{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:21:26Z","timestamp":1791274886972,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.brainres.2014.07.051","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T21:47:01Z","timestamp":1407361621000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["The histone deacetylase (HDAC) inhibitor valproic acid reduces ethanol consumption and ethanol-conditioned place preference in rats"],"prefix":"10.1016","volume":"1583","author":[{"given":"Mouza","family":"Al Ameri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamma","family":"Al Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyazia","family":"Al Maamari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Bahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2014.07.051_bib1","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2174\/138161210791516440","article-title":"Safety and efficacy of baclofen in the treatment of alcohol-dependent patients","volume":"16","author":"Addolorato","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.brainres.2014.07.051_bib2","first-page":"1000120","article-title":"Epigenetic modulation of mood disorders","volume":"4","author":"Archer","year":"2013","journal-title":"J. Genet. Syndr. Gene Ther."},{"key":"10.1016\/j.brainres.2014.07.051_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12035-011-8178-0","article-title":"Neuroanatomical profile of antimaniac effects of histone deacetylases inhibitors","volume":"43","author":"Arent","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2014.07.051_bib4","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/npp.2013.65","article-title":"Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors","volume":"38","author":"Arora","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2014.07.051_bib5","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1038\/npp.2012.122","article-title":"Viral-mediated knockdown of mGluR7 in the nucleus accumbens mediates excessive alcohol drinking and increased ethanol-elicited conditioned place preference in rats","volume":"38","author":"Bahi","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2014.07.051_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00213-011-2630-8","article-title":"Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice","volume":"222","author":"Bahi","year":"2012","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2014.07.051_bib7","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1111\/ejn.12228","article-title":"Striatal modulation of BDNF expression using microRNA124a-expressing lentiviral vectors impairs ethanol-induced conditioned-place preference and voluntary alcohol consumption","volume":"38","author":"Bahi","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2014.07.051_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00213-013-3243-1","article-title":"Chronic psychosocial stress causes delayed extinction and exacerbates reinstatement of ethanol-induced conditioned place preference in mice","volume":"231","author":"Bahi","year":"2014","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2014.07.051_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1369-1600.2010.00310.x","article-title":"Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats","volume":"17","author":"Bahi","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainres.2014.07.051_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00213-013-3019-7","article-title":"Influence of the novel histamine H(3) receptor antagonist ST1283 on voluntary alcohol consumption and ethanol-induced place preference in mice","volume":"228","author":"Bahi","year":"2013","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2014.07.051_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.peptides.2013.02.008","article-title":"Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference","volume":"43","author":"Bahi","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.brainres.2014.07.051_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0376-8716(01)00163-6","article-title":"GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings","volume":"65","author":"Cousins","year":"2002","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.brainres.2014.07.051_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ng0996-98","article-title":"Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors","volume":"14","author":"Crabbe","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2014.07.051_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/epi.4.1.7604","article-title":"Chromatin learns to behave","volume":"4","author":"Crepaldi","year":"2009","journal-title":"Epigenetics"},{"key":"10.1016\/j.brainres.2014.07.051_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2013.10.028","article-title":"Epigenetics and depression: return of the repressed","volume":"155","author":"Dalton","year":"2014","journal-title":"J Affect Disord."},{"key":"10.1016\/j.brainres.2014.07.051_bib16","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"deRuijter","year":"2003","journal-title":"Biochem J."},{"key":"10.1016\/j.brainres.2014.07.051_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2006.03.037","article-title":"Picrotoxin blocks the anxiolytic- and panicolytic-like effects of sodium valproate in the rat elevated T-maze","volume":"537","author":"Dombrowski","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2014.07.051_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2014.02.012","article-title":"Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer","author":"Feng","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.brainres.2014.07.051_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2042-6410-4-1","article-title":"Sex, stress, and epigenetics: regulation of behavior in animal models of mood disorders","volume":"4","author":"Hodes","year":"2013","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.brainres.2014.07.051_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/0269881109348173","article-title":"Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition","volume":"25","author":"Host","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.brainres.2014.07.051_bib21","first-page":"389","article-title":"Biphasic modulation of cocaine-induced conditioned place preference through inhibition of histone acetyltransferase and histone deacetylase","volume":"31","author":"Hui","year":"2010","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.brainres.2014.07.051_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0741-8329(03)00068-5","article-title":"Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose","volume":"30","author":"Janak","year":"2003","journal-title":"Alcohol"},{"key":"10.1016\/j.brainres.2014.07.051_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2007.03.027","article-title":"Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice","volume":"181","author":"Kalda","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2014.07.051_bib24","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/acer.12088","article-title":"Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum","volume":"37","author":"Legastelois","year":"2013","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2014.07.051_bib25","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/0024-3205(84)90290-X","article-title":"Reversal of the anti-conflict action of valproate by various GABA and benzodiazepine antagonists","volume":"34","author":"Liljequist","year":"1984","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2014.07.051_bib26","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2165\/00023210-200216100-00003","article-title":"Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy","volume":"16","author":"Loscher","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2014.07.051_bib27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00335-009-9224-3","article-title":"Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior","volume":"20","author":"Malvaez","year":"2009","journal-title":"Mamm Genome"},{"key":"10.1016\/j.brainres.2014.07.051_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biopsych.2009.07.032","article-title":"Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference","volume":"67","author":"Malvaez","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.07.051_bib29","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bbagrm.2010.05.008","article-title":"Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions","volume":"1799","author":"Marks","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2014.07.051_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1749-6632.2010.05893.x","article-title":"The epigenetic landscape of addiction","volume":"1216","author":"Maze","year":"2011","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.brainres.2014.07.051_bib31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11920-010-0099-5","article-title":"Epigenetic regulation in substance use disorders","volume":"12","author":"McQuown","year":"2010","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.brainres.2014.07.051_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2217\/epi.13.22","article-title":"The multidimensional nature of metabolic syndrome in schizophrenia: lessons from studies of one-carbon metabolism and DNA methylation","volume":"5","author":"Misiak","year":"2013","journal-title":"Epigenomics"},{"key":"10.1016\/j.brainres.2014.07.051_bib33","article-title":"HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation","author":"Montalvo-Ortiz","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2014.07.051_bib34","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.biopsych.2013.01.012","article-title":"Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism","volume":"73","author":"Moonat","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2014.07.051_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1476-5381.2009.00526.x","article-title":"Pharmacology of epigenetics in brain disorders","volume":"159","author":"Narayan","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2014.07.051_bib36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00213-012-2672-6","article-title":"Operant, oral alcoholic beer self-administration by C57BL\/6J mice: effect of BHF177, a positive allosteric modulator of GABA(B) receptors","volume":"222","author":"Orru","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.brainres.2014.07.051_bib37","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1471-4159.2010.07149.x","article-title":"Histone deacetylase inhibition decreases preference without affecting aversion for nicotine","volume":"116","author":"Pastor","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2014.07.051_bib38","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neuropharm.2012.05.007","article-title":"Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration","volume":"63","author":"Ramaker","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2014.07.051_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pbb.2013.02.009","article-title":"The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference","volume":"106","author":"Raybuck","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2014.07.051_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/157015911795017317","article-title":"The inhibition of histone deacetylases reduces the reinstatement of cocaine-seeking behavior in rats","volume":"9","author":"Romieu","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.brainres.2014.07.051_bib41","doi-asserted-by":"crossref","first-page":"9342","DOI":"10.1523\/JNEUROSCI.0379-08.2008","article-title":"Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats","volume":"28","author":"Romieu","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2014.07.051_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145714001047","article-title":"Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours","author":"Sakharkar","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2014.07.051_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1530-0277.2011.01581.x","article-title":"Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol","volume":"36","author":"Sakharkar","year":"2012","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2014.07.051_bib44","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuint.2013.02.001","article-title":"Effects of sodium butyrate on oxidative stress and behavioral changes induced by administration of D-AMPH","volume":"62","author":"Steckert","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2014.07.051_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/1516-4446-2013-1094","article-title":"Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania","volume":"36","author":"Stertz","year":"2014","journal-title":"Rev Bras Psiquiatr."},{"key":"10.1016\/j.brainres.2014.07.051_bib46","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/YCO.0b013e32835d8329","article-title":"Risk architecture of schizophrenia: the role of epigenetics","volume":"26","author":"Svrakic","year":"2013","journal-title":"Curr. Opin. Psychiatry."},{"key":"10.1016\/j.brainres.2014.07.051_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.alcohol.2010.07.009","article-title":"Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking","volume":"45","author":"Tanchuck","year":"2011","journal-title":"Alcohol"},{"key":"10.1016\/j.brainres.2014.07.051_bib48","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0091-3057(84)80063-5","article-title":"The role of GABA in the anticonflict action of sodium valproate and chlordiazepoxide","volume":"21","author":"Vellucci","year":"1984","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2014.07.051_bib49","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1038\/tp.2013.4","article-title":"Chromatin remodeling\u2014a novel strategy to control excessive alcohol drinking","volume":"3","author":"Warnault","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainres.2014.07.051_bib50","doi-asserted-by":"crossref","first-page":"e21100","DOI":"10.1371\/journal.pone.0021100","article-title":"Genomic analysis of individual differences in ethanol drinking: evidence for non-genetic factors in C57BL\/6 mice","volume":"6","author":"Wolstenholme","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2014.07.051_bib51","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1360-0443.2010.03321.x","article-title":"Drugs and addiction: an introduction to epigenetics","volume":"106","author":"Wong","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.brainres.2014.07.051_bib52","doi-asserted-by":"crossref","first-page":"e87915","DOI":"10.1371\/journal.pone.0087915","article-title":"Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling","volume":"9","author":"Zou","year":"2014","journal-title":"PLoS One"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314010245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314010245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T23:55:15Z","timestamp":1538351715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899314010245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":52,"alternative-id":["S0006899314010245"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2014.07.051","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The histone deacetylase (HDAC) inhibitor valproic acid reduces ethanol consumption and ethanol-conditioned place preference in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2014.07.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}