{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:21:01Z","timestamp":1773307261605,"version":"3.50.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.brainres.2014.09.022","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T03:54:14Z","timestamp":1410839654000},"page":"25-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism"],"prefix":"10.1016","volume":"1588","author":[{"given":"Justin S.","family":"Bickford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narjis F.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerelyn A.","family":"Nick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musab","family":"Al-Yahia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn E.","family":"Beachy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Dor\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry S.","family":"Nick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2014.09.022_bib1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1139\/Y08-059","article-title":"Endothelin: 20 years from discovery to therapy","volume":"86","author":"Barton","year":"2008","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2014.09.022_bib2","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1523\/JNEUROSCI.21-14-05272.2001","article-title":"Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury","volume":"21","author":"Biernaskie","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2014.09.022_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.brainres.2014.09.022_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1471-2199-11-74","article-title":"MIQE precis: practical implementation of minimum standard guidelines for fluorescence-based quantitative real-time PCR experiments","volume":"11","author":"Bustin","year":"2010","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.brainres.2014.09.022_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1593\/tlo.09274","article-title":"Transferrin receptor 2 is frequently and highly expressed in glioblastomas","volume":"3","author":"Calzolari","year":"2010","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.brainres.2014.09.022_bib6","doi-asserted-by":"crossref","first-page":"R1412","DOI":"10.1152\/ajpregu.00003.2009","article-title":"Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion","volume":"296","author":"Cao","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.brainres.2014.09.022_bib7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/med.21251","article-title":"Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke","volume":"33","author":"Capra","year":"2013","journal-title":"Med. Res. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2014.09.022_bib8","doi-asserted-by":"crossref","first-page":"S487","DOI":"10.1097\/01.fjc.0000166307.86678.d1","article-title":"Neuroprotective effect of CGS 26303, an endothelin-converting enzyme inhibitor, on transient middle cerebral artery occlusion in rats","volume":"44","author":"Chang","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.brainres.2014.09.022_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12028-010-9413-7","article-title":"Juguloarterial endothelin-1 gradients after severe traumatic brain injury","volume":"14","author":"Chatfield","year":"2011","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.brainres.2014.09.022_bib10","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/jcbfm.2013.99","article-title":"Mechanisms of enhanced basal tone of brain parenchymal arterioles during early postischemic reperfusion: role of ET-1-induced peroxynitrite generation","volume":"33","author":"Cipolla","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2014.09.022_bib11","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1053\/j.gastro.2011.06.077","article-title":"Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe","volume":"141","author":"Corradini","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.brainres.2014.09.022_bib12","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/glia.21198","article-title":"The metabolism and toxicity of hemin in astrocytes","volume":"59","author":"Dang","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2014.09.022_bib13","doi-asserted-by":"crossref","first-page":"e25324","DOI":"10.1371\/journal.pone.0025324","article-title":"Hepcidin is involved in iron regulation in the ischemic brain","volume":"6","author":"Ding","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2014.09.022_bib14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/sj.jcbfm.9600205","article-title":"Induction of prostacyclin\/PGI2 synthase expression after cerebral ischemia-reperfusion","volume":"26","author":"Fang","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2014.09.022_bib15","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1161\/01.STR.31.12.2971","article-title":"Endothelin-1 in subarachnoid hemorrhage: an acute-phase reactant produced by cerebrospinal fluid leukocytes","volume":"31","author":"Fassbender","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2014.09.022_bib16","first-page":"263974","article-title":"Clinical trials in cardiac arrest and subarachnoid hemorrhage: lessons from the past and ideas for the future","volume":"2013","author":"Frontera","year":"2013","journal-title":"Stroke Res. Treat."},{"key":"10.1016\/j.brainres.2014.09.022_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","article-title":"Mechanisms of cell protection by heme oxygenase-1","volume":"50","author":"Gozzelino","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.brainres.2014.09.022_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.21823","article-title":"Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: putative mechanisms and novel approaches","volume":"87","author":"Kolias","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2014.09.022_bib19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00701-009-0295-4","article-title":"Prostacyclin treatment normalises the MCA flow velocity in nimodipine-resistant cerebral vasospasm after aneurysmal subarachnoid haemorrhage: a pilot study","volume":"151","author":"Koskinen","year":"2009","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.brainres.2014.09.022_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.brainres.2011.08.075","article-title":"Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats","volume":"1420","author":"Leonard","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2014.09.022_bib21","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1016\/j.febslet.2012.08.036","article-title":"Endothelin-1 induces hypoxia inducible factor 1alpha expression in pulmonary artery smooth muscle cells","volume":"586","author":"Li","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2014.09.022_bib22","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/jcbfm.2009.19","article-title":"Heme-hemopexin complex attenuates neuronal cell death and stroke damage","volume":"29","author":"Li","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2014.09.022_bib23","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.2174\/0929867043364919","article-title":"Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: pathogenesis and treatment","volume":"11","author":"Lin","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2014.09.022_bib24","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3233\/JAD-2010-091486","article-title":"Endothelin-1 is elevated in Alzheimer\u05f3s disease brain microvessels and is neuroprotective","volume":"21","author":"Luo","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2014.09.022_bib25","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/STROKEAHA.111.648980","article-title":"Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling","volume":"43","author":"Macdonald","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2014.09.022_bib26","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1212\/WNL.0b013e3182695836","article-title":"Role of the vascular endothelium and plaque in acute ischemic stroke","volume":"79","author":"Madden","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2014.09.022_bib27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tips.2004.02.008","article-title":"Historical review: Endothelin","volume":"25","author":"Masaki","year":"2004","journal-title":"Trends Pharmacol Sci."},{"key":"10.1016\/j.brainres.2014.09.022_bib28","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/hs0901.94259","article-title":"Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats","volume":"32","author":"Matsuo","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2014.09.022_bib29","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1113\/expphysiol.2011.058578","article-title":"Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke","volume":"96","author":"Mecca","year":"2011","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.brainres.2014.09.022_bib30","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1161\/STROKEAHA.107.495044","article-title":"High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA","volume":"39","author":"Moldes","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2014.09.022_bib31","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.neuropharm.2012.08.019","article-title":"Neuroprotection afforded by antagonists of endothelin-1 receptors in experimental stroke","volume":"63","author":"Moldes","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2014.09.022_bib32","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00701-009-0350-1","article-title":"Elevated level of endothelin-1 in cerebrospinal fluid and lack of nitric oxide in basilar arterial plasma associated with cerebral vasospasm after subarachnoid haemorrhage in rabbits","volume":"151","author":"Neuschmelting","year":"2009","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.brainres.2014.09.022_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbadis.2009.09.002","article-title":"Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia","volume":"1802","author":"Niizuma","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2014.09.022_bib34","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s007010070013","article-title":"Endothelin-1 initiates the development of vasospasm after subarachnoid haemorrhage through protein kinase C activation, but does not contribute to prolonged vasospasm","volume":"142","author":"Nishizawa","year":"2000","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.brainres.2014.09.022_bib35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tcm.2004.12.002","article-title":"Signaling mechanisms in cerebral vasospasm","volume":"15","author":"Nishizawa","year":"2005","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.brainres.2014.09.022_bib36","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuint.2011.11.009","article-title":"Reactive oxygen species and ischemic cerebrovascular disease","volume":"60","author":"Olmez","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2014.09.022_bib37","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3233\/JAD-2012-111760","article-title":"Endothelin-1 is elevated in Alzheimer\u05f3s disease and upregulated by amyloid-beta","volume":"29","author":"Palmer","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2014.09.022_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1306.001","article-title":"Iron metabolism and the IRE\/IRP regulatory system: an update","volume":"1012","author":"Pantopoulos","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2014.09.022_bib39","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1021\/bi300752r","article-title":"Mechanisms of mammalian iron homeostasis","volume":"51","author":"Pantopoulos","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2014.09.022_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0306-4522(02)00345-7","article-title":"Sources of endothelin-1 in hippocampus and cortex following traumatic brain injury","volume":"115","author":"Petrov","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2014.09.022_bib41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1139\/Y09-022","article-title":"Amelioration of hypoperfusion after traumatic brain injury by in vivo endothelin-1 knockout","volume":"87","author":"Petrov","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2014.09.022_bib42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresrev.2006.02.002","article-title":"Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders","volume":"52","author":"Phillis","year":"2006","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainres.2014.09.022_bib43","doi-asserted-by":"crossref","first-page":"L549","DOI":"10.1152\/ajplung.00081.2012","article-title":"Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1","volume":"304","author":"Pisarcik","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.brainres.2014.09.022_bib44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3171\/jns.1997.87.2.0287","article-title":"Source and cause of endothelin-1 release into cerebrospinal fluid after subarachnoid hemorrhage","volume":"87","author":"Pluta","year":"1997","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2014.09.022_bib45","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/00004647-200205000-00003","article-title":"Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro","volume":"22","author":"Prass","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2014.09.022_bib46","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuropharm.2013.03.025","article-title":"Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke","volume":"71","author":"Regenhardt","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2014.09.022_bib47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2220\/biomedres.30.349","article-title":"Relationship between endothelin-1 and interleukin-1beta in inflamed periodontal tissues","volume":"30","author":"Rikimaru","year":"2009","journal-title":"Biomed. Res."},{"key":"10.1016\/j.brainres.2014.09.022_bib48","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1227\/00006123-199507000-00012","article-title":"The role of endothelin in experimental cerebral vasospasm","volume":"37","author":"Roux","year":"1995","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2014.09.022_bib49","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1089\/neu.2010.1402","article-title":"Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury","volume":"27","author":"Salonia","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2014.09.022_bib50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/biof.80","article-title":"Iron in neuronal function and dysfunction","volume":"36","author":"Salvador","year":"2010","journal-title":"Biofactors"},{"key":"10.1016\/j.brainres.2014.09.022_bib51","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/ki.1994.464","article-title":"Endothelin-1 stimulates cytosolic phospholipase A2 activity and gene expression in rat glomerular mesangial cells","volume":"46","author":"Schramek","year":"1994","journal-title":"Kidney Int."},{"key":"10.1016\/j.brainres.2014.09.022_bib52","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-3-7091-1192-5_37","article-title":"Cerebral microvasculature is an early target of subarachnoid hemorrhage","volume":"115","author":"Sehba","year":"2013","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.brainres.2014.09.022_bib53","doi-asserted-by":"crossref","first-page":"H1978","DOI":"10.1152\/ajpheart.01318.2007","article-title":"Sympathy for the devil: the role of thromboxane in the regulation of vascular tone and blood pressure","volume":"294","author":"Sellers","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.brainres.2014.09.022_bib54","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/jcbfm.1993.108","article-title":"Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat","volume":"13","author":"Sharkey","year":"1993","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2014.09.022_bib55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2174\/092986708783497337","article-title":"Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging","volume":"15","author":"Slemmer","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2014.09.022_bib56","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/ncpcardio0214","article-title":"Drug insight: cyclo-oxygenase 2 inhibitors and cardiovascular risk--where are we now?","volume":"2","author":"Spektor","year":"2005","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.brainres.2014.09.022_bib57","doi-asserted-by":"crossref","first-page":"C1073","DOI":"10.1152\/ajpcell.1996.271.4.C1073","article-title":"ET-1 induces IL-6 gene expression in human umbilical vein endothelial cells: synergistic effect of IL-1","volume":"271","author":"Stankova","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2014.09.022_bib58","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1096\/fj.10-161612","article-title":"Endothelin-1 gene regulation","volume":"25","author":"Stow","year":"2011","journal-title":"FASEB J."},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2014.09.022_bib59","doi-asserted-by":"crossref","first-page":"S332","DOI":"10.1097\/01.fjc.0000166267.17174.0e","article-title":"Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells","volume":"44","author":"Sugiyama","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.brainres.2014.09.022_bib60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3171\/jns.1992.77.1.0096","article-title":"The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage","volume":"77","author":"Suzuki","year":"1992","journal-title":"J. Neurosurg."},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2014.09.022_bib61","first-page":"220","article-title":"The role of eicosanoids in the brain","volume":"17","author":"Tassoni","year":"2008","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.brainres.2014.09.022_bib62","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jnc.12244","article-title":"Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells","volume":"126","author":"Urrutia","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2014.09.022_bib63","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/01.WCB.0000073905.87928.6D","article-title":"Heme and iron metabolism: role in cerebral hemorrhage","volume":"23","author":"Wagner","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2014.09.022_bib64","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/brain\/awm095","article-title":"Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage","volume":"130","author":"Wang","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2014.09.022_bib65","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20101825","article-title":"Regulation of cellular iron metabolism","volume":"434","author":"Wang","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2014.09.022_bib66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/rej.2013.1450","article-title":"Calorie restriction down-regulates expression of the iron regulatory hormone hepcidin in normal and d-galactose-induced aging mouse brain","volume":"17","author":"Wei","year":"2014","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.brainres.2014.09.022_bib67","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1179\/016164111X12881719352534","article-title":"Novel therapy approach in primary stroke prevention: simultaneous inhibition of endothelin converting enzyme and neutral endopeptidase in spontaneously hypertensive, stroke-prone rats improves survival","volume":"33","author":"Wengenmayer","year":"2011","journal-title":"Neurol. Res."},{"key":"10.1016\/j.brainres.2014.09.022_bib68","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/01.RES.0000066663.12256.B2","article-title":"Functional roles of the rho\/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm","volume":"92","author":"Wickman","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.brainres.2014.09.022_bib69","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.expneurol.2006.04.012","article-title":"An analysis of four different methods of producing focal cerebral ischemia with endothelin-1 in the rat","volume":"201","author":"Windle","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2014.09.022_bib70","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3858\/emm.2011.43.2.020","article-title":"Iron mediates endothelial cell damage and blood\u2013brain barrier opening in the hippocampus after transient forebrain ischemia in rats","volume":"43","author":"Won","year":"2011","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.brainres.2014.09.022_bib71","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphar.2014.00034","article-title":"The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body","volume":"5","author":"Worthen","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainres.2014.09.022_bib72","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1021\/bi1004798","article-title":"Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease","volume":"49","author":"Ye","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2014.09.022_bib73","doi-asserted-by":"crossref","first-page":"698313","DOI":"10.1155\/2014\/698313","article-title":"Interleukin 6 and rheumatoid arthritis","volume":"2014","author":"Yoshida","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.brainres.2014.09.022_bib74","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1182\/blood-2014-01-550467","article-title":"Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype","volume":"123","author":"Zumerle","year":"2014","journal-title":"Blood"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314012335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899314012335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:54:38Z","timestamp":1757786078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899314012335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":74,"alternative-id":["S0006899314012335"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2014.09.022","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2014.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}