{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:35:55Z","timestamp":1785785755249,"version":"3.56.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009466","name":"Japan-China Medical Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009466","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.brainres.2010.03.046","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T04:21:03Z","timestamp":1269231663000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage"],"prefix":"10.1016","volume":"1332","author":[{"given":"Koji","family":"Osuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuteru","family":"Usuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimie","family":"Atsuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Takayasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.03.046_bib1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/01.STR.32.1.212","article-title":"Quantitative analysis of gene expressions related to inflammation in canine spastic artery after subarachnoid hemorrhage","volume":"32","author":"Aihara","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3171\/jns.1996.84.5.0792","article-title":"Effects of a hydroxyl radical scavenger on delayed ischemic neurological deficits following aneurysmal subarachnoid hemorrhage: results of a multicenter, placebo-controlled double-blind trial","volume":"84","author":"Asano","year":"1996","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2010.03.046_bib3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/01.STR.0000053848.06436.AB","article-title":"Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage","volume":"34","author":"Borel","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib4","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.STR.27.6.1124","article-title":"Role of oxidants in ischemic brain damage","volume":"27","author":"Chan","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2004.05.079","article-title":"Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats","volume":"1019","author":"Choi","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.03.046_bib6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000069318","article-title":"Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters","volume":"15","author":"Edaravone Acute Infarction Study Group","year":"2003","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.brainres.2010.03.046_bib7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1227\/00006123-198911000-00008","article-title":"Arterial wall changes in cerebral vasospasm","volume":"25","author":"Findlay","year":"1989","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2010.03.046_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.bi.44.070175.001051","article-title":"Superoxide dismutases","volume":"44","author":"Fridovich","year":"1975","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.brainres.2010.03.046_bib9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/320454a0","article-title":"Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor","volume":"320","author":"Gryglewski","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2010.03.046_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-0674(00)00199-X","article-title":"The Stat family in cytokine signaling","volume":"13","author":"Ihle","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.brainres.2010.03.046_bib11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/00006123-199304000-00019","article-title":"Nonmuscle arterial constriction after subarachnoid hemorrhage: role of growth factors derived from platelets","volume":"32","author":"Iwasa","year":"1993","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2010.03.046_bib12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1161\/01.STR.30.4.867","article-title":"Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase","volume":"30","author":"Kamii","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/cvr\/cvp117","article-title":"The tight junction protein ZO-2 mediates proliferation of vascular smooth muscle cells via regulation of Stat1","volume":"83","author":"Kusch","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.brainres.2010.03.046_bib14","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.3171\/jns.1999.90.6.1018","article-title":"Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part II. A cooperative study in North America","volume":"90","author":"Lanzino","year":"1999","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2010.03.046_bib15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/01.STR.27.4.625","article-title":"Incidence of subarachnoid hemorrhage: role of region, year, and rate of computed tomography: a meta-analysis","volume":"27","author":"Linn","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/01.ATV.21.3.321","article-title":"Reactive oxygen species regulate heat-shock protein 70 via the JAK\/STAT pathway","volume":"21","author":"Madamanchi","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.brainres.2010.03.046_bib17","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/01.STR.0000027207.67639.1E","article-title":"Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase","volume":"33","author":"McGirt","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib18","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1016\/S0021-9258(19)44679-6","article-title":"The generation of superoxide radical during the autoxidation of hemoglobin","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.03.046_bib19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0306-3623(97)00311-X","article-title":"Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion","volume":"30","author":"Mizuno","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.brainres.2010.03.046_bib20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/01.STR.32.3.636","article-title":"Intracisternal increase of superoxide anion production in a canine subarachnoid hemorrhage model","volume":"32","author":"Mori","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1227\/01.NEU.0000338067.83059.EB","article-title":"Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage","volume":"64","author":"Munakata","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2010.03.046_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/jscd.2003.2","article-title":"Effect of edaravone on cerebral vasospasm following experimental subarachnoid hemorrhage","volume":"12","author":"Nakagomi","year":"2003","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.brainres.2010.03.046_bib23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/STROKEAHA.107.486654","article-title":"Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage","volume":"39","author":"Nakamura","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib24","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/01.STR.27.11.2102","article-title":"Role of extracellular matrix in experimental vasospasm. Inhibitory effect of antisense oligonucleotide on collagen induction","volume":"27","author":"Onoda","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.03.046_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.12.003","article-title":"Activation of the JAK\u2013STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage","volume":"1072","author":"Osuka","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.03.046_bib26","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/neu.2008.0836","article-title":"Modification of endothelial nitric oxide synthase through AMPK after experimental subarachnoid hemorrhage","volume":"26","author":"Osuka","year":"2009","journal-title":"J. Neurotrauma."},{"key":"10.1016\/j.brainres.2010.03.046_bib27","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0891-5849(95)02222-8","article-title":"Extracellular superoxide dismutase in vessels and airways of humans and baboons","volume":"20","author":"Oury","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2010.03.046_bib28","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/00001756-199704140-00008","article-title":"Stat1 in developing and adult rat brain. Induction after transient focal ischemia","volume":"8","author":"Planas","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2010.03.046_bib29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00006123-199802000-00038","article-title":"Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage","volume":"42","author":"Saito","year":"1998","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2010.03.046_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/01.RES.87.1.12","article-title":"Role of the JAK\/STAT pathway in rat carotid artery remodeling after vascular injury","volume":"87","author":"Seki","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.brainres.2010.03.046_bib31","doi-asserted-by":"crossref","first-page":"C1640","DOI":"10.1152\/ajpcell.1998.275.6.C1640","article-title":"Activation of the JAK\u2013STAT pathway by reactive oxygen species","volume":"275","author":"Simon","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2010.03.046_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1227\/00006123-198502000-00008","article-title":"Arterial wall changes in early human vasospasm","volume":"16","author":"Smith","year":"1985","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2010.03.046_bib33","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1074\/jbc.275.14.10002","article-title":"Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis","volume":"275","author":"Stephanou","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.03.046_bib34","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/01.WCB.0000034148.72481.F4","article-title":"STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury","volume":"22","author":"Takagi","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2010.03.046_bib35","doi-asserted-by":"crossref","first-page":"H2935","DOI":"10.1152\/ajpheart.00887.2006","article-title":"Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation","volume":"292","author":"Torella","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.brainres.2010.03.046_bib36","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00701-002-1020-8","article-title":"Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger","volume":"144","author":"Tosaka","year":"2002","journal-title":"Acta Neurochir. (Wien)"},{"key":"10.1016\/j.brainres.2010.03.046_bib37","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1096\/fj.04-1716fje","article-title":"Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia\/reperfusion-induced apoptosis","volume":"18","author":"Townsend","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2010.03.046_bib38","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0002-9440(10)61210-2","article-title":"Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis","volume":"167","author":"Walters","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2010.03.046_bib39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuroscience.2004.05.022","article-title":"MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia","volume":"127","author":"West","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.03.046_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1227\/00006123-199203000-00005","article-title":"Accelerated nonmuscle contraction after subarachnoid hemorrhage: culture and characterization of myofibroblasts from human cerebral arteries in vasospasm","volume":"30","author":"Yamamoto","year":"1992","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2010.03.046_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/13510002.1996.11747069","article-title":"Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one","volume":"2","author":"Yamamoto","year":"1996","journal-title":"Redox Report"},{"key":"10.1016\/j.brainres.2010.03.046_bib42","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.STR.0000182241.07096.06","article-title":"Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain","volume":"36","author":"Zhang","year":"2005","journal-title":"Stroke"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310006190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310006190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:42:04Z","timestamp":1757785324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899310006190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":42,"alternative-id":["S0006899310006190"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.03.046","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2010.03.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}