{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:59:00Z","timestamp":1791111540638,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.brainres.2011.12.041","type":"journal-article","created":{"date-parts":[[2011,12,31]],"date-time":"2011-12-31T21:25:33Z","timestamp":1325366733000},"page":"7-14","source":"Crossref","is-referenced-by-count":117,"special_numbering":"C","title":["Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome"],"prefix":"10.1016","volume":"1439","author":[{"given":"Sarah E.","family":"Rotschafer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine E.","family":"Dansie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna M.","family":"Ethell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaleel A.","family":"Razak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2011.12.041_bb0005","first-page":"414","article-title":"Discoloration of teeth from tetracyclines \u2014 even today?","volume":"121","author":"Antonini","year":"2010","journal-title":"Res. Sci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0010","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1044\/1092-4388(2009\/08-0001)","article-title":"Phonological accuracy and intelligibility in connected speech of boys with fragile X syndrome or Down syndrome","volume":"52","author":"Barnes","year":"2009","journal-title":"J. Speech Lang. Hear. Res."},{"key":"10.1016\/j.brainres.2011.12.041_bb0025","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1100\/tsw.2006.220","article-title":"Fmr1 KO mice as a possible model of autistic features","volume":"6","author":"Bernardet","year":"2006","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.brainres.2011.12.041_bb0030","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1037\/0735-7044.114.5.983","article-title":"Precontact 50-kHz vocalizations in male rats during acquisition of sexual experience","volume":"114","author":"Bialy","year":"2000","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/jmg.2008.061796","article-title":"Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model","volume":"46","author":"Bilousova","year":"2009","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.brainres.2011.12.041_bb0040","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1037\/0735-7044.104.5.808","article-title":"Ultrasonic vocalizations by rat pups in the cold: an acoustic by-production of laryngeal braking?","volume":"104","author":"Blumberg","year":"1990","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0045","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1037\/0735-7044.110.2.305","article-title":"Thermogenesis, myoclonic twitching, and ultrasonic vocalization in neonatal rats during moderate and extreme cold","volume":"110","author":"Blumberg","year":"1996","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0050","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0306-4522(01)00036-7","article-title":"Fragile X mice develop sensory hyperreactivity to auditory stimuli","volume":"103","author":"Chen","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2011.12.041_bb0255","unstructured":"Dansie, L.E., Phommahaxay, K., Okusanya, A.G., Uwadia, J., Huang, M., Rotschafer, S.E., Razak, K.A., Ethell, D.W., Ethell, I.M., in preparation. Long-lasting effects of minocycline on behavior in young and adult fragile X mice."},{"key":"10.1016\/j.brainres.2011.12.041_bb0060","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1592\/phco.26.4.515","article-title":"Minocycline for short term neuroprotection","volume":"26","author":"Elewa","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.brainres.2011.12.041_bb0065","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1002\/jnr.21273","article-title":"Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets","volume":"85","author":"Ethell","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2011.12.041_bb0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/mrdd.20132","article-title":"Language phenotypes and intervention planning: bridging research and practice","volume":"13","author":"Fidler","year":"2007","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.brainres.2011.12.041_bb0075","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1542\/peds.2008-0317","article-title":"Advances in the treatment of fragile X syndrome","volume":"123","author":"Hagerman","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.brainres.2011.12.041_bb0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ajmg.1320230114","article-title":"Speech disturbances (cluttering) in mildly impaired males with the Martin\u2013Bell\/fragile X syndrome","volume":"23","author":"Hanson","year":"1986","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.brainres.2011.12.041_bb0085","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.0705003104","article-title":"Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice","volume":"104","author":"Hayashi","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0090","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.1371\/journal.pbio.0030386","article-title":"Ultrasonic songs of male mice","volume":"3","author":"Holy","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.brainres.2011.12.041_bb0100","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neulet.2008.10.006","article-title":"Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors","volume":"447","author":"Imbesi","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2011.12.041_bb0105","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1073\/pnas.0711555105","article-title":"Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism","volume":"105","author":"Jamain","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0110","doi-asserted-by":"crossref","first-page":"e12278","DOI":"10.1371\/journal.pone.0012278","article-title":"Altered ultrasonic vocalization and impaired learning and memory in angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3","volume":"5","author":"Jiang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2011.12.041_bb0115","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2008.09.040","article-title":"Minocycline and neurodegenerative diseases","volume":"196","author":"Kim","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2011.12.041_bb0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00442299","article-title":"Developmental and behavioral disturbances in 13 boys with fragile X syndrome","volume":"143","author":"Largo","year":"1985","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.brainres.2011.12.041_bb0125","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/sj.jcbfm.9600268","article-title":"Dose\u2013response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation","volume":"26","author":"Lee","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2011.12.041_bb0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1460-9568.2005.04182.x","article-title":"Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat","volume":"22","author":"Lin","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainres.2009.09.017","article-title":"Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy","volume":"1300","author":"Luzi","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2011.12.041_bb0140","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1163\/156853962X00087","article-title":"Sexual behavior in three inbred strains of mice","volume":"19","author":"McGill","year":"1962","journal-title":"Behaviour"},{"key":"10.1016\/j.brainres.2011.12.041_bb0145","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1037\/0735-7044.122.2.293","article-title":"Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome","volume":"122","author":"McNaughton","year":"2008","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0150","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbr.2005.11.004","article-title":"Social behavior deficits in the Fmr1 mutant mouse","volume":"168","author":"Mineur","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2011.12.041_bb0165","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0163-1047(83)90722-7","article-title":"Ultrasonic vocalizations during sex behavior of male house mice (Mus musculus): A description","volume":"39","author":"Nyby","year":"1972","journal-title":"Behav. Neural Biol."},{"key":"10.1016\/j.brainres.2011.12.041_bb0160","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0003-3472(77)90009-4","article-title":"Phernomonal regulation of male mouse ultrasonic courtship (Mus Musculus)","volume":"25","author":"Nyby","year":"1977","journal-title":"Anim. Behav."},{"key":"10.1016\/j.brainres.2011.12.041_bb0170","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2377-10-91","article-title":"Open-label add-on treatment trial of minocycline in fragile X syndrome","volume":"10","author":"Paribello","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.brainres.2011.12.041_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0031-9384(83)90101-4","article-title":"Female behavior is affected by male ultrasonic vocalizations in house mice","volume":"31","author":"Pomerantz","year":"1983","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2011.12.041_bb0180","first-page":"28","article-title":"Types and functions of ultrasonic vocalizations in laboratory rats and mice","volume":"46","author":"Portfors","year":"2007","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1044\/1092-4388(2008\/001)","article-title":"Syntactic complexity during conversation of boys with fragile X syndrome and Down syndrome","volume":"51","author":"Price","year":"2008","journal-title":"J. Speech Lang. Hear. Res."},{"key":"10.1016\/j.brainres.2011.12.041_bb0190","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1352\/0895-8017(2001)106<0216:RAECDO>2.0.CO;2","article-title":"Receptive and expressive communication development of young males with fragile X syndrome","volume":"106","author":"Roberts","year":"2001","journal-title":"Am. J. Ment. Retard."},{"key":"10.1016\/j.brainres.2011.12.041_bb0195","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1044\/1058-0360(2002\/034)","article-title":"Early communication, symbolic, behavioral, and social profiles of young males with fragile X syndrome","volume":"11","author":"Roberts","year":"2002","journal-title":"Am. J. Speech Lang. Pathol."},{"key":"10.1016\/j.brainres.2011.12.041_bb0200","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF00687814","article-title":"Adult fragile X syndrome clinieo-neuropathologic findings","volume":"67","author":"Rudelli","year":"1985","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2011.12.041_bb0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1469-7998.1972.tb01345.x","article-title":"Ultrasound and mating behaviour in rodents with some observations on other behavioural situations","volume":"168","author":"Sales","year":"1972","journal-title":"J. Zool."},{"key":"10.1016\/j.brainres.2011.12.041_bb0260","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000018387","article-title":"Minocycline-induced lupus. A systematic review","volume":"200","author":"Schlienger","year":"2000","journal-title":"Dermatology"},{"key":"10.1016\/j.brainres.2011.12.041_bb0215","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1601-183X.2005.00123.x","article-title":"Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome","volume":"4","author":"Spencer","year":"2005","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.brainres.2011.12.041_bb0220","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1352\/1944-7558-115.5.433","article-title":"Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures","volume":"115","author":"Utari","year":"2010","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"10.1016\/j.brainres.2011.12.041_bb0225","doi-asserted-by":"crossref","first-page":"19520","DOI":"10.1073\/pnas.0807248105","article-title":"Extracellularproteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long term potentiation coordinately","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2011.12.041_bb0230","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0031-9384(89)90164-9","article-title":"The emission and elicitation of mouse ultrasonic vocalizations: the effects of age, sex and gonadal status","volume":"45","author":"Warburton","year":"1989","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2011.12.041_bb0235","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0031-9384(97)00484-8","article-title":"40- and 70-kHz vocalizations of mice (Mus musculus) during copulation","volume":"63","author":"White","year":"1998","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2011.12.041_bb0240","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S1474-4422(04)00937-8","article-title":"The promise of minocycline in neurology","volume":"3","author":"Yong","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2011.12.041_bb0245","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1073\/pnas.1005620107","article-title":"Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism","volume":"107","author":"Young","year":"2010","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689931102292X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689931102292X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T01:21:08Z","timestamp":1640308868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689931102292X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":45,"alternative-id":["S000689931102292X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2011.12.041","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}