{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:37:52Z","timestamp":1791261472605,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.brainres.2015.03.007","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T17:00:28Z","timestamp":1426093228000},"page":"160-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy"],"prefix":"10.1016","volume":"1623","author":[{"given":"Kelsey","family":"Duncan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel S.","family":"Gonzales-Portillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar V.","family":"Borlongan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2015.03.007_bib44","doi-asserted-by":"crossref","first-page":"e90953","DOI":"10.1371\/journal.pone.0090953","article-title":"Combination therapy of human umbilical cord blood cells and granulocytecolony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury","volume":"9","author":"Acosta","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2015.03.007_bib5","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/brain\/awr094","article-title":"Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain","volume":"134","author":"Andres","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2015.03.007_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.expneurol.2011.05.016","article-title":"Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injury","volume":"231","author":"Barha","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2015.03.007_bib30","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1634\/stemcells.2008-0519","article-title":"Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines","volume":"26","author":"Barkho","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.brainres.2015.03.007_bib1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/leu.2011.167","article-title":"Bone marrow stem cell mobilization in stroke: a \u2018bonehead\u2019 may be good after all!","volume":"25","author":"Borlongan","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.brainres.2015.03.007_bib22","first-page":"e331","article-title":"Apoptotic mechanisms after cerebral ischemia","volume":"40","author":"Broughton","year":"2009","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.brainres.2015.03.007_bib41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0006-8993(00)03133-4","article-title":"Fetal intra-nigral ventral mesencephalon and kidney tissue bridge transplantation restores the nigrostriatal dopamine pathway in hemi-parkinsonian rats","volume":"889","author":"Chiang","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2015.03.007_bib38","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.biochi.2013.06.020","article-title":"The stem cell secretome and its role in brain repair","volume":"95","author":"Drago","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.brainres.2015.03.007_bib40","first-page":"228","article-title":"Prevalence of stroke\u2014United States","volume":"2012","author":"Fang","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.brainres.2015.03.007_bib25","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.brainres.2015.03.007_bib26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2147","article-title":"How widespread is adult neurogenesis in mammals?","volume":"8","author":"Gould","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2015.03.007_bib23","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1161\/01.STR.0000101752.23813.C3","article-title":"Tissue plaminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety data","volume":"34","author":"Graham","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2015.03.007_bib9","doi-asserted-by":"crossref","first-page":"15921","DOI":"10.1073\/pnas.1010209107","article-title":"Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats","volume":"107","author":"Hargus","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S A"},{"key":"10.1016\/j.brainres.2015.03.007_bib29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nn.3706","article-title":"The age and genomic integrity of neurons after cortical stroke in humans","volume":"17","author":"Huttner","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2015.03.007_bib3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature09603","article-title":"Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice","volume":"469","author":"Jackeslioff","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2015.03.007_bib37","first-page":"8","article-title":"Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and aniogenesis","volume":"22","author":"Jul-Yu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2015.03.007_bib8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/stem.294","article-title":"Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival","volume":"28","author":"Lee","year":"2010","journal-title":"Stem. Cells"},{"key":"10.1016\/j.brainres.2015.03.007_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm1548","article-title":"Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease","volume":"13","author":"Lee","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2015.03.007_bib32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2013.05.006","article-title":"Role of HIF-1alpha-activated Epac1 on HSC-mediated neuroplasticity in stroke model","volume":"58C","author":"Lin","year":"2013","journal-title":"Nerobiol. Dis."},{"key":"10.1016\/j.brainres.2015.03.007_bib6","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/STROKEAHA.110.607226","article-title":"Bone marrow stromal cells promote skilled motor recovery and enhance contralesional axonal connections after ischemic stroke in adult mice","volume":"42","author":"Liu","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2015.03.007_bib39","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/CIRCULATIONAHA.109.192667","article-title":"Heart disease and stroke statistics\u20142010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2015.03.007_bib7","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1111\/j.1460-9568.2009.07006.x","article-title":"Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington\u05f3s disease","volume":"30","author":"Mazzocchi-Jones","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2015.03.007_bib21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.biocel.2014.08.003","article-title":"Endogenous neurogenesis following ischaemic brain injury: insights for therapeutic strategies","volume":"56","author":"Merson","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2015.03.007_bib11","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1002\/jcb.23216","article-title":"The therapeutic potential of bone marrow-derived stem cells","volume":"112","author":"Mezey","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainres.2015.03.007_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2015.03.007_bib43","doi-asserted-by":"crossref","first-page":"e2754","DOI":"10.1371\/journal.pone.0002754","article-title":"Arterially perfused neurosphere-derived cells distribute outside the ischemicore in a model of transient focal ischemia and reperfusion in vitro","volume":"3","author":"Pastori","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2015.03.007_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.expneurol.2005.12.011","article-title":"A conditionally immortal clonal stem cell line form human cortical neuroepithelium for the treatment of ischemic stroke","volume":"199","author":"Pollock","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2015.03.007_bib17","doi-asserted-by":"crossref","first-page":"12175","DOI":"10.1073\/pnas.0704091104","article-title":"Behavioral improvement in a primate Parkinson\u05f3s model is associated with multiple homeostatic effects of human neural stem cells","volume":"104","author":"Redmond","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2015.03.007_bib20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature10487","article-title":"Corridors of migrating neurons in the human brain and their decline during infancy","volume":"478","author":"Sanai","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2015.03.007_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.canlet.2011.07.001","article-title":"Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer","volume":"311","author":"Seol","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.brainres.2015.03.007_bib42","doi-asserted-by":"crossref","first-page":"11663","DOI":"10.1073\/pnas.94.21.11663","article-title":"Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex","volume":"94","author":"Snyder","year":"1997","journal-title":"Proc.Nati.Acad.Sci.USA"},{"key":"10.1016\/j.brainres.2015.03.007_bib31","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/jnr.23068","article-title":"Temporal profile of molecular signatures associated with circulating endothelial progenitor cells in human ischemic stroke","volume":"90","author":"Sobrino","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2015.03.007_bib35","first-page":"322","article-title":"Neural repair and neuroprotection with stem cells in ischemic stroke","volume":"25","author":"Stone","year":"2013","journal-title":"Brain Sci."},{"key":"10.1016\/j.brainres.2015.03.007_bib19","doi-asserted-by":"crossref","first-page":"e74857","DOI":"10.1371\/journal.pone.0074857","article-title":"Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site","volume":"8","author":"Tajiri","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2015.03.007_bib4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/jcbfm.2010.138","article-title":"Tumor necrosis factor \u03b1 primes cerebral endothelia cells for erythropoietin-induced angiogenesis","volume":"31","author":"Wang","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2015.03.007_bib34","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1083\/jcb.201210152","article-title":"Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force","volume":"201","author":"Wolf","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2015.03.007_bib28","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.0149-06.2006","article-title":"Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum","volume":"26","author":"Yamashita","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2015.03.007_bib10","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1002\/stem.767","article-title":"Significance of remyelination by neural stem\/progenitor cells transplanted into the injured spinal cord","volume":"29","author":"Yasuda","year":"2011","journal-title":"Stem Cell"},{"key":"10.1016\/j.brainres.2015.03.007_bib12","doi-asserted-by":"crossref","first-page":"12497","DOI":"10.1523\/JNEUROSCI.3719-06.2006","article-title":"Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson\u05f3s disease","volume":"26","author":"Yasuhara","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2015.03.007_bib13","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/jcbfm.2008.68","article-title":"Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats","volume":"28","author":"Yasuhara","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2015.03.007_bib15","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1089\/scd.2009.0011","article-title":"Notch induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals","volume":"18","author":"Yasuhara","year":"2009","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.brainres.2015.03.007_bib36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nbd.2013.06.001","article-title":"Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-\u03b2","volume":"58","author":"Yoo","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2015.03.007_bib27","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/jcbfm.2009.55","article-title":"Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse","volume":"29","author":"Zhang","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2015.03.007_bib33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nm1387","article-title":"Role of matrix metalloproteinkinases in delayed cortical responses after stroke","volume":"12","author":"Zhao","year":"2006","journal-title":"Nat. Med."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899315001894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899315001894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:16:29Z","timestamp":1651450589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899315001894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":44,"alternative-id":["S0006899315001894"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2015.03.007","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2015.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}