{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:38:12Z","timestamp":1789717092203,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"GlaxoSmithKline Pharmaceuticals"},{"name":"Libyan Government"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.brainres.2010.02.045","type":"journal-article","created":{"date-parts":[[2010,2,21]],"date-time":"2010-02-21T04:28:48Z","timestamp":1266726528000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy"],"prefix":"10.1016","volume":"1326","author":[{"given":"Salma","family":"Bukhatwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Yun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.02.045_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1369\/jhc.5B6752.2005","article-title":"Subcellular distribution of components of the ubiquitin-proteasome system in non-diseased human and rat brain","volume":"54","author":"Adori","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.brainres.2010.02.045_bib2","first-page":"265","article-title":"Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies","volume":"22","author":"Barrachina","year":"2006","journal-title":"Neurobiology"},{"key":"10.1016\/j.brainres.2010.02.045_bib4","doi-asserted-by":"crossref","first-page":"30057","DOI":"10.1074\/jbc.M100142200","article-title":"Oxidative modification and inactivation of the proteasome during coronary occlusion\/reperfusion","volume":"276","author":"Bulteau","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.02.045_bib5","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S1357-2725(02)00085-7","article-title":"Impairment of proteasome structure and function in aging","volume":"34","author":"Carrard","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2010.02.045_bib7","doi-asserted-by":"crossref","first-page":"22123","DOI":"10.1074\/jbc.274.32.22123","article-title":"The proteasome, a novel protease regulated by multiple mechanisms","volume":"274","author":"DeMartino","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.02.045_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1750-3639.2007.00054.x","article-title":"Progressive supranuclear palsy: pathology and genetics","volume":"17","author":"Dickson","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainres.2010.02.045_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-3806(01)00181-X","article-title":"The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon","volume":"129","author":"El-Khodor","year":"2001","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2010.02.045_bib10","first-page":"344","article-title":"Molecular cloning and functional analysis of three subunits of yeast proteasome","volume":"11","author":"Emori","year":"1991","journal-title":"Mol. Cell. Biol."},{"issue":"Suppl 12","key":"10.1016\/j.brainres.2010.02.045_bib11","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1002\/mds.20542","article-title":"Alpha-synuclein transgenic mice: relevance to multiple system atrophy","volume":"20","author":"Fillon","year":"2005","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2010.02.045_bib12","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/ana.10207","article-title":"Brain proteasomal function in sporadic Parkinson's disease and related disorders","volume":"51","author":"Furukawa","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2010.02.045_bib13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0014-4886(03)00004-9","article-title":"Alpha-synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy","volume":"181","author":"Gai","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.02.045_bib14","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.290.5493.985","article-title":"Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions","volume":"290","author":"Giasson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.brainres.2010.02.045_bib15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","article-title":"The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction","volume":"82","author":"Glickman","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2010.02.045_bib16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0959-437X(00)00200-8","article-title":"The significance of tau and a-synuclein inclusions in neurodegenerative diseases","volume":"11","author":"Goedert","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.brainres.2010.02.045_bib17","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s00702-004-0212-1","article-title":"Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion\/cellular matrix and vesicle trafficking genes","volume":"111","author":"Grunblatt","year":"2004","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.brainres.2010.02.045_bib18","doi-asserted-by":"crossref","first-page":"15504","DOI":"10.1074\/jbc.271.26.15504","article-title":"Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome","volume":"271","author":"Grune","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.02.045_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0022-510X(98)00095-1","article-title":"Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases","volume":"158","author":"Gu","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2010.02.045_bib20","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1212\/WNL.44.11.2015","article-title":"Preliminary NINDS neuropathologic criteria for Steele\u2013Richardson\u2013Olszewski syndrome (progressive supranuclear palsy)","volume":"44","author":"Hauw","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2010.02.045_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2137(96)80001-X","article-title":"Regulatory features of multicatalytic and 26S proteases","volume":"34","author":"Hoffman","year":"1996","journal-title":"Curr. Top. Cell. Regul."},{"key":"10.1016\/j.brainres.2010.02.045_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2003.12.127","article-title":"Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans","volume":"359","author":"Hope","year":"2004","journal-title":"Neurosci. Lett."},{"issue":"Suppl 6","key":"10.1016\/j.brainres.2010.02.045_bib23","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/mds.10557","article-title":"Neuropathological spectrum of synucleinopathies","volume":"18","author":"Jellinger","year":"2003","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2010.02.045_bib24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1750-3639.1999.tb00549.x","article-title":"Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease","volume":"9","author":"Komori","year":"1999","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainres.2010.02.045_bib25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/416763a","article-title":"A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal","volume":"416","author":"Lam","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2010.02.045_bib26","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/mds.21259","article-title":"Gene expression changes in postmortem tissue from the rostral pons of multiple system atrophy patients","volume":"22","author":"Langerveld","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2010.02.045_bib27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00702-008-0027-6","article-title":"Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems","volume":"115","author":"MacInnes","year":"2008","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.brainres.2010.02.045_bib28","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1096\/fj.06-6734com","article-title":"The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein\u2014implications for Parkinson's disease","volume":"21","author":"Marx","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2010.02.045_bib29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.molcel.2008.10.011","article-title":"Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome","volume":"32","author":"Matiuhin","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.brainres.2010.02.045_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-3940(00)01701-8","article-title":"Proteasomal function is impaired in substantia nigra in Parkinson's disease","volume":"297","author":"McNaught","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.02.045_bib31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3940(02)00296-3","article-title":"Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease","volume":"326","author":"McNaught","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.02.045_bib32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/exnr.2002.8050","article-title":"Altered proteasomal function in sporadic Parkinson's disease","volume":"179","author":"McNaught","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.02.045_bib33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/bbrc.2000.3676","article-title":"Tissue distribution of constitutive proteasomes, immunoproteasomes, and PA28 in rats","volume":"277","author":"Noda","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2010.02.045_bib34","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1093\/brain\/awh303","article-title":"The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations","volume":"127","author":"Ozawa","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2010.02.045_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-510X(89)90219-0","article-title":"Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)","volume":"94","author":"Papp","year":"1989","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2010.02.045_bib36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00005072-199305000-00001","article-title":"Pathology and biology of the Lewy body","volume":"52","author":"Pollanen","year":"1993","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.02.045_bib37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neulet.2005.02.013","article-title":"SUMO-1 marks subdomains within glial cytoplasmic inclusions of multiple system atrophy","volume":"381","author":"Pountney","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.02.045_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3450001","article-title":"The proteasome activator 11S REG (PA28) and class I antigen presentation","volume":"345","author":"Rechsteiner","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2010.02.045_bib39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijdevneu.2004.07.003","article-title":"Tau-inclusion body formation in oligodendroglia: the role of stress proteins and proteasome inhibition","volume":"22","author":"Richter-Landsberg","year":"2004","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainres.2010.02.045_bib40","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ana.410300304","article-title":"Mitochondrial oxidative phosphorylation defects in Parkinson's disease","volume":"30","author":"Shoffner","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2010.02.045_bib47","doi-asserted-by":"crossref","unstructured":"Snyder, H., Mensah, K., Theisler, C., Lee, J., Matouschek, A., Wolozin, B., 2003. Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function. J. Biol. Chem. 278, 11753\u201311759.","DOI":"10.1074\/jbc.M208641200"},{"key":"10.1016\/j.brainres.2010.02.045_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0014-5793(97)00864-8","article-title":"Expression and subcellular localization of mouse 20S proteasome activator complex. PA28","volume":"413","author":"Soza","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2010.02.045_bib42","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2010.02.045_bib43","doi-asserted-by":"crossref","first-page":"44405","DOI":"10.1074\/jbc.M308041200","article-title":"Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function","volume":"278","author":"Tofaris","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.02.045_bib44","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1146\/annurev.biochem.68.1.1015","article-title":"The 26S proteasome: a molecular machine designed for controlled proteolysis","volume":"68","author":"Voges","year":"1999","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.brainres.2010.02.045_bib45","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1111\/j.1460-9568.2006.04718.x","article-title":"MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome","volume":"23","author":"Zeng","year":"2006","journal-title":"Eur. J. NeuroSci."},{"key":"10.1016\/j.brainres.2010.02.045_bib46","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/pmic.200700679","article-title":"Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: consequences for proteomic analyses","volume":"8","author":"Zouambia","year":"2008","journal-title":"Proteomics"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310003926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310003926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:56:23Z","timestamp":1762102583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899310003926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":45,"alternative-id":["S0006899310003926"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.02.045","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2010.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}