{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:19:27Z","timestamp":1783210767951,"version":"3.54.6"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.brainres.2012.11.030","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T03:52:02Z","timestamp":1353642722000},"page":"19-26","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Impairment of fear memory consolidation and expression by antihistamines"],"prefix":"10.1016","volume":"1493","author":[{"given":"Ayako","family":"Nonaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2012.11.030_bib1","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1523\/JNEUROSCI.22-12-05239.2002","article-title":"NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala","volume":"22","author":"Bauer","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.11.030_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1517\/14656566.9.3.351","article-title":"Pharmacotherapy of insomnia","volume":"9","author":"Bhat","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.brainres.2012.11.030_bib3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1124\/dmd.31.3.312","article-title":"P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists","volume":"31","author":"Chen","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.brainres.2012.11.030_bib4","first-page":"609","article-title":"Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats","volume":"22","author":"Chen","year":"2001","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2012.11.030_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature09559","article-title":"Encoding of conditioned fear in central amygdala inhibitory circuits","volume":"468","author":"Ciocchi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2012.11.030_bib6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1124\/dmd.105.007211","article-title":"Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu)","volume":"34","author":"Gupta","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.brainres.2012.11.030_bib7","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/sj.bjp.0707318","article-title":"Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig","volume":"151","author":"Gupta","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.11.030_bib8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2165\/00003495-200666070-00017","article-title":"Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies","volume":"66","author":"Hair","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.brainres.2012.11.030_bib9","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbr.2010.05.032","article-title":"Different effects of scopolamine on the retrieval of spatial memory and fear memory","volume":"221","author":"Huang","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2012.11.030_bib10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2500\/aap.2010.31.3317","article-title":"Comprehensive review of olopatadine: the molecule and its clinical entities","volume":"31","author":"Kaliner","year":"2010","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.brainres.2012.11.030_bib11","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1073\/pnas.92.12.5734","article-title":"Somatodendritic expression of an immediate early gene is regulated by synaptic activity","volume":"92","author":"Link","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.brainres.2012.11.030_bib12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0896-6273(95)90299-6","article-title":"Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites","volume":"14","author":"Lyford","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.11.030_bib13","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/npp.2010.53","article-title":"Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory","volume":"35","author":"Makkar","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2012.11.030_bib14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.neuro.24.1.897","article-title":"Neurobiology of Pavlovian fear conditioning","volume":"24","author":"Maren","year":"2001","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2012.11.030_bib15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2012.11.030_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejphar.2006.03.046","article-title":"Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats","volume":"539","author":"Masuoka","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.11.030_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2007.08.020","article-title":"Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats","volume":"576","author":"Masuoka","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2012.11.030_bib18","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1101\/lm.279006","article-title":"The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice","volume":"13","author":"McKinney","year":"2006","journal-title":"Learn. Membr."},{"key":"10.1016\/j.brainres.2012.11.030_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2133\/dmpk.23.106","article-title":"P-glycoprotein limits the brain penetration of olopatadine hydrochloride, H1-receptor antagonist","volume":"23","author":"Mimura","year":"2008","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.brainres.2012.11.030_bib20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/sj.mp.4001939","article-title":"Mechanisms of fear extinction","volume":"12","author":"Myers","year":"2007","journal-title":"Mol. Psychiatry."},{"key":"10.1016\/j.brainres.2012.11.030_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1046\/j.1440-1681.2003.03791.x","article-title":"Effects of second-generation histamine H1 receptor antagonists on the active avoidance response in rats","volume":"30","author":"Nishiga","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.brainres.2012.11.030_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0149-2918(97)80071-9","article-title":"Sedative effects of antihistamines: safety, performance, learning, and quality of life","volume":"19","author":"Nolen","year":"1997","journal-title":"Clin. Ther."},{"key":"10.1016\/j.brainres.2012.11.030_bib23","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1038\/npp.2008.13","article-title":"Ethanol enhances reactivated fear memories","volume":"33","author":"Nomura","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2012.11.030_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroimage.2011.12.022","article-title":"Memory coding in plastic neuronal subpopulations within the amygdala","volume":"60","author":"Nomura","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2012.11.030_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pbb.2011.12.011","article-title":"Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study","volume":"101","author":"Panhelainen","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"Suppl. 2","key":"10.1016\/j.brainres.2012.11.030_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2222.1990.tb02456.x","article-title":"The pharmacology and mechanisms of action of histamine H1-antagonists","volume":"20","author":"Rimmer","year":"1990","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.brainres.2012.11.030_bib27","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1523\/JNEUROSCI.22-12-05219.2002","article-title":"The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala","volume":"22","author":"Rodrigues","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.11.030_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuron.2004.09.014","article-title":"Molecular mechanisms underlying emotional learning and memory in the lateral amygdala","volume":"44","author":"Rodrigues","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2012.11.030_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000028353","article-title":"Differential effect of antiallergic drugs on IgE-mediated cutaneous reaction in passively sensitized mice","volume":"60","author":"Satoh","year":"2000","journal-title":"Pharmacology"},{"key":"10.1016\/j.brainres.2012.11.030_bib30","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1523\/JNEUROSCI.20-21-08177.2000","article-title":"Activation of ERK\/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning","volume":"20","author":"Schafe","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2012.11.030_bib31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0166-2236(00)01969-X","article-title":"Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective","volume":"24","author":"Schafe","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2012.11.030_bib32","first-page":"1213","article-title":"Motion sickness: advances in pathogenesis, prediction, prevention, and treatment","volume":"77","author":"Shupak","year":"2006","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainres.2012.11.030_bib33","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1056\/NEJM199406093302307","article-title":"The pharmacology and use of H1-receptor-antagonist drugs","volume":"330","author":"Simons","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2012.11.030_bib34","doi-asserted-by":"crossref","first-page":"683961","DOI":"10.1155\/2011\/683961","article-title":"Associative memory storage and retrieval: involvement of theta oscillations in hippocampal information processing","volume":"2011","author":"Stella","year":"2011","journal-title":"Neural Plasticity"},{"key":"10.1016\/j.brainres.2012.11.030_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000086272","article-title":"Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice","volume":"75","author":"Tamura","year":"2005","journal-title":"Pharmacology"},{"key":"10.1016\/j.brainres.2012.11.030_bib36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1081-1206(10)63435-7","article-title":"Effects of semprex-D and diphenhydramine on learning in young adults with seasonal allergic rhinitis","volume":"76","author":"Vuurman","year":"1996","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.brainres.2012.11.030_bib37","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2007.03.034","article-title":"Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study","volume":"120","author":"Walker","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.brainres.2012.11.030_bib38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1101\/lm.90005","article-title":"Mapping neuronal activation and the influence of adrenergic signaling during contextual memory retrieval","volume":"12","author":"Zhang","year":"2005","journal-title":"Learn. Membr."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312018240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899312018240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T00:40:47Z","timestamp":1562373647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899312018240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":38,"alternative-id":["S0006899312018240"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2012.11.030","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}