{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:11:01Z","timestamp":1758049861473,"version":"3.44.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2011-0028239"],"award-info":[{"award-number":["2011-0028239"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.brainres.2012.03.030","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T07:16:19Z","timestamp":1332227779000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Effect of amitriptyline on glycinergic transmission in rat medullary dorsal horn neurons"],"prefix":"10.1016","volume":"1455","author":[{"given":"Jin-Hwa","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Sun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maan-Gee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il-Sung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2012.03.030_bb0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nn778","article-title":"PGE2 selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons","volume":"5","author":"Ahmadi","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2012.03.030_bb0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0165-6147(02)00010-X","article-title":"Techniques: applications of the nerve-bouton preparation in neuropharmacology","volume":"24","author":"Akaike","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2012.03.030_bb0015","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0306-4522(92)90256-2","article-title":"The distribution of binding by isolectin I-B4 from Griffonia simplicifolia in the trigeminal ganglion and brainstem trigeminal nuclei in the rat","volume":"47","author":"Ambalavanar","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2012.03.030_bb0020","series-title":"Goodman and Gilman's the Pharmacological Basis of Therapeutics","first-page":"431","article-title":"Drugs and the treatment of psychiatric disorders: depression and mania","author":"Baldessarini","year":"1995"},{"key":"10.1016\/j.brainres.2012.03.030_bb0025","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ejpain.2008.01.010","article-title":"Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice","volume":"12","author":"Benbouzid","year":"2008","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.brainres.2012.03.030_bb0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00000542-200101000-00024","article-title":"Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na+ currents in rat sensory neurons","volume":"94","author":"Br\u00e4u","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2012.03.030_bb0035","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1113\/jphysiol.1993.sp019874","article-title":"Mechanism of \u03bc-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro","volume":"470","author":"Capogna","year":"1993","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainres.2012.03.030_bb0040","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1124\/mol.108.051490","article-title":"Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release","volume":"75","author":"Chopra","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1096-9861(19960101)364:1<169::AID-CNE13>3.0.CO;2-U","article-title":"Organization of primary afferent axons in the trigeminal sensory root and tract of the rat","volume":"364","author":"Crissman","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0050","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pain.2009.07.038","article-title":"Electrophysiological and morphological properties of neurons in the substantia gelatinosa of the mouse trigeminal subnucleus caudalis","volume":"146","author":"Davies","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.03.030_bb0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jpain.2006.10.001","article-title":"Sodium channel blockade may contribute to the analgesic efficacy of antidepressants","volume":"8","author":"Dick","year":"2007","journal-title":"J. Pain"},{"key":"10.1016\/j.brainres.2012.03.030_bb0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-6273(01)00190-8","article-title":"Calcium stores in hippocampal synaptic boutons mediate short-term plasticity, store-operated Ca2+ entry, and spontaneous transmitter release","volume":"29","author":"Emptage","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.03.030_bb0065","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tibs.2005.04.004","article-title":"Glycine transporters: essential regulators of neurotransmission","volume":"30","author":"Eulenburg","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.brainres.2012.03.030_bb0070","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pain.2005.08.013","article-title":"Algorithm for neuropathic pain treatment: an evidence based proposal","volume":"118","author":"Finnerup","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.03.030_bb0075","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1476-5381.2009.00347.x","article-title":"Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve","volume":"158","author":"Freysoldt","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neures.2003.12.005","article-title":"Sensory processing and functional reorganization of sensory transmission under pathological conditions in the spinal dorsal horn","volume":"48","author":"Furue","year":"2004","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2012.03.030_bb0085","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0896-6273(03)00672-X","article-title":"Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition","volume":"40","author":"Gomeza","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.03.030_bb0090","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0896-6273(03)00673-1","article-title":"Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality","volume":"40","author":"Gomeza","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.03.030_bb0095","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1523\/JNEUROSCI.14-03-01646.1994","article-title":"\u03bc-Opioid agonists inhibit spinal trigeminal substantia gelatinosa neurons in guinea pig and rat","volume":"14","author":"Grudt","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.03.030_bb0100","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1113\/jphysiol.1995.sp020716","article-title":"Inhibition by 5-hydroxytryptamine and noradrenaline in substantia gelatinosa of guinea-pig spinal trigeminal nucleus","volume":"485","author":"Grudt","year":"1995","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainres.2012.03.030_bb0105","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0028-3908(03)00247-8","article-title":"Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants","volume":"45","author":"Gumilar","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2012.03.030_bb0110","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0028-3908(87)90144-4","article-title":"Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline","volume":"26","author":"Hamon","year":"1987","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2012.03.030_bb0115","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1126\/science.1094925","article-title":"GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization","volume":"304","author":"Harvey","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brainres.2012.03.030_bb0120","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s12272-001-1138-x","article-title":"Effects of carbamazepine and amitriptyline on tetrodotoxin resistant Na+ channels in immature rat trigeminal ganglion neurons","volume":"31","author":"Hur","year":"2008","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.brainres.2012.03.030_bb0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0014-2999(84)90189-4","article-title":"Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds","volume":"103","author":"Isenberg","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0130","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/jn.1986.55.6.1153","article-title":"Structure-function relationships in rat medullary and cervical dorsal horns. I. Trigeminal primary afferents","volume":"55","author":"Jacquin","year":"1986","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0135","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1113\/jphysiol.2001.016535","article-title":"Functional roles of presynaptic GABAA receptors on glycinergic nerve terminals in the rat spinal cord","volume":"541","author":"Jang","year":"2002","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainres.2012.03.030_bb0140","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1096-9861(19990830)411:3<399::AID-CNE4>3.0.CO;2-6","article-title":"Substantia gelatinosa neurons in the medullary dorsal horn: An intracellular labeling study in the rat","volume":"411","author":"Li","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0145","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2165\/00003495-199142050-00002","article-title":"The use of antidepressants in the treatment of chronic pain. A review of the current evidence","volume":"42","author":"Magni","year":"1991","journal-title":"Drugs"},{"key":"10.1016\/j.brainres.2012.03.030_bb0150","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"Millan","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0155","doi-asserted-by":"crossref","first-page":"e1116","DOI":"10.1371\/journal.pone.0001116","article-title":"Glycine inhibitory dysfunction turns touch into pain through PKC\u03b3 interneurons","volume":"2","author":"Miraucourt","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2012.03.030_bb0160","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1523\/JNEUROSCI.3923-08.2009","article-title":"Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor-independent mechanical allodynia","volume":"29","author":"Miraucourt","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.03.030_bb0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/neuro.02.003.2008","article-title":"Extrasynaptic and postsynaptic receptors in glycinergic and GABAergic neurotransmission: a division of labor?","volume":"1","author":"Muller","year":"2008","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2012.03.030_bb0170","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0304-3940(89)90485-0","article-title":"Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons","volume":"103","author":"Murase","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.03.030_bb0175","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1744-8069-5-20","article-title":"Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief","volume":"5","author":"Nagata","year":"2009","journal-title":"Mol. Pain"},{"key":"10.1016\/j.brainres.2012.03.030_bb0180","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/sj.bjp.0703049","article-title":"Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters","volume":"129","author":"N\u00fa\u00f1ez","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0185","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(92)90144-Z","article-title":"Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies","volume":"49","author":"Onghena","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.03.030_bb0190","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00004714-199408000-00002","article-title":"Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response","volume":"14","author":"Perry","year":"1994","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0195","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1476-5381.1988.tb16552.x","article-title":"Tricyclic antidepressants block N-methyl-d-aspartate receptors: similarities to the action of zinc","volume":"95","author":"Reynolds","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0200","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1046\/j.1471-4159.1999.0720800.x","article-title":"Calcium channels in the GABAergic presynaptic nerve terminals projecting to meynert neurons of the rat","volume":"72","author":"Rhee","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2012.03.030_bb0205","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0896-6273(92)90244-8","article-title":"Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus","volume":"9","author":"Scanziani","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.03.030_bb0210","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2165\/00003088-198510030-00005","article-title":"Discrepancies between pharmacokinetic studies of amitriptyline","volume":"10","author":"Schulz","year":"1985","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.brainres.2012.03.030_bb0215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1476-5381.2010.00683.x","article-title":"Amitriptyline does not block the action of ATP at human P2X4 receptor","volume":"160","author":"Sim","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0220","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1742-7843.2005.pto_96696601.x","article-title":"Antidepressants in the treatment of neuropathic pain","volume":"96","author":"Sindrup","year":"2005","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.brainres.2012.03.030_bb0225","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0304-3959(85)90162-9","article-title":"Potentiation of morphine antinociception by monoamine reuptake inhibitors in the rat spinal cord","volume":"21","author":"Taiwo","year":"1985","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.03.030_bb0230","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1113\/jphysiol.1996.sp021205","article-title":"Endogenous monoamines inhibit glutamate transmission in the spinal trigeminal nucleus of the guinea-pig","volume":"491","author":"Travagli","year":"1996","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainres.2012.03.030_bb0235","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0166-2236(96)01015-6","article-title":"Presynaptic inhibition of elicited neurotransmitter release","volume":"20","author":"Wu","year":"1997","journal-title":"Trends Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312005124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312005124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:49:38Z","timestamp":1757785778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899312005124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":47,"alternative-id":["S0006899312005124"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2012.03.030","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of amitriptyline on glycinergic transmission in rat medullary dorsal horn neurons","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2012.03.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}