{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:31:14Z","timestamp":1791307874186,"version":"4.3.1"},"reference-count":67,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.brainres.2014.01.008","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T20:32:45Z","timestamp":1390854765000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Neurotoxicity of coral snake phospholipases A2 in cultured rat hippocampal neurons"],"prefix":"10.1016","volume":"1552","author":[{"given":"Nathalia Delazeri","family":"de Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael CaioTamborelli","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilson","family":"Kleber Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rodrigo Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Carlos Cassola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durvanei","family":"Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Lebrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Mendes Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Castro Afeche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Marcourakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina Lopes","family":"Sandoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2014.01.008_bib1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0006-8993(99)01421-3","article-title":"Both oxidative stress-dependent and independent effects of amyloid \u03b2 protein are detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay","volume":"830","author":"Abe","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0896-6273(95)90186-8","article-title":"Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function","volume":"15","author":"Ankarcrona","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2014.01.008_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0006-8993(77)90594-7","article-title":"Rat hippocampal neurons in dispersed cell culture","volume":"126","author":"Banker","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1089\/neu.1995.12.791","article-title":"Mediators of injury in neurotrauma: intracellular signal transduction and gene expression","volume":"12","author":"Bazan","year":"1995","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2014.01.008_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0079-6123(08)63215-X","article-title":"The neuromessenger platelet-activating factor in plasticity and neurodegeneration","volume":"118","author":"Bazan","year":"1998","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10930-005-7838-1","article-title":"Determination of the amino acid sequence of a new phospholipase A(2) (MIDCA1) isolated from Micrurus dumerilii carinicauda venom","volume":"24","author":"Belo","year":"2005","journal-title":"Protein J."},{"key":"10.1016\/j.brainres.2014.01.008_bib7","doi-asserted-by":"crossref","first-page":"7162","DOI":"10.1073\/pnas.92.16.7162","article-title":"Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide\/superoxide in cortical cell cultures","volume":"92","author":"Bonfoco","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2014.01.008_bib8","series-title":"Electron Microscopy. Principles and Techniques for Biologists","author":"Bozzola","year":"1998"},{"key":"10.1016\/j.brainres.2014.01.008_bib9","first-page":"394","article-title":"Neurotoxins from the South American rattle snake venom","volume":"71","author":"Brazil","year":"1972","journal-title":"Taiwan Yi Xue Hui Za Zhi"},{"key":"10.1016\/j.brainres.2014.01.008_bib10","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.jprot.2011.07.011","article-title":"Venomic analysis and evaluation of antivenom cross-reactivity of South American Micrurus species","volume":"74","author":"Ciscotto","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1016\/j.brainres.2014.01.008_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0006-8993(95)00720-B","article-title":"Phospholipase A2-induced neurotoxicity in vitro and in vivo in rats","volume":"693","author":"Clapp","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib12","first-page":"9","article-title":"Anti-apoptotic genes of baculoviruses","volume":"3","author":"Clem","year":"1996","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainres.2014.01.008_bib13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/ana.410380612","article-title":"Neuromuscular effects of Papuan Taipan snake venom","volume":"38","author":"Connolly","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2014.01.008_bib14","first-page":"117","article-title":"Comparative chromatography of Brazilian coral snake (Micrurus) venoms","volume":"100","author":"Da Silva Junior","year":"1991"},{"key":"10.1016\/j.brainres.2014.01.008_bib15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0006-2952(01)00896-6","article-title":"Inhibition of crotoxin phospholipase A(2) activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex","volume":"63","author":"Dorandeu","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2014.01.008_bib16","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00204-010-0631-8","article-title":"Purification and characterization of a cytotoxic neurotoxin-like protein from Naja haje haje venom that induces mitochondrial apoptosis pathway","volume":"85","author":"El Hakim","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.brainres.2014.01.008_bib17","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1021\/pr101091a","article-title":"Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)","volume":"10","author":"Fernandez","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib18","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.brainres.2014.01.008_bib19","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0041-0101(97)00031-7","article-title":"Toxins isolated from the venom of the Brazilian coral snake (Micrurus frontalis frontalis) include hemorrhagic type phospholipases A2 and postsynaptic neurotoxins","volume":"35","author":"Francis","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.brainres.2014.01.008_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1600-0773.1996.tb01386.x","article-title":"Effects on behaviour and EEG of single chain phospholipases A2 from snake and bee venoms injected into rat brain: search for a functional antagonism","volume":"78","author":"Gandolfo","year":"1996","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.brainres.2014.01.008_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfs140","article-title":"The neurotoxicity of anhydroecgonine methyl ester, a crack cocaine pyrolysis product","author":"Garcia","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.brainres.2014.01.008_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3940(79)90117-4","article-title":"Neuronal degeneration induced by stereotaxic injection of beta-bungarotoxin into rat brain","volume":"11","author":"Hanley","year":"1979","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2014.01.008_bib23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1046\/j.0953-816x.2001.01699.x","article-title":"Beta-bungarotoxin is a potent inducer of apoptosis in cultured rat neurons by receptor-mediated internalization","volume":"14","author":"Herkert","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2014.01.008_bib24","doi-asserted-by":"crossref","first-page":"18321","DOI":"10.1074\/jbc.M008837200","article-title":"A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells","volume":"276","author":"Ho","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2014.01.008_bib25","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1523\/JNEUROSCI.06-10-03044.1986","article-title":"Primary culture of identified neurons from the visual cortex of postnatal rats","volume":"6","author":"Huettner","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2014.01.008_bib26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2003.12.046","article-title":"Glucose insufficiency alters neuronal viability and increases susceptibility to glutamate toxicity","volume":"1004","author":"Ioudina","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/325522a0","article-title":"Glutamate activates multiple single channel conductances in hippocampal neurons","volume":"325","author":"Jahr","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2014.01.008_bib28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2005.03.054","article-title":"Neuroprotective effect of N-acetyl cysteine on hypoxia-induced oxidative stress in primary hippocampal culture","volume":"1046","author":"Jayalakshmi","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11373-006-9142-2","article-title":"Genistein and daidzein induce neurotoxicity at high concentrations in primary rat neuronal cultures","volume":"14","author":"Jin","year":"2007","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.brainres.2014.01.008_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/jb\/mvg187","article-title":"Isolation, toxicity and amino terminal sequences of three major neurotoxins in the venom of Malayan krait (Bungarus candidus) from Thailand","volume":"134","author":"Khow","year":"2003","journal-title":"J. Biochem."},{"key":"10.1016\/j.brainres.2014.01.008_bib31","series-title":"Venom Phospolipase A2 Enzymes: Structure, Function and Mechanism","first-page":"1","article-title":"Phospholipase A2 \u2013 a complex multifunctional protein puzzle","author":"Kini","year":"1997"},{"key":"10.1016\/j.brainres.2014.01.008_bib32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0304-3940(99)00709-0","article-title":"Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo","volume":"274","author":"Kolko","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2014.01.008_bib33","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1097\/00001756-200210280-00026","article-title":"Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors","volume":"13","author":"Kolko","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2014.01.008_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0304-3940(02)01385-X","article-title":"Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture","volume":"338","author":"Kolko","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2014.01.008_bib35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nbt1095","article-title":"Baculovirus as versatile vectors for protein expression in insect and mammalian cells","volume":"23","author":"Kost","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.brainres.2014.01.008_bib36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0165-6147(99)01300-0","article-title":"Receptors for a growing family of secreted phospholipases A2","volume":"20","author":"Lambeau","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2014.01.008_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5607\/en.2012.21.1.1","article-title":"Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival?","volume":"21","author":"Lee","year":"2012","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.brainres.2014.01.008_bib38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neuroscience.2012.03.004","article-title":"Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells","volume":"210","author":"Lin","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2014.01.008_bib39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1471-4159.1997.69020581.x","article-title":"Mechanism of cellular 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction","volume":"69","author":"Liu","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2014.01.008_bib40","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/j.biocel.2004.04.011","article-title":"Apoptosis, autophagy, and more","volume":"36","author":"Lockshin","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2014.01.008_bib41","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10529-010-0227-7","article-title":"High-level expression of functional recombinant human coagulation factor VII in insect cells","volume":"32","author":"Masroori","year":"2010","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.brainres.2014.01.008_bib42","series-title":"Snakes Ecology and Evolutionary Biology","first-page":"3","article-title":"Systematics","author":"McDowell","year":"1987"},{"key":"10.1016\/j.brainres.2014.01.008_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00762386","article-title":"Induction of apoptosis in oxygen-deprived cultures of hybridoma cells","volume":"15","author":"Mercille","year":"1994","journal-title":"Cytotechnology"},{"key":"10.1016\/j.brainres.2014.01.008_bib44","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s00018-008-8113-3","article-title":"Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action","volume":"65","author":"Montecucco","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.brainres.2014.01.008_bib45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.brainres.2014.01.008_bib46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.brainresbull.2007.10.007","article-title":"Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: behavioral, electroencephalographic, and neuropathological aspects","volume":"75","author":"Oliveira","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2014.01.008_bib47","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1471-4159.2009.06365.x","article-title":"Mass spectrometry analysis of the phospholipase A(2) activity of snake pre-synaptic neurotoxins in cultured neurons","volume":"111","author":"Paoli","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2014.01.008_bib48","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/brain\/awh642","article-title":"Envenoming bites by kraits: the biological basis of treatment-resistant neuromuscular paralysis","volume":"128","author":"Prasarnpun","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2014.01.008_bib49","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.bbamcr.2008.01.011","article-title":"A presynaptically toxic secreted phospholipase A2 is internalized into motoneuron-like cells where it is rapidly translocated into the cytosol","volume":"1783","author":"Praznikar","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2014.01.008_bib50","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.biochi.2006.06.008","article-title":"Binding to the high-affinity M-type receptor for secreted phospholipases A(2) is not obligatory for the presynaptic neurotoxicity of ammodytoxin A","volume":"88","author":"Prijatelj","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.brainres.2014.01.008_bib51","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.toxicon.2007.07.025","article-title":"Understanding the molecular mechanism underlying the presynaptic toxicity of secreted phospholipases A2","volume":"50","author":"Pungercar","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.brainres.2014.01.008_bib52","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1242\/jcs.01218","article-title":"Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles","volume":"117","author":"Rigoni","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2014.01.008_bib53","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1242\/jcs.01218","article-title":"Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles","volume":"117","author":"Rigoni","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2014.01.008_bib54","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.1120640","article-title":"Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures","volume":"310","author":"Rigoni","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.brainres.2014.01.008_bib55","doi-asserted-by":"crossref","first-page":"34013","DOI":"10.1074\/jbc.M803243200","article-title":"Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores","volume":"283","author":"Rigoni","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2014.01.008_bib56","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/j.1471-4159.2006.03965.x","article-title":"Presynaptic enzymatic neurotoxins","volume":"97","author":"Rossetto","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2014.01.008_bib57","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1432-1033.1996.0231q.x","article-title":"Characterization of alpha-neurotoxin and phospholipase A2 activities from Micrurus venoms. Determination of the amino acid sequence and receptor-binding ability of the major alpha-neurotoxin from Micrurus nigrocinctus nigrocinctus","volume":"238","author":"Rosso","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.brainres.2014.01.008_bib58","doi-asserted-by":"crossref","first-page":"11494","DOI":"10.1021\/bi0349930","article-title":"Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity","volume":"42","author":"Rouault","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2014.01.008_bib59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1079\/PNS19960031","article-title":"Neural integration of tissue and whole-animal regulation of digestive secretions","volume":"55","author":"Roze","year":"1996","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.brainres.2014.01.008_bib60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0006-3495(99)77214-0","article-title":"Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives","volume":"76","author":"Scaduto","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.brainres.2014.01.008_bib61","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1152\/physrev.2000.80.2.717","article-title":"Neurotoxins affecting neuroexocytosis","volume":"80","author":"Schiavo","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2014.01.008_bib62","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1046\/j.1471-4159.2003.02035.x","article-title":"Induction by beta-bungarotoxin of apoptosis in cultured hippocampal neurons is mediated by Ca(2+)-dependent formation of reactive oxygen species","volume":"87","author":"Shakhman","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2014.01.008_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2005.09.033","article-title":"Dissociated primary nerve cell cultures as models for assessment of neurotoxicity","volume":"163","author":"Silva","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.brainres.2014.01.008_bib64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3858\/emm.2012.44.2.031","article-title":"Neuronal autophagy and neurodegenerative diseases","volume":"44","author":"Son","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.brainres.2014.01.008_bib65","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/jnr.10318","article-title":"Long-term lithium treatment prevents neurotoxic effects of beta-bungarotoxin in primary cultured neurons","volume":"69","author":"Tseng","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2014.01.008_bib66","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0006-2952(02)01477-6","article-title":"Neuronal death signaling by beta-bungarotoxin through the activation of the N-methyl-D-aspartate (NMDA) receptor and L-type calcium channel","volume":"65","author":"Tseng","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2014.01.008_bib67","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/pgp.0b013e31803025cd","article-title":"Significantly greater expression of ER, PR, and ECAD in advanced-stage low-grade ovarian serous carcinoma as revealed by immunohistochemical analysis","volume":"26","author":"Wong","year":"2007","journal-title":"Int. J. Gynecol. Pathol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314000407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314000407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T02:23:49Z","timestamp":1565144629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899314000407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":67,"alternative-id":["S0006899314000407"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2014.01.008","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurotoxicity of coral snake phospholipases A2 in cultured rat hippocampal neurons","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2014.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}