{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:29:50Z","timestamp":1784910590790,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Health and Medical Research Council of Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.brainres.2011.03.066","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T15:17:33Z","timestamp":1303485453000},"page":"84-90","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["A substance P antagonist improves outcome when administered 4h after onset of ischaemic stroke"],"prefix":"10.1016","volume":"1393","author":[{"given":"Ren\u00e9e J.","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Helps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2011.03.066_bb0005","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0196-9781(99)00082-0","article-title":"Receptor subtypes involved in tachykinin-mediated oedema formation","volume":"20","author":"Alves","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.brainres.2011.03.066_bb0010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00004647-199607000-00022","article-title":"An alternative method for the quantitation of neuronal damage after experimental middle cerebral artery occlusion in rats: analysis of behavioral deficit","volume":"16","author":"Aronowski","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Suppl 4","key":"10.1016\/j.brainres.2011.03.066_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2165\/00019053-200422004-00004","article-title":"The burden of coronary, cerebrovascular and peripheral arterial disease","volume":"22","author":"Bakhai","year":"2004","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.brainres.2011.03.066_bb0020","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0889-1591(02)00021-1","article-title":"Stress and the inflammatory response: a review of neurogenic inflammation","volume":"16","author":"Black","year":"2002","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2011.03.066_bb0025","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0006-3223(02)01544-5","article-title":"Substance P serum levels are increased in major depression: preliminary results","volume":"53","author":"Bondy","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2011.03.066_bb0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/039463200301600110","article-title":"The role of substance P in cerebral ischemia","volume":"16","author":"Bruno","year":"2003","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0035","first-page":"R476","article-title":"Use of NK1 tachykinin knockout mice to analyze substance P-induced oedema formation","volume":"277","author":"Cao","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0040","author":"Castle"},{"key":"10.1016\/j.brainres.2011.03.066_bb0045","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/sj.cdd.4401035","article-title":"A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death","volume":"9","author":"Castro-Obregon","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainres.2011.03.066_bb0050","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/jcbfm.2009.63","article-title":"A critical role for substance P in the development of traumatic brain oedema","volume":"29","author":"Donkin","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2011.03.066_bb0055","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.neuroscience.2004.02.012","article-title":"Permanent occlusion of the middle cerebral artery upregulates expression of cytokines and neuronal nitric oxide synthase in the spinal cord and urinary bladder in the adult rat","volume":"125","author":"Fu","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2011.03.066_bb0060","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/ana.410270605","article-title":"CGS-19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia","volume":"27","author":"Grotta","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0065","first-page":"1033","article-title":"Substance P activates and modulates neutrophil oxidative metabolism and aggregation","volume":"16","author":"Hafstrom","year":"1998","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/neu.1994.11.187","article-title":"The rotarod: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury","volume":"11","author":"Hamm","year":"1994","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2011.03.066_bb0075","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1357-2725(01)00031-0","article-title":"Substance P","volume":"33","author":"Harrison","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0080","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0028-3908(00)00010-1","article-title":"Neuropeptides\u2014an overview","volume":"39","author":"Hokfelt","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2011.03.066_bb0085","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1139\/y01-046","article-title":"Magnesium sulfate attenuates increased blood-brain barrier permeability during insulin-induced hypoglycemia in rats","volume":"79","author":"Kaya","year":"2001","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0090","first-page":"97","article-title":"Magnesium deficiency enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade","volume":"29","author":"Kramer","year":"1997","journal-title":"J. Cardiol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0095","author":"Landini"},{"key":"10.1016\/j.brainres.2011.03.066_bb0100","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/STROKEAHA.107.492934","article-title":"Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats","volume":"39","author":"Lecrux","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2011.03.066_bb0105","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/00004647-199710000-00016","article-title":"Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model","volume":"17","author":"Li","year":"1997","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2011.03.066_bb0110","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/00004647-200009000-00006","article-title":"Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice","volume":"20","author":"Li","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2011.03.066_bb0115","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/00001756-199512000-00074","article-title":"Reactive astrocytes express substance-P immunoreactivity in the adult forebrain after injury","volume":"7","author":"Lin","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2011.03.066_bb0120","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2011.03.066_bb0125","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1460-9568.2000.00946.x","article-title":"Abnormal substance P release from the spinal cord following injury to primary sensory neurons","volume":"12","author":"Malcangio","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2011.03.066_bb0130","first-page":"739","article-title":"Eicosanoid synthesis by spinal cord astrocytes is evoked by substance P; possible implications for nociception and pain","volume":"21B","author":"Marriott","year":"1991","journal-title":"Adv. Prostaglandin Thromboxane Leukot. Res."},{"key":"10.1016\/j.brainres.2011.03.066_bb0135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-0270(00)00329-0","article-title":"Neurological sequelae and long-term behavioural assessment of rats with transient middle cerebral artery occlusion","volume":"104","author":"Modo","year":"2000","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2011.03.066_bb0205","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/157488909788452997","article-title":"Recent patents in CNS drug discovery: the management of inflammatio in the central nervous system","volume":"4","author":"Nimmo","year":"2004","journal-title":"Recent Pat. CNS Drug Discov."},{"key":"10.1016\/j.brainres.2011.03.066_bb0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.npep.2003.12.003","article-title":"Neurogenic inflammation is associated with development of oedema and functional deficits following traumatic brain injury in rats","volume":"38","author":"Nimmo","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.brainres.2011.03.066_bb0145","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1098-1136(199710)21:2<183::AID-GLIA2>3.0.CO;2-8","article-title":"Functional characterization of substance P receptors on cultured human spinal cord astrocytes: synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production","volume":"21","author":"Palma","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2011.03.066_bb0150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-2999(91)90913-B","article-title":"Nerve induced tachykinin-mediated vasodilation in skeltal muscle is dependent on nitric oxide formation","volume":"205","author":"Persson","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0304-3940(93)90351-K","article-title":"Three openings of the blood-brain barrier produced by forebrain ischemia in the rat","volume":"149","author":"Preston","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2011.03.066_bb0160","first-page":"291","article-title":"Quantitation of histochemical staining by color deconvolution","volume":"23","author":"Rufroik","year":"2001","journal-title":"Anal. Quant. Cytol. Histol."},{"key":"10.1016\/j.brainres.2011.03.066_bb0170","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0028-3908(93)90085-H","article-title":"Met-enkephalin-Arg6-Phe7 in spinal cord and brain following traumatic injury to the spinal cord: influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique","volume":"32","author":"Sharma","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2011.03.066_bb0175","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1523\/JNEUROSCI.21-03-00798.2001","article-title":"Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium","volume":"21","author":"Stumm","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2011.03.066_bb0180","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1358\/dnp.2007.20.4.1103527","article-title":"Inhibition of neurogenic inflammation as a novel treatment for ischaemic stroke","volume":"20","author":"Turner","year":"2007","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.brainres.2011.03.066_bb0185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/3-211-30714-1_56","article-title":"Increased substance P immunoreactivity and oedema formation following reversible ischemic stroke","volume":"96","author":"Turner","year":"2006","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.brainres.2011.03.066_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0006-8993(96)00607-5","article-title":"Sensorimotor impairments in rats with cerebral infarction, induced by unilateral occlusion of the left middle cerebral artery: strain differences and effects of the occlusion site","volume":"735","author":"van der Staay","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2011.03.066_bb0195","first-page":"257","article-title":"Neuropeptide release influences brain oedema formation after diffuse traumatic brain injury","volume":"86","author":"Vink","year":"2003","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.brainres.2011.03.066_bb0200","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1097\/00001756-199707070-00006","article-title":"Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia","volume":"8","author":"Yu","year":"1997","journal-title":"Neuroreport"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899311006615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899311006615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T06:41:49Z","timestamp":1560148909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899311006615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":40,"alternative-id":["S0006899311006615"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2011.03.066","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}