{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:27:10Z","timestamp":1788870430408,"version":"build-2803163510"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institutes of Health\/National Institute of Arthritis, Musculoskeletal and Skin Diseases","award":["AR056288"],"award-info":[{"award-number":["AR056288"]}]},{"DOI":"10.13039\/100008465","name":"Catharine D. Sharpe Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008465","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.brainres.2012.04.026","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T13:32:20Z","timestamp":1335015140000},"page":"51-63","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity"],"prefix":"10.1016","volume":"1461","author":[{"given":"Ling","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Quindlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Lipschutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Winkelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2012.04.026_bb0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0306-4522(95)00343-H","article-title":"Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain","volume":"70","author":"Abbadie","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2012.04.026_bb0010","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1152\/jn.1994.72.2.684","article-title":"Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat","volume":"72","author":"Ahlgren","year":"1994","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2990.2011.01215.x","article-title":"Activation status of integrated stress response pathways in neurons and astrocytes of HAND cortex","volume":"38","author":"Akay","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0020","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0006-291X(86)90384-0","article-title":"C-kinase activation prolongs Ca2+-dependent inactivation of K+ currents","volume":"134","author":"Alkon","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2012.04.026_bb0025","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/1096-9861(20000703)422:3<464::AID-CNE11>3.0.CO;2-#","article-title":"Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord","volume":"422","author":"Alvarez","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0030","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1113\/jphysiol.2006.111534","article-title":"Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice","volume":"575","author":"Amadesi","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0035","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.2106\/00004623-199274100-00005","article-title":"The effects of controlled mechanical loading on group-II, III, and IV afferent units from the lumbar facet joint and surrounding tissue. An in vitro study","volume":"74","author":"Avramov","year":"1992","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.brainres.2012.04.026_bb0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/86075","article-title":"Peripheral group I metabotropic glutamate receptors modulate nociception in mice","volume":"4","author":"Bhave","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0045","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/glia.20783","article-title":"Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity","volume":"57","author":"Byrnes","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2012.04.026_bb0050","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1210\/en.2004-0550","article-title":"Glutamate induces apoptosis in anterior pituitary cells through group II metabotropic glutamate receptor activation","volume":"145","author":"Caruso","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2012.04.026_bb0465","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jor.1100070310","article-title":"Sensory innervation of soft tissues of the lumbar spine in the rat","volume":"7","author":"Cavanaugh","year":"1989","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0060","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2012.04.026_bb0065","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0896-6273(95)90158-2","article-title":"Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry","volume":"15","author":"Chaudhry","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.04.026_bb0070","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2106\/JBJS.E.00880","article-title":"Distribution of A-delta and C-fiber receptors in the cervical facet joint capsule and their response to stretch","volume":"88","author":"Chen","year":"2006","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.brainres.2012.04.026_bb0075","doi-asserted-by":"crossref","first-page":"15219","DOI":"10.1073\/pnas.1107304108","article-title":"Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice","volume":"108","author":"Choi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2012.04.026_bb0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.pharmtox.37.1.205","article-title":"Pharmacology and functions of metabotropic glutamate receptors","volume":"37","author":"Conn","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0085","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0304-3959(01)00334-7","article-title":"Risk factors for neck pain: a longitudinal study in the general population","volume":"93","author":"Croft","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.04.026_bb0470","article-title":"Spinal neuronal hyperexcitability is induced within 1day of a painful facet joint injury","author":"Crosby","year":"2011","journal-title":"BMES Annual Mtg."},{"key":"10.1016\/j.brainres.2012.04.026_bb0095","first-page":"171","article-title":"Kinematics of human cadaver cervical spine during low speed rear-end impacts","volume":"44","author":"Deng","year":"2000","journal-title":"Stapp Car Crash J."},{"key":"10.1016\/j.brainres.2012.04.026_bb0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/313313a0","article-title":"Enhancement of calcium current in Aplysia neurons by phorbol ester and protein kinase C","volume":"313","author":"Deriemer","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2012.04.026_bb0105","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1073\/pnas.0508005103","article-title":"Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways","volume":"103","author":"Di Castro","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2012.04.026_bb0110","doi-asserted-by":"crossref","first-page":"8614","DOI":"10.1523\/JNEUROSCI.20-22-08614.2000","article-title":"Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat","volume":"20","author":"Dina","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0475","series-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","first-page":"315","article-title":"Glutamate and aspartate","author":"Dingledine","year":"1999"},{"key":"10.1016\/j.brainres.2012.04.026_bb0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3940(00)01458-0","article-title":"Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats","volume":"292","author":"Dogrul","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.04.026_bb0135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/neu.2009.0999","article-title":"Simulated whiplash modulates expression of the glutamatergic system in the spinal cord suggesting spinal plasticity is associated with painful dynamic cervical facet loading","volume":"27","author":"Dong","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2012.04.026_bb0130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2008.07.059","article-title":"Painful facet injury induces neuronal stress activation in the DRG: implications for cellular mechanisms of pain","volume":"443","author":"Dong","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.04.026_bb0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuroscience.2011.07.059","article-title":"Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction","volume":"193","author":"Dong","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2012.04.026_bb0140","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1523\/JNEUROSCI.12-08-03025.1992","article-title":"The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli","volume":"12","author":"Dougherty","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pain.2005.06.001","article-title":"Mechanisms involved in the nociception produced by peripheral protein kinase C activation in mice","volume":"117","author":"Ferreira","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.04.026_bb0150","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0091-3057(02)00832-8","article-title":"Antinociceptive effects following intrathecal pretreatment with selective metabotropic glutamate receptor compounds in a rat model of neuropathic pain","volume":"73","author":"Fisher","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2012.04.026_bb0155","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1046\/j.1471-4159.1995.65062800.x","article-title":"Regional deafferentation down-regulates subtypes of glutamate transporter proteins","volume":"65","author":"Ginsberg","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2012.04.026_bb0160","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0028-3908(03)00026-1","article-title":"Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat","volume":"44","author":"Hama","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2012.04.026_bb0165","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6","article-title":"Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus","volume":"418","author":"He","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0170","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1097\/01.brs.0000176239.72928.00","article-title":"Transient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: mechanical factors in painful neck injuries","volume":"301","author":"Hubbard","year":"2005","journal-title":"Spine"},{"key":"10.1016\/j.brainres.2012.04.026_bb0175","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.expneurol.2008.04.042","article-title":"Dorsal root compression produces myelinated axonal degeneration near the biomechanical thresholds for mechanical behavioral hypersensitivity","volume":"212","author":"Hubbard","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0180","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1523\/JNEUROSCI.22-07-02660.2002","article-title":"Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia","volume":"22","author":"Hudson","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0185","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1124\/pr.110.004135","article-title":"Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia","volume":"63","author":"Hutchinson","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainres.2012.04.026_bb0190","doi-asserted-by":"crossref","first-page":"35827","DOI":"10.1074\/jbc.M109.046276","article-title":"Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts","volume":"284","author":"Jong","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2012.04.026_bb0195","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1096\/fasebj.7.15.7903261","article-title":"A new family of neurotransmitter transporters: the high-affinity glutamate transporters","volume":"7","author":"Kanai","year":"1993","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2012.04.026_bb0200","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1523\/JNEUROSCI.21-11-03771.2001","article-title":"Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice","volume":"21","author":"Karim","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0205","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1152\/jn.1996.76.1.175","article-title":"Mechanical states encoded by stretch-sensitive neurons in feline joint capsule","volume":"76","author":"Khalsa","year":"1996","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0210","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0896-6273(00)80837-5","article-title":"A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice","volume":"24","author":"Khasar","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.04.026_bb0215","doi-asserted-by":"crossref","first-page":"10000","DOI":"10.1523\/JNEUROSCI.5030-08.2009","article-title":"Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons","volume":"29","author":"Kim","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0220","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1358\/dnp.2003.16.8.829350","article-title":"Modulation of metabotropic glutamate receptors as potential treatment for acute and chronic neurodegenerative disorders","volume":"16","author":"Lea","year":"2003","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.brainres.2012.04.026_bb0225","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neuroscience.2007.01.015","article-title":"Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms","volume":"146","author":"Lee","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2012.04.026_bb0230","first-page":"373","article-title":"In vivo cervical facet capsule distraction: mechanical implications for whiplash and neck pain","volume":"48","author":"Lee","year":"2004","journal-title":"Stapp Car Crash J."},{"key":"10.1016\/j.brainres.2012.04.026_bb0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jneumeth.2004.02.021","article-title":"A novel rodent neck pain model of facet-mediated behavioral hypersensitivity: implications for persistent pain and whiplash injury","volume":"137","author":"Lee","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2012.04.026_bb0240","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.jbiomech.2005.03.018","article-title":"Tensile cervical facet capsule ligament mechanics: failure and subfailure responses in the rodent","volume":"39","author":"Lee","year":"2006","journal-title":"J. Biomech."},{"key":"10.1016\/j.brainres.2012.04.026_bb0235","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1089\/neu.2008.0700","article-title":"Capsular ligament involvement in the development of mechanical hyperalgesia after facet joint loading: behavioral and inflammatory outcomes in a rodent model of pain","volume":"25","author":"Lee","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2012.04.026_bb0250","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0304-3940(96)12414-9","article-title":"Excitation and sensitization of the heat response induced by a phorbol ester in canine visceral polymodal receptors studied in vitro","volume":"206","author":"Leng","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.04.026_bb0255","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1152\/jn.00485.2003","article-title":"Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons","volume":"91","author":"Li","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0260","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0006-8993(91)90984-4","article-title":"Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord","volume":"547","author":"Liu","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0265","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.orthres.2005.01.002","article-title":"Neurophysiological and biomechanical characterization of goat cervical facet joint capsules","volume":"23","author":"Lu","year":"2005","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0270","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0268-0033(00)00031-0","article-title":"Qualitative analysis of neck kinematics during low-speed rear-end impact","volume":"15","author":"Luan","year":"2000","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.brainres.2012.04.026_bb0275","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1006\/exnr.1999.7166","article-title":"Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord","volume":"159","author":"McAdoo","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0280","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3940(86)90185-0","article-title":"Spinal termination of nociceptive afferent fibres from deep tissues in the cat","volume":"66","author":"Mense","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.04.026_bb0285","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1471-4159.2001.00630.x","article-title":"Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat","volume":"79","author":"Mills","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2012.04.026_bb0290","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(01)03124-9","article-title":"Na+ dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress","volume":"922","author":"Miralles","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0295","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00007632-199801010-00005","article-title":"Simulation of whiplash trauma using whole cervical spine specimens","volume":"23","author":"Panjabi","year":"1998","journal-title":"Spine"},{"key":"10.1016\/j.brainres.2012.04.026_bb0300","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/01.BRS.0000090836.50508.F7","article-title":"Facet joint kinematics and injury mechanisms during simulated whiplash","volume":"29","author":"Pearson","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.brainres.2012.04.026_bb0305","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1097\/00007632-199511001-00002","article-title":"Responses of mechanosensitive afferents to manipulation of the lumbar facet in the cat","volume":"20","author":"Pickar","year":"1995","journal-title":"Spine"},{"key":"10.1016\/j.brainres.2012.04.026_bb0310","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0959-4388(95)80047-6","article-title":"Get receptive to metabotropic glutamate receptors","volume":"5","author":"Pin","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0315","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/cne.21506","article-title":"Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors","volume":"505","author":"Pitcher","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0325","first-page":"169","article-title":"Structural changes in the cervical facet capsular ligament: potential contributions to pain following subfailure loading","volume":"51","author":"Quinn","year":"2007","journal-title":"Stapp Car Crash J."},{"key":"10.1016\/j.brainres.2012.04.026_bb0320","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.pain.2010.07.034","article-title":"Neuronal hyperexcitability in the dorsal horn after painful facet joint injury","volume":"151","author":"Quinn","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.04.026_bb0330","doi-asserted-by":"crossref","first-page":"C1964","DOI":"10.1152\/ajpcell.2001.281.6.C1964","article-title":"Role of glutamate transporters in the regulation of glutathione levels in human macrophages","volume":"281","author":"Rimaniol","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0335","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2007.08.064","article-title":"Chemical and mechanical nerve root insults induce differential behavioral sensitivity and glial activation that are enhanced in combination","volume":"1181","author":"Rothman","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0340","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1089\/neu.2009.1045","article-title":"Cytokine antagonism reduces pain and modulates spinal astrocytic reactivity after cervical nerve root model of radiculopathy","volume":"27","author":"Rothman","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2012.04.026_bb0345","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate","volume":"16","author":"Rothstein","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.04.026_bb0355","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1749-6632.2002.tb04234.x","article-title":"Mechanisms of pain in arthritis","volume":"966","author":"Schaible","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0360","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF00229027","article-title":"The effects of phorbol ester on slowly conducting afferents of the cat's knee joint","volume":"92","author":"Schepelmann","year":"1993","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0365","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0028-3908(99)00092-1","article-title":"Pharmacological agents acting at subtypes of metabotropic glutamate receptors","volume":"38","author":"Schoepp","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2012.04.026_bb0370","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0006-8993(97)00921-9","article-title":"Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody","volume":"773","author":"Shashidharan","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0375","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0304-3959(93)90013-F","article-title":"Behavioral and immunohistochemical changes in an experimental arthritis model in rats","volume":"55","author":"Sluka","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.04.026_bb0380","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.bjp.0704434","article-title":"In vivo evidence for a role of protein kinase C in peripheral nociceptive processing","volume":"135","author":"Souza","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0385","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3171\/spi.2005.3.6.0471","article-title":"Localized cervical facet joint kinematics under physiological and whiplash loading","volume":"3","author":"Stemper","year":"2005","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.brainres.2012.04.026_bb0390","first-page":"331","article-title":"Effect of head-neck position on cervical facet stretch of post mortem human subjects during low speed rear end impacts","volume":"48","author":"Sundararajan","year":"2004","journal-title":"Stapp Car Crash J."},{"key":"10.1016\/j.brainres.2012.04.026_bb0395","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1523\/JNEUROSCI.23-07-02899.2003","article-title":"Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats","volume":"23","author":"Sung","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.04.026_bb0400","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1124\/jpet.103.060350","article-title":"Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats","volume":"309","author":"Sweitzer","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2012.04.026_bb0405","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1113\/eph8702351","article-title":"Anatomy of primary afferents and projection neurons in the rat spinal dorsal horn with particular emphasis on substance P and the neurokinin 1 receptor","volume":"87","author":"Todd","year":"2002","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0410","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/cne.903460205","article-title":"Amino acid immunocytochemistry of primary afferent terminals in the rat dorsal horn","volume":"346","author":"Valtschanoff","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2012.04.026_bb0415","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0006-8993(01)03329-7","article-title":"Rapid changes in expression of glutamate transporters after spinal cord injury","volume":"927","author":"Vera-Portocarrero","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.04.026_bb0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0028-3908(00)00113-1","article-title":"Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain","volume":"40","author":"Walker","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2012.04.026_bb0430","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/089771504323004629","article-title":"Spinal axonal injury transiently elevates the level of metabotropic glutamate receptor 5, but not 1, in cord-projection central neurons","volume":"21","author":"Wang","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2012.04.026_bb0425","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pain.2005.10.015","article-title":"Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in rats","volume":"120","author":"Wang","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2012.04.026_bb0435","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1089\/neu.2010.1460","article-title":"Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury","volume":"27","author":"Weisshaar","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2012.04.026_bb0440","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neulet.2007.04.065","article-title":"Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat","volume":"420","author":"Xu","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.04.026_bb0450","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1115\/1.2798318","article-title":"Cervical spine vertebral and facet joint kinematics under whiplash","volume":"120","author":"Yoganandan","year":"1998","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.brainres.2012.04.026_bb0445","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0001-4575(01)00066-5","article-title":"Biomechanical analyses of whiplash injuries using an experimental model","volume":"34","author":"Yoganandan","year":"2002","journal-title":"Accid. Anal. Prev."},{"key":"10.1016\/j.brainres.2012.04.026_bb0455","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1744-8069-5-36","article-title":"Synaptically evoked glutamate transporter currents in spinal dorsal horn astrocytes","volume":"5","author":"Zhang","year":"2009","journal-title":"Mol. Pain"},{"key":"10.1016\/j.brainres.2012.04.026_bb0460","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312007196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312007196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T13:20:00Z","timestamp":1561641600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899312007196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":91,"alternative-id":["S0006899312007196"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2012.04.026","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717962734.793464757","asserted-by":"object"}]},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}