{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:07:13Z","timestamp":1772561233109,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004888","name":"Illinois Department of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010077","name":"Eastern Illinois University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC 003889"],"award-info":[{"award-number":["DC 003889"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.brainres.2010.04.070","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T07:05:28Z","timestamp":1273043128000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Acute responses to estradiol replacement in the olfactory system of apoE-deficient and wild-type mice"],"prefix":"10.1016","volume":"1343","author":[{"given":"Britto P.","family":"Nathan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tonsor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Struble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.04.070_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1749-6632.1998.tb10651.x","article-title":"Very early changes in olfactory functioning due to Alzheimer's disease and the role of apolipoprotein E in olfaction","volume":"855","author":"Bacon","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2010.04.070_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2826.2008.01809.x","article-title":"Different forms of oestrogen rapidly upregulate cell proliferation in the dentate gyrus of adult female rats","volume":"21","author":"Barha","year":"2009","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainres.2010.04.070_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.yexcr.2005.03.027","article-title":"Identification and molecular regulation of neural stem cells in the olfactory epithelium","volume":"306","author":"Beites","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainres.2010.04.070_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3233\/JAD-2004-6302","article-title":"Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4","volume":"6","author":"Burkhardt","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2010.04.070_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bandc.2004.10.004","article-title":"Apolipoprotein epsilon4 is associated with more rapid decline in odor identification than in odor threshold or Dementia Rating Scale scores","volume":"58","author":"Calhoun-Haney","year":"2005","journal-title":"Brain Cogn."},{"key":"10.1016\/j.brainres.2010.04.070_bib6","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1523\/JNEUROSCI.0330-04.2004","article-title":"Olfactory horizontal basal cells demonstrate a conserved multipotent progenitor phenotype","volume":"24","author":"Carter","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2010.04.070_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neulet.2007.02.030","article-title":"Estradiol replacement increases the low-density lipoprotein receptor related protein (LRP) in the mouse brain","volume":"417","author":"Cheng","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.04.070_bib8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0006-8993(99)01241-X","article-title":"Estrogen protects against 3-methylindole-induced olfactory loss","volume":"824","author":"Dhong","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.04.070_bib9","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1001\/jama.291.24.2959","article-title":"Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study","volume":"291","author":"Espeland","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.brainres.2010.04.070_bib10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0165-3806(89)90186-7","article-title":"Astrocytic shape and glial fibrillary acidic protein immunoreactivity are modified by estradiol in primary rat hypothalamic cultures","volume":"47","author":"Garcia-Segura","year":"1989","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2010.04.070_bib11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/13803390490509439","article-title":"The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer's disease, probable Alzheimer's disease, and healthy elderly controls","volume":"26","author":"Gilbert","year":"2004","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.brainres.2010.04.070_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01175561","article-title":"Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy","volume":"8","author":"Graziadei","year":"1979","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.brainres.2010.04.070_bib13","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/0306-4522(80)90197-9","article-title":"The olfactory marker protein in the olfactory system of the mouse during development","volume":"5","author":"Graziadei","year":"1980","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.04.070_bib14","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroscience.2005.06.017","article-title":"Estrogen-containing hormone therapy and Alzheimer's disease risk: understanding discrepant inferences from observational and experimental research","volume":"138","author":"Henderson","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.04.070_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cne.903630111","article-title":"An immunochemical, ultrastructural, and developmental characterization of the horizontal basal cells of rat olfactory epithelium","volume":"363","author":"Holbrook","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2010.04.070_bib16","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/01.wcb.0000037991.07114.4e","article-title":"Estrogen is neuroprotective via an apolipoprotein E-dependent mechanism in a mouse model of global ischemia","volume":"22","author":"Horsburgh","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2010.04.070_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.10642","article-title":"Globose basal cells are required for reconstitution of olfactory epithelium after methyl bromide lesion","volume":"460","author":"Jang","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2010.04.070_bib18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1139\/y87-095","article-title":"Effect of chronic estrogen on the skin temperature response to naloxone in morphine-dependent rats","volume":"65","author":"Katovich","year":"1987","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2010.04.070_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jneuroim.2008.01.006","article-title":"Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats","volume":"195","author":"Lewis","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2010.04.070_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/exnr.1995.1088","article-title":"Neurodegeneration in the central nervous system of apoE-deficient mice","volume":"136","author":"Masliah","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.04.070_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.expneurol.2005.09.008","article-title":"Time course of response to estradiol replacement in ovariectomized mice: brain apolipoprotein E and synaptophysin transiently increase and glial fibrillary acidic protein is suppressed","volume":"197","author":"McAsey","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.04.070_bib22","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1749-6632.1998.tb10654.x","article-title":"Apolipoprotein E status is associated with odor identification deficits in nondemented older persons","volume":"855","author":"Murphy","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2010.04.070_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/exnr.2001.7762","article-title":"Apolipoprotein E is upregulated in olfactory bulb glia following peripheral receptor lesion in mice","volume":"172","author":"Nathan","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.04.070_bib24","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1210\/en.2003-1707","article-title":"Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons","volume":"145","author":"Nathan","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2010.04.070_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2005.02.011","article-title":"Delayed olfactory nerve regeneration in ApoE-deficient mice","volume":"1041","author":"Nathan","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.04.070_bib26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainres.2006.12.036","article-title":"The distribution of apolipoprotein E in mouse olfactory epithelium","volume":"1137","author":"Nathan","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.04.070_bib27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neulet.2008.05.117","article-title":"Impact of apoE deficiency during synaptic remodeling in the mouse olfactory bulb","volume":"441","author":"Nwosu","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.04.070_bib28","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/j.1532-5415.1998.tb01532.x","article-title":"The APOE epsilon4 allele is associated with decline on delayed recall performance in community-dwelling older adults","volume":"46","author":"O'Hara","year":"1998","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.brainres.2010.04.070_bib29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/oxfordjournals.aje.a117244","article-title":"Estrogen deficiency and risk of Alzheimer's disease in women","volume":"140","author":"Paganini-Hill","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.brainres.2010.04.070_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.yfrne.2009.03.007","article-title":"Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging","volume":"30","author":"Pawluski","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.brainres.2010.04.070_bib31","first-page":"48","article-title":"Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E- containing lipoproteins","volume":"917","author":"Pitas","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2010.04.070_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainres.2008.01.091","article-title":"Effect of 17beta-estradiol on functional outcome, release of cytokines, astrocyte reactivity and inflammatory spreading after spinal cord injury in male rats","volume":"1203","author":"Ritz","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.04.070_bib33","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/01.STR.16.6.980","article-title":"Effects of estradiol on platelet aggregation in cerebral microvessels of mice","volume":"16","author":"Rosenblum","year":"1985","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.04.070_bib34","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","article-title":"Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial","volume":"289","author":"Shumaker","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.brainres.2010.04.070_bib35","first-page":"91","article-title":"Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen","volume":"38","author":"Srivastava","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.brainres.2010.04.070_bib36","doi-asserted-by":"crossref","first-page":"33360","DOI":"10.1074\/jbc.272.52.33360","article-title":"Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway","volume":"272","author":"Srivastava","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2010.04.070_bib37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1010845032399","article-title":"Estrogen increases hepatic lipase levels in inbred strains of mice: a possible mechanism for estrogen-dependent lowering of high density lipoprotein","volume":"220","author":"Srivastava","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.brainres.2010.04.070_bib38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/exnr.1996.6360","article-title":"Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro","volume":"143","author":"Stone","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.04.070_bib39","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1523\/JNEUROSCI.18-09-03180.1998","article-title":"Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: implications for Alzheimer's disease","volume":"18","author":"Stone","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2010.04.070_bib40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0304-3940(99)00352-3","article-title":"Apolipoprotein E immunoreactivity in human and mouse olfactory bulb","volume":"267","author":"Struble","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.04.070_bib41","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0014-4886(03)00215-2","article-title":"Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol","volume":"183","author":"Struble","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.04.070_bib42","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000095340","article-title":"Neocortical and hippocampal glial fibrillary acidic protein immunoreactivity shows region-specific variation during the mouse estrous cycle","volume":"83","author":"Struble","year":"2006","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2010.04.070_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exger.2006.05.013","article-title":"Estradiol regulation of astroglia and apolipoprotein E: an important role in neuronal regeneration","volume":"42","author":"Struble","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainres.2010.04.070_bib44","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-9861(86)90011-1","article-title":"Amino acid sequence of a unique neuronal protein: rat olfactory marker protein","volume":"249","author":"Sydor","year":"1986","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.brainres.2010.04.070_bib45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0140-6736(96)03356-9","article-title":"Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease","volume":"348","author":"Tang","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2010.04.070_bib46","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0306-4522(98)00630-7","article-title":"Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures","volume":"91","author":"Teter","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.04.070_bib47","doi-asserted-by":"crossref","first-page":"16983","DOI":"10.1073\/pnas.0608128103","article-title":"Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2010.04.070_bib48","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0065-3233(08)60642-7","article-title":"Apolipoprotein E: structure\u2013function relationships","volume":"45","author":"Weisgraber","year":"1994","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.brainres.2010.04.070_bib49","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1212\/WNL.54.10.1949","article-title":"Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction","volume":"54","author":"Yaffe","year":"2000","journal-title":"Neurology"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689931000987X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689931000987X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:10:49Z","timestamp":1772557849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689931000987X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":49,"alternative-id":["S000689931000987X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.04.070","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute responses to estradiol replacement in the olfactory system of apoE-deficient and wild-type mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2010.04.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}