{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:11:17Z","timestamp":1775211077147,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Consejo de Desarrollo Cient\u00edfico, Human\u00edstico y T\u00e9cnologico, Universidad del Zulia, Maracaibo, Venezuela","award":["CONDES: CC-0076-11"],"award-info":[{"award-number":["CONDES: CC-0076-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.brainres.2012.03.021","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T17:55:02Z","timestamp":1331920502000},"page":"64-76","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Role of angiotensin II in the brain inflammatory events during experimental diabetes in rats"],"prefix":"10.1016","volume":"1453","author":[{"given":"Renata","family":"Vargas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaimar","family":"Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Pedrea\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninoska","family":"Viera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan P.","family":"Hern\u00e1ndez-Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Mosquera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2012.03.021_bb0005","series-title":"Methods of Enzymatic Analysis","first-page":"271","article-title":"Catalase","author":"Aebi","year":"1982"},{"key":"10.1016\/j.brainres.2012.03.021_bb0010","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2004.02.054","article-title":"The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations","volume":"490","author":"Allen","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0015","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1182\/blood-2003-08-2974","article-title":"Direct evidence of leukocyte adhesion in arterioles by angiotensin II","volume":"104","author":"Alvarez","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2012.03.021_bb0020","doi-asserted-by":"crossref","first-page":"C1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly","volume":"271","author":"Beckman","year":"1996","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/emmm.201000080","article-title":"Angiotensin II revisited: new roles in inflammation, immunology and aging","volume":"2","author":"Benigni","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.brainres.2012.03.021_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1520-6769(199701)20:1<1::AID-NRC180>3.0.CO;2-S","article-title":"Diabetic neuropathy: pathogenesis and current treatment perspectives","volume":"10","author":"Biessels","year":"1997","journal-title":"Neurosci. Res. Commun."},{"key":"10.1016\/j.brainres.2012.03.021_bb0040","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000100980","article-title":"Utrecht Diabetic Encephalopathy Study Group. Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study","volume":"23","author":"Brands","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainres.2012.03.021_bb0045","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1159\/000292047","article-title":"Forced swimming test decreases chemotactic responsiveness and expression of CD11a in rat monocytes","volume":"17","author":"Brice\u00f1o","year":"2010","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.brainres.2012.03.021_bb0050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF00482965","article-title":"Superoxide production by polymorphonuclear leukocytes","volume":"84","author":"Briggs","year":"1986","journal-title":"Histochemestry"},{"key":"10.1016\/j.brainres.2012.03.021_bb0055","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11906-005-0086-0","article-title":"Is angiotensin II made inside or outside of the cell?","volume":"7","author":"Chai","year":"2005","journal-title":"Curr. Hyperten. Rep."},{"key":"10.1016\/j.brainres.2012.03.021_bb0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-4889(97)00129-8","article-title":"Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells","volume":"1401","author":"Chua","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2012.03.021_bb0065","doi-asserted-by":"crossref","first-page":"F515","DOI":"10.1152\/ajprenal.00527.2007","article-title":"Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension","volume":"295","author":"Crowley","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0070","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/sj.bjp.0707454","article-title":"Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats","volume":"152","author":"Dai","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1615\/CritRevImmunol.v30.i4.10","article-title":"Role of CD8 T-cell-mediated autoimmune diseases of the central nervous system","volume":"30","author":"Deckert","year":"2010","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0080","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0165-5728(02)00114-5","article-title":"The adhesion molecule ICAM-1 and its regulation in relation with the blood\u2013brain barrier","volume":"128","author":"Dietrich","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0085","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1210\/jc.2008-2385","article-title":"Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy","volume":"94","author":"Doupis","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2012.03.021_bb0090","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbi.2011.02.008","article-title":"Brain inflammation is induced by co-morbidities and risk factors for stroke","volume":"25","author":"Drake","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2012.03.021_bb0095","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/jcbfm.2008.158","article-title":"Angiotensin II modulates BBB permeability via activation of the AT1 receptor in brain endothelial cells","volume":"29","author":"Fleegal-DeMotta","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2012.03.021_bb0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1742-2094-8-67","article-title":"Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study","volume":"8","author":"Folkersma","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2012.03.021_bb0105","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ana.21744","article-title":"Pathogenic CD8(+) T cells in multiple sclerosis","volume":"66","author":"Friese","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0110","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1537-1891(02)00199-4","article-title":"Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood\u2013brain barrier","volume":"38","author":"Greenwood","year":"2002","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0006-8993(01)02093-5","article-title":"Sequential upregulation of cell adhesion molecules in degenerating rat basal forebrain cholinergic neurons and in phagocytotic microglial cells","volume":"897","author":"Hartlage-R\u00fcbsamen","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.03.021_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/329632","article-title":"Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats","author":"Hern\u00e1ndez-Fonseca","year":"2009","journal-title":"Exp. Diabetes Res"},{"key":"10.1016\/j.brainres.2012.03.021_bb0125","doi-asserted-by":"crossref","first-page":"R208","DOI":"10.1152\/ajpregu.90521.2008","article-title":"Regulation of T-cell function by endogenously produced angiotensin II","volume":"296","author":"Hoch","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0130","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/BST0390891","article-title":"Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease","volume":"39","author":"H\u00f6lscher","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.brainres.2012.03.021_bb0135","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1681\/ASN.2006070707","article-title":"Human T and natural killer cells possess a functional renin\u2013angiotensin system: further mechanisms of angiotensin II induced inflammation","volume":"18","author":"Jurewicz","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0140","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.1979.03290450033020","article-title":"Diabetes and cardiovascular disease. The Framingham study","volume":"241","author":"Kannel","year":"1979","journal-title":"JAMA"},{"key":"10.1016\/j.brainres.2012.03.021_bb0145","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1016\/j.lfs.2003.06.014","article-title":"Effect of losartan on the blood\u2013brain barrier permeability in diabetic hypertensive rats","volume":"73","author":"Kaya","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2012.03.021_bb0150","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/400_2008_15","article-title":"Immune-mediated CNS damage","volume":"51","author":"Kierdorf","year":"2010","journal-title":"Results Probl. Cell Differ."},{"key":"10.1016\/j.brainres.2012.03.021_bb0155","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.amjhyper.2005.09.022","article-title":"Regulation of angiogenic factors in angiotensin II infusion model in association with tubulointerstitial injuries","volume":"19","author":"Kitayama","year":"2006","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.brainres.2012.03.021_bb0160","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1161\/CIRCULATIONAHA.108.832782","article-title":"Regulatory T cells ameliorate angiotensin II-induced cardiac damage","volume":"119","author":"Kvakan","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2012.03.021_bb0165","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2337\/dc06-2052","article-title":"Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity","volume":"30","author":"Last","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.brainres.2012.03.021_bb0170","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s11064-007-9385-y","article-title":"Inflammation, depression and dementia: are they connected?","volume":"32","author":"Leonard","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2012.03.021_bb0175","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/joe.1.06269","article-title":"Oxidative and nitrosative stress in brain mitochondria of diabetic rats","volume":"187","author":"Mastrocola","year":"2005","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0180","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1016\/j.bbi.2011.01.006","article-title":"Adolescent binge alcohol exposure induces long-lasting partial activation of microglia","volume":"25","author":"McClain","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2012.03.021_bb0185","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2004.02.052","article-title":"Cerebral glucose metabolism in diabetes mellitus","volume":"490","author":"McCall","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/1470320309347789","article-title":"The role of central renin\u2013angiotensin system in Parkinson's disease","volume":"11","author":"Mertens","year":"2010","journal-title":"J. Renin Angio. Aldo. Syst."},{"key":"10.1016\/j.brainres.2012.03.021_bb0195","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri2634","article-title":"Transcriptional control of the inflammatory response","volume":"9","author":"Medzhitov","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0200","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2005.10.034","article-title":"Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys","volume":"197","author":"Miklossy","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0205","doi-asserted-by":"crossref","DOI":"10.1177\/1470320311410092","article-title":"Proinflammatory role of angiotensin II in a rat nephrosis model induced by adriamycin","author":"Mu\u00f1oz","year":"2011","journal-title":"J. Renin Angioten. Aldo. Syst"},{"key":"10.1016\/j.brainres.2012.03.021_bb0210","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/01.STR.28.5.1028","article-title":"Cerebrovascular changes in chronic hypertension. Protective effects of enalapril in rats","volume":"28","author":"Nag","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2012.03.021_bb0215","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.2337\/dc11-0969","article-title":"Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes","volume":"34","author":"Novak","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.brainres.2012.03.021_bb0220","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ncl.2006.03.001","article-title":"Psychoneuroimmune implications of type 2 diabetes","volume":"24","author":"O'Connor","year":"2006","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.brainres.2012.03.021_bb0225","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2012.03.021_bb0230","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1212\/01.WNL.0000140705.23869.E9","article-title":"Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression","volume":"63","author":"Ohrui","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2012.03.021_bb0235","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainresbull.2006.07.018","article-title":"Forced swimming test increases superoxide anion positive cells and angiotensin II positive cells in the cerebrum and cerebellum of the rat","volume":"71","author":"Pedreanez","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2012.03.021_bb0240","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.physbeh.2011.06.021","article-title":"Experimental depression induces renal oxidative stress in rats","volume":"104","author":"Pedrea\u00f1ez","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2012.03.021_bb0245","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/ajh.2010.241","article-title":"Blockade of AT1 receptors protects the blood\u2013brain barrier and improves cognition in dahl salt-sensitive hypertensive rats","volume":"24","author":"Pelisch","year":"2011","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.brainres.2012.03.021_bb0250","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.2337\/dc07-0351","article-title":"Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes","volume":"30","author":"Perantie","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.brainres.2012.03.021_bb0255","first-page":"167","article-title":"Are experimental models useful for analysis of pathogenesis of changes in central nervous system in human diabetes?","volume":"41","author":"Piotrowski","year":"2003","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0260","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-2999(98)00329-X","article-title":"Evaluation of the ability of irbesartan to cross the blood\u2013brain barrier following acute intragastric treatment","volume":"352","author":"Polidori","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0270","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1464-5491.2005.01499.x","article-title":"Animal models of diabetes mellitus Diabetes UK","volume":"22","author":"Rees","year":"2005","journal-title":"Diabetic Med."},{"key":"10.1016\/j.brainres.2012.03.021_bb0275","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1080\/15622970903030336","article-title":"Depressive status does not alter renal oxidative and immunological parameters during early diabetic nephropathy in rats","volume":"10","author":"Rincon","year":"2009","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2012.03.021_bb0280","article-title":"Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders","author":"Saavedra","year":"2011","journal-title":"Cell. Mol. Neurobiol"},{"key":"10.1016\/j.brainres.2012.03.021_bb0285","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1353\/hpu.2007.0067","article-title":"Mental health status and diabetes among Whites and Native Americans: is race an effect modifier?","volume":"18","author":"Sahmoun","year":"2007","journal-title":"J. Health Care Poor Underserved"},{"key":"10.1016\/j.brainres.2012.03.021_bb0290","doi-asserted-by":"crossref","first-page":"41","DOI":"10.31887\/DCNS.2011.13.1\/rshelton","article-title":"Inflammation in depression: is adiposity a cause?","volume":"13","author":"Shelton","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.brainres.2012.03.021_bb0295","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/jcbfm.2010.110","article-title":"The effects of poststroke captopril and losartan treatment on cerebral blood flow autoregulation in SHRsp with hemorrhagic stroke","volume":"31","author":"Smeda","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2012.03.021_bb0300","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1464-5491.2006.01959.x","article-title":"Type 1 diabetes as a risk factor for stroke in men and women aged 15\u201349: a nationwide study from Sweden","volume":"23","author":"Sundquist","year":"2006","journal-title":"Diabet. Med."},{"key":"10.1016\/j.brainres.2012.03.021_bb0305","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1357-2725(02)00271-6","article-title":"Inflammation and angiotensin II","volume":"35","author":"Suzuki","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0310","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10571-004-1380-0","article-title":"Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation","volume":"25","author":"Turowski","year":"2005","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0315","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ncb1201-1035","article-title":"Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1","volume":"3","author":"Ullrich","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0320","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1046\/j.1523-1755.2001.00049.x","article-title":"Intrarenal angiotensin II: interstitial and cellular levels and site of production","volume":"60","author":"van Kats","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.brainres.2012.03.021_bb0325","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00005344-200304000-00012","article-title":"Central nervous system blockade by peripheral administration of AT1 receptor blockers","volume":"41","author":"Wang","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0330","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0003-2697(88)90383-1","article-title":"Investigation of the bicin choninic acid protein assay. Identification of the groups responsible for color formation","volume":"175","author":"Wiehelman","year":"1988","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2012.03.021_bb0335","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2011.07.001","article-title":"Brain renin\u2013angiotensin\u2014a new look at an old system","volume":"95","author":"Wright","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2012.03.021_bb0340","article-title":"HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells","author":"Yan","year":"2011","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1016\/j.brainres.2012.03.021_bb0345","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.neuroscience.2010.09.029","article-title":"Angiotensin II induced cerebral microvascular inflammation and increased blood\u2013brain barrier permeability via oxidative stress","volume":"171","author":"Zhang","year":"2010","journal-title":"Neuroscience"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312004830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312004830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T02:23:34Z","timestamp":1641263014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899312004830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":68,"alternative-id":["S0006899312004830"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2012.03.021","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}