{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:09:30Z","timestamp":1791086970162,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.brainres.2014.06.008","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T14:31:11Z","timestamp":1402583471000},"page":"60-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["GILZ: Glitzing up our understanding of the glucocorticoid receptor in psychopathology"],"prefix":"10.1016","volume":"1574","author":[{"given":"Angeline S.","family":"Thiagarajah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Eades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabakar R.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma K.","family":"Guymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric F.","family":"Morand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Leech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2014.06.008_bib1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0165-0173(02)00182-0","article-title":"Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei","volume":"39","author":"Adell","year":"2002","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainres.2014.06.008_bib2","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1210\/jc.2004-1667","article-title":"Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications","volume":"90","author":"Alesci","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2014.06.008_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0447.2007.00965.x","article-title":"Melancholia and atypical depression in the Zurich study: epidemiology, clinical characteristics, course, comorbidity and personality","volume":"115","author":"Angst","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.brainres.2014.06.008_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.immunol.18.1.309","article-title":"Glucocorticoids in T cell development and function","volume":"18","author":"Ashwell","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.brainres.2014.06.008_bib5","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1210\/me.2004-0206","article-title":"FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced leucine zipper expression","volume":"19","author":"Asselin-Labat","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.brainres.2014.06.008_bib6","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1182\/blood.V98.3.743","article-title":"Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB","volume":"98","author":"Ayroldi","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2014.06.008_bib7","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1096\/fj.09-134684","article-title":"Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action","volume":"23","author":"Ayroldi","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.brainres.2014.06.008_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.physbeh.2009.10.019","article-title":"Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior","volume":"100","author":"Bandaru","year":"2010","journal-title":"Physiol. Behav"},{"key":"10.1016\/j.brainres.2014.06.008_bib9","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1002\/art.27566","article-title":"Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis","volume":"62","author":"Beaulieu","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.brainres.2014.06.008_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1073\/pnas.0406458102","article-title":"Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior","volume":"102","author":"Boyle","year":"2005","journal-title":"Proc. Nat. Acad. Sci. U.S.A"},{"key":"10.1016\/j.brainres.2014.06.008_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(92)90459-M","article-title":"The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications","volume":"572","author":"Brady","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.brainres.2014.06.008_bib12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1468-1331.2010.03203.x","article-title":"Efficacy of very-low-dose betamethasone on neurological symptoms in ataxia-telangiectasia","volume":"18","author":"Broccoletti","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.brainres.2014.06.008_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1749-6632.2009.04981.x","article-title":"Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy","volume":"1179","author":"Brown","year":"2009","journal-title":"Ann. N.Y. Acad. Sci.."},{"key":"10.1016\/j.brainres.2014.06.008_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1037\/0033-2909.117.2.285","article-title":"Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity","volume":"117","author":"Burt","year":"1995","journal-title":"Psychol. Bull"},{"key":"10.1016\/j.brainres.2014.06.008_bib15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1053\/j.gastro.2008.09.024","article-title":"Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis","volume":"136","author":"Cannarile","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.brainres.2014.06.008_bib16","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1600-0447.2011.01821.x","article-title":"Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback","volume":"125","author":"Carroll","year":"2012","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.brainres.2014.06.008_bib17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3999(02)00304-5","article-title":"Depression and public health: an overview","volume":"53","author":"Cassano","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.brainres.2014.06.008_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mce.2007.04.013","article-title":"Anti-inflammatory functions of glucocorticoid-induced genes","volume":"275","author":"Clark","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.brainres.2014.06.008_bib19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1074-7613(00)80398-2","article-title":"A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR\/CD3-activated cell death","volume":"7","author":"D\u2019Adamio","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.brainres.2014.06.008_bib20","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.biopsych.2006.05.034","article-title":"Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression","volume":"60","author":"DeBattista","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"Suppl.","key":"10.1016\/j.brainres.2014.06.008_bib21","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.bbi.2013.07.093","article-title":"81. IFN-alpha and IL-6 reduce glucocorticoid sensitivity in murine microglia: a role for FKBP5?","volume":"32","author":"Fagan","year":"2013","journal-title":"Brain Behav. Immun"},{"key":"10.1016\/j.brainres.2014.06.008_bib22","series-title":"Glucocorticoids\u2014New recognition of Our Familiar Friend","article-title":"The role of GILZ in anti-inflammatory and immunosuppressive actions of glucocorticoids","author":"Fan","year":"2012"},{"key":"10.1016\/j.brainres.2014.06.008_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0960-0760(91)90171-Z","article-title":"Effects of adrenal steroids and their reduced metabolites on hippocampal long-term potentiation","volume":"40","author":"Filioini","year":"1991","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.brainres.2014.06.008_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1742-4658.2006.05569.x","article-title":"Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress","volume":"274","author":"Fiol","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.brainres.2014.06.008_bib25","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1038\/tp.2012.14","article-title":"Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder","volume":"2","author":"Frodl","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib26","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00296-010-1713-x","article-title":"Individuals with fibromyalgia and depression: findings from a nationally representative Canadian survey","volume":"32","author":"Fuller-Thomson","year":"2012","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.brainres.2014.06.008_bib27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/sj.mp.4001032","article-title":"Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH\/NE states","volume":"7","author":"Gold","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jad.2005.05.007","article-title":"Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene","volume":"87","author":"Gonda","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2014.06.008_bib29","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1176\/ajp.142.11.1278","article-title":"Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test","volume":"142","author":"Gormley","year":"1985","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1182\/blood-2006-10-052506","article-title":"Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper","volume":"110","author":"Hamdi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2014.06.008_bib31","series-title":"Sympathetic Nervous System Mediated Alterations in the Immunological and Behavioral Effects of Social Defeat. In Integrated Biomedical Science Graduate Program","first-page":"160","author":"Hanke","year":"2010"},{"key":"10.1016\/j.brainres.2014.06.008_bib32","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1002\/hbm.21409","article-title":"Dynamically changing effects of corticosteroids on human hippocampal and prefrontal processing","volume":"33","author":"Henckens","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.brainres.2014.06.008_bib33","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Herman","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2014.06.008_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1520-6394(1998)8:2<71::AID-DA5>3.0.CO;2-N","article-title":"Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment","volume":"8","author":"Heuser","year":"1998","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.brainres.2014.06.008_bib35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000127023","article-title":"Altered hypothalamic\u2013pituitary\u2013adrenocortical regulation in healthy subjects at high familial risk for affective disorders","volume":"62","author":"Holsboer","year":"1995","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2014.06.008_bib36","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The corticosteroid receptor hypothesis of depression","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2014.06.008_bib37","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.4049\/jimmunol.170.9.4833","article-title":"Inhibition of IFN-gamma signaling by glucocorticoids","volume":"170","author":"Hu","year":"2003","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.brainres.2014.06.008_bib38","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.psyneuen.2010.04.016","article-title":"The prednisolone suppression test in depression: dose\u2013response and changes with antidepressant treatment","volume":"35","author":"Juruena","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2014.06.008_bib39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S0033291708003784","article-title":"A population-based twin study of functional somatic syndromes","volume":"39","author":"Kato","year":"2009","journal-title":"Psychol. Med."},{"key":"10.1016\/j.brainres.2014.06.008_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0361-9230(01)00638-4","article-title":"Corticosteroid receptors in the brain: gene targeting studies","volume":"57","author":"Kellendonk","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2014.06.008_bib41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jpsychires.2010.12.002","article-title":"Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder","volume":"45","author":"Klok","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.brainres.2014.06.008_bib42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jsbmb.2004.12.046","article-title":"Gene regulation by the glucocorticoid receptor: structure:function relationship","volume":"94","author":"Kumar","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol"},{"key":"10.1016\/j.brainres.2014.06.008_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J. Affect. Disord"},{"key":"10.1016\/j.brainres.2014.06.008_bib44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/271","article-title":"Cortisol levels during human aging predict hippocampal atrophy and memory deficits","volume":"1","author":"Lupien","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2014.06.008_bib45","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.psyneuen.2008.03.012","article-title":"Glucocorticoid sensitivity in fibromyalgia patients: decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipper","volume":"33","author":"Macedo","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2014.06.008_bib46","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/cyto.1997.0238","article-title":"Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression","volume":"9","author":"Maes","year":"1997","journal-title":"Cytokine"},{"key":"10.1016\/j.brainres.2014.06.008_bib47","doi-asserted-by":"crossref","DOI":"10.1186\/ar1772","article-title":"Hypothalamic\u2013pituitary\u2013adrenal stress axis function and the relationship with chronic widespread pain and its antecedents","volume":"7","author":"McBeth","year":"2005","journal-title":"Arthritis Res. Ther"},{"key":"10.1016\/j.brainres.2014.06.008_bib48","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2014.06.008_bib49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.psych.49.1.377","article-title":"Comorbidity of anxiety and unipolar mood disorders","volume":"49","author":"Mineka","year":"1998","journal-title":"Annu. Rev. Psychol"},{"key":"10.1016\/j.brainres.2014.06.008_bib50","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0893-133X(97)00144-9","article-title":"Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders","volume":"18","author":"Modell","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2014.06.008_bib51","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1046\/j.1460-9568.1998.00381.x","article-title":"Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats","volume":"10","author":"Oitzl","year":"1998","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.brainres.2014.06.008_bib52","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1523\/JNEUROSCI.17-05-01710.1997","article-title":"Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei","volume":"17","author":"Ordway","year":"1997","journal-title":"J. Neurosci. the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.brainres.2014.06.008_bib53","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","article-title":"Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment","volume":"49","author":"Pariante","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib54","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1046\/j.1365-2826.2003.01058.x","article-title":"Depression, stress and the adrenal axis","volume":"15","author":"Pariante","year":"2003","journal-title":"J. Neuroendocrinol"},{"key":"10.1016\/j.brainres.2014.06.008_bib55","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-3956(00)00035-2","article-title":"Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain","volume":"34","author":"Patel","year":"2000","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.brainres.2014.06.008_bib56","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0306-4530(91)90034-Q","article-title":"Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain","volume":"16","author":"Peiffer","year":"1991","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2014.06.008_bib57","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/0028-3908(93)90036-3","article-title":"The effect of repeated combined treatment with nifedipine and antidepressant drugs or electroconvulsive shock on the hippocampal corticosteroid receptors in rats","volume":"32","author":"Przegalinski","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2014.06.008_bib58","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1186\/ar4029","article-title":"In vitro glucocorticoid sensitivity is associated with clinical glucocorticoid therapy outcome in rheumatoid arthritis","volume":"14","author":"Quax","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.brainres.2014.06.008_bib59","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1159\/000126778","article-title":"Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients","volume":"60","author":"Raadsheer","year":"1994","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2014.06.008_bib60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0960-0760(97)00181-7","article-title":"Analysis of glucocorticoid signalling by gene targeting","volume":"65","author":"Reichardt","year":"1998","journal-title":"J. Steroid Biochem. Mol. Biol"},{"key":"10.1016\/j.brainres.2014.06.008_bib61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-2999(00)00677-4","article-title":"The brain mineralocorticoid receptor: greedy for ligand, mysterious in function","volume":"405","author":"Reul","year":"2000","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.brainres.2014.06.008_bib62","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1523\/JNEUROSCI.0736-05.2005","article-title":"Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions","volume":"25","author":"Ridder","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2014.06.008_bib63","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1084\/jem.185.7.1185","article-title":"Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection","volume":"185","author":"Ruzek","year":"1997","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.brainres.2014.06.008_bib64","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0006-8993(91)91612-5","article-title":"Distribution of glucocorticoid and mineralocorticoid receptor messenger RNA expression in human postmortem hippocampus","volume":"561","author":"Seckl","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.06.008_bib65","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1159\/000126180","article-title":"Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo","volume":"55","author":"Seckl","year":"1992","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2014.06.008_bib66","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1136\/bmj.1.4667.1383","article-title":"Stress and the general adaptation syndrome","volume":"1","author":"Selye","year":"1950","journal-title":"Br. Med. J."},{"key":"10.1016\/j.brainres.2014.06.008_bib67","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/2045125312436597","article-title":"Metyrapone in treatment-resistant depression","volume":"2","author":"Sigalas","year":"2012","journal-title":"Ther. Adv. Psychopharmacol"},{"key":"10.1016\/j.brainres.2014.06.008_bib68","doi-asserted-by":"crossref","first-page":"36303","DOI":"10.1074\/jbc.M707287200","article-title":"Differential activities of glucocorticoid-induced leucine zipper protein isoforms","volume":"282","author":"Soundararajan","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2014.06.008_bib69","doi-asserted-by":"crossref","first-page":"44799","DOI":"10.1074\/jbc.M111.279257","article-title":"Novel p65 binding glucocorticoid-induced leucine zipper peptide suppresses experimental autoimmune encephalomyelitis","volume":"286","author":"Srinivasan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2014.06.008_bib70","doi-asserted-by":"crossref","first-page":"249","DOI":"10.31887\/DCNS.2003.5.3\/lstaner","article-title":"Sleep and anxiety disorders","volume":"5","author":"Staner","year":"2003","journal-title":"Dialogues Clin. Neurosci"},{"key":"10.1016\/j.brainres.2014.06.008_bib71","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ecl.2013.05.010","article-title":"Neuropsychiatric findings in cushing syndrome and exogenous glucocorticoid administration","volume":"42","author":"Starkman","year":"2013","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.brainres.2014.06.008_bib72","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/PSY.0b013e31820ad12b","article-title":"Depression and hypothalamic\u2013pituitary\u2013adrenal activation: a quantitative summary of four decades of research","volume":"73","author":"Stetler","year":"2011","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.brainres.2014.06.008_bib73","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis, neuroendocrine factors and stress","volume":"53","author":"Tsigos","year":"2002","journal-title":"J. Psychosom. Res"},{"key":"10.1016\/j.brainres.2014.06.008_bib74","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2249.1999.00811.x","article-title":"Glucocorticoids modulate the development of dendritic cells from blood precursors","volume":"115","author":"van den Heuvel","year":"1999","journal-title":"Clin. Exp. Immunol"},{"key":"10.1016\/j.brainres.2014.06.008_bib75","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1111\/j.1471-4159.2008.05575.x","article-title":"Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain","volume":"106","author":"van der Laan","year":"2008","journal-title":"J Neurochem."},{"key":"10.1016\/j.brainres.2014.06.008_bib76","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.biopsych.2006.02.007","article-title":"Polymorphisms of the glucocorticoid receptor gene and major depression","volume":"59","author":"van Rossum","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib77","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bbi.2009.07.004","article-title":"Deployment-related severe fatigue with depressive symptoms is associated with increased glucocorticoid binding to peripheral blood mononuclear cells","volume":"23","author":"van Zuiden","year":"2009","journal-title":"Brain Behav. Immun"},{"key":"10.1016\/j.brainres.2014.06.008_bib78","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.biopsych.2011.10.026","article-title":"Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study","volume":"71","author":"van Zuiden","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib79","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/386824a0","article-title":"Subgenual prefrontal cortex abnormalities in mood disorders","volume":"386","author":"Wayne","year":"1997","journal-title":"Nature"},{"issue":"985-94","key":"10.1016\/j.brainres.2014.06.008_bib80","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/sj.mp.4001259","article-title":"Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders","volume":"7","author":"Webster","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib81","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000064430","article-title":"The amygdala regulates the pituitary-adrenocortical response and release of hypothalamic serotonin following electrical stimulation of the dorsal raphe nucleus in","volume":"76","author":"Weindenfeld","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2014.06.008_bib82","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1523\/JNEUROSCI.0450-11.2011","article-title":"\u03b2-adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat","volume":"31","author":"Wohleb","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2014.06.008_bib83","unstructured":"World Health Organisation, 2008. The Global Burden of Disease: 2004 Update. Vol., (Ed.), Geneva, Switzerland, pp. 51."},{"key":"10.1016\/j.brainres.2014.06.008_bib84","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/00048670601057759","article-title":"Levels of serum interleukin (IL)-6, IL-1\u03b2, tumour necrosis factor-\u03b1 and leptin and their correlation in depression","volume":"41","author":"Yang","year":"2007","journal-title":"Aust. N. Z. J. Psychiatry."},{"key":"10.1016\/j.brainres.2014.06.008_bib85","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0006-3223(93)90252-9","article-title":"Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders","volume":"34","author":"Yehuda","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.06.008_bib86","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2222.2008.03198.x","article-title":"Chronic rhinosinusitis with and without nasal polyps is associated with decreased expression of glucocorticoid-induced leucine zipper","volume":"39","author":"Zhang","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.brainres.2014.06.008_bib87","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1176\/ajp.156.6.949","article-title":"Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression","volume":"156","author":"Zobel","year":"1999","journal-title":"Am. J. Psychiatry"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314008117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314008117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T22:45:56Z","timestamp":1649371556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899314008117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":87,"alternative-id":["S0006899314008117"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2014.06.008","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GILZ: Glitzing up our understanding of the glucocorticoid receptor in psychopathology","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2014.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}