{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:41:09Z","timestamp":1778895669346,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"the Chongqing Natural Science Foundation","doi-asserted-by":"crossref","award":["2011BB5023"],"award-info":[{"award-number":["2011BB5023"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31070968"],"award-info":[{"award-number":["31070968"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000378"],"award-info":[{"award-number":["81000378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.brainres.2012.10.014","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T04:31:15Z","timestamp":1351053075000},"page":"90-97","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The toll-like receptor 4-mediated signaling pathway is activated following optic nerve injury in mice"],"prefix":"10.1016","volume":"1489","author":[{"given":"Zheng","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongdi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoFeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2012.10.014_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"Adachi","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.brainres.2012.10.014_bib2","doi-asserted-by":"crossref","first-page":"38105","DOI":"10.1074\/jbc.R300028200","article-title":"Toll-like receptor signaling","volume":"278","author":"Akira","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2012.10.014_bib3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1042\/bst0310637","article-title":"Role of adapters in Toll-like receptor signalling","volume":"31","author":"Akira","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.brainres.2012.10.014_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib5","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1523\/JNEUROSCI.0976-10.2010","article-title":"Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage","volume":"30","author":"Alfonso-Loeches","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.014_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2011.05.006","article-title":"Toll-like receptors are key players in neurodegeneration","author":"Arroyo","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.brainres.2012.10.014_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.smim.2007.01.003","article-title":"Viral recognition by Toll-like receptors","volume":"19","author":"Barton","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/cne.903540211","article-title":"Macrophages, microglia, and astrocytes are rapidly activated after crush injury of the goldfish optic nerve: a light and electron microscopic analysis","volume":"354","author":"Battisti","year":"1995","journal-title":"J. Comput. Neurol."},{"key":"10.1016\/j.brainres.2012.10.014_bib9","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/glia.20699","article-title":"Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice","volume":"56","author":"Bettoni","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2012.10.014_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1089\/neu.1999.16.153","article-title":"Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury","volume":"16","author":"Bien","year":"1999","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2012.10.014_bib11","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1523\/JNEUROSCI.3027-07.2007","article-title":"Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury","volume":"27","author":"Boivin","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.014_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2006.12.057","article-title":"Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice","volume":"353","author":"Cao","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2012.10.014_bib13","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1161\/CIRCULATIONAHA.106.603431","article-title":"Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke","volume":"115","author":"Caso","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2012.10.014_bib14","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1523\/JNEUROSCI.4268-04.2005","article-title":"Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines","volume":"25","author":"Chakravarty","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.014_bib15","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1248\/bpb.32.1665","article-title":"Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice","volume":"32","author":"Gao","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.brainres.2012.10.014_bib16","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1038\/sj.onc.1209943","article-title":"NF-kappaB and the immune response","volume":"25","author":"Hayden","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.brainres.2012.10.014_bib17","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/intimm\/dxf089","article-title":"Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation","volume":"14","author":"Hoshino","year":"2002","journal-title":"Int. Immunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jneuroim.2007.08.014","article-title":"Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia\/reperfusion","volume":"190","author":"Hua","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1460-9568.2008.06321.x","article-title":"Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)","volume":"28","author":"Hutchinson","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2012.10.014_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-2094-5-23","article-title":"Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease","volume":"5","author":"Jin","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2012.10.014_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1074-7613(00)80086-2","article-title":"Unresponsiveness of MyD88-deficient mice to endotoxin","volume":"11","author":"Kawai","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.brainres.2012.10.014_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1471-4159.2007.04524.x","article-title":"Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury","volume":"102","author":"Kigerl","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2012.10.014_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1085\/jgp.200409062","article-title":"Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments","volume":"124","author":"Kindzelskii","year":"2004","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.brainres.2012.10.014_bib24","first-page":"1095","article-title":"Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6","volume":"5","author":"Lord","year":"1990","journal-title":"Oncogene"},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2012.10.014_bib25","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.1038\/sj.bjp.0706400","article-title":"The role of inflammation in CNS injury and disease","volume":"147","author":"Lucas","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.10.014_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1742-2094-5-53","article-title":"Expression and distribution of Toll-like receptors 11\u201313 in the brain during murine neurocysticercosis","volume":"5","author":"Mishra","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2012.10.014_bib27","first-page":"47","article-title":"Signal transduction pathways activated by the IL-1 receptor\/toll-like receptor superfamily","volume":"270","author":"O'Neill","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.brainresrev.2008.09.001","article-title":"Toll-like receptors in neurodegeneration","volume":"59","author":"Okun","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainres.2012.10.014_bib29","first-page":"105","article-title":"Toll-like receptors in neurodegeneration","volume":"336","author":"Owens","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jneuroim.2010.07.022","article-title":"Photoreceptor cells constitutively express functional TLR4","volume":"230","author":"Tu","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0079-6123(09)17509-X","article-title":"Toll-like receptors in the CNS: implications for neurodegeneration and repair","volume":"175","author":"van Noort","year":"2009","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2012.10.014_bib31","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1159\/000110455","article-title":"Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease","volume":"20","author":"Walter","year":"2007","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.brainres.2012.10.014_bib32","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.brainres.2012.10.014_bib33","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/ni986","article-title":"TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway","volume":"4","author":"Yamamoto","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.brainres.2012.10.014_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00011-006-6035-9","article-title":"Expression of Toll-like receptor 4 in the brain in a rabbit experimental subarachnoid haemorrhage model","volume":"56","author":"Zhou","year":"2007","journal-title":"Inflamm. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312016435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312016435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T13:37:49Z","timestamp":1643549869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899312016435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":35,"alternative-id":["S0006899312016435"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2012.10.014","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}