{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:00:03Z","timestamp":1792112403998,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Prof. J.S.P Rai, Director General, Bharat Institute of Technology"},{"name":"Bharat Institute of Technology, Meerut, India"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.brainres.2015.10.052","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T01:56:02Z","timestamp":1447120562000},"page":"83-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"special_numbering":"C","title":["Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats"],"prefix":"10.1016","volume":"1630","author":[{"given":"Hariom","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-007X","authenticated-orcid":false,"given":"Bhupesh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2015.10.052_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12640-011-9264-9","article-title":"Effect of aspartame on oxidative stress and monoamine neurotransmitter levels in lipopolysaccharide-treated mice","volume":"21","author":"Abdel-Salam","year":"2012","journal-title":"Neurotoxic. Res."},{"key":"10.1016\/j.brainres.2015.10.052_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000362645","article-title":"The ketogenic diet modifies social and metabolic alterations identified in the pre vpa model of autism spectrum disorder","volume":"36","author":"Ahn","year":"2014","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainres.2015.10.052_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tox.2007.11.003","article-title":"Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity","volume":"244","author":"Ahuja","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.brainres.2015.10.052_bib4","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.brainres.2015.10.052_bib5","first-page":"586","article-title":"Gastroprotective effect of minocycline in experimentally induced gastric ulcers in rats","volume":"7","author":"Asmari","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.brainres.2015.10.052_bib6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/jmg.2008.061796","article-title":"Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model","volume":"46","author":"Bilousova","year":"2009","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.brainres.2015.10.052_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/650382","article-title":"Disruption of the serotonergic system after neonatal hypoxia-ischemia in a rodent model","author":"Buller","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.brainres.2015.10.052_bib8","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1523\/JNEUROSCI.5182-14.2015","article-title":"Idiosyncratic brain activation patterns are associated with poor social comprehension in autism","volume":"35","author":"Byrge","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2015.10.052_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1471-4159.2011.07189.x","article-title":"Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism","volume":"117","author":"Chauhan","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2015.10.052_bib10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbi.2013.12.004","article-title":"Intestinal inflammation in a murine model of autism spectrum disorders","volume":"37","author":"de Theije","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2015.10.052_bib71","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-014-0189-0","article-title":"GABAergic\/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders","author":"El-Ansary","year":"2014","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.brainres.2015.10.052_bib11","first-page":"1302","article-title":"PET and SPECT scans in autistic children","volume":"143","author":"Galuska","year":"2002","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.brainres.2015.10.052_bib12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bcp.2008.11.003","article-title":"Inhibitory modulation of the mitochondrial permeability transition by minocycline","volume":"77","author":"Gieseler","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2015.10.052_bib13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.neuropharm.2012.07.028","article-title":"Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3\u03b2\/\u03b2-catenin pathway","volume":"63","author":"Go","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2015.10.052_bib14","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1111\/j.1460-9568.2007.05873.x","article-title":"Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons","volume":"26","author":"Gonz\u00e1lez","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2015.10.052_bib15","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.ridd.2014.03.037","article-title":"Sleep patterns in children with and without autism spectrum disorders: developmental comparisons","volume":"35","author":"Hodge","year":"2014","journal-title":"Res. Dev. Disabil."},{"key":"10.1016\/j.brainres.2015.10.052_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/15376516.2013.821567","article-title":"Toxicity of valproic acid in isolated rat liver mitochondria","volume":"23","author":"Jafarian","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.brainres.2015.10.052_bib17","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuint.2009.06.001","article-title":"Minocycline attenuates oxidative\/nitrosative stress and cerebral complications of acute liver failure in rats","volume":"55","author":"Jiang","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2015.10.052_bib18","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2174\/18715273113126660170","article-title":"A friend in need may not be a friend indeed: role of microglia in neurodegenerative diseases","volume":"12","author":"Kaushik","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.brainres.2015.10.052_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5487\/TR.2013.29.3.173","article-title":"GIT abnormalities induced by pre vpa exposure in rat offspring","volume":"29","author":"Kim","year":"2013","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.brainres.2015.10.052_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.toxlet.2010.12.018","article-title":"The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats","author":"Kim","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.brainres.2015.10.052_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000108590","article-title":"Dual action of nitric oxide in the pathogenesis of ischemia\/reperfusion-induced mucosal injury in mouse stomach","volume":"75","author":"Kobata","year":"2007","journal-title":"Digestion"},{"key":"10.1016\/j.brainres.2015.10.052_bib22","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S1734-1140(12)70907-6","article-title":"Potential role of licofelone, minocycline and their combination against chronic fatigue stress induced behavioral, biochemical and mitochondrial alterations in mice","volume":"64","author":"Kumar","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.brainres.2015.10.052_bib23","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(13)61539-1","volume":"383","author":"Lai","year":"2014","journal-title":"Autism Lancet"},{"key":"10.1016\/j.brainres.2015.10.052_bib24","first-page":"5","article-title":"Minocycline protects against NLRP3 inflammasome-induced inflammation and P53-associated apoptosis in early brain injury after subarachnoid hemorrhage","author":"Li","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2015.10.052_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2013.11.031","article-title":"The protective effect of HET0016 on brain edema and blood\u2013brain barrier dysfunction after cerebral ischemia\/reperfusion","volume":"1544","author":"Liu","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2015.10.052_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/aur.1338","article-title":"Altered peripheral and central inflammatory responses in a mouse model of autism","volume":"7","author":"Lucchina","year":"2014","journal-title":"Autism Res."},{"key":"10.1016\/j.brainres.2015.10.052_bib27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jneumeth.2010.12.013","article-title":"Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood\u2013brain barrier in a mice hemorrhage model","volume":"195","author":"Manaenko","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2015.10.052_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.nbd.2006.09.008","article-title":"Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline","volume":"25","author":"M\u00e5nsson","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2015.10.052_bib29","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.npp.1301453","article-title":"Abnormal fear conditioning and amygdala processing in an animal model of autism","volume":"33","author":"Markram","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2015.10.052_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10802-012-9668-x","article-title":"Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders","volume":"41","author":"Mazurek","year":"2013","journal-title":"J. Abnorm. Child Psychol."},{"key":"10.1016\/j.brainres.2015.10.052_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbr.2014.01.008","article-title":"Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: similarities to autism spectrum disorders","volume":"263","author":"Merali","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2015.10.052_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbi.2013.06.001","article-title":"Evidence for TNF\u03b1 action on excitatory and inhibitory neurotransmission in the central amygdala: a brain site influenced by stress","volume":"33","author":"Ming","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2015.10.052_bib33","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.neuint.2009.07.006","article-title":"Understanding the molecular mechanism of blood\u2013brain barrier damage in an experimental model of Japanese encephalitis: correlation with minocycline administration as a therapeutic agent","volume":"55","author":"Mishra","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2015.10.052_bib34","doi-asserted-by":"crossref","first-page":"18549","DOI":"10.1074\/jbc.M114.555334","article-title":"Brain-derived neurotrophic factor (BDNF) induces sustained intracellular Ca2+ elevation through the up-regulation of surface transient receptor potential 3 (TRPC3) channels in rodent microglia","volume":"289","author":"Mizoguchi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2015.10.052_bib35","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1177\/0269881113503506","article-title":"Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: possible involvement of antioxidant and nitrergic pathways","volume":"11","author":"Monte","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.brainres.2015.10.052_bib36","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1471-4159.2005.03520.x","article-title":"Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia","volume":"96","author":"Nikodemova","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2015.10.052_bib37","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.biopsych.2012.05.004","article-title":"Levels of soluble platelet endothelial cell adhesion molecule-1 and P-selectin are decreased in children with autism spectrum disorder","volume":"72","author":"Onore","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2015.10.052_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2377-10-91","article-title":"Open-label add-on treatment trial of minocycline in fragile X syndrome","volume":"10","author":"Paribello","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.brainres.2015.10.052_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/15622975.2015.1036116","article-title":"Inhibition of brain retinoic acid catabolism: a mechanism for minocycline\u05f3s pleiotropic actions?","volume":"5","author":"Regen","year":"2015","journal-title":"World J. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.brainres.2015.10.052_bib40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5014\/ajot.48.2.113","article-title":"Play and preschool children with autism","volume":"48","author":"Restall","year":"1994","journal-title":"Am. J. Occup. Ther."},{"key":"10.1016\/j.brainres.2015.10.052_bib41","doi-asserted-by":"crossref","first-page":"17151","DOI":"10.1073\/pnas.0806682105","article-title":"Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation","volume":"105","author":"Riazi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2015.10.052_bib42","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1073\/pnas.0704391104","article-title":"Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid","volume":"104","author":"Rinaldi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2015.10.052_bib43","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/cercor\/bhm117","article-title":"Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid","volume":"4","author":"Rinaldi","year":"2008","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2015.10.052_bib44","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.expneurol.2005.12.016","article-title":"Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood\u2013brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus","volume":"198","author":"Ryu","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2015.10.052_bib45","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s11064-012-0717-1","article-title":"Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats","volume":"37","author":"Sandhya","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2015.10.052_bib46","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2015.10.052_bib47","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.npp.1300767","article-title":"Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism","volume":"31","author":"Schneider","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.brainres.2015.10.052_bib72","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.neurobiolaging.2009.03.004","article-title":"New evidences for fractalkine\/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease","volume":"32","author":"Shan","year":"2011","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.brainres.2015.10.052_bib48","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.physbeh.2015.02.009","article-title":"Melatonin receptor and KATP channel modulation in experimental vascular dementia","volume":"142","author":"Singh","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2015.10.052_bib49","first-page":"166","article-title":"Ultrastructural study of cerebellar dentate nucleus astrocytes in chronic experimental model with valproate","volume":"43","author":"Sobaniec-\u0141otowska","year":"2005","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.brainres.2015.10.052_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0940-2993(96)80094-7","article-title":"Morphological features of encephalopathy after chronic administration of the antiepileptic drug valproate to rats. A transmission electron microscopic study of capillaries in the cerebellar cortex","volume":"48","author":"Sobaniec-Lotowska","year":"1999","journal-title":"Exp. Toxicol. Pathol."},{"issue":"132","key":"10.1016\/j.brainres.2015.10.052_bib51","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1542\/peds.2012-3774","article-title":"Psychotropic medication use and polypharmacy in children with autism spectrum disorders","volume":"2013","author":"Spencer","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.brainres.2015.10.052_bib52","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1111\/j.1460-9568.2005.04483.x","article-title":"Long-term changes in blood\u2013brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat","volume":"22","author":"Stolp","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2015.10.052_bib53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","article-title":"Microglial activation in young adults with autism spectrum disorder","volume":"70","author":"Suzuki","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.brainres.2015.10.052_bib54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1352\/1944-7558-115.5.433","article-title":"Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures","volume":"115","author":"Utari","year":"2010","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"10.1016\/j.brainres.2015.10.052_bib55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13229-015-0004-5","article-title":"Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins","volume":"6","author":"Werling","year":"2015","journal-title":"Mol. Autism"},{"key":"10.1016\/j.brainres.2015.10.052_bib56","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S1740925X05000104","article-title":"Minocycline attenuates nitric oxide-mediated neuronal and axonal destruction in vitro","volume":"1","author":"Wilkins","year":"2004","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.brainres.2015.10.052_bib57","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1001\/archneur.63.8.1161","article-title":"Altered vascular phenotype in autism: correlation with oxidative stress","volume":"63","author":"Yao","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2015.10.052_bib58","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/01.STR.0000206281.77178.ac","article-title":"Microglia potentiate damage to blood\u2013brain barrier constituents: improvement by minocycline in vivo and in vitro","volume":"37","author":"Yenari","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2015.10.052_bib59","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2011.12.012","article-title":"Acute ethanol treatment reduces blood\u2013brain barrier dysfunction following ischemia\/reperfusion injury","volume":"1437","author":"Zeng","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2015.10.052_bib60","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nbd.2006.11.012","article-title":"TNF-alpha knockout and minocycline treatment attenuates blood\u2013brain barrier leakage in MPTP-treated mice","volume":"26","author":"Zhao","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2015.10.052_bib61","article-title":"Minocycline and risperidone prevent microglia activation and rescue behavioral deficits induced by neonatal intrahippocampal injection of lipopolysaccharide in rats","author":"Zhu","year":"2014","journal-title":"PLoS One."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899315008392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899315008392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T07:15:31Z","timestamp":1567322131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899315008392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":63,"alternative-id":["S0006899315008392"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2015.10.052","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2015.10.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}