{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:25:43Z","timestamp":1787682343842,"version":"build-2784847793"},"reference-count":31,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.brainres.2014.03.034","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T20:00:17Z","timestamp":1396641617000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["KCC2 expression changes in Diazepam-treated neonatal rats with hypoxia-ischaemia brain damage"],"prefix":"10.1016","volume":"1563","author":[{"given":"Jun-Yuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Pei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Bin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2014.03.034_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejphar.2012.08.004","article-title":"A comparison of the effects of digoxin, ouabain and milrinone on naloxone-precipitated withdrawal syndrome in mice","volume":"694","author":"Bai","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2014.03.034_bib2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2009.03.003","article-title":"Cation-chloride cotransporters and neuronal function","volume":"61","author":"Blaesse","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2014.03.034_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2008.05.077","article-title":"Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model","volume":"441","author":"Cai","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2014.03.034_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.nbd.2011.04.010","article-title":"The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection","volume":"43","author":"Chip","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2014.03.034_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.expneurol.2008.08.018","article-title":"Diazepam delays the death of hippocampal CA1 neurons following global ischemia","volume":"214","author":"Corbett","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2014.03.034_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2012.09.014","article-title":"Activations of GABAergic signaling, HSP70 and MAPK cascades are involved in baicalin\u05f3s neuroprotection against gerbil global ischemia\/reperfusion injury","volume":"90","author":"Dai","year":"2013","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2014.03.034_bib7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1203\/PDR.0b013e31819ed5c8","article-title":"Hemispheric brain injury and behavioral deficits induced by severe neonatal hypoxia-ischemia in rats are not attenuated by intravenous administration of human umbilical cord blood cells","volume":"65","author":"de Paula","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2014.03.034_bib8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D\u05f3Hooge","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.brainres.2014.03.034_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(99)01229-9","article-title":"Diazepam-induced neuroprotection: dissociating the effects of hypothermia following global ischemia","volume":"829","author":"Dowden","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.03.034_bib10","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1523\/JNEUROSCI.0755-04.2004","article-title":"Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam","volume":"24","author":"Galeffi","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2014.03.034_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neulet.2011.10.027","article-title":"Effects of neotrofin on neonatal hypoxic ischemic brain injury","volume":"505","author":"Gencpinar","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2014.03.034_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0197-0186(91)90043-D","article-title":"Effect of pre- and post-treatments with diazepam on the rat brain GABAergic system during anoxic stress and recovery","volume":"18","author":"Goswami","year":"1991","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2014.03.034_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijdevneu.2007.09.004","article-title":"Long-term histological outcome after post-hypoxic treatment with 100% or 40% oxygen in a model of perinatal hypoxic-ischemic brain injury","volume":"26","author":"Grafe","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainres.2014.03.034_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.03.009","article-title":"Depression of neuronal activity by sedatives is associated with adverse effects after brain injury","volume":"1510","author":"Hertle","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.03.034_bib15","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1161\/STROKEAHA.109.570424","article-title":"Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia","volume":"41","author":"Jaenisch","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2014.03.034_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2007.12.039","article-title":"Mechanism of hyperbaric oxygen preconditioning in neonatal hypoxia-ischemia rat model","volume":"1196","author":"Li","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.03.034_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD009622.pub2","article-title":"Gamma aminobutyric acid (GABA) receptor agonists for acute stroke","volume":"2","author":"Liu","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.brainres.2014.03.034_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000090210","article-title":"Diazepam to improve acute stroke outcome: results of the early GABA-ergic activation study in stroke trial","volume":"21","author":"Lodder","year":"2006","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.brainres.2014.03.034_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuint.2011.10.015","article-title":"Topiramate attenuates cerebral ischemia\/reperfusion injury in gerbils via activating GABAergic signaling and inhibiting astrogliosis","volume":"60","author":"Mao","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2014.03.034_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neures.2008.08.005","article-title":"Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons","volume":"62","author":"Ooba","year":"2008","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2014.03.034_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neures.2008.08.005","article-title":"Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons","volume":"62","author":"Ooba","year":"2008","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2014.03.034_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2014.03.034_bib23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuint.2009.01.024","article-title":"Diazepam neuroprotection in excitotoxic and oxidative stress involves a mitochondrial mechanism additional to the GABAAR and hypothermic effects","volume":"55","author":"Sarnowska","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2014.03.034_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuint.2009.01.024","article-title":"Diazepam neuroprotection in excitotoxic and oxidative stress involves a mitochondrial mechanism additional to the GABAAR and hypothermic effects","volume":"55","author":"Sarnowska","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2014.03.034_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(94)91411-7","article-title":"Postischemic diazepam is neuroprotective in the gerbil hippocampus","volume":"647","author":"Schwartz","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.03.034_bib26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neurobiolaging.2008.05.023","article-title":"Inter-age variability of bona fide unvaried transcripts Normalization of quantitative PCR data in ischemic stroke","volume":"31","author":"Sieber","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2014.03.034_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jneumeth.2010.08.020","article-title":"Comparative evaluation of hypoxic-ischemic brain injury by flow cytometric analysis of mitochondrial membrane potential with JC-1 in neonatal rats","volume":"193","author":"Sung","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2014.03.034_bib28","first-page":"4","article-title":"Benzodizepines: biochemistry of function","author":"Tallman","year":"1980","journal-title":"NIDA Res. Monogr."},{"key":"10.1016\/j.brainres.2014.03.034_bib29","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2014.03.034_bib30","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/j.1460-9568.2005.03975.x","article-title":"Differential expression of KCC2 accounts for the differential GABA responses between relay and intrinsic neurons in the early postnatal rat olfactory bulb","volume":"21","author":"Wang","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2014.03.034_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.08.002","article-title":"Ginseng derivative ocotillol enhances neuronal activity through increased glutamate release: a possible mechanism underlying increased spontaneous locomotor activity of mice","volume":"195","author":"Wang","year":"2011","journal-title":"Neuroscience"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314004120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314004120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T07:00:10Z","timestamp":1565334010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899314004120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":31,"alternative-id":["S0006899314004120"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2014.03.034","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KCC2 expression changes in Diazepam-treated neonatal rats with hypoxia-ischaemia brain damage","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2014.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}