{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:56:14Z","timestamp":1790834174001,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008670","name":"Terumo Foundation for Life Sciences and Arts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.brainres.2010.08.090","type":"journal-article","created":{"date-parts":[[2010,9,4]],"date-time":"2010-09-04T06:41:48Z","timestamp":1283582508000},"page":"17-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Neural development of methyl-CpG-binding protein 2 null embryonic stem cells: A system for studying Rett syndrome"],"prefix":"10.1016","volume":"1360","author":[{"given":"Yasunori","family":"Okabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kusaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Mitsumasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinaka","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideho","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyojiro","family":"Matsuishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichiro","family":"Kosai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2010.08.090_bb0005","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/457675a","article-title":"Neuroscience: Glia\u2014more than just brain glue","volume":"457","author":"Allen","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2010.08.090_bb0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2010.08.090_bb0015","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/mrdd.10027","article-title":"Neuropathology of Rett syndrome","volume":"8","author":"Armstrong","year":"2002","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.brainres.2010.08.090_bb0020","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nn.2275","article-title":"Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology","volume":"12","author":"Ballas","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2010.08.090_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuroscience.2007.07.021","article-title":"Differentiating embryonic stem-derived neural stem cells show a maturation-dependent pattern of voltage-gated sodium current expression and graded action potentials","volume":"149","author":"Biella","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2010.08.090_bb0030","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg1878","article-title":"Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized","volume":"7","author":"Bienvenu","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.brainres.2010.08.090_bb0035","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2010.08.090_bb0040","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.brainres.2010.08.090_bb0045","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2010.08.090_bb0050","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1073\/pnas.92.7.2577","article-title":"Combination gene therapy for liver metastasis of colon carcinoma in vivo","volume":"92","author":"Chen","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2010.08.090_bb0055","first-page":"1717","article-title":"Dopaminergic D2 receptor SPECT imaging in Rett syndrome: increase of specific binding in striatum","volume":"34","author":"Chiron","year":"1993","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.brainres.2010.08.090_bb0060","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1111\/j.1471-4159.2008.05522.x","article-title":"Regulation of neural progenitor cell development in the nervous system","volume":"106","author":"Corbin","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2010.08.090_bb0065","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0887-8994(00)00120-X","article-title":"Substance P immunoreactivity in Rett syndrome","volume":"22","author":"Deguchi","year":"2000","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.brainres.2010.08.090_bb0070","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1113\/jphysiol.1992.sp018932","article-title":"Slow and fast transient potassium currents in cultured rat hippocampal cells","volume":"445","author":"Ficker","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2010.08.090_bb0075","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2010.08.090_bb0080","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neulet.2005.05.056","article-title":"Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse","volume":"386","author":"Ide","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2010.08.090_bb0085","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00702-003-0822-z","article-title":"Rett syndrome\u2014an update","volume":"110","author":"Jellinger","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.brainres.2010.08.090_bb0090","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1253\/circj.68.691","article-title":"Efficient cardiomyogenic differentiation of embryonic stem cell by fibroblast growth factor 2 and bone morphogenetic protein 2","volume":"68","author":"Kawai","year":"2004","journal-title":"Circ. J."},{"key":"10.1016\/j.brainres.2010.08.090_bb0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0896-6273(00)00083-0","article-title":"Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity","volume":"28","author":"Kawasaki","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2010.08.090_bb0100","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mcn.2004.07.006","article-title":"MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions","volume":"27","author":"Kishi","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2010.08.090_bb0105","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/nar\/gkh349","article-title":"The major form of MeCP2 has a novel N-terminus generated by alternative splicing","volume":"32","author":"Kriaucionis","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.brainres.2010.08.090_bb0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1399-0004.1990.tb03499.x","article-title":"CSF and urine biogenic amine metabolites in Rett syndrome","volume":"37","author":"Lekman","year":"1990","journal-title":"Clin. Genet."},{"key":"10.1016\/j.brainres.2010.08.090_bb0115","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1523\/JNEUROSCI.0324-09.2009","article-title":"Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions","volume":"29","author":"Maezawa","year":"2009","journal-title":"J. Neurosci."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2010.08.090_bb0120","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/S0387-7604(01)00380-1","article-title":"Neurobiology and neurochemistry of Rett syndrome","volume":"23","author":"Matsuishi","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.brainres.2010.08.090_bb0125","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng1327","article-title":"A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome","volume":"36","author":"Mnatzakanian","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2010.08.090_bb0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neures.2004.09.005","article-title":"Orexins cause depolarization via nonselective cationic and K+ channels in isolated locus coeruleus neurons","volume":"51","author":"Murai","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2010.08.090_bb0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.devbrainres.2005.03.011","article-title":"A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth","volume":"157","author":"Nagai","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2010.08.090_bb0140","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0022-3476(88)80060-X","article-title":"Cerebrospinal fluid values for monoamine metabolites, gamma-aminobutyric acid, and other amino compounds in Rett syndrome","volume":"112","author":"Perry","year":"1988","journal-title":"J. Pediatr."},{"key":"10.1016\/j.brainres.2010.08.090_bb0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-6273(00)00086-6","article-title":"Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells","volume":"28","author":"Qian","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2010.08.090_bb0150","doi-asserted-by":"crossref","first-page":"21966","DOI":"10.1073\/pnas.0912257106","article-title":"Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities","volume":"106","author":"Samaco","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2010.08.090_bb0155","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.bbrc.2005.12.080","article-title":"Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism","volume":"340","author":"Saywell","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2010.08.090_bb0160","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/jnr.21001","article-title":"Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons","volume":"84","author":"Setoguchi","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2010.08.090_bb0165","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/11.2.115","article-title":"Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation","volume":"11","author":"Shahbazian","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2010.08.090_bb0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.nbd.2007.04.005","article-title":"Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons","volume":"27","author":"Smrt","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2010.08.090_bb0175","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000123038","article-title":"Neuron-astrocyte signaling in the development and plasticity of neural circuits","volume":"16","author":"Stevens","year":"2008","journal-title":"Neurosignals"},{"key":"10.1016\/j.brainres.2010.08.090_bb0180","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ymthe.2006.05.010","article-title":"Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting","volume":"14","author":"Takahashi","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.brainres.2010.08.090_bb0185","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.braindev.2008.05.003","article-title":"Evaluation of CSF neurotransmitters and folate in 25 patients with Rett disorder and effects of treatment","volume":"31","author":"Temudo","year":"2009","journal-title":"Brain Dev."},{"key":"10.1016\/j.brainres.2010.08.090_bb0190","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.expneurol.2009.05.001","article-title":"Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2","volume":"219","author":"Tsujimura","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2010.08.090_bb0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-2007-979741","article-title":"Alterations in dopaminergic function in Rett syndrome","volume":"26","author":"Wenk","year":"1995","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.brainres.2010.08.090_bb0200","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1056\/NEJM198510103131504","article-title":"Reduction of biogenic amine levels in the Rett syndrome","volume":"313","author":"Zoghbi","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2010.08.090_bb0205","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ana.410250109","article-title":"Cerebrospinal fluid biogenic amines and biopterin in Rett syndrome","volume":"25","author":"Zoghbi","year":"1989","journal-title":"Ann. Neurol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310019335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899310019335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:04:57Z","timestamp":1781107497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899310019335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":41,"alternative-id":["S0006899310019335"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2010.08.090","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neural development of methyl-CpG-binding protein 2 null embryonic stem cells: A system for studying Rett syndrome","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2010.08.090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}