{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:49:10Z","timestamp":1791910150962,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.brainres.2012.10.007","type":"journal-article","created":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T17:29:23Z","timestamp":1349890163000},"page":"83-94","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Nitric oxide modulates bladder afferent nerve activity in the in vitro urinary bladder\u2013pelvic nerve preparation from rats with cyclophosphamide induced cystitis"],"prefix":"10.1016","volume":"1490","author":[{"given":"Yongbei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"de Groat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2012.10.007_bib1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.eururo.2010.10.035","article-title":"Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment","volume":"59","author":"Aizawa","year":"2011","journal-title":"Eur. Urol."},{"key":"10.1016\/j.brainres.2012.10.007_bib2","doi-asserted-by":"crossref","first-page":"7008","DOI":"10.1523\/JNEUROSCI.18-17-07008.1998","article-title":"Nitric oxide signaling in pain and nociceptor sensitization in the rat","volume":"18","author":"Aley","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.007_bib3","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0306-3623(93)90156-R","article-title":"The l-arginine\/nitric oxide pathway and non-adrenergic, non-cholinergic relaxation of the lower urinary tract","volume":"24","author":"Andersson","year":"1993","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.brainres.2012.10.007_bib4","first-page":"43","article-title":"Nitric oxide synthase and the lower urinary tract: possible implications for physiology and pathophysiology","volume":"175","author":"Andersson","year":"1995","journal-title":"Scand. J. Urol. Nephrol. Suppl."},{"key":"10.1016\/j.brainres.2012.10.007_bib5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1124\/pr.56.4.4","article-title":"Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence","volume":"56","author":"Andersson","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainres.2012.10.007_bib6","doi-asserted-by":"crossref","first-page":"F333","DOI":"10.1152\/ajprenal.00207.2009","article-title":"Activation of the nitric oxide-cGMP pathway reduces phasic contractions in neonatal rat bladder strips via protein kinase G","volume":"297","author":"Artim","year":"2009","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib7","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1002\/nau.21143","article-title":"Developmental and spinal cord injury-induced changes in nitric oxide-mediated inhibition in rat urinary bladder","volume":"30","author":"Artim","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.brainres.2012.10.007_bib8","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0022-3565(24)35048-7","article-title":"Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor","volume":"290","author":"Baggio","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2012.10.007_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.autneu.2009.07.019","article-title":"Visceral afferents\u2014determinants and modulation of excitability","volume":"153","author":"Beyak","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.007_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(99)00553-4","article-title":"Nitric oxide enhances slow inactivation of voltage-dependent sodium currents in rat nodose neurons","volume":"271","author":"Bielefeldt","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2012.10.007_bib11","first-page":"F226","article-title":"Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder","volume":"275","author":"Birder","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib12","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1523\/JNEUROSCI.22-18-08063.2002","article-title":"Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells","volume":"22","author":"Birder","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.007_bib13","doi-asserted-by":"crossref","first-page":"F423","DOI":"10.1152\/ajprenal.00056.2003","article-title":"Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium","volume":"285","author":"Birder","year":"2003","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib14","doi-asserted-by":"crossref","first-page":"F489","DOI":"10.1152\/ajprenal.00467.2004","article-title":"More than just a barrier: urothelium as a drug target for urinary bladder pain","volume":"289","author":"Birder","year":"2005","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.ju.0000145900.22849.1d","article-title":"Altered inducible nitric oxide synthase expression and nitric oxide production in the bladder of cats with feline interstitial cystitis","volume":"173","author":"Birder","year":"2005","journal-title":"J. Urol."},{"key":"10.1016\/j.brainres.2012.10.007_bib16","series-title":"Textbook of the Neurogenic Bladder","first-page":"19","article-title":"Physiology of the urothelium","author":"Birder","year":"2008"},{"key":"10.1016\/j.brainres.2012.10.007_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-8993(95)00212-9","article-title":"Effect of capsaicin on micturition and associated reflexes in chronic spinal rats","volume":"678","author":"Cheng","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.10.007_bib18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1113\/jphysiol.2005.088435","article-title":"P2X2 knockout mice and P2X2\/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP","volume":"567","author":"Cockayne","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1152\/jn.00211.2007","article-title":"Cyclophosphamide-induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons","volume":"99","author":"Dang","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib20","series-title":"International Consultation on Incontinence","first-page":"105","article-title":"Basic neurophysiology and neuropharmacology","author":"de Groat","year":"1999"},{"issue":"Suppl. 2","key":"10.1016\/j.brainres.2012.10.007_bib21","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1038\/sj.bjp.0706604","article-title":"Integrative control of the lower urinary tract: preclinical perspective","volume":"147","author":"de Groat","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.10.007_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.regpep.2005.09.024","article-title":"Inhibition of substance P activity prevents stress-induced bladder damage","volume":"133","author":"Ercan","year":"2006","journal-title":"Regul. Pept."},{"key":"10.1016\/j.brainres.2012.10.007_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1469-7793.1997.503bb.x","article-title":"ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes\u2014a possible sensory mechanism?","volume":"505","author":"Ferguson","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1113\/jphysiol.1968.sp008656","article-title":"Conduction failure in myelinated and non-myelinated axons at low temperatures","volume":"199","author":"Franz","year":"1968","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00001756-200101220-00032","article-title":"Nitric oxide modulates articular sensory discharge and responsiveness to bradykinin in normal and arthritic rats in vivo","volume":"12","author":"Kelly","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2012.10.007_bib26","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1021\/bi002317h","article-title":"Probing erectile function: S-(2-boronoethyl)-l-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum","volume":"40","author":"Kim","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2012.10.007_bib27","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1523\/JNEUROSCI.4694-07.2008","article-title":"Activation of muscarinic receptors in rat bladder sensory pathways alters reflex bladder activity","volume":"28","author":"Kullmann","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.007_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF00240958","article-title":"Cyclophosphamide cystitis as a model of visceral pain in rats: model elaboration and spinal structures involved as revealed by the expression of c-Fos and Krox-24 proteins","volume":"105","author":"Lanteri-Minet","year":"1995","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2012.10.007_bib29","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1152\/jn.00058.2004","article-title":"Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade","volume":"92","author":"Levy","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib30","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0896-6273(00)80484-5","article-title":"Nitric oxide as an autocrine regulator of sodium currents in baroreceptor neurons","volume":"20","author":"Li","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.10.007_bib31","doi-asserted-by":"crossref","first-page":"R2390","DOI":"10.1152\/ajpregu.00508.2007","article-title":"Effects of l-arginine and l-NAME on chronic partial bladder outlet obstruction in rabbit","volume":"293","author":"Lin","year":"2007","journal-title":"Am. J. Physiol.: Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib32","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0090-4295(96)00423-2","article-title":"Elevated nitric oxide in the urinary bladder in infectious and noninfectious cystitis","volume":"48","author":"Lundberg","year":"1996","journal-title":"Urology"},{"key":"10.1016\/j.brainres.2012.10.007_bib33","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1464-410X.2007.07099.x","article-title":"Inhibitory roles of peripheral nitrergic mechanisms in capsaicin-induced detrusor overactivity in the rat","volume":"100","author":"Masuda","year":"2007","journal-title":"BJU Int."},{"key":"10.1016\/j.brainres.2012.10.007_bib34","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/01.RES.76.3.426","article-title":"Modulation of baroreceptor activity by nitric oxide and S-nitrosocysteine","volume":"76","author":"Matsuda","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.brainres.2012.10.007_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainres.2012.10.007_bib36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/003655999750016348","article-title":"Activation of pelvic afferent nerves from the rat bladder during filling","volume":"201","author":"Morrison","year":"1999","journal-title":"Scand. J. Urol. Nephrol. Suppl."},{"key":"10.1016\/j.brainres.2012.10.007_bib37","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/S0022-5347(05)68161-X","article-title":"Effect of intravesical nitric oxide therapy on cyclophosphamide-induced cystitis","volume":"162","author":"Ozawa","year":"1999","journal-title":"J. Urol."},{"key":"10.1016\/j.brainres.2012.10.007_bib38","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.1523\/JNEUROSCI.6099-08.2009","article-title":"Nitric oxide as an endogenous peripheral modulator of visceral sensory neuronal function","volume":"29","author":"Page","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.007_bib39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-5347(05)67420-4","article-title":"Intravesical oxyhemoglobin initiates bladder overactivity in conscious, normal rats","volume":"164","author":"Pandita","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.brainres.2012.10.007_bib40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000080104","article-title":"Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy","volume":"72","author":"Patil","year":"2004","journal-title":"Pharmacology"},{"key":"10.1016\/j.brainres.2012.10.007_bib41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1113\/jphysiol.2001.013469","article-title":"Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder","volume":"541","author":"Rong","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib42","doi-asserted-by":"crossref","first-page":"F616","DOI":"10.1152\/ajprenal.00096.2002","article-title":"Mast cells mediate substance P-induced bladder inflammation through an NK(1) receptor-independent mechanism","volume":"283","author":"Saban","year":"2002","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib43","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.urology.2007.12.002","article-title":"Nitric oxide-mediated suppression of detrusor overactivity by arginase inhibitor in rats with chronic spinal cord injury","volume":"72","author":"Sasatomi","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.brainres.2012.10.007_bib44","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.expneurol.2009.07.016","article-title":"Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons","volume":"219","author":"Sculptoreanu","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2012.10.007_bib45","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/S0022-5347(01)66301-8","article-title":"Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections","volume":"155","author":"Smith","year":"1996","journal-title":"J. Urol."},{"key":"10.1016\/j.brainres.2012.10.007_bib46","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0022-5347(01)64297-6","article-title":"Improvement in interstitial cystitis symptom scores during treatment with oral l-arginine","volume":"158","author":"Smith","year":"1997","journal-title":"J. Urol."},{"key":"10.1016\/j.brainres.2012.10.007_bib47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0006-8993(94)90090-6","article-title":"Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat","volume":"646","author":"Vizzard","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2012.10.007_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(95)00137-8","article-title":"Increased expression of neuronal nitric oxide synthase in dorsal root ganglion neurons after systemic capsaicin administration","volume":"67","author":"Vizzard","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2012.10.007_bib49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<191::AID-CNE5>3.0.CO;2-Y","article-title":"Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation","volume":"370","author":"Vizzard","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2012.10.007_bib50","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000111212","article-title":"Increased expression of neuronal nitric oxide synthase in bladder afferent and spinal neurons following spinal cord injury","volume":"19","author":"Vizzard","year":"1997","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.007_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0165-1838(97)00025-8","article-title":"Localization of NADPH diaphorase in the thoracolumbar and sacrococcygeal spinal cord of the dog","volume":"64","author":"Vizzard","year":"1997","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.brainres.2012.10.007_bib52","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1523\/JNEUROSCI.21-15-05670.2001","article-title":"P2X3 knock-out mice reveal a major sensory role for urothelially released ATP","volume":"21","author":"Vlaskovska","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.007_bib53","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1152\/jn.2001.86.1.304","article-title":"Nitric oxide modulates Ca2+ channels in dorsal root ganglion neurons innervating rat urinary bladder","volume":"86","author":"Yoshimura","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib54","unstructured":"Yu, Y., de Groat, W.C., 2005. Nitric oxide modulates pelvic afferent nerve activity in cyclophosphamide-pretreated rats in the in vitro urinary bladder-pelvic nerve prep. Society for Neuroscience Abstract Viewer. 294.14."},{"key":"10.1016\/j.brainres.2012.10.007_bib55","doi-asserted-by":"crossref","first-page":"F1146","DOI":"10.1152\/ajprenal.00592.2007","article-title":"Sensitization of pelvic afferent nerves in the in vitro rat urinary bladder\u2013pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment","volume":"294","author":"Yu","year":"2008","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"10.1016\/j.brainres.2012.10.007_bib56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainres.2010.09.018","article-title":"Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder\u2013pelvic afferent nerve preparation of the rat","volume":"1361","author":"Yu","year":"2010","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312016344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312016344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:53:11Z","timestamp":1744285991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899312016344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":56,"alternative-id":["S0006899312016344"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2012.10.007","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}