_bib33","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1161\/01.STR.0000258102.18836.ca","article-title":"Preconditioning suppresses inflammation in neonatal hypoxic ischemia via Akt activation","volume":"38","author":"Yin","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.02.029_bib34","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1006\/bbrc.2002.6710","article-title":"Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells","volume":"292","author":"Zhang","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2010.02.029_bib35","doi-asserted-by":"crossref","first-page":"9794","DOI":"10.1523\/JNEUROSCI.3163-05.2005","article-title":"Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats","volume":"25","author":"Zhao","year":"2005","journal-title":"J. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310003768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310003768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T23:26:58Z","timestamp":1558826818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899310003768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":35,"alternative-id":["S0006899310003768"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.02.029","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}