{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:55:43Z","timestamp":1771469743505,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Netherlands Organization for Scientific Research","award":["VENI 916.76.042"],"award-info":[{"award-number":["VENI 916.76.042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.brainres.2012.02.033","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T18:12:33Z","timestamp":1329934353000},"page":"24-32","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The thalidomide analgesic effect is associated with differential TNF-\u03b1 receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain"],"prefix":"10.1016","volume":"1450","author":[{"given":"Pablo","family":"Andrade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Visser-Vandewalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Del Rosario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Daemen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim A.","family":"Buurman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry W.","family":"Steinbusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govert","family":"Hoogland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2012.02.033_bb0005","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0010","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10072-011-0599-z","article-title":"Role of TNF-alpha during central sensitization in preclinical studies","volume":"32","author":"Andrade","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.brainres.2012.02.033_bb0015","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/j.pain.2011.08.012","article-title":"Tumor necrosis factor-alpha levels correlate with postoperative pain severity in lumbar disc hernia patients: opposite clinical effects between tumor necrosis factor receptor 1 and 2","volume":"152","author":"Andrade","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0020","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1471-4159.2007.04800.x","article-title":"A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury","volume":"103","author":"Arandjelovic","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2012.02.033_bb0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncpneuro0113","article-title":"Mechanisms of disease: neuropathic pain\u2014a clinical perspective","volume":"2","author":"Baron","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0030","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0035","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0040","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1213\/01.ane.0000258060.89380.27","article-title":"Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs","volume":"104","author":"Bianchi","year":"2007","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2012.02.033_bb0045","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0006-8993(96)00747-0","article-title":"Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord","volume":"737","author":"Bitar","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.02.033_bb0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbi.2005.02.003","article-title":"Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice","volume":"20","author":"Bluthe","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2012.02.033_bb0055","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3344\/kjp.2010.23.3.172","article-title":"Antiallodynic effect of thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain","volume":"23","author":"Choi","year":"2010","journal-title":"Korean J. Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0060","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1523\/JNEUROSCI.4476-07.2008","article-title":"Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model","volume":"28","author":"Constantin","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.02.033_bb0065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2006.11.006","article-title":"The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain","volume":"556","author":"Costa","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0070","first-page":"357","article-title":"Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain","volume":"27","author":"Covey","year":"2002","journal-title":"Reg. Anesth. Pain Med."},{"key":"10.1016\/j.brainres.2012.02.033_bb0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2008.08.001","article-title":"Upregulation of the GABA-transporter GAT-1 in the spinal cord contributes to pain behaviour in experimental neuropathy","volume":"444","author":"Daemen","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.02.033_bb0080","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/bja\/aeq067","article-title":"Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population","volume":"104","author":"Davies","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.brainres.2012.02.033_bb0085","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-8993(97)00209-6","article-title":"Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy","volume":"759","author":"DeLeo","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.02.033_bb0090","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00001756-200002280-00033","article-title":"Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model","volume":"11","author":"DeLeo","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2012.02.033_bb0095","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1002\/jnr.22007","article-title":"Neuropathy-induced apoptosis: protective effect of physostigmine","volume":"87","author":"Di Cesare Mannelli","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2012.02.033_bb0100","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s10571-006-9006-3","article-title":"Intra- and extraneuronal changes of immunofluorescence staining for TNF-alpha and TNFR1 in the dorsal root ganglia of rat peripheral neuropathic pain models","volume":"26","author":"Dubov\u00fd","year":"2006","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0105","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrd3030","article-title":"TNF receptor 2 pathway: drug target for autoimmune diseases","volume":"9","author":"Faustman","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.brainres.2012.02.033_bb0110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/(SICI)1097-4695(199904)39:1<142::AID-NEU11>3.0.CO;2-H","article-title":"IGF-I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF-I treatment","volume":"39","author":"Gao","year":"1999","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0120","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/exnr.1999.7193","article-title":"Serial determination of tumor necrosis factor-alpha content in rat sciatic nerve after chronic constriction injury","volume":"160","author":"George","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0115","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.expneurol.2004.11.002","article-title":"Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve","volume":"192","author":"George","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0125","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0092-8674(95)90192-2","article-title":"The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor","volume":"83","author":"Grell","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2012.02.033_bb0130","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1744-8069-6-64","article-title":"Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-alpha expression in a mouse model","volume":"6","author":"Gu","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0140","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1097\/BRS.0b013e3181733188","article-title":"Contralateral neuropathic pain and neuropathology in dorsal root ganglion and spinal cord following hemilateral nerve injury in rats","volume":"33","author":"Hatashita","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.brainres.2012.02.033_bb0145","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.pain.2010.06.005","article-title":"TNF-alpha contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury","volume":"151","author":"He","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0150","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.brainres.2004.08.020","article-title":"Immunocytochemical localization of TNF type 1 and type 2 receptors in the rat spinal cord","volume":"1025","author":"Holmes","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.02.033_bb0155","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.pain.2011.06.017","article-title":"A new definition of neuropathic pain","volume":"152","author":"Jensen","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0160","doi-asserted-by":"crossref","first-page":"15184","DOI":"10.1073\/pnas.0507191102","article-title":"Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness","volume":"102","author":"Johnson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2012.02.033_bb0165","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00011-007-6088-4","article-title":"Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients","volume":"56","author":"Koch","year":"2007","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.brainres.2012.02.033_bb0170","first-page":"2807","article-title":"Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model","volume":"15","author":"Lee","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2012.02.033_bb0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4196\/kjpp.2010.14.2.59","article-title":"Are spinal GABAergic elements related to the manifestation of neuropathic pain in rat?","volume":"14","author":"Lee","year":"2010","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0180","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1126\/science.288.5464.335","article-title":"Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model","volume":"288","author":"Li","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.brainres.2012.02.033_bb0185","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1084\/jem.177.6.1675","article-title":"Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation","volume":"177","author":"Moreira","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.brainres.2012.02.033_bb0190","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jneuroim.2007.04.011","article-title":"TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I","volume":"187","author":"Palin","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-2999(99)00918-8","article-title":"Analgesic effect of thalidomide on inflammatory pain","volume":"391","author":"Ribeiro","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0200","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neulet.2008.03.023","article-title":"Transient early expression of TNF-alpha in sciatic nerve and dorsal root ganglia in a mouse model of painful peripheral neuropathy","volume":"436","author":"Sacerdote","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.02.033_bb0205","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00586-007-0365-3","article-title":"Up-regulation of p55 TNF alpha-receptor in dorsal root ganglia neurons following lumbar facet joint injury in rats","volume":"16","author":"Sakuma","year":"2007","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.brainres.2012.02.033_bb0210","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.173.3.699","article-title":"Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes","volume":"173","author":"Sampaio","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.brainres.2012.02.033_bb0215","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1523\/JNEUROSCI.22-02-00536.2002","article-title":"Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve","volume":"22","author":"Sch\u00e4fers","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.02.033_bb0225","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0304-3959(03)00115-5","article-title":"Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats","volume":"104","author":"Sch\u00e4fers","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0230","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1523\/JNEUROSCI.23-07-02517.2003","article-title":"Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons","volume":"23","author":"Schafers","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.02.033_bb0220","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.neuroscience.2008.08.067","article-title":"Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro","volume":"157","author":"Sch\u00e4fers","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2012.02.033_bb0235","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.1526-05.2005","article-title":"Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury","volume":"25","author":"Scholz","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.02.033_bb0240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3959(97)00154-1","article-title":"The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve","volume":"74","author":"Sommer","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0245","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1212\/01.wnl.0000265062.92340.a5","article-title":"Differential expression of cytokines in painful and painless neuropathies","volume":"69","author":"\u00dc\u00e7eyler","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2012.02.033_bb0250","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0962-8924(00)89088-1","article-title":"Two tumour necrosis factor receptors: structure and function","volume":"5","author":"Vandenabeele","year":"1995","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.brainres.2012.02.033_bb0255","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pain.2006.03.011","article-title":"The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat","volume":"123","author":"Xu","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0260","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1002\/jnr.21726","article-title":"Exogenous tumor necrosis factor-alpha rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn","volume":"86","author":"Youn","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2012.02.033_bb0270","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1749-799X-1-9","article-title":"Effects of TGF-beta1 and IGF-1 on proliferation of human nucleus pulposus cells in medium with different serum concentrations","volume":"1","author":"Zhang","year":"2006","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.brainres.2012.02.033_bb0265","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pain.2010.11.014","article-title":"TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2","volume":"152","author":"Zhang","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.02.033_bb0275","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312003101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312003101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T03:33:19Z","timestamp":1561347199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899312003101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":55,"alternative-id":["S0006899312003101"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2012.02.033","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}