{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:18:21Z","timestamp":1767863901443,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Educational Commission of Heilongjiang Province, China","award":["12541423"],"award-info":[{"award-number":["12541423"]}]},{"name":"Educational Commission of Heilongjiang Province, China","award":["2012RFXXS041"],"award-info":[{"award-number":["2012RFXXS041"]}]},{"name":"Sino-Russian Medical Research Center","award":["CR201418"],"award-info":[{"award-number":["CR201418"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372026"],"award-info":[{"award-number":["81372026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.brainres.2015.07.001","type":"journal-article","created":{"date-parts":[[2015,7,11]],"date-time":"2015-07-11T08:54:59Z","timestamp":1436604899000},"page":"292-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC"],"prefix":"10.1016","volume":"1622","author":[{"given":"Xia","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-9939","authenticated-orcid":false,"given":"Guonian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2015.07.001_bib1","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1073\/pnas.0437946100","article-title":"An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain","volume":"100","author":"Amiry-Moghaddam","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2015.07.001_bib2","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1161\/01.STR.27.9.1616","article-title":"Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model","volume":"27","author":"Belayev","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2015.07.001_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.lfs.2014.01.085","article-title":"Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia","volume":"100","author":"Bhattacharya","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2015.07.001_bib4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation-like state in mice","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.brainres.2015.07.001_bib5","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/nprot.2009.125","article-title":"The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice","volume":"4","author":"Bouet","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2015.07.001_bib6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1089\/neu.2008.0782","article-title":"The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat","volume":"27","author":"Fazzina","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2015.07.001_bib7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","article-title":"Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation","volume":"26","author":"Garcia","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2015.07.001_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12031-014-0284-9","article-title":"Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia","volume":"54","author":"Gheibi","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2015.07.001_bib9","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1074\/jbc.273.11.6001","article-title":"Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation","volume":"273","author":"Han","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2015.07.001_bib10","doi-asserted-by":"crossref","first-page":"11790","DOI":"10.1073\/pnas.0604400103","article-title":"Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury","volume":"103","author":"Ikeda-Matsuo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2015.07.001_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00395-005-0569-9","article-title":"Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels","volume":"101","author":"Johansen","year":"2006","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.brainres.2015.07.001_bib12","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/jcbfm.2012.65","article-title":"Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia","volume":"32","author":"Joseph","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2015.07.001_bib13","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2015.07.001_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainres.2015.07.001_bib15","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/hipo.20211","article-title":"Ischemia-induced modifications in hippocampal CA1 stratum radiatum excitatory synapses","volume":"16","author":"Kovalenko","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainres.2015.07.001_bib16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/STROKEAHA.112.667832","article-title":"High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke","volume":"44","author":"Lapergue","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2015.07.001_bib17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/01.PCC.0000298639.08519.0C","article-title":"Effect of inhaled hydrogen sulfide on metabolic responses in anesthetized, paralyzed, and mechanically ventilated piglets","volume":"9","author":"Li","year":"2008","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.brainres.2015.07.001_bib18","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1007\/s11064-011-0502-6","article-title":"protective effects of exogenous hydrogen sulfide on neurons of hippocampus in a rat model of brain ischemia","volume":"36","author":"Li","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2015.07.001_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(91)91094-H","article-title":"Reduction of protein kinase C activity in the adult rat brain following transient forebrain ischemia","volume":"541","author":"Louis","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2015.07.001_bib20","first-page":"4","article-title":"Hydrogen sulfide (H2S) \u2013 the third gas of interest for pharmacologists","volume":"59","author":"Lowicka","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.brainres.2015.07.001_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/72256","article-title":"Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke","volume":"6","author":"Manley","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2015.07.001_bib22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuroscience.2004.06.088","article-title":"New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice","volume":"129","author":"Manley","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2015.07.001_bib23","doi-asserted-by":"crossref","first-page":"32124","DOI":"10.1074\/jbc.M112.374124","article-title":"A novel hydrogen sulfide-releasing N-methyl-d-aspartate receptor antagonist prevents ischemic neuronal death","volume":"287","author":"Marutani","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2015.07.001_bib24","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuroscience.2009.09.020","article-title":"Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion","volume":"168","author":"McCoy","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2015.07.001_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2015.07.001_bib26","doi-asserted-by":"crossref","first-page":"C169","DOI":"10.1152\/ajpcell.00282.2007","article-title":"H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes","volume":"294","author":"Pan","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.brainres.2015.07.001_bib27","first-page":"242","article-title":"Aquaporin water channels and brain edema","volume":"69","author":"Papadopoulos","year":"2002","journal-title":"Mt. Sinai. J. Med."},{"key":"10.1016\/j.brainres.2015.07.001_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0161-813X(01)00021-3","article-title":"Neurotoxicological effects associated with short-term exposure of Sprague\u2013Dawley rats to hydrogen sulfide","volume":"22","author":"Struve","year":"2001","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.brainres.2015.07.001_bib29","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1038\/jcbfm.2013.148","article-title":"Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat","volume":"33","author":"Sutherland","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2015.07.001_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2012.09.029","article-title":"Beneficial effects of carbamylated erythropoietin against oxygen\u2013glucose deprivation\/reperfusion-induced astrocyte swelling: proposed molecular mechanisms of action","volume":"530","author":"Tang","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2015.07.001_bib31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/ALN.0b013e318167af0d","article-title":"Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse","volume":"108","author":"Volpato","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2015.07.001_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbr.2010.01.026","article-title":"Neuroprotective effects of progesterone following stroke in aged rats","volume":"209","author":"Wang","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2015.07.001_bib33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jnc.12695","article-title":"Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia","volume":"129","author":"Wang","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2015.07.001_bib34","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00134-012-2714-x","article-title":"Effects of exogenous hydrogen sulfide on brain metabolism and early neurological function in rabbits after cardiac arrest","volume":"38","author":"Wei","year":"2012","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.brainres.2015.07.001_bib35","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats","volume":"1491","author":"Yin","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2015.07.001_bib36","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuroscience.2009.10.029","article-title":"Regulation of water permeability through aquaporin-4","volume":"168","author":"Yukutake","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2015.07.001_bib37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-540-79885-9_7","article-title":"Role of aquaporin-4 in cerebral edema and stroke","volume":"190","author":"Zador","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.brainres.2015.07.001_bib38","first-page":"F309","article-title":"Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine","volume":"283","author":"Zelenina","year":"2002","journal-title":"Am. J. Physiol.: Ren. Physiol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899315005119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899315005119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T03:59:50Z","timestamp":1668571190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899315005119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":38,"alternative-id":["S0006899315005119"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2015.07.001","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2015.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}