{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:56:50Z","timestamp":1791122210039,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.brainres.2010.06.018","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T08:36:38Z","timestamp":1276763798000},"page":"216-221","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease"],"prefix":"10.1016","volume":"1348","author":[{"given":"Qun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Xiu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.06.018_bib1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.molimm.2006.03.007","article-title":"Role of complement in rneurodegeneration and neuroinflammation","volume":"44","author":"Bonifati","year":"2007","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.brainres.2010.06.018_bib2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1073\/pnas.98.2.581","article-title":"High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry","volume":"98","author":"Buetow","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11\u201312","key":"10.1016\/j.brainres.2010.06.018_bib3","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1111\/j.1582-4934.2009.00889.x","article-title":"Neuronal death in Alzheimer's disease and therapeutic opportunities","volume":"13","author":"Donev","year":"2009","journal-title":"J. Cell Mol Med."},{"key":"10.1016\/j.brainres.2010.06.018_bib4","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/ageing\/afm128","article-title":"The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980\u20132004 studies","volume":"36","author":"Dong","year":"2007","journal-title":"Age and Ageing."},{"key":"10.1016\/j.brainres.2010.06.018_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/clinchem\/45.1.143","article-title":"Rapid identification of Apolipoprotein E genotypes by multiplex amplification refractory mutation system PCR and capillary gel electrophoresis","volume":"45","author":"Donohoe","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.brainres.2010.06.018_bib6","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s00702-006-0575-6","article-title":"The significance of neuroinflammation in understanding Alzheimer's disease","volume":"113","author":"Eikelenboom","year":"2006","journal-title":"J. Neural Transm."},{"issue":"2","key":"10.1016\/j.brainres.2010.06.018_bib7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1046\/j.1471-4159.1996.67020880.x","article-title":"Fate of cerebrospinal fluid-borne amyloid\/3-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries","volume":"67","author":"Ghersi-Egea","year":"1996","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.brainres.2010.06.018_bib8","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1074\/jbc.274.10.6567","article-title":"T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer","volume":"274","author":"Gregoire","year":"1999","journal-title":"J. Biol Chem."},{"key":"10.1016\/j.brainres.2010.06.018_bib9","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet."},{"issue":"2","key":"10.1016\/j.brainres.2010.06.018_bib10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1046\/j.1471-4159.1998.70020699.x","article-title":"Inflammatory signals induce neurotrophin expression in human microglial cells","volume":"70","author":"Heese","year":"1998","journal-title":"J Neurochem"},{"key":"10.1016\/j.brainres.2010.06.018_bib11","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/35050110","article-title":"A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease","volume":"408","author":"Janus","year":"2000","journal-title":"Nature (London)"},{"issue":"1","key":"10.1016\/j.brainres.2010.06.018_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157015909787602805","article-title":"Implication of complement system and its regulators in Alzheimer's disease","volume":"7","author":"Kolev","year":"2009","journal-title":"Curr Neuropharmacol."},{"key":"10.1016\/j.brainres.2010.06.018_bib13","doi-asserted-by":"crossref","unstructured":"Khera, R., Das, N., 2009. Complement receptor 1: disease associations and therapeutic implications. Mol. Immunol. 761-772.","DOI":"10.1016\/j.molimm.2008.09.026"},{"issue":"10","key":"10.1016\/j.brainres.2010.06.018_bib14","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1074\/jbc.274.10.6507","article-title":"A previously undescribed intron and extensive 5\u2032 upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol Chem."},{"key":"10.1016\/j.brainres.2010.06.018_bib15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1034\/j.1600-065X.2001.1800110.x","article-title":"Structure\u2013function relationships of complement receptor type 1","volume":"180","author":"Krych-Goldberg","year":"2001","journal-title":"Immunol Rev."},{"key":"10.1016\/j.brainres.2010.06.018_bib16","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1006\/bbrc.2000.2222","article-title":"Amyloid-beta peptides interact with plasma proteins and erythrocytes: implications for their quantitation in plasma","volume":"268","author":"Kuo","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2010.06.018_bib17","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet."},{"key":"10.1016\/j.brainres.2010.06.018_bib18","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2010.06.018_bib19","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/35050116","article-title":"A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease","volume":"408","author":"Morgan","year":"2000","journal-title":"Nature."},{"issue":"3077","key":"10.1016\/j.brainres.2010.06.018_bib20","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1126\/science.118.3077.733","article-title":"The immune-adherence phenomenon; an immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis","volume":"118","author":"Nelson","year":"1953","journal-title":"Science."},{"issue":"3","key":"10.1016\/j.brainres.2010.06.018_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/(SICI)1097-4644(19990601)73:3<303::AID-JCB2>3.0.CO;2-2","article-title":"Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity","volume":"73","author":"Osaka","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainres.2010.06.018_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1471-4159.2007.05012.x","article-title":"Complement component C1q inhibits \u03b2-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms","volume":"104","author":"Pisalyaput","year":"2008","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.brainres.2010.06.018_bib23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0171-2985(98)80042-9","article-title":"Regulation of C1 inhibitor synthesis","volume":"199","author":"Prada","year":"1998","journal-title":"Immunobiology."},{"key":"10.1016\/j.brainres.2010.06.018_bib24","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.neurobiolaging.2005.09.043","article-title":"Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes","volume":"27","author":"Rogers","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2010.06.018_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pneurobio.2009.01.001","article-title":"Inflammation in Alzheimer's disease: Amyloid-\u03b2oligomers trigger innate immunity defence via pattern recognition receptors","volume":"87","author":"Salminen","year":"2009","journal-title":"Progr. Neurobiol."},{"issue":"2","key":"10.1016\/j.brainres.2010.06.018_bib26","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1001\/archneur.62.2.192","article-title":"Defining molecular targets to prevent Alzheimer disease","volume":"62","author":"Selkoe","year":"2005","journal-title":"Arch Neurol."},{"key":"10.1016\/j.brainres.2010.06.018_bib27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pneurobio.2003.08.001","article-title":"Yin and Yang: complement activation and regulation in Alzheimer's disease","volume":"70","author":"Shen","year":"2003","journal-title":"Progr. Neurobiol."},{"issue":"11","key":"10.1016\/j.brainres.2010.06.018_bib28","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.4049\/jimmunol.163.11.6132","article-title":"Inhibition of oligodendrocytes apoptosis by sublytic C5b-9 is associated with enhanced synthesis of bcl-2 and mediated by inhibition of caspase-3 activation","volume":"163","author":"Soane","year":"1999","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.brainres.2010.06.018_bib29","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.4049\/jimmunol.167.4.2305","article-title":"C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase\/Akt pathway","volume":"167","author":"Soane","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2010.06.018_bib30","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","article-title":"Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective","volume":"120","author":"Tanzi","year":"2005","journal-title":"J. Cell."},{"key":"10.1016\/j.brainres.2010.06.018_bib31","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI24761","article-title":"The genetic epidemiology of neurodegenerative disease","volume":"115","author":"Tanzi","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2010.06.018_bib32","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.4049\/jimmunol.159.8.4035","article-title":"Monkey model prototype particulate pathogen in a binding and liver clearance of a complexes facilitate erythrocyte bispecific monoclonal antibody","volume":"159","author":"Taylor","year":"1997","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.brainres.2010.06.018_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00001756-200102120-00022","article-title":"Complement anaphylotoxin C3a is selectively protective against NMDA-induced neuronal cell death","volume":"12","author":"van Beek","year":"2001","journal-title":"Neuroreport."},{"issue":"10","key":"10.1016\/j.brainres.2010.06.018_bib34","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ng1009-1047","article-title":"Alzheimer's disease beyond APOE","volume":"41","author":"van Es","year":"2009","journal-title":"Nat Genet."},{"key":"10.1016\/j.brainres.2010.06.018_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0165-5728(89)90053-2","article-title":"Isolation and characterization of complement receptors CR1 from human peripheral nerves","volume":"23","author":"Vedeler","year":"1989","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2010.06.018_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0165-5728(90)90119-8","article-title":"Peripheral nerve CR1 express in situ cofactor activity for degradation of C3b","volume":"26","author":"Vedeler","year":"1990","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2010.06.018_bib37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1471-4159.1997.69010388.x","article-title":"Aggregation state-dependent activation of the classical complement pathway by the amyloid beta peptide","volume":"69","author":"Webster","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2010.06.018_bib38","doi-asserted-by":"crossref","first-page":"10837","DOI":"10.1073\/pnas.162350199","article-title":"Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice","volume":"99","author":"Wyss-Coray","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2010.06.018_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.wad.0000165506.60370.94","article-title":"Complement activation in very early Alzheimer disease","volume":"19","author":"Zanjani","year":"2005","journal-title":"Alzheimer Dis Assoc Disord."},{"key":"10.1016\/j.brainres.2010.06.018_bib40","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/j.1471-4159.2008.05558.x","article-title":"Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease","volume":"106","author":"Zhou","year":"2008","journal-title":"J. Neurochem."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310013533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310013533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T17:14:37Z","timestamp":1711559677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899310013533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":40,"alternative-id":["S0006899310013533"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.06.018","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}