{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:39:30Z","timestamp":1776947970240,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.brainres.2010.06.013","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T04:31:06Z","timestamp":1276489866000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke"],"prefix":"10.1016","volume":"1353","author":[{"given":"Goang-Won","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Ho","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Hwa","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Rum","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Young","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sechul","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.06.013_bib1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0006-8993(02)03239-0","article-title":"Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis","volume":"952","author":"Agnello","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.06.013_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/STROKEAHA.108.521476","article-title":"Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model","volume":"40","author":"Ay","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.06.013_bib3","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.95.7.3908","article-title":"Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats\u2014similarities to astrocyte grafts","volume":"95","author":"Azizi","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2010.06.013_bib4","doi-asserted-by":"crossref","first-page":"10526","DOI":"10.1073\/pnas.97.19.10526","article-title":"Erythropoietin crosses the blood\u2013brain barrier to protect against experimental brain injury","volume":"97","author":"Brines","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2010.06.013_bib5","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1182\/blood.V77.12.2583.2583","article-title":"Erythropoietin receptor characteristics on primary human erythroid cells","volume":"77","author":"Broudy","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2010.06.013_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.cb.03.110187.001331","article-title":"Constitutive and regulated secretion of proteins","volume":"3","author":"Burgess","year":"1987","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.brainres.2010.06.013_bib7","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1073\/pnas.042693799","article-title":"Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury","volume":"99","author":"Celik","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2010.06.013_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1440-1789.2002.00450.x","article-title":"Ischemic rat brain extracts induce human marrow stromal cell growth factor production","volume":"22","author":"Chen","year":"2002","journal-title":"Neuropathology"},{"key":"10.1016\/j.brainres.2010.06.013_bib9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/jnr.10691","article-title":"Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat","volume":"73","author":"Chen","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2010.06.013_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1568006033481483","article-title":"Erythropoietin: cytoprotection in vascular and neuronal cells","volume":"3","author":"Chong","year":"2003","journal-title":"Curr. Drug Targets Cardiovasc. Haematol. Disord."},{"key":"10.1016\/j.brainres.2010.06.013_bib11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/cvr\/cvn090","article-title":"Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties","volume":"79","author":"Copland","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.brainres.2010.06.013_bib12","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1161\/STROKEAHA.109.564872","article-title":"Recombinant human erythropoietin in the treatment of acute ischemic stroke","volume":"40","author":"Ehrenreich","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.06.013_bib13","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1681\/ASN.2005101035","article-title":"Erythropoietin delivery by genetically engineered bone marrow stromal cells for correction of anemia in mice with chronic renal failure","volume":"17","author":"Eliopoulos","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.brainres.2010.06.013_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(02)00041-1","article-title":"Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro","volume":"321","author":"Genc","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.06.013_bib15","doi-asserted-by":"crossref","first-page":"9450","DOI":"10.1073\/pnas.142287899","article-title":"Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma","volume":"99","author":"Gorio","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2010.06.013_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/bies.950150403","article-title":"Protein trafficking along the exocytotic pathway","volume":"15","author":"Hong","year":"1993","journal-title":"Bioessays"},{"key":"10.1016\/j.brainres.2010.06.013_bib17","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/jnr.21056","article-title":"Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat","volume":"84","author":"Horita","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2010.06.013_bib18","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1161\/01.STR.0000032302.91894.0F","article-title":"Behavioral tests after intracerebral hemorrhage in the rat","volume":"33","author":"Hua","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.06.013_bib19","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1128\/MCB.25.17.7412-7422.2005","article-title":"Phosphatidylinositol 3-kinase\/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation","volume":"25","author":"Kadri","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2010.06.013_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0167-4781(94)90224-0","article-title":"Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells","volume":"1219","author":"Kimura","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2010.06.013_bib21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0301-472X(03)00177-2","article-title":"Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells","volume":"31","author":"Kobune","year":"2003","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.brainres.2010.06.013_bib22","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1460-9568.2004.03632.x","article-title":"The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals","volume":"20","author":"Koh","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2010.06.013_bib23","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1111\/j.1460-9568.2007.05471.x","article-title":"Recombinant human erythropoietin suppresses symptom onset and progression of G93A-SOD1 mouse model of ALS by preventing motor neuron death and inflammation","volume":"25","author":"Koh","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2010.06.013_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainres.2008.06.087","article-title":"Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats","volume":"1229","author":"Koh","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2010.06.013_bib25","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.bbrc.2008.05.006","article-title":"Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions","volume":"371","author":"Koh","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2010.06.013_bib26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/scd.2008.0040","article-title":"Erythropoietin increases the motility of human bone marrow multipotent stromal cells (hBM-MSCs) and enhances the production of neurotrophic factors from hBM-MSCs","volume":"18","author":"Koh","year":"2009","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.brainres.2010.06.013_bib27","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1371\/journal.pone.0000156","article-title":"Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2010.06.013_bib28","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awl207","article-title":"Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia","volume":"129","author":"Liu","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2010.06.013_bib29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1460-9568.2006.04919.x","article-title":"Erythropoietin and GDNF enhance ventral mesencephalic fiber outgrowth and capillary proliferation following neural transplantation in a rodent model of Parkinson's disease","volume":"24","author":"McLeod","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2010.06.013_bib30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1227\/01.NEU.0000290907.30814.42","article-title":"Vascular endothelial growth factor gene-transferred bone marrow stromal cells engineered with a herpes simplex virus type 1 vector can improve neurological deficits and reduce infarction volume in rat brain ischemia","volume":"61","author":"Miki","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2010.06.013_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuroscience.2005.06.062","article-title":"I.V. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat","volume":"136","author":"Nomura","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.06.013_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.jcbfm.9600527","article-title":"Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia","volume":"28","author":"Onda","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2010.06.013_bib33","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1083\/jcb.108.5.1647","article-title":"The propeptide of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cells","volume":"108","author":"Stoller","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2010.06.013_bib34","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1161\/01.STR.0000173406.04891.8c","article-title":"Neonatal hypoxia\/ischemia is associated with decreased inflammatory mediators after erythropoietin administration","volume":"36","author":"Sun","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2010.06.013_bib35","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20021067","article-title":"Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis","volume":"198","author":"Villa","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.brainres.2010.06.013_bib36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1471-4159.2005.03033.x","article-title":"Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor","volume":"93","author":"Viviani","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2010.06.013_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/cvr\/cvn153","article-title":"Erythropoietin and mesenchymal stromal cells in angiogenesis and myocardial regeneration: one plus one equals three?","volume":"79","author":"Ward","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.brainres.2010.06.013_bib38","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C","article-title":"Adult rat and human bone marrow stromal cells differentiate into neurons","volume":"61","author":"Woodbury","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2010.06.013_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00228-005-0896-7","article-title":"The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin","volume":"61","author":"Xenocostas","year":"2005","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2010.06.013_bib40","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.jcbfm.9600273","article-title":"Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector","volume":"26","author":"Zhao","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689931001348X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689931001348X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:42:42Z","timestamp":1757785362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689931001348X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":40,"alternative-id":["S000689931001348X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.06.013","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2010.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}